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Topic: Amphotericin B

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	Amphotericin B deoxycholate
		Amphotericin B is poorly soluble in water [2208].
		Amphotericin B binds to sterols, preferentially to the primary fungal cell membrane sterol, ergosterol.
		Amphotericin B deoxycholate is administered by intravenous infusion at doses ranging from 0.3 to 1.5 mg/kg and over 1-4 h [1507, 1666].
	www.doctorfungus.org /thedrugs/Ampho_Deoxycholate.htm (1050 words)

	Amphotericin B - PetPlace.com (Site not responding. Last check: 2007-09-11)
		The amphotericin B is then given at a dose of 0.25 mg per pound (0.5 mg/kg) IV three times a week until a total accumulated dose of 5 to 6 mg per pound (9 to 12 mg/kg) is given.
		The amphotericin B is then repeated at a dose of 0.25 mg per pound (0.5 mg/kg) intravenous three times weekly until a total accumulated dose of 5 to 6 mg per pound (9 to 12 mg/kg) is given.
		The amphotericin B is then given at a dose of 0.125 mg per pound (0.25 mg/kg) IV three times a week until a total accumulated dose of 5 to 6 mg per pound (9 to 12 mg/kg) is given.
	www.petplace.com /drug-library/amphotericin-b/page1.aspx (773 words)

	Amphotericin B (Site not responding. Last check: 2007-09-11)
		Amphotericin B is named for its amphoteric properties, which are acquired from a carboxyl group on the main ring and a primary amino group on mycosamine.
		Amphotericin B is 90—95% protein-bound, primarily to lipoproteins.
		Amphotericin B intravenous is classified pregnancy category B and amphotericin B oral suspension is classified as pregnancy category C. In animal studies, the oral suspension has been associated with an increase in fetal death.
	www.cai.mcgill.ca /meded/drugdb/amphotericin_b/amphotericin_b_db.htm (4746 words)

	Amphotericin B - Wikipedia, the free encyclopedia
		Amphotericin B (Fungilin®, Fungizone®, Abelcet®, AmBisome®, Fungisome®, Amphocil®, Amphotec®) is a polyene antimycotic drug, used intravenously in systemic fungal infections.
		Oral preparations of amphotericin B are used to treat oral thrush; these are virtually nontoxic.
		From studies it appears that liposomal amphotericin B preparations exhibit fewer side-effects while having similar efficacy.
	en.wikipedia.org /wiki/Amphotericin (588 words)

	Amphotericin B (Site not responding. Last check: 2007-09-11)
		Amphotericin B is reportedly compatible with the following solutions and drugs: D5W, D5W in sodium chloride 0.2%, heparin sodium, heparin sodium with hydrocortisone sodium phosphate, hydrocortisone sodium phosphate/succinate and sodium bicarbonate.
		In humans (and presumably animals), amphotericin B is poorly absorbed from the GI tract and must be given parenterally to achieve sufficient concentrations to treat systemic fungal infections.
		Approximately 90-95% of amphotericin in the vascular compartment is bound to serum proteins.
	www.elephantcare.org /Drugs/amphote.htm (1815 words)

	Clinical Updates in Fungal Infections (Site not responding. Last check: 2007-09-11)
		Amphotericin B, a polyene antibiotic synthesized by Streptomyces nodosus, an organism found in soil, is capable of binding irreversibly to ergosterol in the fungal cytoplasmic membrane, thus increasing membrane permeability with ultimate fungal cell death.
		Lipid formulations of amphotericin B were developed to improve the amphipathic nature of amphotericin B and facilitate drug insertion within the fungal cytoplasmic membrane while reducing uptake in human cells, thereby limiting toxicity.
		The pharmacokinetics and tissue distribution of the lipid amphotericin B formulations are largely influenced by the physical and chemical properties of the lipid vehicle.
	www.nfid.org /publications/clinicalupdates/fungal/ampho.html (2586 words)

	Fungizone Indications, Dosage, Storage, Stability - Amphotericin B - RxList Monographs
		Amphotericin B may be useful in the treatment of American mucocutaneous leishmaniasis, but it is not the drug of choice as primary therapy.
		Since patient tolerance varies greatly, the dosage of amphotericin B must be individualized and adjusted according to the patient’s clinical status (e.
		The concentrate (5 mg amphotericin B per mL after reconstitution with 10 mL Sterile Water for Injection USP) may be stored in the dark, at room temperature for 24 hours, or at refrigerator temperatures for one week with minimal loss of potency and clarity.
	www.rxlist.com /cgi/generic2/amphoter_ids.htm (1024 words)

	amphotericin B topical
		Amphotericin B topical is used to treat skin infections that are caused by the yeast Candida.
		Amphotericin B topical may also be used for purposes other than those listed in this medication guide.
		Amphotericin B topical is available with a prescription under the brand name Fungizone in a 3% cream, lotion, or ointment.
	hw.healthdialog.com /kbase/multum/d03207a1.htm (1088 words)

	Liposomal Amphotericin B (L-AMB)
		Liposomal amphotericin B (L-AMB) is a lipid formulation of amphotericin B.
		The mechanism of action and intrinsic antifungal activity of L-AMB is the same as the parent compound, amphotericin B [2208].
		Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia.
	www.doctorfungus.org /thedrugs/Ampho_liposomal.htm (1136 words)

	ADAP drugs: amphotericin B (Site not responding. Last check: 2007-09-11)
		Amphotericin B is used to treat many fungal infections including histoplasmosis and Cryptococcus.
		Amphotericin B can cause fevers, chills, headache, anorexia, nausea, vomiting, diarrhea, kidney damage, and suppression of bone marrow which can lead to anemia.
		Amphotericin B infused rapidly is safe and better tolerated than the old long infusions.
	www.aegis.com /factshts/network/access/drugs/amph.html (388 words)

	Lipid Formulations for Amphotericin B: Does the Emperor Need New Clothes? -- Graybill 124 (10): 921 -- Annals of ... (Site not responding. Last check: 2007-09-11)
		Amphotericin B lipid complex in the treatment of 228 cases of invasive mycosis [Abstract].
		Liposomal amphotericin B in the treatment of fungal infections in neutropenic patients: a single-centre experience of 133 episodes in 116 patients.
		Efficacy of amphotericin B encapsulated in liposomes (AmBisome) in the treatment of invasive fungal infections in immunocompromised patients.
	www.annals.org /cgi/content/full/124/10/921 (1594 words)

	DrugsWatcher.com Articles on Drug names > AMPHOTERICIN B (Site not responding. Last check: 2007-09-11)
		Amphotericin B lipid soluble formulations versus amphotericin B in...
		AmBisome, amphotericin B in Intralipid (6 trials, 379 patients), amphotericin B colloidal dispersion (ABCD) (2 trials, 262 patients), and amphotericin B lipid complex (ABLC) (1 trial, 105 patients) all decreased the occurrence of nephrotoxicity, but conventional amphotericin B was rarely administered under optimal circumstances...
		Amphotericin B is not effective against bacterial infections f2c...
	www.drugswatcher.com /AMPHOTERICIN_B_s186.html (921 words)

	Amphotericin B Use (Site not responding. Last check: 2007-09-11)
		Acute reactions to amphotericin B are seen within 90 minutes of the infusion and usually remit by 3-4 hours.
		If azotemia occurs with a serum creatinine 3 mg/dl, the dose of amphotericin B may be reduced or held after a careful assessment of the risks versus benefits to the patient (discuss with Infectious Disease consultant).
		Optimal dosing of amphotericin B for most fungal infections is not known.
	www.uphs.upenn.edu /bugdrug/antibiotic_manual/ampho.htm (623 words)

	Amphotericin B in Children with Malignant Disease: a Comparison of the Toxicities and Pharmacokinetics of Amphotericin ... (Site not responding. Last check: 2007-09-11)
		Amphotericin B in Children with Malignant Disease: a Comparison of the Toxicities and Pharmacokinetics of Amphotericin B Administered in Dextrose versus Lipid Emulsion -- Nath et al.
		Amphotericin B in Children with Malignant Disease: a Comparison of the Toxicities and Pharmacokinetics of Amphotericin B Administered in Dextrose versus Lipid Emulsion
		Amphotericin B (AmB) is an antifungal agent used as treatment for patients with established or suspected fungal infections
	aac.asm.org /cgi/content/full/43/6/1417 (4140 words)

	Amphotericin B in Lipid Emulsion: Stability, Compatibility, and In Vitro Antifungal Activity -- Walker et al. 42 (4): ...
		Amphotericin B in Lipid Emulsion: Stability, Compatibility, and In Vitro Antifungal Activity -- Walker et al.
		In vitro renal toxicity and in vivo therapeutic efficacy in experimental murine cryptococcosis of amphotericin B (Fungizone) associated with Intralipid.
		Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: a preliminary study.
	aac.asm.org /cgi/content/full/42/4/762 (2955 words)

	MedlinePlus Drug Information: Amphotericin B (Systemic) (Site not responding. Last check: 2007-09-11)
		Amphotericin B is available only with your doctor's prescription.
		Children—Although there is no specific information comparing use of amphotericin B in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		There is no specific information comparing use of amphotericin B in the elderly with use in other age groups.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202032.html (846 words)

	Ion Channel Behavior of Amphotericin B in Sterol-Free and Cholesterol- or Ergosterol-Containing Supported ... (Site not responding. Last check: 2007-09-11)
		One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium.
		The structuring effects of amphotericin B on pure and ergosterol- or cholesterol-containing dipalmitoylphosphatidylcholine bilayers: a differential scanning calorimetry study.
		Equilibrium binding of amphotericin B and its methyl ester and borate complex to sterols.
	www.biophysj.org /cgi/content/full/83/6/3245 (4269 words)

	Efficacy of aerosolized amphotericin B desoxycholate and liposomal amphotericin B in the treatment of invasive ... (Site not responding. Last check: 2007-09-11)
		Efficacy of aerosolized amphotericin B desoxycholate and liposomal amphotericin B in the treatment of invasive pulmonary aspergillosis in severely immunocompromised rats -- Ruijgrok et al.
		desoxycholate or liposomal amphotericin B. In vitro surfactant
		Aerosolized amphotericin B inhalations as prophylaxis of invasive aspergillus infections during prolonged neutropenia: results of a prospective randomized multicenter trial.
	jac.oupjournals.org /cgi/content/full/48/1/89 (3372 words)

	Evidence-based assessment of primary antifungal prophylaxis in patients with hematologic malignancies -- Cornely et al. ...
		Liposomal amphotericin B was administered at a dose of 1 mg/kg/d in a double-blind placebo-controlled study.
		Prophylactic administration of liposomal amphotericin B is superior to treatment in a murine model of invasive aspergillosis after hematopoietic cell transplantation.
		Amphotericin B colloidal dispersion (Amphocil) vs fluconazole for the prevention of fungal infections in neutropenic patients: data of a prematurely stopped clinical trial.
	www.bloodjournal.org /cgi/content/full/101/9/3365 (4421 words)

	MedMaster - Amphotericin B Lipid Complex Injection Drug Search - Drug Price Search
		Amphotericin is used to kill fungi that can cause many serious and life-threatening infections.
		Amphotericin is not effective against bacterial infections or viruses.
		If you are receiving amphotericin in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin).
	www.drug-price-search.com /drug/?name_id=16&level=2&flag=0 (783 words)

	Treatment of Megabacteria in Budgerigars by In-Water Medication with Soluble Amphotericin B (Site not responding. Last check: 2007-09-11)
		Amphotericin is a polyene macrolide antifungal agent which acts to bind the sterols (chiefly ergosterol) in fungal cell walls, altering permeability.
		The practical administration of Amphotericin B is the major obstacle to flock treatments for megabacteriosis.
		An inclusion complex of gamma cyclodextrin and Amphotericin B was formed by adding an excess of Amphotericin B powder to a saturated solution of gamma cyclodextrin.
	www.vet.uga.edu /IVCVM/1998/gestier/gestier.htm (1154 words)

	Amphotericin B,Liposomal Amphotericin B,Amphotericin B Lipid Complex,Amphotericin B Cholesterol Complex, Amphotericin B ... (Site not responding. Last check: 2007-09-11)
		Amphotericin B,Liposomal Amphotericin B,Amphotericin B Lipid Complex,Amphotericin B Cholesterol Complex, Amphotericin B Liposomal,Amphotericin B liposomal Complex,Systemic Mycosis,Amphotericin B and Nephrotoxicity, FUNGISOME
		Amphotericin B is the most potent wide spectrum drug for treatment of Systemic Fungal Infections.
		FUNGISOME is a true liposomal preparation of Amphotericin B in which lipid complex of liposomes is constituted of lecithin and cholesterol.
	www.fungisome.com (210 words)

	Safety and toxicity of amphotericin B in glucose 5% or intralipid 20% in neutropenic patients with pneumonia or fever ...
		Safety and toxicity of amphotericin B in glucose 5% or intralipid 20% in neutropenic patients with pneumonia or fever of unknown origin: randomised study
		On the basis of published data, amphotericin B and intralipid 20% should be regarded as chemically incompatible
		The combination of amphotericin B and intralipid should not be given to patients
	www.bmj.com /cgi/content/abstract/317/7155/379 (630 words)

	Diagnosis and treatment of invasive pulmonary aspergillosis in neutropenic patients -- Reichenberger et al. 19 (4): 743 ...
		Fiberoptic local endobronchial instillation of antimycotic agents (Amphotericin B or Miconazol) as an additive treatment of invasive aspergillosis and aspergilloma of the lung.
		Aerolized amphotericin B inhalations as prophylaxis of invasive aspergillosis infections during prolonged neutropenia: result of a prospective randomized multicenter trial.
		Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases.
	erj.ersjournals.com /cgi/content/full/19/4/743 (6544 words)

	Amphotericin B (Site not responding. Last check: 2007-09-11)
		Amphotericin B prevents fungal organisms from producing vital substances required for growth and function.
		Adequate studies of the use of amphotericin B use during pregnancy have not been done.
		Amphotericin B may pass into breast milk; caution is advised.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,31,00.html (569 words)

	Amphotericin B
		mphotericin B is prescribed to transplant patients to treat or prevent the development of aspergillus infection, a type of fungal infection.
		Amphotericin B must be taken for the entire duration of treatment in order to achieve the best results.
		Many of the side effects of amphotericin B are dose-related and may go away when your health care provider adjusts your dosage.
	www.clevelandclinic.org /TRANSPLANT/services/lung/guide/amphotericin-b.htm (379 words)

	Cryptococcal Meningitis
		There have been some reports suggesting the liposomal amphotericin B – a drug involving microscopic spheres of lipids (fats) that contain amphotericin B – is less toxic than the standard form of amphotericin B (Fungizone®).
		However, recent studies conclude that liposomal amphotericin B is equally toxic – and less effective – than Fungizone.
		Still, liposomal amphotericin B is sometimes prescribed for patients who become very ill while taking Fungizone or develop kidney problems.
	www.aidsmeds.com /OIs/Meningitis3.htm (725 words)

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