| | The Potential of Organic-Based Amylose-Ethylcellulose Film Coatings as Oral Colon-Specific Drug Delivery Systems |
 | | Amylose, in the form of an amylose-butan-1-ol dispersion, and ethylcellulose, dissolved in either ethyl lactate, ethanol, or propanol and plasticized with dibutyl sebacate, were mixed in various proportions and applied using a fluidized bed coater to achieve a range of film thicknesses on 5-aminosalicylic acid pellets. |
 | | Amylose was extracted from pea starch and obtained in the form of an amylose-butan-1-ol complex aqueous dispersion |
 | | The slow release may be related to the limited amount of amylose present within the film, which would prevent the formation of a continuous amylose network throughout the film structure, leading to the amylose being less accessible to enzymatic attack and hence hindering digestion of the coating. |
| www.aapspharmscitech.org /view.asp?art=pt010322&pdf=yes (3401 words) |