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Topic: Allele frequency


  
  allele frequency
allele frequency The relative number of copies of an allele in a population, expressed as a proportion of the total number of copies of all alleles at a given locus in a population.(From Glossary of Biotechnology for Food and Agriculture)
The allele frequency of these sequence variants in a normal Swedish population was found to be 6.8% for the H1.2 GCC GTC shift, indicating that this is a...
The common allele of the Arg72Thr variant associated with type 2 diabetes with an allele frequency of the Arg allele of 0.667 (95% CI 0.658-0.677) among 4,639...
www.mongabay.com /igapo/biotech/allele_frequency.html   (201 words)

  
 Genomics|HuGENet|Reviews|MTHFR Gene and Congenital Anomalies|PubMed ID: 10791559
Among whites outside of Europe the allele frequency of C677T was similar, in the aggregate, to the frequencies observed in Britain and Ireland.
For example, the allele frequency was high in a group of Cayapa Amerindians from Ecuador (52) and in a group of Brazilian Amerindians (51) (43 and 45 percent, respectively); however, in members of the Tupi Parakana tribe, the allele frequency was 11 percent (69).
Still among controls, the frequency of C677T/A1298C compound heterozygotes was 15 percent in the Canadian study (11) (18 percent in the mothers and 11 percent in the children), 20 percent in the Dutch study (12), and appeared to be 17 percent in a U.S. study (13).
www.cdc.gov /genomics/hugenet/reviews/MTHFR.htm   (5553 words)

  
 Allele frequency - Wikipedia, the free encyclopedia
Allele frequency is a measure of the relative frequency of an allele on a genetic locus in a population.
Then the allele frequency is the fraction or percentage of loci that the allele occupies within the population.
The frequencies of all the alleles of a given gene often are graphed together as an allele frequency distribution histogram.
en.wikipedia.org /wiki/Allele_frequency   (830 words)

  
 Bio 101 - Introductory Biology: Population Genetics Homework   (Site not responding. Last check: 2007-10-10)
The allele W (the associated phenotype is "waxy") in corn is inherited as a single-locus trait.
Frequency of the M allele is p = frequency of MM + 1/2 frequency of MN p = (0.53) + 0.5 (0.40) = 0.73
Frequency of the N allele is q = frequency of NN + 1/2 frequency of MN q = (0.07) + 0.5 (0.40) = 0.27
academic.reed.edu /biology/courses/BIO101/popgen.html   (1777 words)

  
 Genetics@TTU   (Site not responding. Last check: 2007-10-10)
The occurrence of particular alleles within a population is known as allele frequency.
It is inherited as a recessive allele and effects approximately 1 in 1700 newborns in Caucasian populations.
Since the cystic fibrosis allele is recessive, it is not easy to identify heterozygotes (although this is changing with the development of molecular probes for the cystic fibrosis allele) but using the Hardy-Weinberg equation we can calculate the expected allele frequency.
genetics.biol.ttu.edu /genetics/Lecture/red15.html   (1779 words)

  
 Web PopGen
The allele frequency(s) of the Source population may be different than the allele frequency of the sink populations.
allele in population n, m is the frequency of migrants to the population and 1-m is the frequency of individuals which do not migrate.
allele in population, p' is the frequency of the A
www.radford.edu /~rsheehy/Gen_flash/popgen/Popgen_help/help.html   (1444 words)

  
 Welcome to GoLive CyberStudio 3
Among Caucasians, who have historically lived primarily in the northern hemisphere, the frequency of the sickle cell allele is very low, because it causes anemia and is therefore a detriment to the individual.
This is because having one copy of the sickle cell allele confers resistance to malaria, the benefit of which outweighs the detriment of anemia.
Allele frequencies for a gene can be determined within a population.
www.emunix.emich.edu /~rwinning/genetics/populat4.htm   (734 words)

  
 SC109   (Site not responding. Last check: 2007-10-10)
The purpose of this laboratory is to examine the conditions necessary for maintaining the status quo and se how selection changes allele frequency.  This will be done by simulating the evolutionary process using your class as a sample population.
Allele Frequency:  The allele frequencies, p and q, should be calculated for the population after five generations of random mating.
In this case, the total number of alleles in the population is equal to the number of students in the class X  2.
www.agpowermicro.org /sc109/labs/10.htm   (1078 words)

  
 Population Genetics
Alleles of a gene don't all exist at an equal frequency within a population.
Population genetics studies the frequencies of alleles within a population, and the probabilities of inheriting a particular trait based on those frequencies.
The frequency of homozygous A is 0.16 or 16%, the frequency of homozygous B is 0.36, or 36%, and the frequency of heterozygotes is 0.48 (2 x 0.24), or 48%.
www.emunix.emich.edu /~rwinning/genetics/populat.htm   (645 words)

  
 DownFreq Documentation - Documentation for DOWNFREQ program
DOWNFREQ is a very simple program which can be used to get rough estimates of marker allele frequencies, and to down code the number of alleles at a marker locus based on their frequencies in the pedigree data.
However, asymptotically this also will give an unbiased estimate of the allele frequencies, and when you have large sets of small pedigrees with founders often untyped, this method may be more reliable than the former.
Typically, it is possible to look at the allele frequency estimates, and collapse them down into four marker alleles with approximately equal allele frequencies of 25%, if you are careful enough in the downcoding process.
watson.hgen.pitt.edu /docs/Downfreq2-Document.html   (1413 words)

  
 Allele frequency models
One model assumes that the allele frequencies in each population are independent draws from a distribution that is specified by a parameter called
This says that frequencies in the different populations are likely to be similar (probably due to migration or shared ancestry).
Roughly speaking, this prior says that we expect allele frequencies in different populations to be reasonably different from each other.
pritch.bsd.uchicago.edu /software/readme/node19.html   (161 words)

  
 Random mating and linkage
Allele frequency influences heterozygote frequency; heterozygotes most frequent at intermediate allele frequency.
In a random mating population, the covariance between uniting alleles is 0.
The covariance between alleles at two loci equals the deviation of the observed gametic frequency from the gametic frequency expected under random union of gametes.
www.wsu.edu:8080 /~mmorgan/biol519f01/node20.html   (492 words)

  
 The Evolution of Populations   (Site not responding. Last check: 2007-10-10)
A gene pool "consists of all alleles at all gene loci in all individuals in a population."
The frequency of genotypes within a population is dependent on the frequency of alleles (and
The frequency of an allele within a population is equal to the number of alleles of a given type within the population divided by the total number of alleles found at a given locus
www.mansfield.ohio-state.edu /~sabedon/campbl23.htm   (2105 words)

  
 Zoology 304, Evolution
That is, both alleles necessarily change frequency at the same rate, and that rate is greater when the allele at lower frequency is dominant.
If you would like to explore this model of selection, by experimenting (i.e., playing) with the parameters of selection coefficient, allele frequency, and dominance and then plotting the results, send a request to Dr. King, and the program which created these graphs will be returned as an attachment.
Here is a graphical representation for a dominant allele, presuming a rather high initial frequency of 1 in a million (i.e., a fairly small, isolated sub-population of people, as if Chicago were surrounded by an impassable desert).
www.science.siu.edu /zoology/king/304/prob04.htm   (665 words)

  
 Estimation of Quantitative Trait Locus Allele Frequency via a Modified Granddaughter Design -- Weller et al. 162 (2): ...
The relative frequency of the QTL alleles is of paramount importance
with population allelic frequencies of 0.7 and 0.3.
that the population frequency of the allele that increases protein
www.genetics.org /cgi/content/full/162/2/841   (4819 words)

  
 MUTATION AND MIGRATION
The first part on the right is accounts for alleles not mutated (1-u), and the second part accounts for the increase in p due to mutation from a to A (the frequency of a times the mutation rate to A).
To select against the a allele, we first will assume complete dominance, i.e., that the deleterious effects of the a allele are only observed in the aa homozygote.
There is an evolutionary pressure changing allele frequencies in one direction (into the harbor), and an opposing evolutionary force eliminating those alleles (sewage killing off genetically intolerant fish).
biomed.brown.edu /Courses/BIO48/7.mutation   (1386 words)

  
 High-Throughput SNP Allele-Frequency Determination in Pooled DNA Samples by Kinetic PCR -- Germer et al. 10 (2): 258 -- ...
The relative allele frequency is determined on the basis of the
Figure 3 is a scatter graph that summarizes all the allele frequency determinations in Tables 1, 2, and 3.
Shown is a scatter-plot of all the measurements of allele frequency made in Tables 1, 2, and 3 comparing the known frequencies (determined by DNA concentration for Table 1 and by individual genotyping and allele counting for Tables 1 and 2) with the measured frequencies.
www.genome.org /cgi/content/full/10/2/258   (5516 words)

  
 Hardy-Weinberg Equilibrium Tutorial
What if the allele had a frequency of 20%; however, we were wrong, the resistant allele is a recessive allele not a dominant allele.
In this case p represents the frequency of the "A" allele and q represents the "a" allele.
Correct, The frequency of the "A" allele is 82.5% {(2*137+56)/400} and the frequency of the red-phase foxes is 68.5% (137/200).
www.cst.cmich.edu /users/swans1bj/hwe/hwetutorial.html   (7477 words)

  
 PCB 4673 Computer Lab Assignment 3
If one allele's true frequency is 0.90 and the other's is 0.10, a small sample is more likely to show an increase in the frequency of the common allele than a decrease.
Set the initial frequencies at all six loci at "independently" and set the initial frequency of the "A" allele at locus 1 at a value of your choice.
In the previous section of this assignment, you learned that, in small populations, the change in allele frequencies across generations was unpredictable, and the fixation of one allele or the other occurred at random.
www.bio.fsu.edu /courses/pcb4673/computer_lab_assignment3.html   (1944 words)

  
 Generating variation: mutation models
allele in generation 1, the allele had to be an
alleles in the previous generation is identical, so the probability of choosing an allele that has that particular ancestor is
Use as a test: if allele frequencies influenced by random sampling alone, then the distribution of allele frequencies should follow the Ewens sampling formula.
www.wsu.edu /~mmorgan/biol519f01/node13.html   (405 words)

  
 A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays -- Simpson et ...
is the estimated allele frequency of A, is the expected allele frequency of A, n is the
in a heterozygote, the proportions of A allele
The control pool allele frequency was 0.05 greater than the case pool allele frequency shown on the x-axis.
nar.oxfordjournals.org /cgi/content/full/33/3/e25   (2625 words)

  
 Allele Frequency
It merely would have shown that if you start off with a population consisting of two colors, and kill off most of one color, you end up with a population that is predominantly the other color.” That statement perfectly supports the theory of evolution.
Evolution is only concerned about the change in allele frequency in a population.
In this case the ratio of light to dark moths changed which changes the allele frequency.
www.ridgecrest.ca.us /~do_while/sage/v7i9e.htm   (973 words)

  
 ALFRED   (Site not responding. Last check: 2007-10-10)
A resource of gene frequency data on human populations
We are in the process of migrating to the latest NCBI build.
ALFRED now has 3786 polymorphisms, 520 populations and 89717 frequency tables (one population typed for one site).
alfred.med.yale.edu /alfred   (76 words)

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