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| | British Journal of Pharmacology - Vasoconstriction is determined by interstitial rather than circulating angiotensin II (Site not responding. Last check: 2007-10-10) |
 | | Neither the vasoconstrictor metabolites Ang III and IV (Li et al., 1995), nor the vasodilator metabolite Ang-(1 − 7) (Ferrario et al., 1997; Tom et al., 2001) were present in detectable amounts. |
 | | For instance, previous in-vivo (Siragy et al., 1995; Dell'italia et al., 1997) and in-vitro (de lannoy et al., 1997; 1998) studies have shown that interstitial fluid Ang II may be higher than circulating Ang II. |
 | | Taken together, the similar potencies of Ang I and II in the present and previous studies (Danser et al., 1995; Maassenvandenbrink et al., 1999; Saris et al., 2000), can be fully explained on the basis of the interstitial Ang II levels that are reached in the vessel wall during Ang I and II application. |
| www.nature.com /bjp/journal/v135/n1/full/0704452a.html (5949 words) |
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