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	Brain & Nervous System > Institute for Brain Science Completes Brain Atlas
		By establishing this baseline of the normal mouse brain, the Atlas allows researchers to compare the brain with others altered to mimic neurological and psychiatric diseases found in humans.
		Through its unique structure and Allen's contribution, the team was able to focus exclusively on the Atlas, completing the project on time and under budget and achieving scientific and technological milestones that many research institutions could not.
		Located in Seattle, Washington, the 501(c)(3) nonprofit Allen Institute for Brain Science, www.alleninstitute.org, was founded in 2001 by philanthropists Paul G. Allen and Jody Patton to identify and address key issues in neuroscience, particularly those that can advance the understanding of human behavior.
	www.emaxhealth.com /85/7573.html (1150 words)

	Paul Allen - Wikipedia, the free encyclopedia
		Allen resigned from Microsoft in 1983 after being diagnosed with Hodgkin's disease which was successfully treated by several months of radiation therapy and a bone marrow transplant.
		Allen is a key developer and investor in the controversial development of the South Lake Union neighborhood of Seattle as a biotechnology hub.
		Allen has made investments estimated at US$200 million as of 2005, and has promoted for city funding of a "South Lake Union Trolley" from Seattle's Westlake Center to the south end of Lake Union which some suggest would be of questionable contribution to the overall mass transit plan of the city.
	en.wikipedia.org /wiki/Paul_Allen (1254 words)

	KOMO : Scientists To Create The 'Allen Brain Atlas' (Site not responding. Last check: 2007-10-16)
		The first project for the nonprofit Allen Institute for Brain Science will be the Allen Brain Atlas, a project to map the role of genes in brain development.
		Allen's startup gift for the initiative boosts to $600 million the total he has donated from a fortune estimated at $20 billion.
		The Allen Brain Atlas is expected to take about five years and will release data, starting in the first quarter of 2004.
	www.komotv.com /news/printstory.asp?id=27224 (304 words)

	BLAZERS: Allen Institute for Brain Science
		Initially, the Allen Brain Atlas project will build a gene expression atlas of the brain of a mouse — an animal that has long been a human surrogate for biomedical research and whose genome map became available just one year after the human genome was completed.
		Because the brain is our most complex organ, it is estimated that up to 20,000 genes (2/3 of the entire genome) may play a critical role in the development and functioning of a healthy human brain.
		The Atlas project team is under the leadership of Allen Institute co-founder Jo Allen Patton and project director Dr. Mark Boguski, a well-known researcher in bioinformatics and genomics.
	www.nba.com /blazers/news/Allen_Institute_for_Brain_Scie-84505-41.html (1302 words)

	Allen pays for study of brain's links to genes
		Allen's project, Insel noted, is on a much larger scale aiming to identify 10,000 genes a year.
		The Allen Brain Atlas aims to build a three-dimensional, Web-accessible map of the mouse brain identifying which genes are active in which portions of the brain.
		Allen said in the statement that the $100 million is seed money to launch the research institute, based for now in 30,000 square feet of leased laboratory space on North 34th Street in Fremont.
	seattlepi.nwsource.com /health/139723_brain16.html (1065 words)

	Online map of brain genes to be released
		The non-profit Allen Institute for Brain Science, based in Fremont, was created by a $100 million donation from Allen to marry computing and neurobiology with the aim of deciphering how genes influence brain development, disease and perhaps someday even memory, behavior and cognition.
		The Allen Brain Atlas is focused on locating active genes in the mouse brain because of the animal's wide use in science as a comparative model.
		Allen and his colleagues say the ultimate goal of the project is to do for brain research what the Human Genome Project has done for biomedical research in general -- combining information technology and biotechnology to provide scientists with a powerful new set of tools for answering questions.
	seattlepi.nwsource.com /local/203536_brain13.html (1124 words)

	Allen's brain project praised
		Paul Allen says his latest and largest philanthropic grant of $100 million to start a brain research project in Seattle comes from a lifelong interest in science and his successful battle in 1983 against Hodgkin's disease, a cancer of the lymph system.
		Allen said the new brain institute, as it grows in size and personnel, likely will move to South Lake Union (where he is financially backing the creation of a "biotechnology hub" for Seattle).
		Allen said he expects Boguski and his scientific team to publish their first results identifying active genes in specific areas of the brain early next year.
	seattlepi.nwsource.com /local/139959_allen17.html (695 words)

	Institute unveils full atlas of mouse brain - Science - MSNBC.com
		This screenshot from the Allen Brain Atlas shows a computationally reconstructed, three-dimensional rendering of mouse brain anatomy.
		The new Allen Brain Atlas is being made available online without cost to neuroscientists studying brain circuits and chemistry, a potential boon to cancer and other disease research because of similarities between the brains of mice and human beings.
		The formal announcement of the mouse brain atlas' completion was made by the Allen Institute for Brain Science on Tuesday in Washington, D.C. "We're trying to advance science worldwide, and being able to allow unfettered access to the data for scientists," Allen told reporters.
	www.msnbc.msn.com /id/15014341 (713 words)

	Online NewsHour: Report \| Brain Gene Map Offers Hope \| November 29, 2006 \| PBS
		The tool is the Allen Brain Atlas, a three-dimensional catalog of all the genes active in the brain.
		Allan Jones is scientific director of the Allen Brain Institute.
		The value of the Brain Atlas is it has just leapfrogged us to the next level of understanding.
	www.pbs.org /newshour/bb/health/july-dec06/brain_11-29.html (1867 words)

	Seahawks Rise, as Does Seattle, in Hometown Tycoon's Vision - New York Times
		Allen's company, Vulcan, is building a residential and research complex in the South Lake Union part of Seattle, near downtown.
		Allen is redesigning whole parts of Seattle with the help of what could amount to almost a billion dollars in public investment.
		Allen, a librarian's son, is little known, and his appearance on the football field and in the locker room at last week's Seahawks game caused the kind of stir usually reserved for Bigfoot sightings.
	www.nytimes.com /2006/01/21/national/21allen.html?ex=1295499600&en=3274ba8d9ec4fe62&ei=5090&partner=rssuserland&emc=rss (881 words)

	Overview of Allen Brain Atlas Data
		To facilitate the annotation of ABA ISH data, and to create a standardized 3D framework upon which to superimpose gene expression data, the project is generating detailed reference atlases of the mouse brain to accompany the ABA data.
		Three-dimensional alignment and registration of ISH data to a standardized atlas requires the atlas to be prepared in an identical fashion to the ISH data, namely 8-week old male C57BL/6J mice brains with unfixed, fresh-frozen tissue preparation.
		ISH data for a given gene is aligned to the reference atlas through a three dimensional registration process that alleviates issues of different planes of section between brains.
	www.brain-map.org /overviewpdf.do (889 words)

	Boston.com / News / Nation / Microsoft cofounder funds brain research
		SEATTLE -- Microsoft Corp. cofounder Paul Allen is donating $100 million to establish a new brain research center, he announced yesterday.
		Starting with the brain of a mouse, the project seeks to discover which genes are active in different regions of the brain and to help expand understanding of the human brain, said a statement from the Allen Institute.
		Allen's startup gift for the initiative boosts to $600 million the amount he has given from a fortune estimated at $20 billion, including $240 million to build the Experience Music Project, a museum about rock music in Seattle.
	www.boston.com /news/nation/articles/2003/09/17/microsoft_cofounder_funds_brain_research (256 words)

	FuturePundit: Paul Allen Brain Atlas To Map All Brain Genes In Mouse
		Paul Allen is ponying up $100 million dollars to map all the genes that are activated in mouse brain cells in 3 to 5 years.
		Note that Allen is therefore accelerating work on identifying genes active in the brain by at least an order magnitude over that of the NIMH Brain Molecular Anatomy Project.
		This first effort by the Allen Institute for Brain Science is known as the Allen Brain Atlas project.
	www.futurepundit.com /archives/001649.html (1158 words)

	Paul Allen
		Allen and Gates write the first microcomputer BASIC for the Altair, a computer kit based on Intel's new 8080 chip.
		Allen was forced to resign from Microsoft in 1983 after being diagnosed with Hodgkin's disease which was successfully treated by several months of radiation therapy.
		Currently Allen is the owner of the Portland Trail Blazers (an NBA basketball team) and the Seattle Seahawks of the National Football League.
	www.thocp.net /biographies/allen_paul.htm (1020 words)

	Boing Boing: Paul Allen's Brain Atlas: digital, 3D, neural map breakthrough
		Mice brains and human brains have significant differences, but are similar enough that a complete "atlas" of the mouse brain is seen by many scientists to be as important a milestone as the Human Genome Project, which mapped the DNA sequence.
		Paul Allen, who co-founded Microsoft 30 years ago with Bill Gates and is one of the world's richest men, donated $100 million to create a searchable 3-D digital map called the Allen Brain Atlas.
		Allen's funding helped to assemble a dream team of scientists, who methodically scanned ultra-thin slices of mouse brain with the aid of robot helpers.
	www.boingboing.net /2006/09/26/paul_allens_brain_at.html (393 words)

	USATODAY.com - Billionaire plugs $100M into brain research (Site not responding. Last check: 2007-10-16)
		Paul Allen, who donated $100 million to establish a brain-science center, is among a select group of philanthropists who have shared their fortunes with a variety of causes:
		Allen's brainchild grew out of a meeting in 2001 of leading neuroscientists and genomics experts Allen had flown to Seattle for a discussion of how the two fields might be connected with some help.
		Allen, one of the world's richest men with a net worth of $21.5 billion, is a philanthropist known for his diversity in interests.
	www.usatoday.com /tech/news/2003-09-16-paul-allen-donation_x.htm (689 words)

	The Seattle Times: Local News: Paul Allen's "brain atlas" unlocking mysteries of the ultimate computer
		The type of brain map that used to grace high-school biology texts looked like a quilt: A pink chunk labeled "vision" bumped up against a blue blob that was the seat of language and a yellow swath representing motor perception.
		Allen, who donated $100 million to the lab, said he is so pleased with the results that he will consider similar, large-scale science projects in the future.
		Experts say the Allen Brain Atlas, which will be formally unveiled today, will boost understanding of brain circuits and chemistry — and what goes wrong in conditions ranging from schizophrenia and autism to Parkinson's disease and drug addiction.
	seattletimes.nwsource.com /html/localnews/2003275752_brain26m.html (1167 words)

	Well-Funded Scientists Map Mouse Brain
		The new Allen Brain Atlas is being made available online without cost to neuroscientists studying brain circuits and chemistry, a potential boon to cancer and other disease research because of similarities between the brains of mice and human beings, according to a statement issued by the Allen Institute of Brain Science.
		Even before completion of the mouse brain map, the institute's work had become vital to scientists delving into the genetics of multiple sclerosis, which is caused by degeneration of nerve cells, said Dr. Ben Barres, a Stanford University neurology professor.
		Allen donated $100 million to start the lab in 2003 and the mouse brain atlas cost $41 million, well under the $50 million that had been budgeted, Jones said.
	www.happynews.com /news/9262006/funded-scientists-map-mouse-brain.htm (650 words)

	news_12_31_03
		Allen put up the US $100 million that the three-year mission is expected to consume, and he has promised to put the entire thing on the Web, in quarterly installments, for individual researchers to access free of charge.
		Ideally, the Atlas would study the proteins directly, but because proteins are hard to detect in fine detail and at high production speeds, the Atlas will instead follow an easier target: nucleic acids that ferry data from the nucleus to the structures that translate them into protein.
		Given a 1.5-centimeter-long brain and a 25-micron-thick slice, you get 600 slices per brain; with the ability to see just three genes per slice and the goal of looking at 20,000 genes altogether, you require 7,000 brains (perhaps 8,000 for good measure).
	www.maaddsg.org /news_12_31_03.htm (2886 words)

	Corante > Brain Waves > Monthly Archives
		The project was established by the European Brain Council and is the first project aimed at analyzing the cost of all brain disorders of the Brain in Europe, bringing together scientific edge in epidemiology and health economics on major brain disorders in Europe.
		Supporting this work were organizations like the European Brain Council, the European Federation of Neurological Associations and the Global Alliance of Mental Illness Advocacy Networks, and The European DANA Alliance for the Brain.
		Brain Awareness Week is a growing international effort organized by the Dana Foundation to advance public awareness about the progress and benefits of brain research.
	www.corante.com /brainwaves/archives/2005_03.html (1994 words)

	RedOrbit - Science - Scientists Map the Mouse Brain Genome
		The atlas maps the use, or expression, of the mouse genome onto known brain anatomy to help reveal which genes are turned on in different brain regions.
		The Allen Brain Atlas uses a technique called in situ hybridization to indicate where each gene being studied is turned on, using a series of tissue sections taken throughout the brain.
		These stained sections are photographed under a microscope, and the data is uploaded onto the Allen Brain Atlas for display on a Web-based image browser.
	www.redorbit.com /news/display?id=111371 (587 words)

	PaulAllen.com
		While the physiology of the human brain is well-documented, its biology and functioning—how it receives and stores information—is still largely a mystery.
		Their answer: to create an unprecedented 21st century map of the brain, utilizing recent advances in computer science, bioinformatics, image analysis and the sequencing of the human genome.
		The Institute's first project, the Allen Brain Atlas, will combine the disciplines of neuroanatomy and genomics to create the most comprehensive map ever created of the brain from the cellular level.
	www.paulallen.com /Template.aspx?contentId=21 (193 words)

	The Scientist : Gene expression mapped across mouse brain (Site not responding. Last check: 2007-10-16)
		Previous research has analyzed gene expression in the mammalian brain, but at different resolutions than the Allen Brain Atlas, according to Carrolee Barlow of Brain Cells, Inc. in San Diego, who was not involved in the work.
		The atlas researchers used the data to analyze overall gene expression in the brain, finding that about 80% of mouse genes are expressed somewhere in the adult brain.
		The atlas detected many but not all recognized markers of 12 major brain regions; it missed several genes known to be highly specific to certain regions.
	www.the-scientist.com /news/display/37348 (802 words)

	Allen Brain Atlas Completed - Medgadget - www.medgadget.com
		The atlas, available to anyone for free, is a three-dimensional map of 21,000 genes expressed in the brain of a mouse.
		Many of the discrete regions of the brain perform similar functions in all mammals, and greater than 90 percent of all mouse genes have a direct counterpart in humans.
		So, the real size of the Allen Brain Atlas is around 60 TeraBytes, which is a far cry from a PetaByte.
	www.medgadget.com /archives/2006/09/allen_brain_atl.html (1018 words)

	[No title]
		On the 100th anniversary of flight, Paul G. Allen confirmed that he is the sponsor behind the innovative SpaceShipOne project - the first non-government effort to demonstrate a low-cost manned space effort.
		Allen and aerospace engineer Burt Rutan joined forces in 2001 to create a supersonic craft for the "X PRIZE," a contest to spur aerospace innovation among the private sector.
		Allen said, "SpaceShipOne is a tangible example of continuing humankind's efforts to travel into space, effectively demonstrating that private resources can make a big difference in this field of discovery and invention."
	www.vulcan.com /feature/feature_detail.asp?recNo=31 (182 words)

	Allen Institute for Brain Science
		The goal of our inaugural project, the Allen Brain Atlas, is to create a detailed cellular-resolution, genome-wide map of gene expression in the mouse brain.
		The completion of the sequencing of the mouse brain and the availability of techniques to probe gene expression amenable to scale-up and automation have made this an achievable, albeit ambitious, goal.
		The Allen Brain Atlas has created an automated platform for high-throughput in situ hybridization (ISH) that allows a highly systematic approach for analyzing gene expression in the brain.
	alleninstitute.org /content/projects.htm (345 words)

	Allen Institute for Brain Science Completes Brain Atlas :: PNNOnline ::
		The completion of the Allen Institute for Brain Science's inaugural project signals a remarkable leap forward in one of the last frontiers of medical science -- the brain.
		The Institute has announced the completion of the groundbreaking Allen Brain Atlas, a Web-based, three-dimensional map of gene expression in the mouse brain.
		Located in Seattle, Washington, the 501(c)(3) nonprofit Allen Institute for Brain Science, was founded in 2001 by philanthropists Paul G. Allen and Jody Patton to identify and address key issues in neuroscience, particularly those that can advance the understanding of human behavior.
	www.pnnonline.org /article.php?sid=6996&mode=thread&order=0&thold=0 (1017 words)

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