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Topic: Almotriptan

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	MedlinePlus Drug Information: Almotriptan
		Almotriptan is used to treat the symptoms of migraine headache (severe throbbing headache that sometimes comes along with nausea and sensitivity to sound and light).
		Almotriptan does not prevent migraine attacks or reduce the number of headaches you have.
		Almotriptan should not be used to treat hemiplegic or basilar migraine or headaches caused by other conditions (such as cluster headaches).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a603028.html (821 words)

	Pharmacy Times: Almotriptan (Axert)
		Almotriptan was approved for marketing in the United States by the FDA in May 2001 (Axert, Pharmacia Inc., Chicago, IL) for the treatment of migraine headaches with or without aura in adult patients.
		Almotriptan is primarily excreted renally (75%) and needs to be adjusted for patients with impaired renal function.
		Almotriptan is contraindi-cated in patients with a known history of ischemic heart disease or uncontrolled hypertension.
	www.pharmacytimes.com /article.cfm?ID=300 (583 words)

	Almotriptan malate (Axert)
		Almotriptan is minimally protein bound, and it has a mean half-life of 3 to 4 hours.
		Evaluation of almotriptan in long term open-label studies, where multiple migraine attacks were treated for up to one year, 5% (63 out of 1347) withdrew due to adverse effects.
		The use of almotriptan is contraindicated in patients with cardiovascular disease and uncontrolled hypertension.
	uuhsc.utah.edu /pharmacy/bulletins/almotriptan_malate.html (507 words)

	Almotriptan Drug Information, Professional
		Almotriptan is not intended for the prophylactic therapy of migraine.
		Almotriptan is not indicated for use in cluster headaches.
		Almotriptan was not clastogenic in an in vivo mouse micronucleus assay but was weakly clastogenic in in vitro cytogenetic assays in human lymphocytes.
	www.drugs.com /MMX/Almotriptan.html (2034 words)

	MedlinePlus Drug Information: Almotriptan (Systemic) (Site not responding. Last check: 2007-11-01)
		Almotriptan often relieves other symptoms that occur together with a migraine headache, such as nausea, vomiting, sensitivity to light, and sensitivity to sound.
		These unwanted effects usually occurred when almotriptan was given in amounts that were large enough to cause harmful effects in the mother.
		Although there is no specific information comparing use of almotriptan in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/500301.html (1398 words)

	Drugs and Treatments - Axert Oral - (Axert) - Patient Handout from RxList (Site not responding. Last check: 2007-11-01)
		Almotriptan does not prevent future migraines or reduce how often you may get a headache.
		Almotriptan belongs to a group of drugs called triptans.
		Before taking almotriptan, tell your doctor or pharmacist if you are allergic to it; or to other triptan migraine drugs; or if you have any other allergies.
	www.rxlist.com /drugs/search.aspx?query=Axert (1267 words)

	almotriptan side effects (Site not responding. Last check: 2007-11-01)
		Almotriptan is used to treat vascular headaches such as migraine headaches.
		Almotriptan is in the FDA pregnancy category C. This means that it is not known whether almotriptan will harm an unborn baby.
		Since almotriptan is taken to treat migraines or cluster headaches as they occur and not to prevent them, missing a dose does not usually occur.
	www.medicationadvisor.com /side_effects/almotriptan.htm (1687 words)

	Early Treatment of Acute Migraine With Almotriptan Provides Significant Clinical Benefit to Migraineurs: Presented at ...
		The multicentre, randomised, double-blind, placebo-controlled, parallel-group trial was designed to determine the efficacy of 12.5 mg of almotriptan in the acute treatment of mild, moderate, and severe migraine.
		With respect to tolerability, almotriptan was similar to placebo.
		These results suggest that medications such as almotriptan may encourage patients to treat their migraine attacks earlier, which may result in a reduced need for rescue medications, Dr. Mathew concluded.
	www.docguide.com /dg.nsf/PrintPrint/039DF2F7A3148EF0852571470064CFD7 (495 words)

	Medscape Search: almotriptan
		The pharmacokinetics of almotriptan are linear over a range of oral doses up to 200mg in healthy volunteers.
		Almotriptan is a new anti-migraine agent with nanomolar affinity for human 5-HT(1B), 5-HT(1D), and 5-HT(1F) receptors, weak affinity for 5-HT(1A) and 5-HT(7) receptors and no significant affinity for more than 20 other pharmacological receptors.
		The interaction between almotriptan, a 5-HT1B/1D agonist, and the potent CYP3A4 inhibitor ketoconazole was examined in 16 healthy volunteers.
	search.medscape.com /uslclient/searchAll.do?queryText=almotriptan (870 words)

	Axert - Drugs & Vitamins - Drug Library - DrugDigest
		Almotriptan is taken at the first symptoms of a migraine attack.
		This does not apply, almotriptan is not for regular use.
		Almotriptan is not for regular use to prevent migraine attacks.
	www.drugdigest.org /DD/DVH/Uses/0,3915,550245\|Axert,00.html (752 words)

	Drug Profiles: AXERT® (almotriptan malate tablets) For Migraines
		Axert (almotriptan) is an abortive medication used for the treatment of Migraine attacks in adults.
		Almotriptan (al-moh-TRIP-tan) is used to treat Migraine attacks.
		Almotriptan often relieves many symptoms that occur together with the pain of a Migraine, such as nausea, vomiting, sensitivity to light, and sensitivity to sound.
	www.migraines.org /treatment/proaxert.htm (1598 words)

	ANA: Low Dose Almotriptan Provides Rapid Pain Relief (Site not responding. Last check: 2007-11-01)
		At 1 hour, 34.5% of patients in the almotriptan arm and 21.6% of those in the placebo arm reported pain relief.
		At this time point, a pain-free status was reported by 12.5% of the almotriptan patients and 5.7% of the placebo patients.
		These findings show that a lower dose of almotriptan than conventionally used is effective at providing rapid pain relief, as early as 1 hour after treatment, said Dr. Seifert.
	www.pslgroup.com /dg/23DE82.htm (480 words)

	IHS: Almotriptan Provides Sustained Freedom from Migraine Pain (Site not responding. Last check: 2007-11-01)
		The effect of almotriptan on the percentage of patients achieving a sustained pain-free state was evaluated from three randomized, double- blind, placebo- controlled trials.
		Two trials evaluated almotriptan 6.25 mg and 12.5 mg, and one trial evaluated almotriptan 12.5 mg and sumatriptan 100 mg.
		Overall, almotriptan 12.5 mg was comparable to sumatriptan 100 mg with respect to the proportion of patients achieving sustained pain-free status.
	www.pslgroup.com /dg/1FFB92.htm (437 words)

	Pharmacy Choice - Pharmaceutical News - Almotriptan effective in patients with poor response to sumatriptan - September ...
		Two-hour pain-relief rates were significantly higher with almotriptan compared to placebo (47.5% vs. 23.2%; p<0.001)," study data showed.
		"A significant treatment effect for almotriptan was also seen in pain-free rates at 2 h (33.3% vs. 14.1%; p<0.005) and sustained freedom from pain (20.9% vs. 9.0%; p<0.05)," according to the report.
		"Almotriptan 12.5 mg is an effective and well-tolerated alternative for patients who respond poorly to sumatriptan 50 mg," the researchers concluded.
	www.pharmacychoice.com /News/article.cfm?Article_ID=9055 (526 words)

	Davis's Drug Guide for Nurses, Eighth Edition
		Instruct patient to administer almotriptan as soon as symptoms of a migraine attack appear, but it may be administered any time during an attack.
		If first dose does not relieve headache, additional almotriptan doses are not likely to be effective; notify health care professional.
		Caution patient not to use almotriptan if she is pregnant, suspects she is pregnant, plans to become pregnant, or is breastfeeding.
	www.drugguide.com /monograph_library/new_releases/almotriptan.htm (541 words)

	Almotriptan (Systemic) - MayoClinic.com
		Almotriptan has not been studied in pregnant women.
		It is not known whether almotriptan passes into human breast milk.
		Studies on this medicine have been done only in patients 18 years of age and older, and there is no specific information comparing use of almotriptan in children with use in other age groups.
	www.mayoclinic.com /health/drug-information/DR500301 (1412 words)

	Newly Approved Drug Therapies (706): Axert (almotriptan malate) tablets, Pharmacia
		However, this class of compounds has the potential to cause coronary vasospasm, and as a result Axert is not advised for patients with ischemic or vasospastic coronary artery disease.
		Almotriptan binds with high affinity to 5-HT 1D, 5-HT 1B and 5-HT 1F receptors.
		The therapeutic activity of almotriptan in migraine can most likely be attributed to agonist effects at 5-HT 1B/1D receptors on the extracerebral, intracranial blood vessels that become dilated during a migraine attack, and on nerve terminals in the trigeminal system.
	www.centerwatch.com /patient/drugs/dru706.html (532 words)

	RemedyFind: patient ratings of Axert etc. (Almotriptan) for Migraine Disease
		Almotriptan was first approved in Spain in 1999 it is approved for marketing in 16 other European countries, and has now (May 2001) received FDA approval for use in the USA for migraine symptoms.
		Almotriptan maintains a consistency of response across three attacks and patients continue to respond to almotriptan for up to 1 year.
		The incidence of treatment-related adverse events with almotriptan is comparable to that of placebo and significantly lower than that with sumatriptan.
	www.remedyfind.com /treatments/11/152 (1245 words)

	ANA: Low Dose Almotriptan Provides Rapid Pain Relief
		"This dose of almotriptan was associated with a rapid onset and a high degree of pain relief," said Tad Seifert, MD, chief resident in neurology, Houston Headache Clinic, University of Texas-Houston, United States.
		Mathew randomised 549 patients to receive either 12.5 mg of almotriptan or placebo for treatment of headache.
		The patients, who ranged in age from 18 to 65 years old, had had a history of migraine for more than 1 year, had 1 to 6 migraine attacks per month, and met the International Headache Society criteria for migraine.
	www.docguide.com /dg.nsf/PrintPrint/641D1C13DA5A3F9685256DD60055D047 (547 words)

	Axert Online, Description, Chemistry, Ingredients, Blackbox - Almotriptan Malate - RxList Monographs
		Almotriptan malate is chemically designated as 1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-l]methyl]sulfonyl]pyrrolidine (±)-hydroxybutanedioate (1:1), and its structural formula is:
		Almotriptan is a white to slightly yellow crystalline powder that is soluble in water.
		for oral administration contains almotriptan malate equivalent to 6.25 or 12.5 mg of almotriptan.
	www.rxlist.com /cgi/generic2/almotriptan.htm (135 words)

	Almotriptan - Patient UK
		Never give it to others even if their condition appears to be the same as yours.
		Make sure you know how you react to this medicine before driving, operating machinery or doing any other jobs, which could be dangerous, if you were not fully alert.
		Almotriptan should not be used in combination with migraine treatments containing ergotamine.
	www.patient.co.uk /showdoc/30003878 (746 words)

	Clinical Trial: A Study of the Effectiveness and Safety of Almotriptan Versus Placebo in the Treatment of Migraine ...
		The purpose of this study is to evaluate the effectiveness and safety of almotriptan malate (AXERT®) 12.5 milligram tablets compared with placebo for the acute treatment of migraine headache at the earliest onset of headache pain.
		Almotriptan malate (AXERT®) is approved for the treatment of migraine headache, with or without aura, in adults.
		This is a multicenter, randomized, double-blind, placebo-controlled, parallel group study of adult patients with a diagnosis of migraine headache, with or without aura.
	clinicaltrials.gov /ct/show/NCT00210509 (484 words)

	Healthopedia.com - Almotriptan (Oral) (Axert) - Drugs Information, Side Effects, & Interactions
		You should not use this medicine if you have had an allergic reaction to almotriptan, or if you have uncontrolled high blood pressure, a history of heart attack or stroke, or certain heart problems.
		Do not take almotriptan within 24 hours after taking another migraine headache medicine such as dihydroergotamine (DHE 45®, Migranal®), ergotamine (Cafergot®, Ergomar®, Wigraine®), methysergide (Sansert®), naratriptan (Amerge®), rizatriptan (Maxalt®), sumatriptan (Imitrex®), or zolmitriptan (Zomig®).
		You may have a higher risk of heart disease if you have high blood pressure, high cholesterol, or diabetes, or if you smoke, are overweight, have a family history of heart disease, are a man over 40 years old, or are a woman who has had a hysterectomy or has gone through menopause.
	www.healthopedia.com /drugs/quick/almotriptan (757 words)

	Safety Issues with Almotriptan Nurse Practitioner - Find Articles (Site not responding. Last check: 2007-11-01)
		Safety changes have been made to the labeling of the migraine treatment almotriptan malate (Axert) that include reports of acute myocardial infarction, which occurred within a few hours of almotriptan administration.
		Because the adverse events occurred in close proximity to the use of almotriptan, the FDA states that a causal relationship cannot be ruled out.
		However, the agency noted that because of the nature of postmarketing surveillance, it is impossible to definitively determine the proportion of the reported adverse events that were actually caused by almotriptan or to reliably assess causation in individual cases.
	www.findarticles.com /p/articles/mi_qa3958/is_200412/ai_n9467195 (175 words)

	Almotriptan
		If you have an allergy to almotriptan or any other part of this medicine.
		Tell healthcare provider if you are allergic to any medicine.
		Almotriptan reduces swelling of blood vessels in the brain that cause the migraine.
	www.umm.edu /altmed/ConsDrugs/Almotriptancd.html (572 words)

	ALMOTRIPTAN - ORAL (Axert) side effects, medical uses, and drug interactions.
		ALMOTRIPTAN - ORAL (Axert) side effects, medical uses, and drug interactions.
		USES: Almotriptan is used to treat migraine headache attacks.
		It does not prevent migraine headaches from occurring and should not be used for other types of headaches (e.g., cluster headaches, tension headaches).
	www.medicinenet.com /almotriptan-oral/article.htm (433 words)

	Dose finding, placebo-controlled study of oral almotriptan in the acute treatment of migraine -- Dahlöf et al. 57 ...
		Dose finding, placebo-controlled study of oral almotriptan in the acute treatment of migraine -- Dahlöf et al.
		Dose finding, placebo-controlled study of oral almotriptan in the acute treatment of migraine
		to a single dose of placebo or oral almotriptan 2, 6.25, 12.5,
	www.neurology.org /cgi/content/abstract/57/10/1811 (306 words)

	Almotriptan
		CYP3A4 inhibitors: Likely to increase almotriptan serum concentration.
		Ergot-containing drugs: Prolong vasospastic reactions; do not use almotriptan or ergot-containing drugs within 24 hours of each other.
		MAO inhibitors (moclobemide [MAO type A inhibitor]): Almotriptan clearance decreased by 27%; C
	www.musc.edu /pharmacyservices/Drugs/A/Almotriptan.htm (591 words)

	Almotriptan (Systemic)
		Tell your doctor if you have ever had any unusual or allergic reaction to almotriptan.
		If your dose is different, do not change it unless your doctor tells you to do so.
		Use of any information is solely at the user's own risk.
	allnutritionals.com /drugs/a/almotriptan-systemic.shtml (1365 words)

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