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Topic: Alaproclate

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	NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857.
		The increase in cGMP induced by harmaline (20 mg/kg subcutaneously) was dose-dependently antagonized by alaproclate (5-40 mg/kg subcutaneously).
		Alaproclate at 15 mg/kg subcutaneously blocked the increase in cGMP in cerebellum caused by NMDA itself at 200 mg/kg subcutaneously.
		In contrast to alaproclate, the K+ channel antagonist, 4-aminopyridine, 5 mg/kg subcutaneously, produced per se an increase in cGMP levels in the rat cerebellum by 300% which was antagonized by the NMDA receptor antagonists, dizocilpine, phencyclidine and (+/-)- CCP, the nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester and by alaproclate.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/978061.html (258 words)

	Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate (Site not responding. Last check: 2007-10-17)
		The present studies investigates the effects of a 5HT3-antagonist (ondansetron: 0.01, 0.1, 1, 10 micrograms), a 5HT2-antagonist (methysergide: 2, 10, 20 mg/kg) and a serotonin uptake inhibitor (alaproclate: 2, 10, 20 mg/kg) on the neocortical electrical activity of young scopolamine-treated and aged rats.
		The scopolamine (0.2 and 0.8 mg/kg)-induced increase in EEG spectral components was not reversed by ondansetron, methysergide or alaproclate.
		The HVS activity stabilizing effect of pilocarpine (2 mg/kg) was not enhanced by ondansetron, methysergide or alaproclate.
	www.uku.fi /neuro/ab9120.htm (225 words)

	The effects of increased serotonergic and decreased cholinergic activities on spatial navigation performance in rats. (Site not responding. Last check: 2007-10-17)
		PG - 25-9 AB - In the present set of experiments the effects of a serotonin (5-HT) reuptake blocker, alaproclate (alap) and of a muscarinic antagonist, scopolamine (scop) on place navigation (hidden platform) and cued navigation (visible platform) water maze tasks were investigated.
		Alaproclate 7.5 mg/kg and 20 mg/kg, but not 2.5 mg/kg produced a significant impairment.
		The combination of the highest dose of alaproclate (20 mg/kg) and of scopolamine (0.8 mg/kg) produced a far greater place navigation deficit than scopolamine (0.8 mg/kg) alone.
	www.hvsimage.com /papers/PMID-%201924509.htm (246 words)

	Alaproclate effects on voltage-dependent K+ channels and NMDA receptors: studies in cultured rat hippocampal neurons ... (Site not responding. Last check: 2007-10-17)
		Alaproclate effects on voltage-dependent K+ channels and NMDA receptors: studies in cultured rat hippocampal neurons and fibroblast cells transformed with Kv1.2 K+ channel cDNA.
		Alaproclate effects on voltage-dependent K+ channels and NMDA receptors: studies in cultured rat hippocampal neurons and fibroblast cells transformed with Kv1.2 K+ channel cDNA.The effects of alaproclate on voltage-dependent K+ currents and N-methyl-D-aspartate (NMDA) and gamma-aminobutyric acidA (GABAA) receptor currents were investigated in cultured rat hippocampal neurons using whole-cell voltage clamp recording techniques.
		Alaproclate produced a concentration-dependent block of the sustained voltage-dependent K+ current activated by depolarization from -60 to +40 mV (IC50, 6.9 microM).
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/7984377.html (320 words)

	The effects of alaproclate and p-chlorophenylalanine on cued navigation performance in rats. (Site not responding. Last check: 2007-10-17)
		Alaproclate (20 mg/kg i.p.) increased escape distance and slightly decreased swimming speeds of the rats.
		The effects of alaproclate did not differ between PCPA and sham treated (arabic gum 400 mg/kg/day x 3 i.p.) rats.
		The results demonstrate that alaproclate induced cued navigation behavioral deficit is maintained after a marked depletion of cerebral serotonin.
	www.hvsimage.com /papers/PMID-%201531758.htm (240 words)

	Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, weight loss, ... (Site not responding. Last check: 2007-10-17)
		Effects of alaproclate, potassium channel blockers, and lidocaine on the release of 3H-acetylcholine from the guinea-pig ileum myenteric plexus.
		The results are in agreement with the hypothesis that the effect of alaproclate on the evoked 3H-acetylcholine secretion is not mediated by a neurotransmitter receptor, or a potassium channel sensitive to tetraethylammonium, 4-aminopyridine, apamin, or barium or quinine, but is due to a local anaesthetic effect.
		The mechanism underlying the effect of alaproclate on the spontaneous release remains to be established.
	ultram-online-rx.com /ref-nifedipine/nifedipine-research-abs3.1146.html (701 words)

	Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow -- ...
		Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow -- Wilkinson et al.
		Articles by Wilkinson, A. Articles by Akerman, K. Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow
		The effect of alaproclate was stereoselective because the
	jpet.aspetjournals.org /cgi/content/abstract/271/3/1314 (238 words)

	The SURE Program: Past Programs
		A compound that would reduce or eliminate the pleasurable effects of cocaine, as it is believed quipazine and alaproclate might, would be a great boon to the treatment process.
		The study at the Yerkes Primate Center was an examination of the agonists quipazine and alaproclate, two drugs that increase serotonin levels in the brain.
		By utilizing stimulus termination as an alternate method of reinforcement, the specificity of the effects of alaproclate and quipazine on cocaine-maintained behavior have become clearer.
	www.sciencenet.emory.edu /undergrad/SURE/Articles/1998_art_dooley.html (888 words)

	Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, weight loss, ... (Site not responding. Last check: 2007-10-17)
		The accumulation of 14C-5-hydroxytryptamine in human platelets in vitro and plasma levels of a number of hypophyseal hormones and cortisol in healthy male volunteers were determined after acute oral administration of zimelidine and alaproclate, two selective inhibitors of serotonin (5-HT) uptake.
		Alaproclate (100 mg) significantly inhibited the accumulation of 14C-5-HT by 42% at 90 minutes but showed no significant effect at 4 hours.
		Plasma levels of prolactin, growth hormone, luteinizing hormone, follicle stimulating hormone, and thyroid stimulating hormone remained unchanged after zimelidine and alaproclate, and the levels were comparable to those after placebo.
	auramon.com /ref-follicle/follicle-research-abs5.437.html (1274 words)

	Effects of 5-hydroxytryptamine uptake blockers on the concentration in brain of 5-hydroxytryptamine and ...
		The effect of alaproclate was studied in male rats, pro-oestrous female rats, rats ovariectomized and injected s.c.
		Alaproclate caused a significant decrease in the 5-HIAA/5-HT ratio in the AH and PH of the brain of male rats, in the PH and raphe nuclei in pro-oestrous rats and model 1, and in the raphe nuclei alone in model 2.
		In male rats the injection of parachlorophenylalanine produced a marked reduction in the brain concentrations of 5-HT and 5-HIAA, but the 5-HIAA/5-HT ratio was unchanged by a subsequent injection of alaproclate.
	joe.endocrinology-journals.org /cgi/content/abstract/104/3/407 (339 words)

	BPJonline Whiting et al 7:1 (2003) (Site not responding. Last check: 2007-10-17)
		The effects of the antidepressants, alaproclate, fluoxetine, fluvoxamine, maprotilene, tranylcypromine and zimelidine on rat uterine smooth muscle contraction were investigated.
		Cumulative concentration-effect curves for oxytocin and KCl were constructed in strips of estrogen-primed rat uterus after incubation with antidepressant compounds (100 µM).
		Alaproclate, fluvoxamine, and tranylcypromine produced slight rightward shifts of the concentration-effect curves to oxytocin whereas fluoxetine produced a large leftward shift.
	www.science.mcmaster.ca /biopharm/bpj/bpj_7_1.html (140 words)

	Newswise
		When Howell treated the monkeys with alaproclate 30 minutes prior to cocaine administration, cerebral blood flow did not increase significantly indicating that the compound blocked cocaine from activating the prefrontal cortex.
		The prefrontal cortex, which plays various roles in the brain, is a major component of the dopamine system that controls feelings of pleasure and reward.
		"But the fact that alaproclate can block the effects of cocaine does not necessarily mean it will be a good medication for controlling addiction," Howell cautions.
	www.newswise.com /articles/2001/11/PET.YPC.html (740 words)

	[No title] (Site not responding. Last check: 2007-10-17)
		The antinociceptive effects of three predominantly serotonergic reuptake inhibitors, alaproclate, citalopram and
		In the present study, effects of subchronic (14 days) treatment with the monoamine uptake inhibitors nortriptyline (30 mumol/kg per day),
		(32 mumol/kg per day) and alaproclate (39 mumol/kg per day), as well as with the benzodiazepine
	www.vrac.iastate.edu /~berleant/MedRep/CT/Clomiprami~TACHYKININ.htm (67 words)

	Dopamine and agonists
		drug delivery, the 5-HT uptake inhibitor alaproclate (3.0 and 10.0 mg/kg) and the 5-HT direct agonist quipazine (0.3-1.0 mg/kg) decreased response rates at doses that had no significant effect on behavior maintained by an identical schedule of stimulus termination.
		The neurochemical bases of the observed drug interactions on behavior were investigated further using in vivo microdialysis techniques in a separate group of awake monkeys to monitor drug-induced changes in extracellular dopamine (DA).
		Pretreatment with alaproclate or quipazine attenuated cocaine-induced increases in extracellular DA at the same pretreatment doses that decreased cocaine self-administration.
	lansbury.bwh.harvard.edu /da_and_agonists.htm (18591 words)

	Patent 4606940: Small particle formation and encapsulation
		In this process, coacervation of the encapsulating material is believed to result from the change of solvent character of the solution, which disturbs the system, when taken together with the electrolyte initially present and causes coacervation.
		Suitable pharmaceutically active compounds whose solubility decreases from one solvent system to another, are, for example, budesonide, felodipine, bacampicillin, griseofulvin, indomethacin, erythromycin, theophylline, salicylic acid, nifedipine, remoxipride, chlorzoxazone, lidocaine and alaproclate.
		A suitable encapsulating material which will form a coacervate is, for example, gelatin (preferably of the type B; acid processed), methylcellulose, hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethylcellulose, cellulose acetate phthalate and polyvinylpyrrolidone.
	www.freepatentsonline.com /4606940.html (2396 words)

	Nerurología. Una zona del cerebro situada detrás de los ojos regula el orgasmo masculino
		Para cerciorarse de que la serotonina era el factor que controlaba el periodo de latencia entre los orgasmos, los científicos administraron alaproclate, fármaco que, al igual que el Prozac, inhibe la reabsorción de serotonina, en el hipotálamo de los animales.
		En estas ratas, el intervalo entre coitos tuvo una duración tres veces mayor en comparación con los animales a los que no se les inyectó el compuesto.
		En cambio, un grupo de ratones a los que les inyectaron el alaproclate a menos de un milímetro del hipotálamo no presentó ningún tipo de disfunción sexual.
	www.el-mundo.es /salud/273/11N0128.html (445 words)

	Postgraduate Medicine: Alzheimer's Disease Symposium: Treating Alzheimer's disease
		In addition, selegiline has been evaluated in a 2 year, multicenter, placebo-controlled clinical trial; results are due out as this article goes to press.
		Some medications intended to enhance serotonin function have shown significant behavioral and cognitive efficacy (eg, citalopram), while others have shown minimal or no behavioral or cognitive effects (eg, zimelidine, l-tryptophan [Trofan, Tryptacin], alaproclate) (1,3).
		The finding in Alzheimer's patients of regional decreases in glucose utilization and abnormal oxidative metabolism has led to medication studies aimed at correcting these abnormalities.
	www.postgradmed.com /issues/1997/06_97/tariot.htm (2980 words)

	Abstract: Centrophenoxine
		Any conclusion as to whether these drugs represent significant improvements over the extremely modest effects of piracetam must await the outcome of these studies.
		Among other experimental drugs of interest in AD are 4-amino-pyridine and 3,4-diaminepyridine, compounds with multiple pharmacologic effects that facilitate oxidative metabolism; Active lipid, a compound designed to fluidize cell membranes; centrophenoxine, a stimulant also thought to deplete age-related lipofuscin accumulation; aluminum chelators, such as desferrioxamine; and alaproclate, a 5-HT reuptake inhibitor.
		In view of the emerging neurochemical evidence that AD involves multiple neurotransmitter systems, it may be that therapeutic strategies involving combination treatments or even an individualized 'cocktail' approach will be necessary to develop effective treatments for what may be the most tragic and dehumanizing of all mental disorders.
	www.lef.org /prod_hp/abstracts/centrophenoxineabs.html (6803 words)

	Nat' Academies Press, Prevention and Treatment of Alcohol Problems: Research Opportunities (1990)
		See Relapse prevention Age alcohol price and consumption by, 77, 81 and cognitive function recovery, 276 Agent.
		See Alcohol Age-graded influences, 48 Aggregate-level descriptive studies, 161 - 162 Aggressive behavior, 4, 52, 54 AIDS research, 39, 313, 316 Alanine aminotransferase (SGPT), 155 - 156 AlAnon, 179, 181 - 182, 194 Alaproclate, 173 AlaTeen, 181 - 182 Alcohol.
		See also Alcoholics; Alcohol use as clinical entity, 24, 131, 222 comorbidity with drug use, 14, 144, 158
	www.nap.edu /books/0309041821/html/325.html (926 words)

	Pharmacological Treatment of Dementia: File Inventory
		Various non-cholinergic neurotransmitter/ neuropeptide modifying agents ________________________________________________________________________________________________ 137et118.doc Microsoft Word® Document MS Word® 2002 35KB 1 page Contents: Evidence Table 118.
		Study results: Alaproclate ________________________________________________________________________________________________ 138et119.doc Microsoft Word® Document MS Word® 2002 41KB 2 pages Contents: Evidence Table 119.
		Study results: Anapsos ________________________________________________________________________________________________ 139et120.doc Microsoft Word® Document MS Word® 2002 34KB 1 page Contents: Evidence Table 120.
	www.ahrq.gov /clinic/demphinv.htm (5546 words)

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