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Topic: Albendazole

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	666. Albendazole (WHO Food Additives Series 25)
		Albendazole has been used in 80 countries to treat gastrointestinal parasitic infections in humans at a dose rate of 400 mg/person, and there are a number of published reports on its use.
		Some of the effects observed in general toxicity studies with albendazole may be explained by one of the biological actions of the benzimadazoles, which is to interfere with tubulin polymerization and thus inhibit spindle formation and mitosis.
		Metabolism of albendazole in cattle, sheep, rats and mice.
	www.inchem.org /documents/jecfa/jecmono/v25je02.htm (6709 words)

	PWA Health Group: albendazole
		Albendazole (Zentel) is an oral drug used to treat a variety of worm infections.
		Albendazole lowered the amount of parasites in some people, but it did not kill the infection in anyone with E. bieneusi.
		Albendazole has also been given to people with cryptosporidiosis in a small, uncontrolled study.
	www.aidsinfonyc.org /pwahg/info/albe.html (1207 words)

	Effect of clotrimazole on microsomal metabolism and pharmacokinetics of albendazole
		Albendazole is a broad spectrum anthelmintic drug widely used in human and veterinary medicine.
		After albendazole incubation, albendazole sulfone formation was completely inhibited by 50 µM clotrimazole in intestinal incubations and a 50% inhibition was observed in hepatic incubations.
		Regarding the formation of albendazole sulfoxide, an inhibition close to 50% was observed in liver and intestine at 10 µM clotrimazole.
	www.aapspharmaceutica.com /search/view.asp?ID=43095 (319 words)

	Albendazole for lymphatic filariasis
		Mass treatment with albendazole co-administered with another antifilarial drug is part of a global programme to eliminate lymphatic filariasis.
		Microfilariae prevalence and density were statistically significantly lower with the combination of albendazole and ivermectin compared with ivermectin alone in two of three trials (649 participants).
		Albendazole combined with ivermectin appears to have a small effect on microfilaraemia, but this was not consistently demonstrated.
	www.cochrane.org /reviews/en/ab003753.html (632 words)

	World J Gastroenterol
		In vitro Albendazole inhibits the growth of trophozoites of G.intestinalis and their adhesion to cultured intestinal epithelial cells and disturbs the activity of microtubules and microribbons in the trophozoite's adhesive disk.
		They concluded that albendazole was proved as effective as metronidazole in the treatment of giardia infection in children with the absence of anorexia.
		Giardia lamblia isolates: in vitro susceptibility to metronidazole and albendazole.
	www.wjgnet.com /1007-9327/10/1215.asp (1915 words)

	The Body: Albendazole Info Sheet
		Albendazole (Zentel) is an oral drug used to treat a variety of worm infections.
		Albendazole lowered the amount of parasites in some people, but it did not kill the infection in anyone with E. bieneusi.
		Albendazole has also been given to people with cryptosporidiosis in a small, uncontrolled study.
	www.thebody.com /pwa/alben.html (1312 words)

	Albendazole for the treatment of pinworms - [Medication] - Quest Diagnostics Patient Health Library
		Albendazole may be used in cases of pinworm infections that cannot be treated with other pinworm medications.
		Albendazole is not recommended for use in pregnant women or in people with poorly functioning livers.
		Albendazole is used for infections caused by parasites.
	www.questdiagnostics.com /kbase/topic/detail/drug/hw50146/detail.htm (272 words)

	albendazole - [Medication]
		Albendazole is used to treat infections caused by worms such as pork tapeworm and dog tapeworm.
		Albendazole is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby.
		Albendazole is available with a prescription under the brand name Albenza in 200 mg tablets.
	www.peacehealth.org /kbase/multum/d03806a1.htm (868 words)

	Albendazole Induced Rupture Of Pulmonary Hydatid Cysts
		The rupture alongside continued albendazole therapy was curative in 2 cases and a regrowth was observed in 5 cysts.
		Albendazole therapy can cause a rupture in some patients with pulmonary hydatid disease and should be suspected in any such patient who presents with sudden onset respiratory symptoms.
		Albendazole was continued in all patients to prevent potential risk of the dissemination of the disease.
	www.ispub.com /ostia/index.php?xmlFilePath=journals/ijpm/vol6n1/cyst.xml (1074 words)

	Albendazole
		Albendazole interferes with various energy-producing processes of helminths (worms), including impairing the uptake of glucose (sugar) for energy.
		Albendazole is a medication which is used as an adjunct in the treatment of hydatid disease.
		Hydatid disease is caused by the parasite Echinococcus granulosus or Echinococcus multilocularis and presents as fluid-filled sacs (cysts) that grow in the liver, lungs and brain of infected individuals.
	www.greatvistachemicals.com /pharmaceuticals-bulk-drugs/albendazole.html (277 words)

	Albendazole
		Albendazole was implicated as being an oncogen in 1984, but subsequent studies were unable to demonstrate any oncogenic or carcinogenic activity of the drug.
		Albendazole has been associated with teratogenic and embryotoxic effects in rats, rabbits and sheep when given early in pregnancy.
		In humans, albendazole is recommended to be used with caution in patients with liver or hematologic diseases.
	www.elephantcare.org /Drugs/albend.htm (683 words)

	BioMed Central \| Full text \| Patterns of geohelminth infection, impact of albendazole treatment and re-infection after ...
		Our objectives were to describe the initial pattern of geohelminth infection, assess the impact of treatment with 400 mg albendazole and to monitor re-infection after treatment in order to develop recommendations for further local and regional control efforts.
		A study that was conducted in Durban only about 350 km south of the study area found that albendazole reduced the median EPG of children infected before treatment by 44.1% [23].
		Hall A, Nahar Q: Albendazole and infections with Ascaris lumbricoides and Trichuris trichiura in children in Bangladesh.
	www.biomedcentral.com /1471-2334/4/27 (4422 words)

	Healthopedia.com Drugs Information - Albendazole : Proper Use (Albenza)
		No special preparations (fasting, laxatives, or enemas) or other steps are necessary before, during, or immediately after treatment with albendazole.
		Albendazole is best taken with meals, especially with food containing fat, to help your body absorb the medicine better.
		The number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking albendazole.
	www.healthopedia.com /drugs/detailed/albendazole/proper-use.html (600 words)

	Filaria Journal \| Full text \| Treatment of co-infection with bancroftian filariasis and onchocerciasis: a safety and ...
		In order to use a combination of ivermectin and albendazole for the elimination of lymphatic filariasis, it is important to assess the potential risk of increased adverse events in individuals infected with both lymphatic filariasis and onchocerciasis.
		Recently albendazole has been introduced for use in combined chemotherapy with either ivermectin or DEC as the treatment regime for the global elimination of lymphatic filariasis [8].
		Albendazole combined with either ivermectin or DEC has been demonstrated to effectively clear bancroftian microfilaraemia [9].
	www.filariajournal.com /content/2/1/15 (3678 words)

	Albendazole
		Albendazole has been shown to be teratogenic in laboratory animals and should not be used during pregnancy, if at all possible.
		Food: Albendazole serum levels may be increased if taken with a fatty meal (increases the oral bioavailability by 4-5 times).
		Active metabolite, albendazole, causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae; glycogen is depleted, glucose uptake and cholinesterase secretion are impaired, and desecratory substances accumulate intracellulary.
	www.metagenics.com /ADAM/41/001500.html (878 words)

	ZENTEL® TABLETS 200 mg (tablets); ZENTEL® SUSPENSION 20 mg/mL (suspension)
		Albendazole is a benzimidazole carbamate with anthelmintic and antiprotozoal activity against intestinal and tissue parasites.
		Albendazole is known to be teratogenic and embryotoxic in animals.
		The safety of albendazole during pregnancy has not been established, and ZENTEL should not be taken by pregnant women at any stage of their pregnancy or by women who are likely to become pregnant, during or shortly after the course of therapy.
	home.intekom.com /pharm/smith_kb/zentel.html (676 words)

	BioMed Central \| Full text \| A randomised controlled trial of the effects of albendazole in pregnancy on maternal ...
		We then analysed the treatment trial by intention-to-treat: for each analysis, comparisons were made between albendazole and placebo recipients, first, for all participants, and second, for the sub-group of mothers with hookworm at enrolment (in whom any effect of treatment was expected to be greater).
		The suppressive effect observed in mothers was in keeping with the results of studies in laboratory animals indicating suppression of type 1 responses to mycobacteria in the presence of helminths [15-17] and reduced efficacy of BCG against challenge with virulent Mycobacterium tuberculosis in mice co-infected with Schistosoma mansoni [18].
		Studies in both laboratory animals [16,17] and humans [20,23,24], including a placebo-controlled trial of albendazole treatment prior to BCG immunisation among helminth-infected, Ethiopian adults [24], have indicated a suppressive effect of helminths on the immune response elicited by BCG.
	www.biomedcentral.com /1471-2334/5/115 (4009 words)

	To Save Money on Albendazole Click Here for Albendazole Discount Sources. (Site not responding. Last check: 2007-10-21)
		Treatment of co-infection with bancroftian filariasis and onchocerciasis: a safety and efficacy study of albendazole with...
		Treatment of co-infection with bancroftian filariasis and onchocerciasis: a safety and efficacy study of albendazole with ivermectin compared to treatment of single infection with bancroftian...
		Albendazole is approved in several European and most Third World...
	www.institute-dc.org /res/3/Albendazole.html (301 words)

	Untitled Document
		After absortion, albendazole is rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is generally considered to be the form responsible for the therapeutic activity of albendazole.
		Albendazole sulfoxide is further metabolized to albendazole sulfone and other primary oxidative metabolites and is excreted from the body (Dayan, 2003).
		Albendazole is found to inhibit the polymerization of the parasite tubulin into microtubules.
	www.stanford.edu /class/humbio103/ParaSites2005/Albendazole/index.htm (783 words)

	American Chemical Society: Journal of Agricultural and Food Chemistry
		A liquid chromatographic procedure for the determination of albendazole ([5-(propylthio)-1H-benzimidazol-2yl]carbamic acid methyl ester) and its major metabolites, albendazole sulfoxide, albendazole sulfone, and albendazole-2- aminosulfone in rainbow trout, tilapia, and salmon muscle with adhering skin tissue is described.
		The average recoveries from the fortified muscle tissue of the three fish species for albendazole (25-100 ppb), albendazole sulfoxide (15.5-62 ppb), albendazole sulfone (1-10 ppb), and albendazole-2- aminosulfone (10-100 ppb) were 94, 77, 82, and 67%, respectively.
		The procedure was validated and then applied to the determination of albendazole and its three major metabolites in the muscle tissue of the three fish species obtained after orally dosing with albendazole.
	pubs.acs.org /hotartcl/jafcau/inthenews/jf021176i_rev.html (268 words)

	Filaria Journal \| Full text \| Tolerability and efficacy of single dose albendazole, diethylcarbamazine citrate (DEC) or ...
		The tolerability and efficacy of single dose albendazole (400 mg), diethylcarbamazine citrate (DEC) (6 mg/kg bodyweight) or co-administration of albendazole (400 mg) + DEC (6 mg/kg bodyweight) was studied in 54 asymptomatic Wuchereria bancrofti microfilaraemic volunteers in a double blind hospital-based clinical study.
		The efficacy of single dose albendazole (400 mg) in terms of reduction in microfilaria density at the end of one year (particularly considering its use in endemic communities in cycles of one year) is equal to DEC alone or it's co-administration with DEC.
		Although variability in the sensitivity to albendazole by intestinal parasites from different regions of the world has been reported [25], a recent study using a genetic marker, (for the β-tubulin gene), has shown that strains of Wuchereria bancrofti from different parts of India are sensitive to benzimidazole compounds [26].
	www.filariajournal.com /content/1/1/1 (4187 words)

	Albendazole-induced pseudomembranous colitis.
		Albendazole is an antibiotic that is chemically related to metronidazole.
		The spectrum of antimicrobial activity of albendazole and its efficacy in the treatment of intestinal microsporidiosis are reviewed.
		Pathogenic mechanisms for the development of pseudomembranous colitis and the epidemiology of this condition in patients with AIDS are discussed.
	www.aegis.com /aidsline/1996/oct/M96A0757.html (376 words)

	Clinical Study: 85-I-0127, Treatment of Patients with Cysticercosis with Praziquantel or Albendazole (Site not responding. Last check: 2007-10-21)
		The purpose of this study is to evaluate, treat and follow patients with cysticercosis, an infection with the larval form of the pork tapeworm, T. solium.
		The drugs praziquantel and albendazole are used to treat cysticercosis, but it is not clear if these drugs are effective in all patients, such as those with calcified cysts or brain enlargement.
		Albendazole and praziquantel treatment in neurocysticercosis of the fourth ventricle
	clinicalstudies.info.nih.gov /cgi/detail.cgi?A_85-I-0127.html (555 words)

	Order Albendazole Online
		Albenza (albendazole) is an orally administered broad-spectrum anthelmintic.
		Albendazole may cause birth defects or be harmful to an unborn baby.
		If you are taking albendazole for hookworms or whipworms, your doctor may want you to take iron supplements.
	www.health.am /drugstore/albendazole.php (478 words)

	ALBENDAZOLE
		Albendazole is a drug used to treat infections caused by parasites. It can be given to treat a rare brain infection (neurocysticercosis) or it can be given to treat a parasitic infection that causes important diarrhea (microsporidiosis).
		Albendazole may cause decreases in white blood cells (needed to help fight infection), decreases in platelets (needed to help your blood clot), and increases in liver enzymes (sign of liver damage).
		Albendazole tablets should be stored in a cool (20-25°C) dry place, protected from light and well out of the reach of children.
	www.tthhivclinic.com /FactSheets/html/ALBENDAZOLE.html (681 words)

	Albenza Side Effects, and Drug Interactions - Albendazole - RxList Monographs
		Praziquantel: In the fed state, praziquantel (40 mg/kg) increased mean maximum plasma concentration and area under the curve of albendazole sulfoxide by about 50% in healthy subjects (n=10) compared with a separate group of subjects (n=6) given albendazole alone.
		Cimetidine: Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n=7) compared with albendazole (20 mg/kg/day) alone (n=12).
		Albendazole sulfoxide plasma concentrations were unchanged 4 hours after dosing.
	www.rxlist.com /korean.php?u=http://www.rxlist.com/cgi/generic/albendazole_ad.htm (322 words)

	Pre-treatment with corticosteroids and a single cycle of high dose albendazole for subarachnoidal cysticercosis -- ...
		Pre-treatment with corticosteroids and a single cycle of high dose albendazole for subarachnoidal cysticercosis -- Márquez-Caraveo et al.
		Albendazole was given at a dose of 30 mg/kg of body weight per
		Albendazole trial at 15 or 30 mg/kg/day for subarachnoid and intraventricular cysticercosis
	jnnp.bmjjournals.com /cgi/content/full/75/6/938 (820 words)

	In-vitro activity of rifabutin and albendazole singly and in combination with other clinically used antimicrobial ... (Site not responding. Last check: 2007-10-21)
		albendazole and rifabutin at a concentration of 4 mg/L, singly or
		Albendazole and rifabutin had different effects (Table I).
		Albendazole inhibits Pneumocystis carinii proliferation in inoculated immunosuppressed mice.
	jac.oxfordjournals.org /cgi/content/full/44/5/653 (2656 words)

	Albendazole (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-10-21)
		Although there is very little specific information comparing use of albendazole in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		There is no specific information comparing use of albendazole in the elderly with use in other age groups.
		Cysticercosis involving the eye—Patients who are being treated with albendazole for pork tapeworms of the nervous system (neurocysticercosis) should be examined for lesions in the eye; use of albendazole may increase the chance of side effects involving the eye
	www.mayoclinic.com /health/drug-information/DR202668 (1432 words)

	Albendazole - Drugs & Vitamins - Drug Library - DrugDigest
		You should take albendazole with a high fat meal to increase how much of the drug gets into the body.
		Albendazole tablets may be crushed and mixed with applesauce or pudding, which is an easy way to give it to children.
		Until you know how albendazole affects you, do not drive, use machinery, or do anything that needs mental alertness.
	www.drugdigest.org /DD/DVH/Uses/0,3915,7835\|Albendazole,00.html (719 words)

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