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Topic: Allotransplantation

Related Topics

Organ transplant

Xenotransplantation

Marker

Transgenic

	COMPOSITE TISSUE ALLOTRANSPLANTATION AND RECONSTRUCTIVE SURGERY: The first clinical applications
		This kind of autotransplantation differs from tissue allotransplantation (formerly called homotransplantation) which is defined by the transfer of (allo)grafts harvested from a different subject in the same species (inter-human transplantation).
		First, tissue allotransplantation obtains the preeminent objective of any tissue reconstruction; the " like with like " replacement, … where a thumb would be reconstructed with a thumb but not with a toe.
		On the contrary, allotransplantation is unsuitable for certain pathologies: breast reconstruction, for example, would not be justified nor technically feasible considering the difficulty to withhold a breast based on a reliable vascular pedicle.
	www.maitrise-orthop.com /corpusmaitri/orthopaedic/111_petit/petitus.shtml (4619 words)

	History of Allotransplantation (Site not responding. Last check: 2007-10-19)
		After the first human cardiac allograft procedure performed by Barnard in1967 the field of cardiac transplantation witnessed a surge in both enthusiasm and attempted trials, which was followed by a marked drop in procedures throughout the 1970s because of poor survival rates.
		Proponents of allotransplantation at the time of the first heart transplantation cited the more than 60-year history of experimental cardiac transplantation, beginning with Carrel's original work in 1905.
		In light of these findings, few would deny cardiac allotransplantation its present claim to "success." To further understand the evolution of this achievement, however, we may now look back upon the early years of cardiac allotransplantation and try to address the proposed threefold inquiry.
	www.unav.es /emp/allohis.html (1174 words)

	Establishment of submandibular gland allotransplantation model in miniature swine (Site not responding. Last check: 2007-10-19)
		Allotransplantation of submandibular gland might be possible to be a treatment of severe xerophthalmia.
		Conclusions: The results showed that the successful model can be established in miniature swine and acute rejection existed after the allotransplantation of submandibular gland without using immunosuppressive agent.
		Further studies are needed to determine whether the allografts can survive over a long period with its secretory function and whether the secretion meet the requirement under immunosuppressive therapy.
	iadr.confex.com /iadr/china04/preliminaryprogram/abstract_52490.htm (295 words)

	N°82 Composite tissue allotransplantation (CTA) of the face (Full or partial facial transplant) February 06, 2004
		On February 19th 2002, Doctor Lantieri of the Henri Mondor (AH-HP) Hospital, referred to CCNE concerning the ethical issue of vascularised composite tissue allotransplantation of the face.
		Because of the presence of tissues (a considerable amount of skin, muscles, and sometimes bone) that express the highest degree of antigenecity, allotransplantation of all or part of a face signifies exposure to maximum risk of rejection, unless the availability of effective, but also lifelong, immunosuppressive treatment, is assured.
		Treating major facial burns by allotransplantation of a face harvested from a person in a state of cerebral death may seem to be an attractive option.
	www.ccne-ethique.fr /english/avis/a_082.htm (2367 words)

	Xenotransplantation: Risks, Clinical Potential, and Future Prospects
		After the first human cardiac allograft procedure performed by Barnard in 1967 (7) the field of cardiac transplantation witnessed a surge in both enthusiasm and attempted trials, which was followed by a marked drop in procedures throughout the 1970s because of poor survival rates.
		If we view the current status of experimental accomplishments in xenotransplantation with the same scrutiny as that of allotransplantation at the time of Barnard's endeavor, we are left with similar conclusions; first, comparable graft survival time has been achieved in animal models of xenotransplantation as was evident for allotransplantation before 1967.
		As was the case during the early years of allotransplantation, clinical xenotransplantation must persevere under the consideration of and often in spite of scrutiny by its most demanding critics, for while "success has a hundred fathers, failure is an orphan" (43).
	www.cdc.gov /Ncidod/EID/vol2no1/michler.htm (4444 words)

	Bioethics Working Groups at Boston University:Xenotransplantation (Site not responding. Last check: 2007-10-19)
		The reasons for sustained interest in xenotransplantation are several, but one, almost ironically, stems from the significant progress made in the field of allotransplantation in recent years.
		Allotransplantation, or the transplantation of tissues from one individual to another within the same species, has enjoyed tremendous success as new highly effective immunosuppressive agents have been developed and surgical techniques have improved.
		Even in allotransplantation, donors are sought who are “matched,” or genetically similar, to the recipient because the strength of the immune response, and hence the likelihood of rejection, will be less between two individuals with similar genetic backgrounds.
	www.bu.edu /bioethics/pages/xenoscharf.html (3975 words)

	Comparing autolgous and allogeneci stem cell transplants
		Five-year treatment-related mortality (TRM) was 30%, 14% and 8% and five-year recurrence rate was 21%, 43% and 58% after allotransplantation, purged and unpurged autotransplantation, respectively.
		In multivariate analysis, allotransplantation had a fourfold increase in TRM, but a 50% decrease in recurrence.
		The decreased recurrence after allotransplantation is offset by an increased TRM.
	www.lymphomation.org /comparing-sct.htm (292 words)

	Protocols - General Clinical Research Center at the University of Minnesota
		This is a Phase I/II study designed to assess the safety and efficacy of sequential islet allotransplantation for the reestablishment of stable glycemic control in type 1 diabetic recipients with established renal allografts.
		The primary objective of the study is to assess the safety of islet allotransplantation and protocol-regulated treatment products (i.e., concomitant therapy) as determined by the incidence, timing, and severity of adverse events as well as their relationship to the islet transplant procedure(s) and additional protocol-regulated treatment products.
		The secondary objective is to assess the proportion of type 1 diabetis subjects who achieve insulin independense in the first year after solitary and sequential islet allotransplantation using the proposed immunosuppressive protocol.
	www.gcrc.umn.edu /gcrc/proto.php?p804 (242 words)

	Human Hand Transplant Nears \| News Release \| Jewish Hospital (Site not responding. Last check: 2007-10-19)
		The team based its decision to proceed with the human hand transplant on the encouraging experimental results from their own research and the consensus of leading researchers who attended a scientific meeting held in November of 1997 in Louisville.
		The International Symposium on Composite Tissue Allotransplantation sponsored by Jewish Hospital Foundation, Inc. hosted internationally recognized experts who discussed research in transplantation, immunology, ethical issues, feasibility of the hand transplant procedure, and patient concerns.
		A team was assembled consisting of hand and microsurgeons and researchers from Kleinert, Kutz and Associates Hand Care Center, PLLC and University of Louisville School of Medicine's transplant surgeons and researchers to consider the feasibility of human hand transplants.
	www.jhhs.org /newsrelease.asp?id=142 (1295 words)

	News & Headlines: Physicians and Researchers Convene to Discuss Transplant Issues
		Ethical considerations in allotransplantation were also presented by Mark Siegler, MD, MacLean Center for Clinical Medical Ethics, University of Chicago.
		"This is really an historical time in composite tissue allotransplantation, which at the moment is hand transplantation, but may include lower limb transplantation in the future, as well.
		The symposium also included presentations by the world's first larynx transplant recipient, and the nation's first hand transplant recipient, as they gave their perspective on the innovative experimental procedures they have undergone.
	www.otohns.net /?id=7610 (647 words)

	Active Skim View of: Appendix C-Immunosuppression in Allotransplantation
		-- > C Immunosuppression in Allotransplantation This appendix is based on the workshop presentation of Barry Kahan and is included here to provide the reader with background information about the key features considered in developing new immunosupressive drugs or therapies.
		Many new immunosuppressive medications have been developed in the past two decades for the treatment of graft rejection in allotransplantation.
		The first available anticytokine was cyclosporine, which has twice the effectiveness of azathioprine in extending kidney allograft survival.
	www.nap.edu /nap-cgi/skimit.cgi?isbn=0309055490&chap=123-126 (240 words)

	Faculty Interests - Dr Haughey (Site not responding. Last check: 2007-10-19)
		We have been involved in investigating allotransplantation of the tongue in an animal model.
		No EMG responses were seen on the transplant side when the unoperated, control hypoglossal nerve was stimulated, and spontaneous, voluntary motor unit potentials were present on the transplant side after deliberate, terminal transection of the contralateral, control XII nerve.
		We conclude that allotransplantation of the canine hemitongue is possible, and evidence of functional neuromuscular recovery has been demonstrated.
	oto.wustl.edu /haughey/haugh1.htm (278 words)

	Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal ...
		The affinity of ABI793 was similar to that of two mouse anti-human CD154 antibodies (including the non-humanized version of hu5c8) however closer investigation demonstrated that ABI793 recognized a different epitope on CD154 to that of the murine antibodies.
		Schuler et al then proceeded to determine the efficacy of the antibodies when used as a monotherapy in life-supporting renal allotransplantation in Cynomolgus monkeys.
		If you have or suspect you may have a health problem, you should consult your physician or other health care provider.
	www.bioportfolio.com /LeadDiscovery/PubMed-090406.html (1287 words)

	txt001rdb: Molecular mechanisms of immunity in corneal allotransplantation and xenotransplantation
		Corneal allotransplantation is the most common and successful form of solid organ transplantation in humans.
		The differential fate of intracameral versus orthotopical corneal xenografts, the speed of rejection of orthotopic corneal xenografts, and the involvement of humoral and/or cell-mediated immune responses in corneal xenograft rejection are general worthy areas for further investigation.
		Ying Qian and M. Reza Dana (2001) Molecular mechanisms of immunity in corneal allotransplantation and xenotransplantation.
	www-ermm.cbcu.cam.ac.uk /01003246h.htm (8812 words)

	Nat' Academies Press, Xenotransplantation: Science, Ethics, and Public Policy (1996)
		This appendix is based on the workshop presentation of Barry Kahan and is included here to provide the reader with background information about the key features considered in developing new immunosupressive drugs or therapies.
		--> C Immunosuppression in Allotransplantation This appendix is based on the workshop presentation of Barry Kahan and is included here to provide the reader with background information about the key features considered in developing new immunosupressive drugs or therapies.
		A new class of highly selective immunosuppressives has revolutionized allotransplantation since the early 1980s.
	www.nap.edu /books/0309055490/html/123.html (1727 words)

	One-stage allotransplantation of thoracic segment of the trachea in a patient with idiopathic fibrosing mediastinitis ...
		One-stage allotransplantation of thoracic segment of the trachea in a patient with idiopathic fibrosing mediastinitis and marked tracheal stenosis -- Levashov et al.
		One-stage allotransplantation of thoracic segment of the trachea in a patient with idiopathic fibrosing mediastinitis and marked tracheal stenosis
		attempt at one-stage allotransplantation of the trachea with omentopexy of
	www.ejcts.ch /cgi/content/abstract/7/7/383 (456 words)

	Arch Surg -- Abstract: Allotransplantation of whole spleen in patients with hepatic malignant tumors or hemophilia A. ...
		Arch Surg -- Abstract: Allotransplantation of whole spleen in patients with hepatic malignant tumors or hemophilia A. Operative technique and preliminary results, January 1995, Liu et al.
		Allotransplantation of whole spleen in patients with hepatic malignant tumors or hemophilia A. Operative technique and preliminary results
		Therefore, allotransplantation of the spleen can be used in the
	archsurg.ama-assn.org /cgi/content/abstract/130/1/33 (309 words)

	Xenotransplantation (Site not responding. Last check: 2007-10-19)
		In 1954, surgeon Joseph Murray started a revolution in the Medical industry by performing the first human organ transplant, a kidney transplant between identical twins(1).
		Initially, allotransplantation received some hindrance due to the ability of the human immune system to reject any foreign object.
		With the introduction of cyclosporin, a powerful drug that minimizes the rejection of foreign tissue, allotransplantion possibilities have expanded spectacularly(3).
	cseserv.engr.scu.edu /StudentWebPages/MSaeed/ResearchPaper.htm (4121 words)

	Hand Transplant
		Lymphadenectomy prior to rat hind limb allotransplantation prevents graft-versus-host disease in chimeric hosts.
		Elastic Properties of Bone in Composite Tissue Allotransplantation: The Rat Hind Limb Model.
		Klapheke, MM, Composite tissue allotransplantation: Psychiatric considerations in hand or arm transplantation, Psychosomatics, 40, 149-150, 1999.
	www.handtransplant.com /procedure/publications.htm (2100 words)

	Research - Face Transplant
		Composite tissue allotransplantation (CTA): Current Status and Future Insights” European J Trauma, 7 (6): 267-274, 2000.
		"Allograft allotransplantation with composite tissue of two ears and skin of head and neck: A report of one case" Chinese Journal of Plastic Surgery.
		The case for local immunosuppression in composite tissue allotransplantation.
	plasticsurgeryresearch.louisville.edu /research__face_transplant.htm (2373 words)

	The long term outcome of limbal allografts: the search for surviving cells -- Henderson et al. 85 (5): 604 -- British ...
		Limbal allotransplantation is increasingly being used for ocular surface repair in patients with limbal stem cell dysfunction.
		Limbal stem cell allotransplantation can provide long term benefits, as measured by objective criteria.
		The clinical outcome for each patient at 3-5 years after limbal allotransplantation is summarised in Table 2.
	bjo.bmjjournals.com /cgi/content/full/85/5/604 (2627 words)

	Origin of hepatocellular carcinoma recurring after allotransplantation revealed by microsatellite analysis -- Pfeiffer ... (Site not responding. Last check: 2007-10-19)
		Origin of hepatocellular carcinoma recurring after allotransplantation revealed by microsatellite analysis -- Pfeiffer et al.
		Origin of hepatocellular carcinoma recurring after allotransplantation revealed by microsatellite analysis
		Copyright © 1997 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists.
	jcp.bmjjournals.com /cgi/content/abstract/50/9/792 (183 words)

	INTERNATIONAL DOCTORS AND RESEARCHERS MEET TO DISCUSS LEADING EDGE TRANSPLANTS AT SYMPOSIUM
		Composite tissue allotransplantation (CTA Ð multiple tissue transplant) will be presented by world-renowned surgeons and researchers at the symposium.
		Eight of the original presenters from the first international symposium in November 1997 will return to the conference center at the Jewish Hospital's Rudd Heart and Lung Center to discuss what they have learned from the experimental procedures performed over the past two years.
		Ethical considerations in allotransplantation will also be discussed.
	www.handtransplant.org /news_release/051600.html (441 words)

	[Characteristics of cellular immunosuppression models of allotransplantation reactions].
		[Characteristics of cellular immunosuppression models of allotransplantation reactions].
		[Characteristics of cellular immunosuppression models of allotransplantation reactions].Two developed experimental models based on induction of suppression by alloantigens in mice and on testing of its effect on the level of proliferative immune reaction during systemic or local adoptive transfer of spleen suppressor cells to syngeneic mice were used.
		Formation of immunosuppressive mechanisms has been shown to depend on alloantigen (H-2, Mls) properties.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/6194323.html (111 words)

	COE - Recommendation 1399 (Site not responding. Last check: 2007-10-19)
		The advancement of transplantation technology has allowed considerable success in human-to-human organ transplants (allotransplantation) and is promising a radical breakthrough for the transplantation of animal cells, tissues, and organs into humans (xenotransplantation).
		Whereas rejection problems and the transfer of diseases can be satisfactorily controlled in allotransplantation, these risks remain today uncontrollable for xenotransplantations.
		Research to solve these problems should be stepped up prior to any clinical trial.
	xenotransplant.ineu.org /organtrans/news/19990129coe1399rec.htm (301 words)

	Infectious Disease Issues in Xenotransplantation -- Boneva et al. 14 (1): 1 -- Clinical Microbiology Reviews
		or between individuals within the same species is called allotransplantation.
		During identified periods after allotransplantation, recipients are at risk for immunosuppression-associated endogenous and
		Allotransplantation has also contributed to the transmission of both infection and cancer (reviewed in reference 32).
	cmr.asm.org /cgi/content/full/14/1/1?maxtoshow=&HITS=10&hits=10&... (8709 words)

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