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Topic: Alanine transaminase


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In the News (Mon 16 Nov 09)

  
 [No title]   (Site not responding. Last check: 2007-10-13)
279 : Q5KXX9_GEOKA 0.37 0.44 16 389 22 392 364 5 17 393 Q5KXX9 Aspartate transaminase (Transaminase A) (280 : Q5KXX9_GEOKA 0.37 0.44 404 777 22 392 364 5 17 393 Q5KXX9 Aspartate transaminase (Transaminase A) (281 : Q8PW02_METMA 0.36 0.43 16 388 29 390 362 4 11 394 Q8PW02 Aspartate aminotransferase (EC 2.6.1.1).
355 : Q5KXX9_GEOKA 0.36 0.43 780 1171 4 392 382 5 17 393 Q5KXX9 Aspartate transaminase (Transaminase A) (356 : Q8Q094_METMA 0.36 0.41 779 1168 5 379 374 7 17 380 Q8Q094 Aspartate aminotransferase (EC 2.6.1.1).
572 : AAT_RICCN 0.34 0.38 406 772 25 394 357 6 23 401 Q92JE7 Aspartate aminotransferase (EC 2.6.1.1) (573 : Q795M6_BACSU 0.34 0.41 18 388 22 384 360 7 14 386 Q795M6 Alanine transaminase.
www.infobiogen.fr /db/hssp/1xi9.hssp   (15924 words)

  
 Nitrogen Metabolism and the Urea Cycle
Alanine transaminase has an important function in the delivery of skeletal muscle carbon and nitrogen (in the form of alanine) to the liver.
In the liver alanine transaminase tranfers the ammonia to
This reaction is catalyzed by alanine transaminase, ALT.
web.indstate.edu /thcme/mwking/nitrogen-metabolism.html   (4052 words)

  
 Responses - Alanine Transaminase and ALS   (Site not responding. Last check: 2007-10-13)
She has been told that she cannot receive the treatment of choice due to her level of alanine transaminase which is 56.
Alanine transaminase is an enzyme that is located both in liver and in muscle and can be elevated in diseases that effect either.
To my knowledge, there would be no reason that an alanine transaminase level of 56 would prohibit anyone from receiving Riluzole or Myotrophin for treatment of ALS.
www.mdausa.org /experts/question.cfm?id=1069&disease=66   (208 words)

  
 Process and reagent for the determination of transaminase - Patent 4728604
Composition useful in determining the presence of a transaminase comprising D-lactate dehydrogenase obtained from a lactic acid producing bacteria, alpha-oxoglutarate, an amino acid selected from the group consisting of alanine and aspartate, NADH and a buffer at a pH from 6.5 to 8.5.
Composition of claim 8, comprising from 250 to 20,000 U/l D-lacetate dehydrogenase, from 2.5 to 100 mMol/l alpha-oxoglutarate, from 50 to 1,000 mMol/l alanine, from 0.1 to 0.25 mMol/l NADH, and from 10 to 500 mMol/l of a buffer of pH from 6.5 to 8.5.
Composition of claim 9 comprising from 250 to 20,000 U/l D-lactate dehydrogenase from 2.5 to 100 mMol/l of alpha-oxoglutarate, from 20 to 1,000 mMol/l aspartate, from 0.01 to 0.25 mMol/l NADH, from 100 to 20,000 U/l malate dehydrogenase, and from 10 to 500 mMol/l of a buffer of pH from 6.5 to 8.5.
www.freepatentsonline.com /4728604.html   (1977 words)

  
 alanine on Encyclopedia.com
Alanine is not essential to the human diet, since it can be synthesized from other cellular metabolites.
Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the West of Scotland Coronary Prevention Study.(Pathophysiology)
Glutamine and Alanine Kinetics in Humans: Role of the Liver.
www.encyclopedia.com /html/a1/alanine.asp   (511 words)

  
 ALT   (Site not responding. Last check: 2007-10-13)
This test determines the level of the enzyme alanine transaminase (ALT) in the blood.
ALT is an enzyme that takes part in the metabolism (chemical processing by the body) of the amino acid, alanine.
ALT is present in many different kinds of tissue in the body.
www.northmemorial.com /HealthEncyclopedia/content/1031.asp   (306 words)

  
 Amino Acid Metabolism
Alanine is transferred to the circulation by many tissues, but mainly by muscle, in which alanine is formed from pyruvate at a rate proportional to intracellular pyruvate levels.
The key feature of the cycle is that in 1 molecule, alanine, peripheral tissue exports pyruvate and ammonia (which are potentially rate-limiting for metabolism) to the liver, where the carbon skeleton is recycled and most nitrogen eliminated.
Alanine is also important in intertissue nitrogen transport as part of the glucose-alanine cycle.
web.indstate.edu /thcme/mwking/amino-acid-metabolism.html   (3753 words)

  
 dializedabs abstract   (Site not responding. Last check: 2007-10-13)
Thus, presumably due to the action of alanine transaminase, there is a rapid exchange, essentially complete, between the hydrogens of the amino acid and the hydrogens of body water.
O, resulted in a gradual decline in the enrichment of alanine from albumin, while the enrichments in plasma free alanine and body water were negligible.
The fractional rate of synthesis of albumin, calculated from the increase in the enrichment in the alanine from the plasma albumin, was 4.0 ± 0.5%/day and calculated from the rate of decrease of enrichment 4.6 ± 0.2%/day.
www.cwru.edu /artsci/math/alexander/abstracts/dializedabs.html   (228 words)

  
 Common Liver Function Tests
This test measures the level of alanine aminotransferase (an enzyme found predominantly in the liver) that is released into the bloodstream after acute liver cell damage.
This test measures the level of aspartate transaminase (an enzyme that is found in the liver, kidneys, pancreas, heart, skeletal muscle, and red blood cells) that is released into the bloodstream after liver or heart problems.
This test measures the level of gamma-glutamyl transpeptidase (an enzyme that is produced in the liver, pancreas, and biliary tract).
www.healthsystem.virginia.edu /uvahealth/adult_liver/tests.cfm   (497 words)

  
 References - glyoxylate and aminotransferase - HORT640 - Metabolic Plant Physiology - Department of Horticulture and ...
Plant J. Liepman AH, Olsen LJ 2003 Alanine aminotransferase homologs catalyze the glutamate:glyoxylate aminotransferase reaction in peroxisomes of Arabidopsis.
Takada Y, Noguchi T 1985 Characteristics of alanine: glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates.
Watts RW 1992 Alanine glyoxylate aminotransferase deficiency: biochemical and molecular genetic lessons from the study of a human disease.
web.ics.purdue.edu /~drhodes/hort640c/referen/glyoxat.htm   (1573 words)

  
 Liver Function Tests
Sometimes liver function tests are referred to as a liver panel and they typically measure: alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), albumin, total protein, and total and direct bilirubin.
Alanine transaminase is an enzyme that plays a role in processing proteins, and it's found in the liver, heart, muscles, and kidneys.
Aspartate transaminase is an enzyme that plays a role in metabolism, the process that converts the fuel from food into energy the body needs.
kidshealth.org /parent/general/sick/labtest6.html   (459 words)

  
 Method for determination of transaminases and relative diagnostic kit - Patent 4329425
The method according to claim 1 in which the total GOT and GPT transaminase activity is determined by determining the change in ultraviolet absorbance after reaction of the transaminase in the serum or plasma with both of said substrates.
The decrease of extinction at 340 nm represents a measure of the quantity of the pyruvic acid produced and, as a consequence, of the activities of both transaminases.
In this case, the decrease of extinction is in direct relationship to the amount of transformation of both alanine and cysteinsulfinic acid to pyruvic acid, respectively caused by GPT and GOT, and it will be a measure of the sum of the two enzymatic activities.
www.freepatentsonline.com /4329425.html   (1220 words)

  
 Tables
   Alanine transaminase (units/L)    Aspartate transaminase (units/L)    Alkaline phosphatase (units/L)    Lactate dehydrogenase (units/L) b
   Alanine transaminase (units/L)    Aspartate transaminase (units/L) -glutamyl transferase (units/L)    Alkaline phosphatase (units/L) c
Normal values: alanine transaminase, 0-35 units/ L; aspartate transaminase, 0-35 units/L; alkaline phosphatase, 30-114 units/L; lactate dehydrogenase, 118-242 units/L; total bilirubin, <1.2 mg/dL; direct bilirubin, <0.2 mg/dL;
www.medscape.com /content/2002/00/44/02/440227/440227_tab.html   (152 words)

  
 International Conference on Psychophysiology of Panic Attacks
It is understood that transaminases and alkaline phosphatase levels are increased during panic attacks.
This study examines the influence of examination stress during panic situation, on Aspartate transaminase, Alanine transaminase and alkaline phosphatase among students.
Aspartate transaminase and alanine transaminase enzymes were assayed by the method King (1965).
anxiety-panic.com /conference/c004ah.cfm   (302 words)

  
 Recombinant Human Alanine Aminotransferase (ALT/SGPT) - ENZ-280
Recombinant Alanine Aminotransferase produced in E.Coli is a single, non-glycosylated, polypeptide chain containing having a molecular mass of 54,479 Dalton.
Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus.
Strenuous physical labor is important as a cause of elevated alanine aminotransferase levels in Japanese patients with chronic hepatitis C viremia.
www.prospec.co.il /~prospec/cart/catalog/rALT.html   (368 words)

  
 A comparison in the progression of liver fibrosis in chronic hepatitis C between persistently normal and elevated ...
An estimated 20-30% of patients with chronic hepatitis C (HCV) infection have persistently normal alanine transaminase (PNALT).
Detectable serum hepatitis C virus (HCV) RNA in HCV patients with persistently normal alanine transaminase (PNALT) has been found to be associated with significant liver damage.
The primary outcome of this study was to compare the histological progression of fibrosis in patients with PNALT and elevated alanine transaminase (ALT).
www.natap.org /2003/april/042403_1.htm   (3445 words)

  
 Proton magnetic resonance studies of glutamate-alanine transaminase-catalyzed deuterium exchange. Evidence for proton ...
alanine which contains deuterium in the alpha position and hydrogen in
The two classes of deuterated alanine may conceivably arise by a
It is also postulated that alanine binds at the active site in such a way
www.jbc.org /cgi/content/abstract/251/4/1088   (456 words)

  
 Liver Testing Information below is from the Nemours Foundation and found on their website   (Site not responding. Last check: 2007-10-13)
The liver is a complex organ, located in the upper right corner of the abdomen, which has many vital roles.
Alanine transaminase is an enzyme that is important in the processing of proteins.
This enzyme is found in large amounts in the liver, and small amounts of this enzyme are also found in the heart, muscle, and kidney.
www.hi-schoolpharmacy.com /nwwellness/liver.htm   (532 words)

  
 Liver Functions -- Recommendations and Resources   (Site not responding. Last check: 2007-10-13)
The reference range is 30-50 g/L. Alanine transaminase (ALT)
Alanine transaminase (ALT), also called Serum Glutamic Pyruvic Transaminase (SGPT) or Alanine aminotransferrase (ALAT) is an enzyme present in hepatocytes (liver cells).
When a cell is damaged, it leaks this enzyme into the blood, where it is measured.
www.becomingapediatrician.com /health/86/liver-functions.html   (1158 words)

  
 AACE: Studies Reveal Good News Regarding Liver Safety of Pioglitazone   (Site not responding. Last check: 2007-10-13)
The first thiazolidinedione to be commercially introduced, troglitazone, was removed from the market on March 21, 2000, after the FDA reported it was investigating 63 confirmed fatalities involving the drug.
Continuing studies of troglitazone show increases in alanine transaminase levels of more than 3 times normal, indicating liver toxicity in significant numbers of troglitazone users.
In contrast, continuing studies of PIO show reductions of alanine transaminase levels in the overwhelming majority of type 2 patients.
www.pslgroup.com /dg/233352.htm   (504 words)

  
 Toxicity With Selective Serotonin Reuptake Inhibitors -- SOLOMONS et al. 162 (6): 1225 -- American Journal of Psychiatry
Investigations demonstrated elevated levels of liver enzymes: alanine transaminase, 378 µmol/liter (her level at admission was 26 µmol/liter); aspartate transaminase, 609 µmol/liter (her level at admission was 11 µmol/liter); lactic hydrogenase, 850 µmol/liter (her level at admission was 101 µmol/liter); and serum creatinine, 763 µmol/liter (her level at admission was 66 µmol/liter).
Liver enzyme levels decreased with fluvoxamine discontinuation but increased within 4 days of rechallenge, from an alanine transaminase level of 208 to 379 µmol/liter and an aspartate transaminase level of 121 to 181 µmol/liter.
Epigastric and right upper quadrant pain developed after 4 days of citalopram use, with the liver enzyme aspartate transaminase rising from 34 to 251 µmol/liter and alanine transaminase from 94 to 282 µmol/liter.
ajp.psychiatryonline.org /cgi/content/full/162/6/1225   (539 words)

  
 Dorlands Medical Dictionary   (Site not responding. Last check: 2007-10-13)
The enzyme can also act on γ-aminobutyrate and S-β-aminoisobutyrate; it has been listed as a secondary activity of the enzyme 4-aminobutyrate transaminase but may be a separate enzyme.
(ALT) (al´ə-nēn trans-am´ĭ-nās) [EC 2.6.1.2] an enzyme of the transferase class that catalyzes the reversible transfer of an amino group from alanine to &#945;-ketoglutarate to form glutamate and pyruvate, with pyridoxal phosphate as a cofactor.
Serum enzyme activity (SGPT) is greatly increased in liver disease and also elevated in infectious mononucleosis.
www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_a_21zPzhtm   (1370 words)

  
 A Brief Review of Alanine Aminotransferase Activity
The enzyme alanine aminotransferase (ALT) was previously known as serum glutamic pyruvic transaminase (SGPT).
ALT is a cytoplasmic enzyme that catalyzes the transamination of alpha-ketoglutarate and L-alanine, forming glutamate and pyruvate (Fig.
Enzymatic function of alanine aminotransferase in the transamination of alpha-ketoglutarate and L-alanine to glutamate and pyruvate
www.vet.uga.edu /vpp/CLERK/figlio   (1032 words)

  
 {omega}-Amino Acid:Pyruvate Transaminase from Alcaligenes denitrificans Y2k-2: a New Catalyst for Kinetic Resolution of ...
{omega}-Amino Acid:Pyruvate Transaminase from Alcaligenes denitrificans Y2k-2: a New Catalyst for Kinetic Resolution of {beta}-Amino Acids and Amines -- Yun et al.
90% of that in the absence of alanine.
Purification, characterization, and molecular cloning of a novel amine:pyruvate transaminase from Vibrio fluvialis JS17.
aem.asm.org /cgi/content/full/70/4/2529   (3121 words)

  
 Amino acid degradation
These two enzymes, alanine transaminase and aspartate transaminase, are also important in the diagnosis of heart attacks and liver diseases.
Therefore, elevated levels of alanine transaminase and aspartate transaminase in the serum are indicative of liver or heart damage.
In the absence of an amino acid substrate, PLP is covalently linked to the transaminase enzyme.
www.db.uth.tmc.edu /faculty/faculty/alevine/1521_2000/aadeg.htm   (811 words)

  
 AllRefer Health - ALT (Alanine Transaminase, Serum Glutamate Pyruvate Transaminase, SGPT) - Test/Medical Exams/Tests
A test that measures the amount of ALT in serum.
ALT is an enzyme involved in the metabolism of the amino acid alanine.
ALT is in a number of tissues but is in highest concentrations in the liver.
health.allrefer.com /health/alt-info.html   (305 words)

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