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Topic: Androgen and estrogen metabolism

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Mickey Rourke

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Hugh Jackman

	Prostate Enlargement (Benign Prostatic Hypertrophy)
		The effect of androgen and estrogen on secretory epithelial cells and basal cells of the rat ventral prostate after long-term castration.
		Estrogen suppression as a pharmacotherapeutic strategy in the medical treatment of benign prostatic hyperplasia: evidence for its efficacy from studies with mepartricin.
		The results also suggest that BPH is a component of the metabolic syndrome and that BPH patients may share the same metabolic abnormality of a defective insulin-mediated glucose uptake and secondary hyperinsulinaemia, as patients with the metabolic syndrome.
	www.lef.org /protocols/abstracts/abstr-095.html (5055 words)

	Peter Ofner (Site not responding. Last check: 2007-10-26)
		Metabolism of radiotestosterone to 3 beta,6 alpha- and 3 beta,7 alpha-dihydroxy 5 alpha-steroids by rat ventral, canine and human prostate in organ culture.
		Reductive metabolism of 5 alpha-dihydrotestosterone by rat ventral and dorsolateral prostate: kinetic parameters of the enzymes.
		Metabolism of estradiol and estrone in organ cultures of dorsolateral and ventral prostate of untreated and sex hormone-implanted rats.
	www.hsph.harvard.edu /academics/archives/mct/home/archives/ofner.html (489 words)

	Estrogen Metabolism (Site not responding. Last check: 2007-10-26)
		Estrogen Metabolism Assessment for hormone replacement therapy, HRT, hormonal imbalances, menopause, breast cancer, heart disease, osteoporosis, autoimmune disorders, obesity, alcohol consumption, alternative medicine supplements, natural...
		The alteration of estrogen metabolism by PCB exposure is a mechanism by which...
		Each woman's estrogen metabolism is different, so that the balance between the pro- and anti-cancer...
	femalebalancecream.com /3/estrogen-metabolism.html (412 words)

	Your Menopause Type - Is Estriol Safer Than Estradiol?
		Recall that estrogen is a generic term for any substance, whether natural or synthetic, that has the same biological activity as estradiol.
		Steroidogenic Pathway as well as estrogen metabolites, it is understood that 16-hydroxyestrone is a metabolite of estriol.
		Estradiol may be alternatively metabolized to the 2 hydroxy-estradiol (good metabolite) or back through estrone into 16-hydroxyestone (bad metabolite) or on to 2 hydroxy-estrone (good metabolite).
	www.yourmenopausetype.com /menopausequestionsandanswers/04232000.html (1718 words)

	Estrogen metabolism (Site not responding. Last check: 2007-10-26)
		Michnovicz, JJ and Bradlow, HL Altered estrogen metabolism and excretion in.
		As I say, there are over 40 estrogen metabolites, yet because they end up in directed pathways and hydroxyestradiol eventually converts to hydroxyestrone,.
		Much less attention has been focused on the role of estrogen metabolites which have recently been shown to act on the hypothalamus as well as on the.
	www.selectphysician.com /estrogen+metabolism.html (308 words)

	Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human ...
		Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells.
		The androgen receptor (AR) is a member of the steroid receptor superfamily that may require coactivators for proper or maximal transactivation.
		Using a purified AR N-terminal peptide as a probe to screen the human testis expression library, we identified an androgen-enhanced AR N-terminal-associated protein ARA160, which consists of 1,093 amino acids with an apparent molecular mass of 160 kDa.
	www.aegis.com /aidsline/1999/nov/A99B0961.html (419 words)

	Sex steroid metabolism in the tibial growth plate of the rat. (Site not responding. Last check: 2007-10-26)
		To assess whether growth plate-specific production of sex steroids is possible, we have surveyed the presence of several key-enzymes involved in androgen and estrogen metabolism in the tibial growth plate of female and male rats during development.
		Using in situ hybridization, mRNAs of aromatase p450, type I and II 17beta-hydroxysteroid dehydrogenase (HSD), steroid sulfatase (STS), and 5alpha-reductase were detected in proliferating and hypertrophic chondrocytes of the growth plate.
		In conclusion, our findings clearly indicate the presence of various enzymes involved in sex steroid metabolism in the tibial growth plate, especially in sexually maturing rats, a timepoint at which sex steroids have major effects on longitudinal growth.
	www.arclab.org /medlineupdates/abstract_12239116.html (244 words)

	Diet and urinary steroids in black and white North American men and black South African men (Site not responding. Last check: 2007-10-26)
		The total androgen and estrogen content decreased significantly in Black North American men on the vegetarian diet and increased in Black South African men fed a Western diet.
		Data indicated that a vegetarian diet modified androgen and estrogen metabolism in North American men and that a Western diet was associated with higher levels of urinary steroid hormones in young Black South African men.
		Further clarification is needed of the relationship of the increased urinary excretion of steroid hormones in Black South African men, a low-risk group fed a Western diet, and the decreased excretion in Black and White North American men, high-risk groups fed a vegetarian diet, to the development of prostatic cancer.
	www.meb.uni-bonn.de /cgi-bin/mycite?ExtRef=ICDB/80707412 (264 words)

	SPORES - Current SPORE Programs
		In this study, we propose to systematically test the hypothesis that common genetic polymorphisms for enzymes that catalyze the synthesis and bioactivation of androgens and estrogen (CYP11A1, CYP17, CYP 19, HSD3B2, HSD17B1, HSD17B3, AKR1C3, SRD5A2), either individually or in combination, are risk factors for prostate cancer.
		This hypothesis will be tested in a case-control study that uses two sets of previously identified cases - those with a strong family history of prostate cancer (n=449 from 181 families) and those with a reported negative prostate cancer family history (n=500) - and a population-based control group (n=510).
		At the conclusion of this project, we will have provided important insight into the potential role of a group of genes important in androgen and estrogen metabolism and generated hypotheses about how these interact in the etiology of prostate cancer.
	spores.nci.nih.gov /current/prostate/prostate_docs/pr-tindall.html (3361 words)

	BioMed (Site not responding. Last check: 2007-10-26)
		Raeside, J.I. Christie, H.L. Renaud, R.I. Waelchli, R.O. and Betteridge K.J. Estrogen metabolism in the equine conceptus and endometrium during early pregnancy in relation to estrogen concentrations in yolk-sac fluid.
		Raeside, J.I., Christie, H.L., and Renaud, R.L. Androgen and estrogen metabolism in the reproductive tract and accessory sex glands of the domestic boar (Sus scrofa).
		Raeside, J.I., Christie, H.L., and Renaud, R.L. Metabolism of estrone and estradio-17-beta by the accessory sex glands of the male pig.
	www.ovc.uoguelph.ca /biomed/Faculty/raeside.shtm (216 words)

	Stephen A. Watts, Ph.D.
		Postdoctoral Associate, University of New Hampshire, 1986-88 Chemical Control of Spermatogenesis; Ph.D., University of South Florida, 1986 Metabolic Changes in the Pyloric Caeca During the Annual Reproductive Cycle of Luidia clathrata (Echinodermata: Asteroidea).
		Physiology and biochemistry of growth and stress in aquatic organisms; Steroid metabolism and physiology;; Environmental and hormonal control of growth and reproduction; Physiological ecology; Nutrition; Aquaculture.
		Androgen and Estrogen Metabolism During Sex Differentiation in Mono-sex populations of the Nile Tilapia, Oreochromis niloticus.
	main.uab.edu /show.asp?durki=16387 (220 words)

	AllergyKits
		Fructose And Mannose Metabolism A and B and C Kits
		Porphyrin And Chlorophy II Metabolism A and B and C Kits
		Tryptophan Metabolism A and B and C Kits
	www.alhvials.com /AllergieKits.html (124 words)

	Biochemistry Metabolism Contents
		Metabolic pathways (Kyoto Encyclopedia of Genes and Genomes)
		Metabolic Pathways of Biochemistry - Glycolysis and Gluconeogenesis
		Metabolic Pathways of Biochemistry - Glycogen Biosynthesis & Galactose Pathway
	www.rit.edu /~pac8612/Biochemistry/503(703)/content.html (83 words)

	Pathway Search Result
		hsa00230 Purine metabolism 272 AMPD3; adenosine monophosphate deaminase (isoform E) [EC:3.5.4.6] [SP:AMD3_HUMAN] 2982 GUCY1A3; guanylate cyclase 1, soluble, alpha 3 [EC:4.6.1.2] 353 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7] [SP:APT_HUMAN] 4830 NME1; non-metastatic cells 1, protein (NM23A) expressed in [EC:2.7.4.6] [SP:NDKA_HUMAN] 953 ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [EC:3.6.1.5] [SP:ENP1_HUMAN]
		hsa00271 Methionine metabolism 191 AHCY; S-adenosylhomocysteine hydrolase [EC:3.3.1.1] [SP:SAHH_HUMAN]
		hsa00530 Aminosugars metabolism 6675 UAP1; UDP-N-acteylglucosamine pyrophosphorylase 1 [EC:2.7.7.23] [SP:UAP1_HUMAN]
	www.sph.umich.edu /~ghoshd/COMPBIO/Meta/PathwaySearchResult2.htm (1084 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Energy Citations Database (ECD) Document #5516088 - Estrogen and androgen dynamics in the cynomolgus monkey
		Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
		Estrogen and androgen dynamics in the cynomolgus monkey
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=5516088 (139 words)

	Division of Pediatric Endocrinology, Fellowship Training: U-M C.S. Mott Children's Hospital
		Disorders of calcium, phosphorus and vitamin D metabolism
		Disorders of carbohydrate metabolism including diabetes mellitus and hypoglycemia
		Broad clinical competence also includes the ability to perform endocrine testing carefully and safely and interpret these results accurately.
	www.med.umich.edu /pediatrics/division/endo/fellowship.htm (735 words)

	Publications, Graham Mair, Biological Sciences, Science and Engineering, Flinders University, Adelaide, Australia (Site not responding. Last check: 2007-10-26)
		Rowell, C.B., Watts, S.A., Wibbels, T., Hines, G.A., and Mair, G.C. Androgen and estrogen metabolism during sex differentiation in monosex populations of the Nile tilapia, Oreochromis niloticus.
		Characterization of androstenedione and 17b-estradiol metabolism during the proposed critical period of sex differentiation in the tilapia Oreochromis niloticus.
		Vera Cruz, E.M., Mair, G.C. and Recometa, R.D. (1992) Growth and gonadal maturation of androgen treated Nile tilapia, Oreochromis.
	www.scieng.flinders.edu.au /biology/people/mair_g/publications.html (3495 words)

	[No title] (Site not responding. Last check: 2007-10-26)
		If you click on the link above, you will get a local copy of the enzyme description prepared by the Kegg Project.
		In this local copy, only one link has been set -- a link that will allow you to access the document directly from Kegg (with links into their lovely metabolic maps, descriptions of the enzyme as it occurs in sequenced organisms, and so forth).
		We certainly appreciate the efforts Kegg has made in composing this wonderful integration.
	www.ergo-light.com /ERGO/CGI/fr.cgi?org=&user=&fr=2.8.2.4 (97 words)

	PATHWAY List (Site not responding. Last check: 2007-10-26)
		Synthesis and degradation of ketone bodies - Schizosaccharomyces pombe(2/2)
		Urea cycle and metabolism of amino groups - Schizosaccharomyces pombe(15/17)
		Glycine, serine and threonine metabolism - Schizosaccharomyces pombe(23/30)
	udgenome.ags.udel.edu /fungi/pathway/path.php (99 words)

	hair, hair loss, alopecia, excess hair, and treatments
		can men have pattern baldness as a result of production defects in the enzymes involved in steroid metabolism ?
		how can we really be sure that androgenetic alopecia is caused by androgen hormones ?
		what is a normal blood concentration for androgens and estrogens in men and women ?
	www.keratin.com /ac/baldnessbiology/index.shtml (474 words)

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