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 | | METHODS: Anal manometry was performed on eight healthy volunteers and 15 patients with chronic anal fissure before and after oral administration of nifedipine 20 mg. |
 | | Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland, U.K. The aim of the present study was to compare the sensitivity to nifedipine of contraction, obtained with 5-hydroxytryptamine (5-HT) and high K+, of arteries from three vascular territories (coronary, cerebral and pulmonary), selecting arteries of equivalent diameter (0.4-0.8 mm). |
 | | Moreover, the KCl-induced contraction in the sheep pulmonary artery is mediated, in part, by a mechanism independent of Ca2+ influx. |
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