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Topic: Amyloid precursor protein

	Amyloid Plaque: 1998
		Amyloid plaques were systematically quantified in representative sections of the temporal, frontal, cingulate, insular, and parietal cortices and in the amygdala and hippocampus.
		Both the frequency of plaques immunopositive for beta-amyloid, amyloid precursor protein, and apolipoprotein E and that of microglial cells in the cortex and in the white matter were determined semiquantitatively.
		Amyloid plaques are formed by the progressive deposition and transformation of soluble amyloid beta-protein monomers into insoluble and fibrillar aggregates that contain amyloid beta-protein in a beta-pleated sheet conformation.
	lansbury.bwh.harvard.edu /Literature/Review/amyloid_plaque_1998.htm (19185 words)

	Solution Studies and Structural Model of the Extracellular Domain of the Human Amyloid Precursor Protein -- Gralle et ...
		The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
		Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.
		The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I).
	www.biophysj.org /cgi/content/full/83/6/3513 (5498 words)

	Amyloid Precursor Protein: A Practical Approach
		Amyloid precursor protein (APP) is an extensively studied transmembrane protein, and its derivative, amyloid b-protein, has been implicated as the primary cause of Alzheimer's disease.
		In the search for an effective treatment for Alzheimer's disease, APP is a unique model protein that illustrates the wide array of basic and sophisticated techniques available for characterization.
		Amyloid Precursor Protein: A Practical Approach presents a variety of biological techniques utilized in genetics, molecular biology, cell biology, and biochemistry to elucidate the structure and function of this transmembrane protein.
	www.ramex.com /title.asp?id=11248 (509 words)

	Amyloid precursor protein (APP)
		Mice deficient for the amyloid precursor protein gene.
		The APP promoter region was isolated from a 129 mouse library by using a 1.0 kb
		A platelet-derived growth factor (PDGF)-beta promoter was used to drive a human beta-amyloid precursor protein (hAPP) minigene encoding the APP(717V-->F) mutation associ....
	www.bioscience.org /knockout/app.htm (183 words)

	OMIM - Online Mendelian Inheritance in Man
		The amino acid composition, molecular mass, and NH2-terminal sequence of this amyloid protein were found to be almost identical to those described for the amyloid deposited in the congophilic angiopathy of Alzheimer disease and Down syndrome.
		The amyloid precursor proteins in the Dutch and Icelandic forms of cerebroarterial amyloidosis are both protease inhibitors and both have been found to have a substitution in their genes that give rise to a substitution of glutamine.
		Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
	web.utk.edu /~saydin/omimab.html (9867 words)

	Regulation of Amyloid Precursor Protein Catabolism Involves the Mitogen-Activated Protein Kinase Signal Transduction ...
		-amyloid precursor protein in the absence of the cytoplasmic tail.
		Echlers MRW, Riordon JF (1991) Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins.
		-Amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.
	www.jneurosci.org /cgi/content/full/17/24/9415 (5710 words)

	OMIM Entry 104760 (Site not responding. Last check: 2007-11-05)
		The major protein subunit (A4) of the amyloid fibril of tangles, plaques, and blood vessel deposits is a polypeptide identified as the cleavage product of a larger precursor protein with features of a cell surface receptor (Kang et al., 1987).
		The protein deposits in neurofibrillary tangles, neuritic plaques, and neuropil threads in the cerebral cortex of patients with Alzheimer disease and Down syndrome ( 190685) contain forms of beta-amyloid precursor protein and ubiquitin-B ( 191339) that are aberrant in the C terminus.
		Immunization with amyloid-beta attenuatesAlzheimer-disease-like pathology in the PDAPP mouse.
	www.hgmp.mrc.ac.uk /cgi-bin/wrapomim?104760 (9445 words)

	UniProtKB Entry - UniProt [the Universal Protein Resource]
		The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures.
		The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.
		After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes.
	www.pir.uniprot.org /cgi-bin/upEntry?id=P08592 (1932 words)

	Identification and expression of the first nonmammalian amyloid-{beta} precursor-like protein APLP2 in the amphibian ... (Site not responding. Last check: 2007-11-05)
		APP and pre APLP lineages predated the mammalian-amphibian split.
		Pangalos, M.N., Shioi, J. and Robakis, N.K. (1995) Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2.
		Hammond, D.N. (1989) Neurite outgrowth and the amyloid protein precursor.
	content.febsjournal.org /cgi/content/full/271/10/1906 (4230 words)

	GeneCard for APLP2
		Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.
		Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family.
		The gene for the amyloid precursor-like protein APLP2 is assigned to humanchromosome 11q23-q25.
	www.genecards.org /cgi-bin/carddisp?APLP2 (714 words)

	Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with ...
		The amyloid precursor protein undergoes proteolysis at several sites to yield a number of functionally relevant peptides, including beta-amyloid and the soluble amyloid precursor protein derivatives alpha-soluble amyloid precursor protein and beta-soluble amyloid precursor protein.
		We tested for age-related alterations in these amyloid precursor protein proteolytically derived peptides by measuring the levels of alpha-soluble amyloid precursor protein, total soluble amyloid precursor proteins (alpha- and beta-soluble amyloid precursor protein combined) and beta-amyloid in cerebrospinal fluid from three-, 13- and 23-month-old Fischer-344 rats.
		Western blot analysis using selective antibodies revealed 50% less total soluble amyloid precursor protein and a-soluble amyloid precursor protein in cisternal cerebrospinal fluid from 23-month-old rats compared with three- and 13-month-old animals.
	www.arclab.org /medlineupdates/abstract_10501466.html (296 words)

	The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor ... (Site not responding. Last check: 2007-11-05)
		Muresan, Z., Muresan, V. A phosphorylated, carboxy-terminal fragment of {beta}-amyloid precursor protein localizes to the splicing factor compartment.
		Trommsdorff, M., Borg, J.-P., Margolis, B., Herz, J. Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein.
		Wang, H. Y., Zamorano, J., Keegan, A. A Role for the Insulin-Interleukin (IL)-4 Receptor Motif of the IL-4 Receptor alpha -Chain in Regulating Activation of the Insulin Receptor Substrate 2 and Signal Transducer and Activator of Transcription 6 Pathways.
	mcb.asm.org /cgi/content/abstract/16/11/6229 (3424 words)

	Amyloid Precursor Protein (APP), b-Amyloids (b1-40, 1-42) & Endoplasmic Reticulum Associated Binding Protein (ERAB) ...
		Amyloid Precursor Protein (APP), b-Amyloids (b1-40, 1-42) and Endoplasmic Reticulum Associated Binding Protein (ERAB) antibodies
		Polymerization of beta-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition.
		Mutations in the APP gene cause some forms of familial AD (FAD) by releasing an increased amounts of b-amyloid.
	www.4adi.com /flr/amyloids.html (562 words)

	Amyloid Precursor Protein: A Practical Approach (Site not responding. Last check: 2007-11-05)
		The amyloid precursor protein (APP) is a single transmembrane protein that is widely studied as a unique model to illustrate a wide array of basic and advanced biological techniques in many laboratories.
		An important feature is that they describe modifications of standard procedures used to examine a membrane protein that are potentially useful in themselves but also can inspire readers to consider similar alterations in their own experimental procedures.
		Most of the experiments can be carried out is a regularly equipped laboratory, but a few are included for scientists who have all the latest toys at hand.
	www.booksmatter.com /b0849322456.htm (144 words)

	beta
		Beta-amyloid protein is derived from the amyloid protein precursor (APP)
		Gao, YH, Pimplikar, SW (2001) The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus.
		Moechars, D, Lorent, K and Van Leuven, F (1999) Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis.
	www.lifesci.sussex.ac.uk /home/Julian_Thorpe/ad_beta.htm (9061 words)

	Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by ...
		Amyloid beta-protein, the principal constituent of amyloid fibrils found in
		is derived by proteolysis of the beta-amyloid precursor protein by unclear
		Presenilin-1, Nicastrin, Amyloid Precursor Protein, and {gamma}-Secretase Activity Are Co-localized in the Lysosomal Membrane
	jcs.biologists.org /cgi/content/abstract/109/5/991 (1436 words)

	Amyloid Precursor Protein [APP] , C-terminus : AB5352
		Recognizes full length APP and C-terminal fragments resulting from cleavage by secretase.
		Western blot: 1:500-1:2000: The low abundance of full length APP in untreated cells means that poor response is seen with immunoblotting of whole cell lysates.
		We recommend that membrane fractions be prepared to increase the loading of APP as well as remove potential interferences from soluable proteins.
	www.chemicon.com /Product/ProductDatasheet.asp?ProductItem=AB5352 (179 words)

	The Disabled 1 Phosphotyrosine-Binding Domain Binds to the Internalization Signals of Transmembrane Glycoproteins and ... (Site not responding. Last check: 2007-11-05)
		cells and is coexpressed with APP in hippocampal neurons.
		Michaely, P., Li, W.-P., Anderson, R. W., Cohen, J. C., Hobbs, H. The Modular Adaptor Protein ARH Is Required for Low Density Lipoprotein (LDL) Binding and Internalization but Not for LDL Receptor Clustering in Coated Pits.
		Ho, A., Sudhof, T. Binding of F-spondin to amyloid-{beta} precursor protein: A candidate amyloid-{beta} precursor protein ligand that modulates amyloid-{beta} precursor protein cleavage.
	mcb.asm.org /cgi/content/abstract/19/7/5179 (2403 words)

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