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Topic: Amiodarone

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Ventricular fibrillation

Digoxin

Atrial fibrillation

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	Acute Silica Toxicity: Attenuation by Amiodarone-induced Pulmonary Phospholipidosis (Site not responding. Last check: 2007-11-07)
		Amiodarone, an iodinated, benzofuran derivative with a cationic, amphiphilic structure, is approved for use in the treatment of life-threatening ventricular tachyarrhythmias.
		Response of alveolar macrophages to amiodarone and desethylamiodarone in vitro.
		Response of alveolar macrophages to amiodarone: preferential accumulation of amiodarone and desethylamiodarone in alveolar macrophages.
	ehp.niehs.nih.gov /members/1994/102-4/antonini-full.html (6265 words)

	Amiodarone (Site not responding. Last check: 2007-11-07)
		Amiodarone is a class III antiarrhythmic agent used in the treatment of ventricular arrhythmias and the suppression of atrial and ventricular arrhythmias.
		Amiodarone shows beta blocker-like and calcium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects.
		Amiodarone is structurally similar to thyroxine (a thyroid hormone), which contributes to the effects of amiodarone on thyroid function.
	www.yotor.com /wiki/en/am/Amiodarone.htm (1535 words)

	MedlinePlus Drug Information: Amiodarone (Systemic) (Site not responding. Last check: 2007-11-07)
		Amiodarone (am-ee-OH-da-rone) belongs to the group of medicines known as antiarrhythmics.
		Amiodarone produces its helpful effects by slowing nerve impulses in the heart and acting directly on the heart tissues.
		Amiodarone increases the sensitivity of your skin to sunlight; too much exposure could cause a serious sunburn.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202029.html (1652 words)

	amiodarone (Cordarone) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com (Site not responding. Last check: 2007-11-07)
		Amiodarone was approved by the FDA for clinical use as an antiarrhythmic agent in December of 1985.
		Amiodarone is considered a "broad spectrum" antiarrhythmic medication, that is, it has multiple and complex effects on the electrical activity of the heart which is responsible for the heart's rhythm.
		Amiodarone increases the blood levels of digoxin (Lanoxin) when the two drugs are given together.
	www.medicinenet.com /amiodarone/article.htm (696 words)

	Amiodarone: From Last to First-Line Antiarrhythmic Therapy
		During IV infusion, the recommended dose of the diluted amiodarone hydrochloride is administered in 3 phases: a rapid loading phase, a slow loading phase, and a maintenance infusion phase.
		Amiodarone is highly protein bound and has a high affinity for adipose tissue, resulting in a high volume of distribution (approximately 50 L).
		Amiodarone inhibits hepatic and renal clearance of procainamide, leading to increased concentrations of procainamide and its active metabolite, N-acetylprocainamide.
	www.continuingeducation.com /pharmacy/amiodarone/pharmaco.html (1764 words)

	Ophthalmic Hyperguide. Neuro-ophthalmology: Amiodarone Optic Neuropathy
		In contrast to amiodarone keratopathy, the data on amiodarone optic neuropathy are less convincing for causality using the Hill criteria.
		The researchers postulated that amiodarone may have a chronic neurotoxic effect on the optic nerve via a drug-induced lipidosis, but the linkage to a clinical presentation of anterior ischemic optic neuropathy was not defined.
		Amiodarone keratopathy is temporally associated with drug onset, a dose-dependent effect seen in the majority of patients on the drug, produces a characteristic and specific corneal appearance that cannot be attributed to alternative etiologies, has been pathologically proven to be due to drug deposition in the epithelium, and typically resolves after discontinuation of the drug.
	www.ophthalmic.hyperguides.com /tutorials/neuro/amiodarone/tutorial.asp (1256 words)

	Amiodarone: From Last to First-Line Antiarrhythmic Therapy
		Although amiodarone therapy typically is initiated in the hospital under the direction of a cardiologist, long-term amiodarone monitoring and evaluation often become the responsibility of the primary care physician.
		Amiodarone discontinuation, if therapeutically possible, may be attempted, although hyperthyroid symptoms and cardiac status may worsen as the antiadrenergic effects of the drug wear off.
		Proarrhythmia secondary to amiodarone therapy is a concern because of the drug's propensity to markedly prolong the QT interval with a potential for torsade de pointes.
	www.continuingeducation.com /pharmacy/amiodarone/adverse.html (3090 words)

	Cleveland Clinic Journal of Medicine Online CME: What Internists Should Know about Amiodarone (Site not responding. Last check: 2007-11-07)
		Amiodarone is not a good choice for this patient as he has left ventricular dysfunction.
		Amiodarone is commonly used for refractory atrial fibrillation.
		The recurrence of atrial fibrillation in this patient with coronary artery disease is because of the proarrhythmic effect of amiodarone.
	www.clevelandclinicmeded.com /ccjmcme/amiodarone (208 words)

	Amiodarone
		Amiodarone can interact with grapefruit and grapefruit juice, and the interaction may have dangerous effects.
		Amiodarone is in the FDA pregnancy category D. This means that it is known to be harmful to an unborn baby.
		Symptoms of an amiodarone overdose include tiredness, dizziness, confusion, a slow heart rate, yellowing of the skin or eyes, diarrhea, abdominal pain, and worsening irregular heartbeats.
	www.drugs.com /amiodarone.html (1348 words)

	ACUTE CARE, INC. - Emergency Physicians - Practice Opportunities, Information
		The administration of 300mg amiodarone (Cordarone) in cardiac arrest patients experiencing ventricular fibrillation, is creating compelling evidence, in the minds of many clinicians, that challenges previously identified antidysrythmics (lidocaine, procainamide, bretylium).
		While amiodarone was well-tolerated in this critically ill population, there was a higher incidence of hypotension and of bradycardia requiring therapy in the amiodarone group.
		Amiodarone is primarily a class III antiarrythmic that prolongs duration of action potential and effective refractory period, also providing noncompetitive alpha and beta adrenergic inhibition.
	www.acutecare.com /amiocard.htm (597 words)

	Amiodarone to prevent a-fib after heart surgery
		It´s well known that Amiodarone has a high content of Iodine in its molecule and, in a high percentage of patients it may provoke clinical and/or subclinical changes on respect to thyroid gland function such as hyperthyroidism or mild changes in TSH or Thyroxine.
		Amiodarone has been very questioned among cardiologists because of its benefit/risk ratio and also because there are the other therapies such as Propafenone Clorhidrate that might have similar benefits at lower risk.
		Thyroid function studies after amiodarone therapy would have been interesting, although the number of patients studied here was probably too small to reliably exclude any alteration in thyroid function occurring in a small number of patients.
	www.journalclub.org /vol2/a59.html (1621 words)

	CHEST: Bronchoalveolar lavage cell count and differential are not reliable indicators of amiodarone-induced pneumonitis (Site not responding. Last check: 2007-11-07)
		Amiodarone has been used since 1969 in the United States for treatment of ventricular arrhythmias that were refractory to other treatments.
		Patients were begun on a regimen of intravenous amiodarone because of frequent sustained ventricular tachycardia unresponsive to conventional therapy with intravenous antiarrhythmic medications.
		Oral amiodarone therapy was begun in patients who did not respond to conventional oral antiarrhythmic therapy for recurrent sustained monomorphic ventricular tachycardia or ventricular fibrillation.
	www.findarticles.com /p/articles/mi_m0984/is_n4_v102/ai_12738150 (1148 words)

	CHEST: Is Amiodarone an Underrecognized Cause of Acute Respiratory Failure in the ICU? - ) (Site not responding. Last check: 2007-11-07)
		Amiodarone is a commonly used anti-arrhythmic agent, with well-recognized chronic toxicity.
		Amiodarone is the one of the most commonly prescribed anti-arrhythmic agents worldwide.[1] Although initially developed as a new class of antianginal vasodilator, its derivative, desethylamiodarone, proved to be a powerful antiarrhythmic agent with atypical class III Vaughan-Williams properties, provoking substantial clinical interest.
		Thus, despite amiodarone's intended therapeutic target being the heart, amiodarone concentrations measured in unfractionated pulmonary parenchyma significantly exceed that of the heart.[7] Accumulated concentrations of amiodarone's derivative in particular lung compartments, such as the type II pneumocyte, further exaggerate this effect.
	www.findarticles.com /p/articles/mi_m0984/is_1_120/ai_76994076 (870 words)

	Ventricular Tachycardia After Amiodarone: Report of an Unusual Case
		Amiodarone has been approved for treatment of patients with ventricular and supraventricular tachyarrhythmias.1—3 Previous reports have found that it is effective for the conversion of atrial fibrillation and subsequent maintenance of sinus rhythm.2—6 In this report, we describe a case of atrial fibrillation that converted with amiodarone.
		The amiodarone dose was changed to 200 mg daily for 5 days, but 400 mg twice a week for 4 weeks, that is, the patient received 1,800 mg amiodarone weekly.
		Although low-dose amiodarone reduces the occurrence of atrial fibrillation in patients in which therapy is indicated, it can potentially cause serious ventricular arrhythmias, as was seen in the patient presented in this case report.
	www.jrnlappliedresearch.com /articles/Vol3Iss2/Tak.htm (1379 words)

	The Role of Intravenous Amiodarone in the Management of Cardiac Arrhythmias -- Desai et al. 127 (4): 294 -- Annals of ...
		intravenous amiodarone and 47% for quinidine and digoxin.
		With the advent of intravenous amiodarone and its aforementioned
		Efficacy and tolerance of high-dose intravenous amiodarone for recurrent, refractory ventricular tachycardia.
	www.annals.org /cgi/content/full/127/4/294 (5014 words)

	MedlinePlus Drug Information: Amiodarone Oral
		Amiodarone may cause lung disease that can be serious or life-threatening.Tell your doctor if you have or have ever had any type of lung disease.
		Amiodarone is used to treat and prevent certain types of ventricular arrhythmias (abnormal heart rhythm).
		Amiodarone is in a class of medications called antiarrhythmics.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a687009.html (1174 words)

	EMS News @ Firehouse.com - 12/03/01 - Amiodarone vs. Lidocaine (Site not responding. Last check: 2007-11-07)
		Data presented at the American Heart Association's (AHA) Scientific Sessions 2001 in Anaheim, Calif., demonstrated that the antiarrythmic agent IV amiodarone (marketed as Cordarone I.V.) is almost twice as effective as lidocaine in keeping cardiac arrest patients alive until they reach a hospital.
		The trial found that 22.8% of cardiac arrest patients treated with IV amiodarone survived to hospital admission compared with 12% of patients treated with lidocaine.
		Dosages: Amiodarone IV was administered as a bolus dose of 5 mg/kg, whereas 1.5 mg/kg of lidocaine was administered.
	www.firehouse.com /ems/news/01/12/3_FHdrugs.html (491 words)

	Sympatholytic Action of Intravenous Amiodarone in the Rat Heart -- Du et al. 91 (2): 462 -- Circulation
		to amiodarone in vivo or in vitro, the degree of this depletion
		Anti-arrhythmic effects of amiodarone and desethylamiodarone on malignant ventricular arrhythmias arising as a consequence of ischaemia and reperfusion in the anaesthetised rat.
		Amiodarone: biochemical evidence for binding to a receptor for class I drugs associated with the rat cardiac sodium channel.
	circ.ahajournals.org /cgi/content/full/91/2/462 (5768 words)

	Evidence-Based Analysis of Amiodarone Efficacy and Safety -- Connolly 100 (19): 2025 -- Circulation (Site not responding. Last check: 2007-11-07)
		was 2.4% on amiodarone and 0.8% on placebo.
		Amiodarone: clinical efficacy and electrophysiology during long-term therapy for recurrent ventricular tachycardia or ventricular fibrillation.
		Amiodarone versus quinidine in the prophylaxis of atrial fibrillation.
	circ.ahajournals.org /cgi/content/full/100/19/2025 (6656 words)

	Is it time to choose amiodarone for postoperative atrial fibrillation? -- Saltman 125 (6): 1202 -- The Journal of ... (Site not responding. Last check: 2007-11-07)
		Amiodarone reduces the incidence of atrial fibrillation after coronary artery bypass grafting.
		Amiodarone vs sotalol as prophylaxis against atrial fibrillation after heart surgery: a meta-analysis.
		Amiodarone versus a ß-blocker to prevent atrial fibrillation after cardiovascular surgery.
	jtcs.ctsnetjournals.org /cgi/content/full/125/6/1202 (953 words)

	Cordarone Online, Description, Chemistry, Ingredients - Amiodarone - RxList Monographs (Site not responding. Last check: 2007-11-07)
		Cordarone is a member of a new class of antiarrhythmic drugs with predominantly Class III (Vaughan Williams’ classification) effects, available for oral administration as pink, scored tablets containing 200 mg of amiodarone hydrochloride.
		The inactive ingredients present are colloidal silicon dioxide, lactose, magnesium stearate, povidone, starch, and FDandC Red 40.
		Amiodarone HCl is a white to cream-colored crystalline powder.
	www.rxlist.com /cgi/generic/amiodarone.htm (135 words)

	Amiodarone, Eastern Carolina
		Amiodarone is a drug occasionally used to treat life-threatening arrhythmias of the heart.
		Consequently, people taking amiodarone should avoid drinking grapefruit juice (and eating grapefruit) to prevent potentially serious side effects.
		Dramatic inhibition of amiodarone metabolism induced by grapefruit juice.
	www.uhseast.com /115990.cfm (334 words)

	Healthopedia.com Drugs Information - Amiodarone : Before Using (Cordarone, Cordarone I.V., Cordarone Intravenous, ...
		In addition, there is concern that amiodarone could cause slow heartbeat in the newborn.
		Breast-feeding—Although amiodarone passes into breast milk, it has not been shown to cause problems in nursing babies.
		However, amiodarone has been shown to cause growth problems in rats.
	www.healthopedia.com /drugs/detailed/amiodarone/before-using.html (573 words)

	Amiodarone
		Amiodarone can cause a lung problem that can be serious and life-threatening.
		If you have an allergy to amiodarone or any other part of the medicine.
		Amiodarone decreases the effects of chemicals on the heart.
	www.umm.edu /altmed/ConsDrugs/Amiodaronecd.html (549 words)

	NEJM -- Amiodarone or an Implantable Cardioverter-Defibrillator for Congestive Heart Failure
		As compared with placebo, amiodarone was associated with a similar
		Corsello, A. An implantable cardioverter defibrillator but not amiodarone reduced risk of death in congestive heart failure.
		ICDs vs. Amiodarone for Patients with HF and LV Dysfunction.
	content.nejm.org /cgi/content/short/352/3/225 (927 words)

	Amiodarone drug information, Amiodarone side effects
		If you have suffered from the use of Amiodarone, fill in this form to have a lawyer help you evaluate your case.
		In some cases, amiodarone has been associated with serious and even fatal side effects such as lung problems...
		doctor the risks and benefits associated with the use of amiodarone.
	www.drugs.com /ds/Amiodarone (390 words)

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