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| | DCCPS (Site not responding. Last check: 2007-10-12) |
 | | The specific aims of this proposal are, in a cohort study, to examine the relative contribution of ANAb levels and streptococcal infections to exacerbations of tics in 50 children with TS-like PANDAS, 50 with TS-nonPANDAS, and 50 Controls (ages 6-13 years). |
 | | Aim 3 will test whether speculated elevated ANAb titers and specific Western blot bands in TS-PANDAS will be reduced by preabsorption of serum with streptococcal cell wall proteins extracted with group C phage lysin and with streptococcal M-proteins (wild and recombinant). |
 | | ANAb titers/specific bands, measured at baseline, after an exacerbation of tics, and 6 weeks thereafter, will be compared to changes in tic severity, obsessive-compulsive behaviors, and GABHS markers (ASO and anti-DNAse B) (Aim 4). |
| dccps.nci.nih.gov /grants/abstract.asp?ApplID=2762023 (336 words) |
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