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Topic: Alpha subunit of glycoprotein hormones

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Glycoprotein main page The glycoprotein hormones are a family of cystine rich proteins consisting of an alpha and beta subunit. The alpha subunit is common to each of the hormones for a given species. The glycoprotein hormones are characterised by there heavy glycosylation and are cystine rich molecules with 5 conserved disulphides in alpha and 6 in beta. www.chem.gla.ac.uk /protein/glyco/GPH.html   (377 words)

REPRODUCTIVE BIOLOGY: ON FOLLICLE-STIMULATING HORMONE FSH shares an identical alpha-subunit with three other glycoprotein hormones: luteinizing hormone, which induces testosterone production in males and the final maturation of oocytes and subsequent ovulation in females; thyroid-stimulating hormone, which regulates thyroid function; and chorionic gonadotropin, which signals pregnancy. The structure shows that both hormone subunits are involved in determining the specificity of binding to the appropriate receptor, but that both charge and stereochemistry dictate specificity, with a role for alpha-subunit amino acids primarily in the stereochemical attributes. Although the nature of FSH and other glycoprotein hormones has been known for more than 30 years, there is still no orally active therapeutic drug. scienceweek.com /2005/sc050218-5.htm   (1737 words)

pars distalis Expression of the common alpha-subunit mRNA of glycoprotein hormones during the chick pituitary organogenesis, with special reference to the pars tuberalis. Early expression of the glycoprotein hormone alpha-subunit in the pars tuberalis of the rat pituitary gland during ontogenesis. Occurrence of colloid-containing follicles in the pars distalis of pituitary glands from aging guinea pigs. www.arclab.org /node_pages/523.html   (1737 words)

Thyroid-Stimulating Hormone The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle-stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. TSH is a glycoprotein hormone composed of two subunits which are non-covalently bound to one another. Secretion of thyroid-releasing hormone, and hence, TSH, is inhibited by high blood levels of thyroid hormones in a classical negative feedback loop. arbl.cvmbs.colostate.edu /hbooks/pathphys/endocrine/hypopit/tsh.html   (239 words)

Thyroid-Stimulating Hormone The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle-stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. TSH is a glycoprotein hormone composed of two subunits which are non-covalently bound to one another. Secretion of thyroid-releasing hormone, and hence, TSH, is inhibited by high blood levels of thyroid hormones in a classical negative feedback loop. arbl.cvmbs.colostate.edu /hbooks/pathphys/endocrine/hypopit/tsh.html   (239 words)

Partial Restoration Of Lutropin Activity by an Intersubunit Disulfide Bond: Implications For Structure/Function Studies -- Einstein et al. 226 (6): 581 -- Experimental Biology and Medicine Glycoprotein Hormone Assembly in the Endoplasmic Reticulum: I. THE GLYCOSYLATED END OF HUMAN {alpha}-SUBUNIT LOOP 2 IS THREADED THROUGH A {beta}-SUBUNIT HOLE Moyle WR, Campbell RK, Rao SNV, Ayad NG, Bernard MP, Han Y, Wang Y. Model of human chorionic gonadotropin (hCG) and lutropin receptor (LHR) interaction that explains signal transduction of the glycoprotein hormones. Moyle WR, Campbell RK, Myers RV, Bernard MP, Han Y, Wang X. Co-evolution of ligand-receptor pairs. www.ebmonline.org /cgi/content/full/226/6/581   (239 words)

Differential Gonadotropin-Releasing Hormone Stimulation of Rat Luteinizing Hormone Subunit Gene Transcription by Calcium Influx and Mitogen-Activated Protein Kinase-Signaling Pathways -- Weck et al. 12 (3): 451 -- Molecular Endocrinology Burnside J, Buckland PR, Chin WW 1988 Isolation and characterization of the gene encoding the alpha subunit of the rat pituitary glycoprotein hormones. Horn F, Windle JJ, Barnhart KM, Mellon PL 1992 Tissue-specific gene expression in the pituitary: the glycoprotein hormone alpha-subunit gene is regulated by a gonadotropin-specific protein. Differential Gonadotropin-Releasing Hormone Stimulation of Rat Luteinizing Hormone Subunit Gene Transcription by Calcium Influx and Mitogen-Activated Protein Kinase-Signaling Pathways -- Weck et al. mend.endojournals.org /cgi/content/full/12/3/451   (239 words)

Medicine on Earth: Amedeo Who's Who in Medicine The effects of aging on the secretion of the common alpha-subunit of the glycoprotein hormones in men. Ceda GP, Davis RG, Rosenfeld RG, Hoffman AR The growth hormone (GH)-releasing hormone (GHRH)-GH-somatomedin axis: evidence for rapid inhibition of GHRH-elicited GH release by insulin-like growth factors I and II. Ceda GP, Fielder PJ, Henzel WJ, Louie A, Donovan SM, Hoffman AR, Rosenfeld RG Differential effects of insulin-like growth factor (IGF)-I and IGF-II on the expression of IGF binding proteins (IGFBPs) in a rat neuroblastoma cell line: isolation and characterization of two forms of IGFBP-4. www.medicineonearth.com /display.php?id=315   (239 words)

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