| | CHEST: Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema - ... (Site not responding. Last check: 2007-10-21) |
 | | Kasahara and colleagues (2) have shown that in the lungs of patients with emphysema, the incidence of apoptosis in alveolar wall cells is increased, in association with a decrease in the expression of endothelial survival factors such as vascular endothelial growth factor and its receptor, kinase insert domain-containing receptor. |
 | | Furthermore, we have recently shown (4) that the induction of apoptosis in alveolar epithelial cells causes the loss of alveolar wall structures and emphysematous changes in mice, suggesting that apoptosis in alveolar wall cells is causally related to the development of emphysema. |
 | | To maintain the pulmonary architecture, the loss of alveolar wall cells resulting from apoptosis must be offset by the proliferation of the remaining alveolar wall cells. |
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