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Topic: Amikacin

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	Amikacin - Wikipedia, the free encyclopedia
		Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
		Amikacin may be administered once or twice a day but must be given by the intravenous or intramuscular route.
		Amikacin may be combined with a beta-lactam antibiotic for empiric therapy for people with neutropenia and fever.
	en.wikipedia.org /wiki/Amikacin (176 words)

	Amikacin
		Amikacin is indicated for the treatment of infections of: central nervous system, urogenital system, biliary and intestinal tracts, skin and subcutaneous tissues, intraabdominal infections, pneumonia, caused by Gram-negative microorganisms, secondary infections after combustion, bacterial septicemia, infections of the bones and joints (caused by sensitive to Amikacin microorganisms).
		In adults and children with normal renal function, Amikacin is administered intramuscularly as an intravenous bolus or by slow intravenous infusion in a dose of 5 mg/kg body weight given every 8 hours or 7.5 mg/kg body weight every 12 hours for a period of 7 to 10 days.
		Amikacin has a bactericidal action which is due to the inhibition of the protein synthesis in the cells of the microorganisms.
	www.bpg.bg /sopharma/amikacin.phtml (693 words)

	Amikacin (Amikacin sulfate) [www.sopharma.com]
		Amikacin is a semisynthetic aminoglycoside antibiotic with bacterial type of action.
		Amikacin readily penetrates in tissues, crosses the placental barrier and diffuses into the pleural and amniotic fluid.
		Amikacin, in a concentration of 0.25%, can be applied successfully for lavage of abscess cavities, pleural cavity and peritoneum.
	www.bpg.bg /sopharma/categories/408/40802amikacin.html (422 words)

	Amikacin (Amiglyde-V®) - PetPlace.com (Site not responding. Last check: 2007-10-01)
		Amikacin is a semi-synthetic antibiotic derived from kanamycin, a member of the aminoglycoside antibiotic family.
		Amikacin is effective against specific bacteria and is not effective against fungi and viruses.
		Amikacin should be avoided in animals with kidney disease, dehydration and neuromuscular disease.
	www.petplace.com /drug-library/amikacin-amiglyde-v/page1.aspx (587 words)

	Amikacin Sulfate
		1.3 grams of amikacin sulfate is equivalent to 1 gram of amikacin.
		While amikacin is less susceptible to this effect, it is usually recommended to avoid mixing these compounds together in the same syringe or IV bag, unless administration occurs promptly.
		Since amikacin is less affected by this effect than either tobramycin or gentamicin, it is assumed that reduction in serum levels will also be minimized using this procedure.
	www.elephantcare.org /Drugs/amikacin.htm (2211 words)

	Amikin Online, Description, Chemistry, Ingredients, Blackbox - Amikacin - RxList Monographs
		Renal and eighth-nerve function should be closely monitored especially in patients with known or suspected renal impairment at the onset of therapy and also in those whose renal function is initially normal but who develop signs of renal dysfunction during therapy.
		The concurrent use of amikacin with potent diuretics (ethacrynic acid, or furosemide) should be avoided since diuretics by themselves may cause ototoxicity.
		Amikacin sulfate is a semi-synthetic aminoglycoside antibiotic derived from kanamycin.
	www.rxlist.com /cgi/generic3/amikacin.htm (666 words)

	MedlinePlus Drug Information: Amikacin Sulfate Injection
		Amikacin eliminates bacteria that cause many kinds of infections, including lung, skin, bone, joint, stomach, blood, and urinary tract infections.
		If you are told to store additional amikacin in the freezer, always move a 24-hour supply to the refrigerator for the next day's use.
		If you are receiving amikacin in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682661.html (774 words)

	Amikacin
		Amikacin is an intravenous antibiotic which is used in treatment of severe infections.
		Amikacin has been available for many years and its use is limited to infections that are resistant to routinely used antibiotics.
		Patients who are treated with Amikacin should have frequent blood tests to monitor their kidney function tests as well as the Amikacin level.
	www.tirgan.com /amikacin.htm (123 words)

	Amikacin (Amikin®), Serum, Peak
		Amikacin is used to treat serious infections caused by susceptible aerobic gram-negative bacilli (eg, a number of the Enterobacteriaceae, P.
		Because amikacin is the only currently available aminoglycoside effective against many gentamicin- and tobramycin-resistant organisms, many infectious disease experts have felt that its use should be restricted to minimize the emergence of additional resistant strains.
		Amikacin is cleared by the kidney and accumulates in renal tubular cells.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/td001000.htm (644 words)

	amikacin Consumer Drug Information
		Amikacin may cause damage to the kidneys and/ or nerves.
		Amikacin is used to treat severe or serious bacterial infections.
		You may not be able to use amikacin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
	www.drugs.com /mtm/amikacin.html (1017 words)

	ACS :: Cancer Drug Guide: amikacin sulfate
		Amikacin sulfate is an antibiotic that belongs to a group of drugs called aminoglycosides.
		Amikacin sulfate blocks protein synthesis in bacteria, resulting in death of the organism.
		Amikacin sulfate is given as a shot into the muscle (intramuscular) or an injection into a vein over 20 to 30 minutes, 2 to 3 times a day.
	www.cancer.org /docroot/CDG/content/CDG_amikacin_sulfate.asp (563 words)

	Aidsmap \| Amikacin
		Amikacin is an approved antibiotic used for treating severe bacterial infections.
		A study of liposomal amikacin in nine people with non-tuberculous mycobacteria (mostly MAI infection), has been reported.
		Liposomal amikacin (LA) for the treatment of non-tuberculous mycobacteria (NTM) in HIV disease.
	www.aidsmap.com /en/docs/EA1037A6-8B76-40B5-A308-E3053FB6D3E0.asp (207 words)

	Population Pharmacokinetic Study of Amikacin Administered Once or Twice Daily to Febrile, Severely Neutropenic Adults ...
		and biological indices on the pharmacokinetics of amikacin.
		of strains susceptible to amikacin are inhibited are <8 mg/liter,
		Efficacy and toxicity of single daily doses of amikacin and ceftriaxone versus multiple daily doses of amikacin and ceftazidime for infection in patients with cancer and granulocytopenia.
	aac.asm.org /cgi/content/full/42/4/849 (4853 words)

	Lung Tissue Concentrations of Nebulized Amikacin during Mechanical Ventilation in Piglets with Healthy Lungs -- ...
		Fractionated urinary output of amikacin between 0 and 3, 3 and 6, 6 and 9, 9 and 12, 12 and 15, 15 and 18 h after nebulization of 1,000 mg of amikacin to 12 piglets.
		The mean cumulative urinary output of amikacin in the corresponding period of time is 207 ± 76 mg.
		Mean concentration of amikacin in lung tissue according to the time after the second aerosol administration (fl bars) or the second intravenous infusion (gray bars).
	ajrccm.atsjournals.org /cgi/content/full/165/2/171 (3834 words)

	Pharmacokinetics and Urinary Excretion of Amikacin in Low-Clearance Unilamellar Liposomes after a Single or Repeated ...
		The use of amikacin for first-line therapy is limited, despite its excellent bactericidal activity against gram-negative organisms.
		Total amikacin concentrations (mean ± standard deviation; n = 4) in the plasma of rhesus monkeys after the administration of low-clearance liposomal amikacin.
		Comparison of the effects of amikacin and kanamycins A and B on dimyristoylphosphatidylglycerol bilayers.
	aac.asm.org /cgi/content/full/43/3/503 (4950 words)

	Spread of Amikacin Resistance in Acinetobacter baumannii Strains Isolated in Spain Due to an Epidemic Strain -- Vila et ...
		Spread of Amikacin Resistance in Acinetobacter baumannii Strains Isolated in Spain Due to an Epidemic Strain -- Vila et al.
		strain or to the spread of an amikacin resistance gene.
		Dissemination of amikacin resistance gene aphA6 in Acinetobacter spp.
	jcm.asm.org /cgi/content/full/37/3/758 (2426 words)

	Efficacy and Toxicity of Single Daily Doses of Amikacin and Ceftriaxone versus Multiple Daily Doses of Amikacin and ...
		of amikacin and ceftazidime for the empiric therapy of infection
		Vancomycin, ticarcillin, and amikacin compared with ticarcillin-clavulanate and amikacin in the empirical treatment of febrile, neutropenic children with cancer.
		Randomized trial of empiric antibiotic therapy with ticarcillin in combination with gentamicin, amikacin or netilmicin in febrile patients with granulocytopenia and cancer.
	www.annals.org /cgi/content/full/119/7_Part_1/584 (6136 words)

	NEJM -- Ceftazidime combined with a short or long course of amikacin for empirical therapy of gram-negative bacteremia ...
		Without a change in antibiotics, the response rates were 81 percent with ceftazidime and long-course amikacin, 48 percent with ceftazidime and short-course amikacin (P = 0.002), and 40 percent with azlocillin and long-course amikacin (P less than 0.001).
		Linear logistic-regression analysis showed that therapy with ceftazidime and long-course amikacin was the most favorable prognostic factor of the response to infection, whereas the presence of leukemia or shock was the least favorable.
		We conclude that ceftazidime should be given in combination with a conventional full course of an aminoglycoside (amikacin) when used for the empirical treatment of gram-negative bacteremia in cancer patients with granulocytopenia.
	content.nejm.org /cgi/content/abstract/317/27/1692 (485 words)

	amikacin - [Medication]
		Amikacin may cause damage to the kidneys and/or nerves.
		Other drugs, especially those that affect the kidneys, can interact with amikacin resulting in dangerous side effects and/or decreased effectiveness.
		Amikacin is available with a prescription generically and under the brand names Amikin.
	www.peacehealth.org /kbase/multum/d00087a1.htm (958 words)

	Cefepime plus amikacin versus piperacillin-tazobactam plus amikacin for initial antibiotic therapy in haematology ...
		Cefepime plus amikacin versus piperacillin-tazobactam plus amikacin for initial antibiotic therapy in haematology patients with febrile neutropenia: results of an open, randomized, multicentre trial -- Sanz et al.
		Cefepime plus amikacin versus piperacillin–tazobactam plus amikacin for initial antibiotic therapy in haematology patients with febrile neutropenia: results of an open, randomized, multicentre trial
		Piperacillin–tazobactam plus amikacin versus ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer.
	jac.oxfordjournals.org /cgi/content/full/50/1/79 (4142 words)

	Clinical Trial: Once-Daily Amikacin Plus Cloxacillin in Febrile Neutropenic Children
		In the area where Pseudomonas aeruginosa prevalence in febrile neutropenic children is low, the combination of cloxacillin and amikacin is an appropriate approach.
		This study would like to compare the efficacy and safety including cost between these two amikacin administrations (once-daily or twice-daily) in combination with cloxacillin as an empirical therapy in febrile neutropenic children.
		Hypothesis: Once-daily amikacin plus cloxacillin can be used to treat febrile neutropenic children in Khon Kaen, Thailand.
	clinicaltrials.gov /ct/show/NCT00129688 (372 words)

	KoiVet.com - Amikacin Dosing - Revisited
		The basic dosage in your book is given at 5 mg/kg, but the dosage by length in your chart appears to give 20 - 25 mg/kg.
		Still, I would add that if you dose Amikacin (any Aminoglycoside) more than three times, you could kill or cripple the fish.
		In the reprint of the book, I think I am going to re-do the Amikacin dosing chart, using ACTUAL weights (what a pain), and basing it on 10mg/kg - for what it's worth.
	koivet.com /html/articles/articles_details.php?article_id=277&... (361 words)

	Drugs and Treatments - Amikacin IV - (Amikin) - Patient Handout from WebMD (Site not responding. Last check: 2007-10-01)
		This drug has caused kidney problems, nerve damage or permanent hearing loss, even at usual doses.
		Before using this, tell your doctor if you have: kidney disease, hearing disorders, muscle disorders, allergies (especially to antibiotics).
		Amikacin is not recommended for use during pregnancy.
	rxlist.com /drugs/drug-18378-Amikacin+IV.aspx?drugid=18378&... (937 words)

	Amikacin
		Hypersensitivity to amikacin sulfate or any component of the formulation; cross-sensitivity may exist with other aminoglycosides
		Vanhaeverbeek M, Siska G, Douchamps J, et al, "Comparison of the Efficacy and Safety of Amikacin Once or Twice-a-Day in the Treatment of Severe Gram-Negative Infections in the Elderly,"Int J Clin Pharmacol Ther Toxicol, 1993, 31(3):153-6.
		Vogelstein B, Kowarski A, and Lietman PS, "The Pharmacokinetics of Amikacin in Children,"J Pediatr, 1977, 91(2):333-9.
	www.musc.edu /pharmacyservices/Drugs/A/Amikacin.htm (1112 words)

	Amikacin, Plasma
		Kanamycin interferes with measurement of amikacin, giving falsely elevated results.
		Patient samples which contain kanamycin A, kanamycin B, 3', or 4' dideoxykanamycin B will yield falsely elevated values for amikacin.
		However, these drugs are not usually coadministered with amikacin.
	www.medicine.uiowa.edu /Path_Handbook/handbook/test110.html (184 words)

	Drugs and Treatments - Amikacin Inj - (Amikin) - Patient Handout from WebMD
		Drugs and Treatments - Amikacin Inj - (Amikin) - Patient Handout from WebMD
		Small amounts of this drug have been detected in breast milk.
		What should I know before taking Amikacin Inj?
	webmd.com /drugs/drug-3889-Amikacin+Inj.aspx?...+Inj&pagenumber=4 (927 words)

	AMIKACIN INJECTION (Amikin) side effects, medical uses, and drug interactions.
		AMIKACIN INJECTION (Amikin) side effects, medical uses, and drug interactions.
		WARNING: This drug has caused kidney problems, nerve damage or permanent hearing loss, even at usual doses.
		MedicineNet does not provide medical advice, diagnosis or treatment.
	www.medicinenet.com /amikacin_injection/article.htm (544 words)

	Consumer Reports Medical Guide - Amikacin Sulfate Injection
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		Before administering amikacin, tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially diuretics ('water pills'), cisplatin (Platinol), amphotericin (Amphotec, Fungizone), other antibiotics, and vitamins.
		If you experience any of the following symptoms, call your health care provider immediately: dizziness, vertigo, ringing in the ears, hearing loss, numbness, muscle twitching or weakness, difficulty breathing, decreased urination, rash, itching, or sore throat.
	www.consumerreports.org /mg/drug-reports/amikacin-sulfate-injection.htm (884 words)

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