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Amylin - Wikipedia, the free encyclopedia Amylin, or Islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone secreted by pancreatic β-cells at the same time as insulin (in a roughly 100:1 ratio). Amylin functions as part of the endocrine pancreas and contributes to glycemic control. Although amylin's normal role may not yet be fully known, it aids in limiting glycemic excursions by slowing gastric emptying, promoting satiety, and inhibiting inappropriate secretion of glucagon, a catabolic hormone that opposes the effects of insulin and amylin. en.wikipedia.org /wiki/Amylin   (283 words)

Amylin Pharmaceuticals, Inc.   (Site not responding. Last check: 2007-10-10) Amylin Pharmaceuticals is a biopharmaceutical company committed to improving lives through the discovery, development and commercialization of innovative medicines. Amylin's scientists are primarily focused on investigating the potential utility of new peptide hormone candidates. Amylin's approach and dedication are rooted in the belief that they will be "Changing Lives" for millions of people - not only with the drugs currently in late-stage development, but also with their pipeline of future therapies. company.monster.com /amyp   (163 words)

Pramlintide - Wikipedia, the free encyclopedia It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. By substituting for amylin, pramlintide aids in the absorption of glucose by slowing gastric emptying, promoting satiety, and the inhibiting inappropriate secretion of glucagon, a catabolic hormone that opposes the effects of insulin and amylin. Since native human amylin is highly amyloidogenic and potentially toxic, the strategy for designing pramlintide was to substitute residues from rat amylin, which is not amyloidogenic (but would presumably retain clinical activity). en.wikipedia.org /wiki/Pramlintide   (293 words)

Amylin Pharmaceuticals, Inc. - Physiology Q and A   (Site not responding. Last check: 2007-10-10) Co-located with insulin in the pancreatic β-cells, amylin is also co-secreted with insulin in response to nutrient stimuli with a secretory and plasma concentration profile similar to that of insulin. Amylin and insulin are co-secreted in response to carbohydrate and amino acids following a meal stimulus. In early stage type 2 diabetes (a condition of amylin hypersecretion), amyloid deposition begins to occur in the pancreatic islets and researchers propose that this pathologic process may contribute to β-cell dysfunction and destruction in type 2 diabetes. www.amylin.org /physiology/qa.html   (1358 words)

Amylin Pharmaceuticals, Inc.   (Site not responding. Last check: 2007-10-10) Amylin Pharmaceuticals, Inc. is a biopharmaceutical company committed to improving lives through the discovery, development, and commercialization of innovative medicines. Amylin's research and development activities leverage the company's expertise in metabolism to develop promising therapies to treat diabetes, obesity and cardiovascular disease. Amylin's approach and dedication are rooted in the belief that they will be "Changing Lives" for millions of people - not only with the drugs currently marketed, but also with their pipeline of future therapies. www.biospace.com /company_profile.aspx?CompanyId=1734   (279 words)

JOSEPH COOK JR. - AMYLIN PHARMACEUTICALS INC (AMLN): 2002-02-18 Pramlintide is a synthetic analog of human amylin, a normally occurring hormone known to be deficient in people with diabetes. But, it was not until 1987 that a researcher at Oxford University was able to show that there is a second hormone produced by the same beta cells that is also missing in the condition of Type 1 diabetes. Amylin Pharmaceuticals is the only company with exclusive rights to two late- stage, first-in-class agents for diabetes, and a third compound headed for Phase II this year. www.twst.com /ceos/amln3.html   (3418 words)

2003_12 | Can Amylin Analogue Lead To Better Diabetes Control? Amylin is part of the complex interplay of glucose regulation. Amylin has been found to complement the effects of insulin in postprandial glucose control by affecting three pathways that contribute to the overall glycemic control in a way that the currently available agents, either oral or insulin, cannot mimic. Of note is that placebo-controlled crossover studies in both type 1 and type 2 diabetes have demonstrated almost total prevention of the initial surge of glucose levels in the first 30 to 60 minutes after a meal in people receiving pramlintide, thus limiting or preventing the postprandial hyperglycemia. www.managedcaremag.com /archives/0312/0312.biotech.html   (1208 words)

SignOnSanDiego.com > News > Business -- Amylin weight-loss drug is promising Amylin released the early-stage clinical trial results of its drug pramlintide at an obesity conference in Greece. The drug is a synthetic analog of human amylin, a hormone known to play a role in the regulation of appetite and food intake by helping people to feel full, said Dan Bradbury, Amylin's chief operating officer. Amylin recently started enrolling people in what will be a 16-week escalating dose study of about 400 obese, non-diabetic people. www.signonsandiego.com /news/business/20050604-9999-1b4amylin.html   (425 words)

Amylin Pharmaceuticals News   (Site not responding. Last check: 2007-10-10) Amylin Pharmaceuticals, Inc. today announced an extensive program of clinical trials which will assess the safety and efficacy of multiple neurohormones used in combination to treat obesity. Amylin Pharmaceuticals Inc. plans to expand its trials of multiple neurohormones used in combination to treat obesity. Amylin Pharmaceuticals Inc., which makes drugs to treat diabetes, said Tuesday that it will begin a series of five clinical trials to test the safety and efficacy of several compounds in treating obesity. www.topix.net /com/amln   (655 words)

JOSEPH COOK, JR. - AMYLIN PHARMACEUTICALS - (AMLN): 01-02-19 Cook: Amylin was founded in 1987 following the discovery that a second hormone, amylin, is produced by the beta cells in the pancreas. Amylin is utilizing the extensive knowledge of diabetes acquired from the SYMLIN program as we develop a second compound, AC2993 (synthetic exendin-4). Amylin has the plans and the resources to do this, so execution of these plans is our primary objective. www.twst.com /ceos/amln2.html   (2637 words)

Linco Research, Inc. - Total Human Amylin ELISA Kit Amylin is a 37 amino acid hormone that is co-secreted with insulin from pancreatic beta cells in response to hyperglycemia. Amylin appears to work in concert with insulin to regulate plasma glucose concentrations in the bloodstream, suppressing the postprandial secretion of glucagon and slowing the rate of gastric emptying. The Total Human Amylin ELISA is a monoclonal antibody-based sandwich immunoassay for determining total amylin levels in human plasma. www.lincoresearch.com /products/ezhat-51k.html   (247 words)

The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the ... Amylin injection elicited a strong c-Fos expression in the area postrema (AP), the nucleus of the solitary tract (NTS), the external part of the lateral parabrachial nucleus (LPBN), and the central nucleus of the amygdala (CeA; between bregma -2.20 and -3.00). In the intact rat, amylin induced a strong c-Fos response in the AP and the NTS. Viscerotopic representation of the upper alimentary tract in the rat: sensory ganglia and nuclei of the solitary and spinal trigeminal tracts. ajpregu.physiology.org /cgi/content/full/286/1/R114   (5831 words)

Amylin Pharmaceuticals News - Page 2 Amylin Pharmaceuticals beat Wall Street estimates for the third quarter as losses were narrower and sales were higher than analysts had expected. Amylin Pharmaceuticals, Inc. today announced positive results from a 16-week study evaluating the safety and efficacy of adding SYMLIN to an established regimen of basal insulin glargine in patients with type 2... Amylin Pharmaceuticals, Inc. today announced that in connection with the previously announced redemption of its 2.25% convertible senior notes due June 30, 2008, issued in 2003, holders of all of the... www.topix.net /com/amln/page2   (950 words)

Omeris: Amylin plans Ohio production facility Amylin announced it has acquired an existing 150,000 square foot building and 26 acres of land on Trade Port Drive in West Chester. Amylin will also benefit from Ohio’s new tax structure, which is eliminating taxes on tangible personal property and profits, reduces personal income tax by 21% and exempts taxes on sales to destinations outside Ohio. On December 9, 2005 in London, Amylin was awarded the inaugural SCRIP award for the Biotech Company of the Year, for bringing to market two novel antidiabetic drugs. www.omeris.org /news/Amylin_Dec05.asp   (691 words)

Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats -- Reidelberger et al. ... Amylin and CCK-8 had similar dose-dependent effects on meal patterns (Tables 1 and 2). Amylin dose dependently reduced the volume of saline emptied from the stomach during the 5-min test period (Fig. Adrenomedullin, amylin, calcitonin gene-related peptide and their fragments are potent inhibitors of gastric acid secretion in rats. ajpregu.physiology.org /cgi/content/full/280/3/R605   (4695 words)

[No title] Amylin Pharmaceuticals is engaged in the discovery and development of potential drug candidates for the treatment of metabolic disorders. Amylin Pharmaceuticals' second diabetes drug candidate, AC2993, is targeted for the treatment of type 2 diabetes. Further information on Amylin and its pipeline in metabolism is available at http://www.amylin.com. www.lycos.com /info/pharmaceuticals--amylin-pharmaceuticals.html   (236 words)

Weiss & Yourman - Amylin Complaint Amylin is engaged in the discovery, development and commercialization of potential drug candidates for the treatment of metabolic disorders. Amylin's success was dependent upon its ability to raise monies to fund its cash-starved operations and defendants induced thousands of investors to purchase Amylin shares in hopes of profiting from Amylin's one drug - SYMLIN - and achieving FDA approval for the use and distribution of the drug. Amylin Pharmaceuticals, Inc. today reported a net loss applicable to common stock of $10.0 million, or $0.16 per share, for the third quarter ended September 30, 2000, compared to a net loss applicable to common stock of $7.0 million, or $0.17 per share, for the third quarter of 1999. www.wyca.com /complnts/amln-com.htm   (6829 words)

Pramlintide (Symlin - Amylin Pharmaceuticals) Pramlintide, a synthetic analog of the pancreatic hormone amylin, was approved by the FDA for the treatment of diabetes types 1 and 2. In a functioning pancreas, amylin is secreted with insulin in response to caloric intake. Amylin prevents hyperglycemia by slowing gastric emptying, suppressing glucagon secretion, and decreasing food consumption by providing a feeling of satiety. uuhsc.utah.edu /pharmacy/bulletins/pramlintide.html   (671 words)

Amylin Peptide antibodies from RDI Divison of Fitzgerald Industries Intl Amylin appears to work with insulin to regulate plasma/glucose concentrations in the bloodstream, suppressing secretion of glucagon after eating and restraining the rate of gastric emptying. Amylin (24-37) peptide fragment forms amyloid deposits, however, smaller fragments eg residues 20 to 29, are also capable of generating amyloid. A soluble factor from pancreatic carcinoma cells selectively stimulates amylin secretion from islet cells, explaining the detection of excessive quantities of amylin found in cases of pancreatic cancer. www.researchd.com /miscabs/amylinp.htm   (399 words)

Amylin plays key role in preventing bone loss- From The Laboratories at Baylor College of Medicine Amylin’s normal function is to prevent the loss of bone or its resorption. Amylin inhibits the production of the osteoclasts, keeping their numbers down so that their activities do not outpace those of the osteoblasts, which deposit new bone. Mice that lack amylin have less bone mass than those who produce the hormone because they destroy bone more rapidly than is seen in classical osteoporosis said Karsenty. www.bcm.edu /fromthelab/vol03/is3/04apr_n1.htm   (595 words)

Amylin Amylin also has CGRP-like effects on bone metabolism. Amylin has specific binding sites in the CNS and it may regulate gastric emptying and influence carbohydrate metabolism. ADM is produced in peripheral tissues, adrenal medulla, lung, and kidney. www.gencompare.com /amylin.htm   (740 words)

News: Amylin Pharmaceuticals Announces BYETTA Revenue. Genetic Engineering News - Biotechnology from Bench to Business A replay of the call will also be available by phone for 24 hours beginning approximately one hour after the close of the call and can be accessed at (888) 286-8010 (domestic) or (617) 801-6888 (international), passcode 52039618. Amylin has developed and gained approval for two first-in-class medicines for diabetes, SYMLIN(R) (pramlintide acetate) injection and BYETTA(R) (exenatide) injection. Further information on Amylin Pharmaceuticals and its pipeline in metabolism is available at http://www.amylin.com. www.genengnews.com /news/bnitem.aspx?name=3495922   (376 words)

Amylin Replacement With Pramlintide in Type 1 and Type 2 Diabetes: A Physiological Approach to Overcome Barriers With ... Amylin response in patients with type 1 or type 2 diabetes is demonstrated after a liquid Sustacal meal. Amylin is absent in patients with type 1 diabetes, and amylin secretion is markedly impaired in insulin-requiring patients with type 2 diabetes. Preclinical and clinical studies indicate that amylin complements the effects of insulin by regulating the rate of glucose inflow to the bloodstream. clinical.diabetesjournals.org /cgi/content/full/20/3/137   (4528 words)

Amylin's Gila Monster Of A Diabetes Drug - Forbes.com   (Site not responding. Last check: 2007-10-10) Late yesterday, Amylin (nasdaq: AMLN - news - people) unveiled the results of the first of three clinical trials that it and its partner Eli Lilly (nyse: LLY - news - people) hope will lead to U.S. regulatory approval for the medicine, exenatide, to treat adult-onset diabetes. Amylin shares sunk to their lowest levels ever in 1998 when Johnson and Johnson (nyse: JNJ - news - people) ended a collaboration on another diabetes drug, Symlin. Lilly and Amylin are splitting development costs and profits on what could be a $1 billion drug. www.forbes.com /2003/08/07/cx_mh_0807amln.html   (787 words)

Amylin Amylin Pharmaceuticals will webcast a conference call to discuss the BYETTA approval and commercialization plans on Friday, April 29, 2005 at 12:00 p.m. Further information on Amylin Pharmaceuticals, its marketed products, and its pipeline in metabolism is available at www.amylin.com. These and additional risks and uncertainties are described more fully in Amylin and Lilly's most recently filed SEC documents such as their Annual Reports on Form 10-K. Amylin and Lilly undertake no duty to update these forward-looking statements. www.amylin.com /pipeline/byetta.cfm   (1452 words)

ICOS Corporation - Lilly Alliance This Alliance has capitalized on the strengths of both organizations; the dedication and expertise of the Amylin people and their strong leadership have been key to the overall success of the collaboration." Amylin Pharmaceuticals and Eli Lilly and Company jointly developed and launched BYETTA®, approved by the FDA in April 2005 as adjunctive therapy to improve blood sugar control in patients with type 2 diabetes who have not achieved adequate control on meformin and/or a sulfonylurea, two common oral diabetes medications. Find out more about Amylin Pharmaceuticals at www.amylin.com. www.lilly.com /about/partnering/alliances/commercial/amylin.html   (221 words)

A Cure for Amylin's Stock? [Fool.com] December 17, 2006 After the market closed on Monday, Amylin announced mid-stage results from a small phase 2 clinical study of exenatide LAR, a longer-acting formulation of the already approved Byetta GLP-1 drug, which treats type 2, or adult-onset, diabetes. Amylin shares were bid up considerably on the news. These shares aren't for the faint of heart, but aggressive investors may want to explore Amylin as an opportunity to play on the growing epidemic of metabolic diseases such as diabetes and obesity. www.fool.com /News/mft/2005/mft05082307.htm   (759 words)

An Insulin-Degrading Enzyme Inhibitor Decreases Amylin Degradation, Increases Amylin-Induced Cytotoxicity, and ... Amylin (islet amyloid polypeptide) is the chief component of amylin, and insulin (by 50, 50, and 73%, respectively). contribute to the degradation of amylin is incomplete. diabetes.diabetesjournals.org /cgi/content/full/52/9/2315   (3668 words)

Insulin and Amylin: Restoring Balance in Glycemic Control Pramlintide, the recently approved analogue of the human hormone amylin, is the first antihyperglycemic agent for type 1 diabetes since the introduction of insulin more than 80 years ago. Cite safety and efficacy data from clinical trials of the amylin hormone analogue pramlintide that show its effect on patients with type 1 or type 2 diabetes. This information is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options for a specific patient's medical condition. www.cecity.com /aade/amylin/disclaim.htm   (732 words)

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