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Topic: Alkaline phosphatase

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	Reference.com/Encyclopedia/Alkaline phosphatase
		In bacteria, alkaline phosphatase is located in the periplasmic space, external to the cell membrane.
		All mammalian alkaline phosphatase isoenzymes except placental (PLAP and SEAP) are inhibited by homoarginine and similarly all except the intestinal and placental ones are blocked by levamisole.
		In humans, alkaline phosphatase is present in all tissues throughout the entire body, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta.
	www.reference.com /browse/wiki/Alkaline_phosphatase (688 words)

	Alkaline Phosphatase
		Alkaline Phosphatases are a group of enzymes found primarily the liver (isoenzyme ALP-1) and bone (isoenzyme ALP-2).
		Since the mucosal cells that line the bile system of the liver are the source of alkaline phosphatase, the free flow of bile through the liver and down into the biliary tract and gallbladder are responsible for maintaining the proper level of this enzyme in the blood.
		Thus the serum alkaline phosphatase is a measure of the integrity of the hepatobiliary system and the flow of bile into the small intestine.
	www.drkaslow.com /html/alkaline_phosphatase.html (975 words)

	Alkaline Phosphatase Test \| Principal Health News
		The alkaline phosphatase of the liver is produced by the cells lining the small bile ducts (ductoles) in the liver.
		Alkaline phosphatase from the intestine is increased in a person with inflammatory bowel disease, such as ulcerative colitis.
		Alkaline phosphatase is measured by combining the person's serum with specific substances with which alkaline phosphatase is known to react.
	www.principalhealthnews.com /topic/topic100586408 (697 words)

	Dairy Chemistry
		The activity of phosphatase per unit of milk seems to be inversely correlated to milk yield, reaching a minimum in 1 or 2 weeks after calving and rising gradually to a maximum in about 25 weeks.
		Alkaline phosphatase is associated with the fat globule of milk, i.e., it is adsorbed to the fat globule membrane surface.
		Phosphatase tests currently described in Standard Methods for the Examination of Dairy Products are based on the principle that the alkaline phosphatase enzyme in raw milk liberates phenol from a disodium phenyl phosphate substrate (Scharer Method) or phenolphthalein from a phenolphthalein monophosphate substrate (Rutgers Method) when tests are conducted at suitable temperature and pH.
	drinc.ucdavis.edu /dairychem1.htm (841 words)

	Dr. Koop - ALP (alkaline phosphatase) isoenzyme
		A blood test to measure the amounts of different forms of alkaline phosphatase.
		Alkaline phosphatase is an enzyme in the blood, intestines, liver, and bone cells.
		When bones are growing, liver cells are damaged, or a biliary obstruction occurs, alkaline phosphatase levels rise considerably.
	www.drkoop.com /ency/93/003497.html (389 words)

	A TD-700 Fluorometer Method for Alkaline Phosphatase Fluorescence
		Because of their critical functions in eukaryotic cells, methods for measuring protein phosphatases were established at least as early as 1953(1).
		In 1965 Fernley and Walker(2) decribed the use of 4-methylumbelliferyl phosphate (MUP) as a substrate for alkaline phosphatase.
		Calculate the amount of alkaline phosphatase from the fluorescence measurement and the linear equation determined from the AP standard concentration vs. fluorescence, step 3.4.6.
	www.turnerdesigns.com /t2/doc/appnotes/998_2679.html (1219 words)

	Alkaline Phosphatase, Serum
		Alkaline phosphatase is used as a tumor marker.
		Serum alkaline phosphatase is a member of a family of zinc metalloprotein enzymes that function to split off a terminal phosphate group from an organic phosphate ester.
		Liver alkaline phosphatase is increased in cholestasis and inflammatory liver disease as well as in infiltrative liver disease.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/pr014700.htm (1023 words)

	LEE BIOSOLUTIONS PORCINE ALKALINE PHOSPHATASE BULK MANUFACTURER
		Alkaline phosphatase (ALP) is a hydrolase enzyme responsible for removing phosphate groups in the 5- and 3- positions from many types of molecules, including nucleotides, proteins, and alkaloids.
		Alkaline Phosphatase research:Serum soluble factors induce the proliferation, alkaline phosphatase activity and transforming growth factor-beta signal in osteoblastic cells in the patient with hepatitis C-associated osteosclerosis.
		Alkaline Phosphatase research: Inhibition of growth and increase of alkaline phosphatase activity in cultured human oral cancer cells by all-trans retinoic acid.
	www.leebio.com /products/?uid=187 (672 words)

	Alkaline phosphatase definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms
		Alkaline phosphatase: An enzyme made in the liver, bone, and the placenta and normally present in high concentrations in growing bone and in bile.
		Alkaline phosphatase is released into the blood during injury and during such normal activities as bone growth and pregnancy.
		The enzyme is termed alkaline phosphatase because it works under alkaline (non-acidic) conditions, as opposed to acid phosphatase.
	www.medterms.com /script/main/art.asp?articlekey=8701 (273 words)

	The Individualist: Intestinal Alkaline Phosphatase (IAP)
		The activity of intestinal alkaline phosphatase and serum alkaline phosphatase is strongly correlated with ABH secretor phenotypes.
		The intestinal component of alkaline phosphatase is involved with both the breakdown of dietary cholesterol and the absorption of calcium.
		The activity of intestinal alkaline phosphatase was found to be strongly correlated with ABO blood groups and secretor phenotypes, while neither the placenta alkaline phosphatase activity nor the tissue unspecific alkaline phosphatase activity demonstrated any dependence on blood groups or secretor phenotypes.
	www.dadamo.com /wiki/wiki.pl/Intestinal_Alkaline_Phosphatase_(IAP) (1866 words)

	[No title]
		The identity of the alcohol varies depending on the specific phosphatase, and could be some small organic molecule such as a nucleotide (the building blocks of nucleic acids) or an amino acid in a protein (a serine, tyrosine, or threonine).
		The enzyme alkaline phosphatase is a non-specific phosphatase (unlike most enzymes it recognizes a wide variety of molecules as substrates) that is found in bacteria, fungi, and higher animals.
		The hydrolysis of p-nitrophenyl phosphate as catalyzed by alkaline phosphatase.
	chem.pdx.edu /~yanm/alkalinephosphatase.doc (1121 words)

	[No title]
		Alkaline phosphatase (EC:3.1.3.1) (ALP) [1] is a zinc and magnesium-containing metalloenzyme which hydrolyzes phosphate esters, optimally at high pH.
		In streptomyces species alkaline phosphatase is involved in the synthesis of streptomycin (SM), an antibiotic, express a phosphatase (EC:3.1.3.39) (gene strK) which is highly related to ALP.
		Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymic activity, and folds into a 10-stranded beta-sheet structure [4].
	www.ebi.ac.uk /interpro/DisplayIproEntry?ac=IPR001952 (530 words)

	Leukocyte alkaline phosphatase (LAP)
		This is a test that measures the amount of an enzyme called alkaline phosphatase within white blood cells (leukocytes).
		Alkaline phosphatase is an enzyme present in different forms thoughout the body.
		LAP (alkaline phosphatase within white blood cells) is useful in confirming the presence of certain disorders.
	www.healthcentral.com /ency/408/003651.html (650 words)

	Phosphate Binding in the Active Site of Alkaline Phosphatase and the Interactions of 2-Nitrosoacetophenone with ...
		Nucleotide sequence of the alkaline phosphatase gene of Escherichia coli.
		Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene.
		Cloning and expression of the bovine intestinal alkaline phosphatase gene: biochemical characterization of the recombinant enzyme.
	www.biophysj.org /cgi/content/full/86/6/3873 (4636 words)

	MedlinePlus Medical Encyclopedia: ALP isoenzyme test
		Alkaline phosphatase (ALP) is a substance found in all body tissues.
		Each type has a different chemical structure, called an isoenzyme -- its structure depends on where in the body it is produced.
		Many drugs affect the level of alkaline phosphatase in the blood.
	www.nlm.nih.gov /medlineplus/ency/article/003497.htm (689 words)

	Liver Function Tests
		Alkaline phosphatase is an enzyme, which is associated with the biliary tract.
		Alkaline phosphatase may be elevated in primary biliary cirrhosis, alcoholic hepatitis, PSC, gallstones in choledocholithiasis.
		It is used often times to confirm that the alkaline phosphatase is of the hepatic etiology.
	www.gastromd.com /lft.html (1219 words)

	Dibutyryl cAMP-Inducible Alkaline Phosphatase in Animal Cell Plasma Membranes: Fluorescence Detection of Mutant Clones ...
		The extents to which the cyclic nucleotide further induces alkaline phosphatase in these two strains are different, however, indicating that they represent two classes of mutants.
		Studies using amino acids and synthetic peptides as alkaline phosphatase inhibitors suggest that only one alkaline phosphatase isoenzyme predominates, in both the parental and the mutant cell lines, with or without induction by cyclic nucleotide.
		Thus, the mutations all appear to affect factors specific to the expression of alkaline phosphatase activity rather than factors that affect general cellular responsiveness or permeability to dibutyryl cyclic AMP.
	www.pnas.org /cgi/content/abstract/80/13/3918 (365 words)

	biomeda - Secondary Antibodies - Page 1
		Alkaline Phosphatase Goat Anti-Human IgA + IgG + IgM (H+L)
		Alkaline Phosphatase Goat Anti-Human IgG + IgM (H+L)
		Alkaline Phosphatase Goat Anti-Human IgG and IgM (H+L)
	www.biomeda.com /secondary-antibodies/c12p1.html (421 words)

	Alkaline Phosphatase (ALP) - Diagnostics Product Matrix - Medcompare
		Description: For the quantitative in vitro determination of Alkaline Phosphatase in serum or plasma.
		For determination of alkaline phosphatase (ALP) in serum or plasma.
		Description: Intended for the quantitative determination of alkaline phosphatase activity in serum or plasma.
	www.medcompare.com /matrix/564/Alkaline-Phosphatase-(ALP).html (837 words)

	CiteULike: Amperometric detection of alkaline phosphatase activity at a horseradish peroxidase enzyme electrode based ... (Site not responding. Last check: )
		Amperometric detection of alkaline phosphatase activity at a horseradish peroxidase enzyme electrode based on activated carbon: potential application to electrochemical immunoassay.
		This method was easily capable of measuring 10(-12) M alkaline phosphatase and had a calculated detection limit of 2.2 x 10(-14) M. The horseradish peroxidase electrode system was investigated further as a method for non-competitive electrochemical enzyme immunoassay using thyrotropin (TSH) as the model analyte.
		After addition of the analyte, a second biotinylated anti-thyrotropin monoclonal antibody and the substrate, streptavidin-labelled alkaline phosphatase was added and the current (generated by enzyme channelling of hydrogen peroxide) measured as a function of TSH concentration.
	www.citeulike.org /user/biblio24/article/803570 (386 words)

	Alkaline phosphatase isoenzymes.
		This high incidence of alkaline phosphatasemia has resulted in not only a need to identify the source of the elevated alkaline phosphatase; it has also led to a marked proliferation in laboratory procedures aimed at identifying the various isoenzymes of alkaline phosphatase.
		No single technique adequately delineates all of the alkaline phosphatase isoenzymes, but the combination of heat fractionation, electrophoresis, and the measurement of an additional hepatobiliary enzyme has been shown to be able to identify the source of origin of more than 95% of all cases of alkaline phosphatasemia.
		The individual isoenzymes of alkaline phosphatase are discussed in detail, and the underlying pathophysiology is reviewed so that physiologic elevations of alkaline phosphatase are not confused with pathologic increases in alkaline phosphatase.
	www.medscape.com /medline/abstract/752443 (212 words)

	Jaundice: Approach to the Patient With Liver Disease: Merck Manual Professional
		For example, hepatitis serology should be obtained (see Hepatitis: Serology) for suspected acute or chronic hepatitis, PT or INR for suspected hepatic insufficiency, albumin and globulin levels for suspected chronic liver disease, and antimitochondrial antibody levels for suspected primary biliary cirrhosis.
		In cases of isolated elevation of alkaline phosphatase, γ‑glutamyl transpeptidase (GGT) should be obtained; levels are elevated in hepatobiliary disease but not if the high alkaline phosphatase level is due to a bone disorder.
		Liver infiltration can also increase alkaline phosphatase disproportionately to aminotransferases but usually increases bilirubin only slightly or not at all.
	www.merck.com /mmpe/sec03/ch022/ch022d.html (2644 words)

	alkaline phosphatase - Gastroenterology and Liver Diseases Forum
		An alkaline phosphatase of 153 is mildly elevated.
		The mechanism is unknown but probably represents local areas of bile duct obstruction with induction and leakage into serum of hepatic alkaline phosphatase from these obstructed areas.
		The increase in alkaline phosphatase in these disorders is thought to be related to hepatic dysfunction despite the absence of overt liver disease.
	www.medhelp.org /forums/gastro/messages/36244.html (571 words)

	Adult Health Advisor 2006.4: Alkaline Phosphatase Test
		The amount of alkaline phosphatase in your blood is measured to help diagnose liver and bone disease.
		The way alkaline phosphatase is measured varies more than for most other blood tests, so check the normal reference range from your lab when you see your result.
		Because many organs in the body contain alkaline phosphatase, it is sometimes important to know where the increased amount of the enzyme in the blood is coming from.
	www.fairview.org /healthlibrary/content/aha_alkphosp_crs.htm (518 words)

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