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Topic: Albumin

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In the News (Wed 19 Jun 19)

  Albumin - LoveToKnow 1911
The albumins contain in all cases the elements carbon, hydrogen, nitrogen, sulphur and oxygen; their composition, however, varies within certain limits: C= 50-55%, H = 6.9-7'.3%,N = 15-19%,S =0.32.4%7 0=1 92 4%, General char- crystallized albumin is C = 51.48%, H = 6.76%, N= acters.
Albumins (as classified above) are soluble in water, dilute acids and alkalies, and in saturated neutral salt solutions; they are coagulated by heat.
An important nucleo-proteid is haemoglobulin or haemoglobin, the colouring matter of the red blood corpuscles of vertebrates; a related substance, haemocyanin, in which the iron of haemoglobin is replaced by copper, occurs in the blood of cephalopods and crayfish.
www.1911encyclopedia.org /Albumin   (2283 words)

 What's all this fuss about albumin?
Albumin is an intravascular protein with a concentration of approx 40 g/l.
Remember that albumin is the main protein both in the plasma and in the interstitium and it is the COP gradient rather than the absolute plasma value that is important: this is what distinguishes hypoalbuminaemia derived from redistribution (capillary leak) from that of pure full body deficiency.
Albumin is an important intravascular and extravascular protein; it contributes strongly to the maintenance of colloid osmotic pressure.
www.4um.com /tutorial/currents/albumin.htm   (1852 words)

 Albumin   (Site not responding. Last check: 2007-10-13)
Albumin is a globular protein with a MW of 69,000.
Albumin is measured by its ability to bind to bromcresol green.
Albumin is also higher in heparinized plasma than serum (due to non-specificity of bromcresol green which also binds to globulins, including fibrinogen), however newer procedures have been developed to minimize this phenomenon.
www.diaglab.vet.cornell.edu /clinpath/modules/chem/albumin.htm   (513 words)

 The physiology of albumin
Albumin is catabolized at a rate of 9 - 12 g/day (the same rate as it was produced) by pinoctosis in cells adjacent to the vascular endothelium.
The ratio of albumin to water is, however higher in the intravascular space (the extracellular fluid is 2/3 interstitial and 1/3 intravascular), hence the colloidal effect.
Albumin cyclically leaves the circulation, through the endothelial barrier at the level of the capillaries, passes into the interstitium and returns to the bloodstream through the lymph system via thoracic duct.
www.ccmtutorials.com /misc/albumin/page_02.htm   (379 words)

 Albumin   (Site not responding. Last check: 2007-10-13)
Albumin is the major protein found in blood plasma and constitutes 1.8% to 2.6% of blood volume depending on the individual.
Albumin provides the critical colloid osmotic or oncotic pressure that regulates the passage of water through the capillaries by virtue of the fact that it diffuses very poorly through the capillary walls.
Albumin is transfused to replace proteins and fluids in burn patients and in cases of shock due to hemorrhage or surgery.
www.ajwrb.org /albumin.shtml   (365 words)

Albumin, produced only in the liver, is the major plasma protein that circulates in the bloodstream.
Albumin is also very important in the transportation of many substances such as drugs, lipids, hormones, and toxins that are bound to albumin in the bloodstream.
For example, a patient's albumin is 3.5 and the globulin is 2.5, the ratio is 1.4 Although the A/G ratio may still be used, serum protein electrophoresis is now used to compare the amount of albumin with globulin.
www.rnceus.com /lf/lfalb.html   (673 words)

 Clinical Review of Appropriate Uses for Albumin - Lesson
Albumin, globulin, and fibrinogen are the principal proteins in plasma.
Albumin is a monodisperse solution with an average molecular weight of 66,300 D to 69,000 D. Albumin is highly water-soluble and carries a strong negative charge (–17) at pH 6.4 to 7.4.
Paracentesis with intravenous infusion of albumin with peritoneovenous shunting in cirrhosis with refractory ascites.
www.uspharmacist.com /NewLook/CE/Albumin/lesson.htm   (4230 words)

Albumin is a protein made in the liver and distributed through the body by the circulatory system.
Albumin is one of the many proteins found in plasma.
Albumin, like many alternatives to blood transfusions, can be used effectively by physicians rendering non-blood medical management to any patient who desires it.
www.bloodlessmed.com /Pages/Techniques/ALBUMIN.htm   (328 words)

 eMedicine - Hypoalbuminemia : Article Excerpt by: Ruben Peralta, MD, FACS
Pathophysiology: Serum albumin levels are dependent on the rate of synthesis, the amount secreted from the liver cell, the distribution in body fluids, and the level of degradation.
Preproalbumin is an albumin molecule with a 24 amino acid extension at the N terminus.
Tracer studies with iodinated albumin show that intravascular albumin is distributed into the extravascular spaces of all tissues, with the majority being distributed in the skin.
www.emedicine.com /med/byname/hypoalbuminemia.htm   (578 words)

 BioMed Central | Full text | Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro
Albumin is the most abundant protein in blood plasma, and due to its ligand binding properties, serves as a circulating depot for endogenous and exogenous (e.g.
Thus the albumin may serve as a circulating depot, whereas the unbound substances are the pharmacologically active moieties [1,2].
Pharmaceutical-grade albumin (200 g/L) was purchased from Baxter/Immuno, Octapharma, and Pharmacia and Upjohn.
www.biomedcentral.com /1472-6904/4/4   (3634 words)

 Talecris Biotherapeutics Albumin Products
Albumin use may reduce the need for blood transfusions by decreasing the amount of excessive bleeding typically associated with use of nonprotein colloids.
Albumin and nonprotein colloids (hetastarch [6% hydroxyethyl starch] or dextran) are blood volume expanders that are frequently used perioperatively to enhance intravascular blood volume, improve hemodynamics, and reduce the need for blood transfusions.
Albumin versus hydroxyethyl starch in cardiopulmonary bypass surgery: a meta-analysis of postoperative bleeding.
www.plasbumin.com /healthcare_answercenter.cfm   (1202 words)

 No Difference in the Effectiveness of Albumin Versus Normal Saline for the Treatment of Hypotension in Mechanically ...
Group 1 was given volume expander in the form of 5% albumin at a dose of 10ml/kg while group 2 received normal saline at a dose of 10ml/kg.
Disadvantages of this study: 1) The use of albumin in the normal saline group if additional volume expander was required after the first 3 doses - this "treatment contamination" may have reduced the study's ability to detect differences in outcomes such as weight gain, oxygenation status and the development of chronic lung disease.
In the 2 trials that specifically addressed albumin vs NS for the treatment of hypotension, a total of 74 events occurred in the albumin group vs 61 events in the normal saline group.
www.med.umich.edu /pediatrics/ebm/cats/albumin2.htm   (1174 words)

 RedOrbit - Science - New Form of Urinary Albumin in Early Diabetes   (Site not responding. Last check: 2007-10-13)
The contribution of Osicka and Comper (1) was to isolate the 66 500- Da immunochemically nonreactive albumin from diabetic urine by further purification by HPLC after removal of immunochemically reactive albumin on a column of immobilized anti-human albumin antibodies.
Degradation of albumin by the renal proximal tubule cells and the subsequent fate of its fragments.
Alterations in renal degradation of albumin in early experimental diabetes in the rat: a new factor in the mechanism of albuminuria.
www.redorbit.com /news/display/?id=109742   (1352 words)

 difference between albumin and prealbumin, The Advances in Skin & Wound Care - Find Articles   (Site not responding. Last check: 2007-10-13)
Albumin is one of the most abundant proteins found in blood, accounting for more than 50% of total serum proteins.
The liver manufactures albumin; the albumin concentration reflects the protein status of the blood and internal organs.3 The main purpose of albumin within blood is to maintain colloidal osmotic pressure, which keeps fluid within the vascular space.4 This is why patients with very depleted albumin levels may develop edema, ascites, or pulmonary edema.
This means that albumin concentrations rise slowly during nutritional therapy (refeeding) and in patients recovering from stress.5 Reliable changes in albumin require at least 2 to 3 weeks of nutritional intervention; earlier changes are likely due to hemoconcentration issues.
www.findarticles.com /p/articles/mi_qa3977/is_200109/ai_n8963813   (897 words)

 Serum albumin - Wikipedia, the free encyclopedia
Serum albumin, often referred to simply as albumin, is the most abundant plasma protein in humans and other mammals.
Albumin is essential for maintaining the osmotic pressure needed for proper distribution of body fluids between intravascular compartments and body tissues.
Bovine serum albumin, or BSA, is commonly used in molecular biology laboratories.
en.wikipedia.org /wiki/Serum_albumin   (283 words)

 Therapeutic uses of albumin
The inclusion of albumin in “colloid versus crystalloid” debates has led to claims that the latter are safer than the former.
It appears that, without strong data supporting the use of this agent, and with alternatives available (hydroxyethyl starch), the continued prescription of albumin as a volume expander is neither clinically indicated nor cost effective.
Currently, albumin is the fluid of choice in preventing renal failure in patients with spontaneous bacterial peritonitis (Sort P, 1999).
www.ccmtutorials.com /misc/albumin/page_08.htm   (353 words)

 Albumin Therapy - Ask An Expert
The half-life of albumin in plasma is approximately 16 hours, with about 90% of the dose remaining in the intravascular space 2 hours after administration.
In the past it was common practice to add intravenous albumin as adjunct therapy in patients with low serum albumin levels receiving parenteral or enteral nutrition.
Salt-poor albumin is a historical term for 25% albumin that is no longer applicable but persists in the medical community.
www.albumintherapy.com /us/en/ask.html   (1766 words)

 Albumin for nephrotic syndrome
Albumin is a protein that is made in the liver and released into the blood.
Albumin is primarily used for short-term treatment of nephrotic syndrome.
However, albumin is particularly effective when nephrotic syndrome is causing pleural effusion, pulmonary edema, or acute renal failure.
www.webmd.com /hw/kidney_failure/tv7231.asp   (291 words)

From both studies they concluded that the overall conformation of albumin in neutral solution is rigid and very similar to the 80x80x80x30 heart-shaped structure derived from crystallography of human albumin.
The albumin is said to act as a sink for NO(+) and as a modulator for its transfer from the vessel wall to red cell hemoglobin.
Brennan, S.O. (1985) The molecular abnormality of albumin Parklands: 365 Asp-His.
www.albumin.org   (5124 words)

 Albumin infusion for low serum albumin in preterm newborn infants
Cartlidge and Rutter (Cartlidge 1986) showed serum albumin levels in the early neonatal period increased significantly with gestational age from a mean of 19 g/litre (90% confidence interval ~12 to ~28 g/litre) below 30 weeks to a mean of 31 g/litre (90% confidence interval ~22 to ~39 g/litre) at term.
Albumin accounts for approximately 50% of the serum proteins and is the major protein produced by the liver (Vanek 1998).
Albumin (which comes in a number of commercial preparations with concentrations ranging from 4 - 20%) is also a scarce and expensive resource with hospitals frequently experiencing shortages (Golub 1994).
www.nichd.nih.gov /cochrane/Jardine/JARDINE.HTM   (4185 words)

 Lupus Diagnosis and Testing
Albumin is an important blood protein that is made by the liver and excreted by the kidneys.
It may be used to diagnose, evaluate and monitor the disease course in a person with cancer, intestinal or renal problems, liver disease, and immune disorders.
The normal amount of albumin in the blood ranges from 3.4 to 5.4 grams per deciliter (gm/dl).
www.uklupus.co.uk /albumin.html   (193 words)

 Millipore - Technical Library - Montage Albumin Deplete Kit
The kit’s centrifugal columns are prepacked with an affinity resin that removes >65% of albumin from typical human serum samples.
To accurately assess albumin removal, all sample loads were volume normalized to the undepleted starting sample.
Radial immunodetection assay revealed an average of 66% albumin reduction across the 10 separate depletions with a standard deviation of 3.2 and a CV of 2.1%.
www.millipore.com /publications.nsf/docs/pf1770en00   (523 words)

 Albumin: The Test
Since albumin is low in many different diseases and disorders, albumin testing is used in a variety of settings to help diagnose disease, to monitor changes in health status with treatment or with disease progression, and as a screen that may serve as an indicator for other kinds of testing.
In this case, the amount of albumin (or protein) in the urine also may be measured.
Low albumin levels may also suggest conditions in which your body does not properly absorb and digest protein (like Crohn’s disease or sprue) or in which large volumes of protein are lost from the intestines.
www.labtestsonline.org /understanding/analytes/albumin/test.html   (346 words)

 MedlinePlus Drug Information: Albumin Microspheres Sonicated (Systemic)   (Site not responding. Last check: 2007-10-13)
The albumin microspheres sonicated preparation is given by injection into a vein before ultrasound to help diagnose problems of the heart.
The albumin microspheres sonicated preparation is to be given only by or under the direct supervision of a doctor with specialized training in ultrasound procedures.
There is no specific information comparing use of albumin microspheres sonicated in the elderly with use in other age groups.
www.nlm.nih.gov /medlineplus/druginfo/uspdi/203714.html   (740 words)

 Albumin: Common Questions   (Site not responding. Last check: 2007-10-13)
Individuals who have chronic liver disease and kidney disorders are at highest risk for developing abnormal albumin levels.
Albumin testing is more often used to test for liver or kidney disease or to learn if your body is not absorbing enough amino acids which are used to produce proteins such as albumin.
The microalbumin test measures very small levels of albumin in your urine and may indicate whether you are at risk for developing kidney disease.
www.labtestsonline.org.uk /understanding/analytes/albumin/faq.html   (239 words)

 Human albumin administration in critically ill patients: systematic review of randomised controlled trials • Why ...
Efficacy of albumin supplementation in the surgical intensive care unit: a prospective, randomized study.
Fluid resuscitation in circulatory shock: a comparison of the cardiorespiratory effects of albumin, hetastarch, and saline solutions in patients with hypovolemic and septic shock.
Woods MS, Kelley H. Oncotic pressure, albumin and ileus: the effect of albumin replacement on postoperative ileus.
www.bmj.com /cgi/content/full/317/7153/235   (4864 words)

 Albumin Microspheres Sonicated (Systemic) - MayoClinic.com
It is not known whether albumin microspheres sonicated pass into breast milk.
Studies on this agent have been done only in adult patients, and there is no specific information comparing use of albumin microspheres sonicated in children with use in other age groups.
The presence of other medical problems may affect the use of albumin microspheres sonicated.
www.mayoclinic.com /health/drug-information/DR203714   (758 words)

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