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Topic: Allostery

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	allostery@Everything2.com
		Allostery is fundamental to a lot of biochemical processes.
		The origins of allostery can be seen directly by looking at atomic level structures of proteins (see X-ray crystallography).
		These high maginification structures show how the protein is in one shape when bound to one molecule and another shape when bound to a second.
	everything2.com /?node_id=602535 (579 words)

	allostery (Site not responding. Last check: 2007-10-19)
		"Allostery" is derived from the Greek "other site", referring to the typical scenario in which an enzyme's allosteric and active sites are distinct.
		The concerted model of allostery postulates that enzyme subunits are connected in such a way that a conformational change in one subunit is necessarily conferred to all other subunits.
		The sequential model of allostery holds that subunits are not connected in such a way that a conformational change in one induces a similar change in the others.
	www.yourencyclopedia.net /allostery.html (578 words)

	Allosteric regulation - Wikipedia, the free encyclopedia
		Effectors that enhance the protein's activity are referred to as allosteric activators, while those that decrease the protein's activation are called allosteric inhibitors.
		The term allostery comes from the Greek allos, "other", and stereos, "shape", referring to the regulatory site of an allosteric protein being separate from its active site.
		The concerted model of allostery, also referred to as the symmetry model or MWC model, postulates that enzyme subunits are connected in such a way that a conformational change in one subunit is necessarily conferred to all other subunits.
	en.wikipedia.org /wiki/Allostery (629 words)

	UCSC Biomedical Research - Prof. David Kliger
		Allostery down regulates the ligand-binding strength of the R quaternary state in the T state, enabling efficient off-loading of oxygen to the tissues.
		Time-resolved CD and MCD of the tryptophan amino acid residues showed that photolysis of ligands from the R state first triggers formation of the Trp b37-Asp a94 hydrogen bond, pictured here in the "hinge" region of the interface that connects the two dimers of the hemoglobin tetramer.
		Allostery is a mechanism that regulates the function of many proteins by changing the shape of an active site on the protein when a ligand binds to another site.
	biomedical.ucsc.edu /Kliger.html (765 words)

	The Topics Archive » Blog Archive » Coarse-Grained Model Of Entropic Allostery (Site not responding. Last check: 2007-10-19)
		Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule.
		An alternative entropic mechanism of “allostery” suggests that the inducer ligand changes the intramolecular vibrational entropy, not just the mean static structure.
		We present a quantitative, coarse-grained model of entropic allostery, which suggests design rules for internal cohesive potentials in proteins employing this effect.
	www.aviationplace.com /_wp/tech/index.php?p=10 (214 words)

	CiteULike: Is allostery an intrinsic property of all dynamic proteins?
		Is allostery an intrinsic property of all dynamic proteins?
		Allostery involves coupling of conformational changes between two widely separated binding sites.
		Allostery is a consequence of re-distributions of protein conformational ensembles.
	www.citeulike.org /user/cactus/article/355198 (459 words)

	The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin -- Frauenfelder ...
		The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin -- Frauenfelder et al.
		The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin
		Allostery is a consequence of the existence of these taxonomic substates.
	www.pnas.org /cgi/content/full/98/5/2370 (3590 words)

	CiteULike: Tag allostery (Site not responding. Last check: 2007-10-19)
		posted to allostery p38 by lna on 2005-06-06 16:39:07 as
		Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors.
		The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin.
	www.citeulike.org /tag/allostery (1338 words)

	Global Allostery Model of Hemoglobin. MODULATION OF O2 AFFINITY, COOPERATIVITY, AND BOHR EFFECT BY HETEROTROPIC ...
		Summary of the global allostery plots (the log K versus log L plots) of MWC parameters of Hb (circles) and des-His-Tyr-Hb (squares) at pH 6.6-9.0.
		molecular mechanism of cooperativity and allostery of Hb.
		The present global allostery model is based upon the thorough characterization of the structure and function of deoxy and
	www.jbc.org /cgi/content/full/277/37/34508 (6976 words)

	Crystal Structure of Anticoagulant Thrombin Variant E217K Provides Insights into Thrombin Allostery -- Carter et al. ...
		allostery is also of potential importance for the development
		of thrombin and the role of thrombin allostery in hemostasis.
		The E217K variant of human thrombin was produced as before (20).
	www.jbc.org /cgi/content/full/279/25/26387 (4006 words)

	The Effect of Water on the Rate of Conformational Change in Protein Allostery -- Goldbeck et al. 81 (5): 2919 -- ...
		The role of solvation in allostery has long been recognized in principle, but only recently has it been studied explicitly.
		allostery in human hemoglobin, in which four heme prosthetic groups
		To investigate the kinetic implications of water activity in hemoglobin allostery, we studied the effect of PEG osmolyte on
	www.biophysj.org /cgi/content/full/81/5/2919 (6902 words)

	Enzyme Kinetics Chapter 5 - Sequential hypothesis of allostery (Site not responding. Last check: 2007-10-19)
		The concerted hypothesis was based on the assumption that one enzyme molecule could contain only one type of subunit - R or T. The sequential hypothesis accepts the possibility that mixed enzymes, containing both types may occur.
		To some extent the symmetry hypothesis can be seen as an extreme case of the sequential one in which the T/R combinations can exist, but they are so unstable that they don't to any significant extent.
		So far we've been studying allostery in general terms.
	www-biol.paisley.ac.uk /Kinetics/Chapter_5/chapter5_3_2.html (559 words)

	Laboratoire de didactique et épistémologie des sciences - Index
		Health studies and patient education have seriously started their initiation into it through the training of hospital staff.
		Furthermore allostery is at the center of a few museum exhibitions.
		However the most original use of this model is to be found in the company, in the context of "learning companies".
	www.ldes.unige.ch /ang (1059 words)

	Enzyme catalysis, kinetics, and allostery
		Oligomerization enables cooperativity between multiple binding sites, a property referred to as allostery or allosteric regulation of enzymes (yet again, single polypeptide, multi-domain proteins show allosteric behavior).
		Protein complexes are often referred to as oligomeric proteins.
		The symmetry model of allosterism describes the cooperative binding of ligands to an enzyme complex.
	www.whatislife.com /reader/enzyme/enzyme.html (3420 words)

	S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support ...
		Crawford and coworkers did not actually test the role of allostery.
		and cannot exhibit allostery, were a key component of the design
		of the proportion of Hb capable of exhibiting allostery.
	www.bloodjournal.org /cgi/content/full/102/1/410 (2965 words)

	Computer-based learning of cooperativity and allostery -- Franco and Canela 1 (3): 161 -- Bioinformatics
		Computer-based learning of cooperativity and allostery -- Franco and Canela 1 (3): 161 -- Bioinformatics
		The aim of this article is to facilitate the understanding of enzyme
		cooperativity and allostery by undergraduate and postgraduate students with
	bioinformatics.oxfordjournals.org /cgi/content/abstract/1/3/161 (175 words)

	Enzyme Kinetics Chapter 5 - Concerted hypothesis of allostery (Site not responding. Last check: 2007-10-19)
		Enzyme Kinetics Chapter 5 - Concerted hypothesis of allostery
		The concerted hypothesis of allostery, introduced by Monod, Wyman and Changeux, is a simple and elegant explanation for positive substrate cooperativity and the influence of allosteric effectors which are common features of allosteric enzymes.
		It is based on the idea that an allosteric enzyme consists of a number of subunits which can exist in two different conformations, or three dimensional structures.
	www-biol.paisley.ac.uk /kinetics/chapter_5/chapter5_3_1.html (686 words)

	allostery Information
		I tried allostery starting on Jan of 2005 and ending on 2006
		I also tried apophthegmatic as well as ectopic eyelash
		Overall, I would say that allostery is a stinking diet product
	www.worldchildfree.org /health4018.php (273 words)

	OhioLINK ETD: Subramaniam, Srisunder
		Studies of conformational changes and dynamics accompanying substrate recognition, allostery and catalysis in bacteriophage lambda integrase
		These results and a new paradigm for site recognition and catalytic activation by large multidomain enzymes form the heart of the dissertation.
		bacteriophage lambda integrase; site specific recombination; DNA cleaving enzymes; enzyme dynamics; enzyme catalysis; molecular recognition; substrate recognition; NMR spectroscopy; allostery; protein folding; binding-coupled protein folding
	rave.ohiolink.edu /etdc/view?acc_num=osu1111655332 (406 words)

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