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Sex hormone binding globulin - Wikipedia, the free encyclopedia Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to sex hormones, specifically testosterone and estradiol. In addition SHBG is produced by the testis; testis-produced SHBG is also called androgen-binding protein. Also, high androgen levels decrease SHBG, while high estrogen and thyroxine levels increase it. en.wikipedia.org /wiki/Sex_hormone_binding_globulin   (265 words)

Meiotic Arrest and Germ Cell Apoptosis in Androgen-Binding Protein Transgenic Mice -- Selva et al. 141 (3): 1168 -- ... Apoptotic DNA fragmentation in the testis of nontransgenic littermates (lanes 1 and 3) and ABP transgenic animals (lanes 2 and 4). that in ABP transgenic mice pachytene spermatocytes and metaphase ABP that is responsible for the interruption of spermatogenesis. endo.endojournals.org /cgi/content/full/141/3/1168   (6530 words)

Vitamin A:The Forgotten Bodybuilding Nutrient The utilization of protein requires vitamin A. Several animal studies have shown that liver reserves of vitamin A are depleted by a high dietary intake of protein, while vitamin A increases in non-liver tissues. In one study researchers fed radioactively-labeled vitamin A to rats on low-protein and high-protein diets, using the amount of radioactivity present in exhaled gases, urine and feces as a measure of the metabolism of vitamin A, and found that vitamin A is indeed used at a higher rate on a high-protein diet. Rats fed diets deficient in vitamin A synthesize protein at a lower rate than rats fed adequate vitamin A. Cultured skeletal muscle cells increase the amount of protein per cell when exposed to vitamin A and D, but not when exposed to vitamin D alone. www.westonaprice.org /men/vitaminabodybuilding.html   (1324 words)

Follicle-stimulating hormone - Wikipedia, the free encyclopedia In men, FSH enhances the production of androgen-binding protein by the Sertoli cells of the testes and is critical for spermatogenesis. Each monomeric unit is a protein molecule with a sugar attached to it; two of these make the full, functional protein. The protein dimer contains 2 polypeptide units, labelled alpha and beta subunits. en.wikipedia.org /wiki/Follicle-stimulating_hormone   (595 words)

Damassa Laboratory Androgens are steroid hormones that play a critical role in the normal development and maintenance of "male" sexual characteristics. A key element in the action of androgens is believed to be the binding of these steroids to nuclear androgen receptors. Studies to examine the role of SHBG in androgen action are being conducted using a novel rodent model. www.tufts.edu /sackler/cmdb/damassa-lab.htm   (215 words)

BioMed Central | Full text | Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding ... ABPα, ABPβ and ABPγ proteins are secretoglobins, a family of secreted proteins [23] that bind lipophilic ligands (for a review, see [24]) and are present in mammals and birds [25,26], but whose roles in cellular and physiological function all remain obscure [27,28]. Figure 5 provides another perspective where the Abp expressions for the two sexes are arrayed on phylogenetic trees of the Abpa and Abpbg paralogues with the intent of discovering possible correlations of expressions of these genes with their evolutionary history. Karn and Dlouhy [32] showed that salivary ABP is ubiquitous in Old World and New World rodents, regardless of their diets, and noted that ABP binds androgens specifically and with relatively high affinity (see also [44] and [41]). www.biomedcentral.com /1471-2148/5/40   (6562 words)

Comparative Evolutionary Genomics of Androgen-Binding Protein Genes -- Emes et al. 14 (8): 1516 -- Genome Research that mouse salivary androgen-binding protein (ABP) subunit genes Dlouhy, S.R., Taylor, B.A., and Karn, R.C. The genes for mouse salivary androgen-binding protein (ABP) subunits Hwang, J.M., Hofstetter, J.R., Bonhomme, F., and Karn, R.C. The microevolution of mouse salivary androgen-binding protein (ABP) paralleled subspeciation of Mus musculus. www.genome.org /cgi/content/full/14/8/1516   (6707 words)

Androgen-binding proteins in sheep epididymis: age-related effects on androgen-binding protein, cytosolic androgen ... The androgen-binding protein (ABP) and the cytosol androgen receptor (Rc) were measured in the epididymis of sheep aged 50, 120 and 200 days. Specific binding protein was not detected at 50 days (infantile); near puberty (120 days), ABP was more concentrated in caput and cauda epididymal cytosols (117 and 183 fmol/mg protein respectively) than in corpus (53 fmol/mg) although Rc levels were low (3-5 fmol/mg). Histological studies of the epididymis in the three groups of animals showed that the cell differentiation started in the cauda where the principal epithelial cells were higher (47-56 micron) than in the caput (31-38 micron) at 50 days. www.arclab.org /medlineupdates/abstract_6542125.html   (283 words)

Androgen-Binding Protein and Reproduction: Where Do We Stand? -- Munell et al. 23 (5): 598 -- Journal of Andrology Binding of the photoaffinity ligand 17 beta-hydroxy-4, 6-androstadien-3-one to rat androgen-binding protein: comparison with the binding of 17 beta-hydroxy-5alpha-androstan-3-one. Purification and characterization of androgen binding protein from the rat epididymis. Binding of sex-hormone-binding globulin (SHBG) to testicular membranes and solubilized receptors. www.andrologyjournal.org /cgi/content/full/23/5/598   (7782 words)

DNA Sequences and Their Binding Proteins Required for Sertoli Cell-Specific Transcription of the Rat Androgen-Binding ... The probe migrated with the mobility of a 20-kDa protein. binding proteins are estimated to be 60 kDa and 70 kDa. Musto NA, Gunsalus GL, Bardin CW 1980 Purification and characterization of androgen binding protein from the rat epididymis. mend.endojournals.org /cgi/content/full/11/9/1387   (7601 words)

Secretoglobins: Sexually Dimorphic Expression of Androgen-Binding Protein mRNA in Mouse Lacrimal Glands -- Remington ... Vercaeren I, Vanaken H, Devos A, Peeters B, Verhoeven G, Heyns W. Androgens transcriptionally regulate the expression of cystatin-related protein and the C3 component of prostatic binding protein in rat ventral prostate and lacrimal gland. The tissue source and cellular control of the apparent size of androgen binding protein (Abp), a mouse salivary protein whose electrophoretic mobility is under the control of sex-limited saliva pattern (Ssp). The microevolution of mouse salivary androgen-binding protein (ABP) paralleled subspeciation of Mus musculus. www.iovs.org /cgi/content/full/46/1/31   (4290 words)

Glucocorticoid receptor mRNA and protein in fetal rat lung in vivo: modulation by glucocorticoid and androgen -- ... We report that glucocorticoid and androgen have opposing effects on GR levels in late-gestation fetal rat lung cells in vivo. The androgen receptor of the urogenital tract of the fetal rat is regulated by androgen. A and B forms of the androgen receptor are expressed in a variety of human tissues. ajplung.physiology.org /cgi/content/full/275/1/L103   (3880 words)

Interactive Fly, Drosophila Androgen-binding protein (ABP) and sex hormone-binding globulin (SHBG) are extracellular steroid-binding proteins that are homologous to the COOH-terminal domain of vitamin K-dependent protein S, a protein important in blood clotting. This protein is homologous to the Drosophila melanogaster protein Crumbs (Crb), and is denoted CRB1 (crumbs homolog 1). PATJ is a homolog of Drosophila Discs Lost, a protein that is crucial for epithelial polarity and that exists in a complex with the apical polarity determinant, Crumbs. www.sdbonline.org /fly/gene/crumbs2.htm   (2241 words)

presentations Maloney, M.S. and Daniel, J.L. Con A binds to the membranellar and somatic cilia of Stentor and to the developing oral primordium during oral regeneration. Maloney, M.S. and Torlina, H.T. The identification of a 20 kDa protein in the myonemes and membranellar band of the ciliate Stentor coeruleus. Proteins immunologically related to a 23 kDa cytoskeletal protein from Stentor are found in Paramecium and Tetrahymena. www.butler.edu /biology/presentations.html   (2200 words)

RatMap: The Rat Genome Database. Locus Search   (Site not responding. Last check: 2007-10-30) Abstract: Androgens and their nuclear receptor regulate genes necessary for development of the male phenotype, a process that is thought to be modulated by extracellular androgen carrier proteins. Two of these carrier proteins, testicular androgen-binding protein (ABP) and plasma sex hormone-binding globulin (SHBG), are encoded by the same gene, but differ in glycosylation and possibly amino acid sequence. Moreover, a Mr 93,000 immunoreactive protein was transiently expressed in fetal liver during the time of ABP and HDC gene expression. ratmap.gen.gu.se /ShowSingleCitation.htm?citno=390   (373 words)

Kyung Won Chung, Ph.D. Research Effects of ethanol on androgen binding receptors in male rats. Studies will also be undertaken to determine whether ethanol has an adverse effect on the androgen binding protein (ABP) which is produced by Sertoli cells and causes the retention of androgen in the seminiferous tubules and in the epididymis. The more immediate goals of this study are to characterize a 23 kilodalton zinc binding protein (ZBP) that is missing in cryptorchid testes and to investigate its physiological functions. w3.ouhsc.edu /cell_biology/faculty/chungresearch.html   (575 words)

publications The genes for mouse salivary Androgen- binding protein (Abp) subunits alpha and gamma are located on chromosome 7. Karn, R.C. The mouse salivary androgen-binding protein (ABP) Alpha subunit closely resembles chain 1 of the cat allergen Fel dl. Maloney, M.S. Con A binds to the membranellar and somatic cilia of Stentor and to the developing oral primordium during oral regeneration. www.butler.edu /biology/publications.html   (1980 words)

CREDENTIALS Englebienne, P. and Doyen, G.: Androgen-binding protein from hydatidiform mole is antigenically related to pregnancy polypeptides. Englebienne, P.: Identification and characterization of an abnormal androgen-binding protein in trophoblastic diseases. Implications for the measurement of SHBG binding capacity in human serum. users.skynet.be /englebienne/credentials.html   (845 words)

eMedicine - Follicle-Stimulating Hormone Abnormalities : Article Excerpt by Serge A Jabbour FSH stimulates testicular growth and enhances the production of an androgen-binding protein by the Sertoli cells, which are a component of the testicular tubule necessary for sustaining the maturing sperm cell. This androgen-binding protein causes high local concentrations of testosterone near the sperm, an essential factor in the development of normal spermatogenesis. Disorders of androgen biosynthesis: This involves mutations of the genes that encode the enzymes necessary for testosterone biosynthesis. www.emedicine.com /med/byname/follicle-stimulating-hormone-abnormalities.htm   (2382 words)

Life Extension Daily News Investigators from India have reported the effects of vitamins C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells. Sertoli cellular androgen binding protein (ABP) and lactate were also quantified. Kumar and colleagues published their study in Reproductive Toxicology (Effects of vitamin C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells. www.lef.org /news/LefDailyNews.htm?NewsID=1711&Section=VITAMINS   (410 words)

W M LEE AND OTHERS   (Site not responding. Last check: 2007-10-30) Sex hormone binding globulin (SHBG) is a homodimeric plasma protein found in mammals that binds sex steroids with high affinity and regulates their bioavailability. The protein is identical in structure and properties to the androgen binding protein (ABP) found in the male reproductive tract. It was found that the chimeric proteins assumed similar steroid-binding affinity and specificity as the wild-type proteins when the amino (N)-terminal half of SHBG was derived from the same species. journals.endocrinology.org /joe/153/joe1530373.htm   (418 words)

ANDROGEN RECEPTOR REGULATION OF REPRODUCTIVE FUNCTION Abstract: The androgen receptor (AR) is a ligand activated transcriptional regulatory protein that mediates androgen induced male sexual development and function. Effects of phosphorylation on AR function will be determined by coexpression of mutant and wild type AR expression vectors in the luciferase reporter gene assay using a variety of cell types and promoter sequences. AR homo- and/or heterodimerization will be studied with a focus on two proteins that interact with AR to enhance DNA binding (AR binding proteins l and 2). www.med.unc.edu /wrkunits/1dean/research/Wilson438.html   (471 words)

ABP AND THE REGULATION OF GERM CELL APOPTOSIS IN TESTIS However, ABP's precise mode of action is not known. In order to understand the functions of ABP and, in a broader sense, the role of androgens in the control of spermatogenesis, we have studied transgenic mice expressing high amounts of ABP. To test the above hypothesis, we propose to determine the effects of excess ABP produced in the transgenic animals on (1)-- testicular levels of testosterone, dihydrotestosterone, estradiol, and the androgen and estrogen receptors. www.med.unc.edu /wrkunits/1dean/research/Petrusz300.html   (374 words)

The Androgen Microenvironment of the Human Testis and Hormonal Control of Spermatogenesis -- JAROW and ZIRKIN 1061 (1): ... The Androgen Microenvironment of the Human Testis and Hormonal Control of Spermatogenesis -- JAROW and ZIRKIN 1061 (1): 208 -- Annals of the New York Academy of Sciences affinity for the androgen receptor, intratesticular DHT is not protein) are insufficient to account for this difference. www.annalsnyas.org /cgi/content/abstract/1061/1/208   (417 words)

The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions -- Heinlein and Chang 16 ... Androgens may stimulate the MAPK pathway through stimulation of the nonreceptor tyrosine kinase c-Src (Src). In addition to these receptors, a plasma membrane, G protein-coupled receptor may also directly bind androgens or indirectly influence the activity of a membrane androgen-binding protein. Luzardo OP, Machin RP, Diaz-Chico BN, Fernandez L 2000 Photoaffinity labeling identification of a specific binding protein for the anabolic steroids stanozolol and danazol: an oligomeric protein regulated by age, pituitary hormones and, and ethinyl estradiol. mend.endojournals.org /cgi/content/full/16/10/2181   (5442 words)

Sex hormone-binding globulin, androgen-binding protein, and vitamin K- dependent protein S are homologous to laminin A, ... Sex hormone-binding globulin, androgen-binding protein, and vitamin K- dependent protein S are homologous to laminin A, merosin, and Drosophila crumbs protein -- Joseph and Baker 6 (7): 2477 -- The FASEB Journal Sex hormone-binding globulin, androgen-binding protein, and vitamin K- dependent protein S are homologous to laminin A, merosin, and Drosophila crumbs protein and to an integral membrane protein, Drosophila crumbs protein. www.fasebj.org /cgi/content/abstract/6/7/2477   (600 words)

George H. Whipple Laboratory for Cancer Research (Director Dr. Chawnshang Chang) Takeda H, and Chang C (1991) "Immunocytochemical and in situ hybridization analysis of androgen receptor expression during the development of mouse prostate gland." Journal of Endocrinology. Yeh S, and Chang C (1997) "The effects of androgen and 17b-estradiol on the transcriptional activity of androgen receptor in the presence of androgen receptor coactivator, ARA70 in the human prostate DU145 cells." (Waites G. Frick J and Baker G ed) pp17-22 Monduzzi Editore Italy. Schirar A, Chang C, and Rousseau JP (1997) "Localization of androgen receptor in nitric oxide synthase- and vasoactive intestinal peptide-containing neurons of the major pelvic ganglion innervating the rat penis." Journal of Neuroendocrinology 9, 141-150. www.urmc.rochester.edu /ChangARLab/Publications/UofW.html   (1918 words)

Peter Petrusz, Ph.D Professor   (Site not responding. Last check: 2007-10-30) These include the androgen receptor, two enzymes (5a-reductase and aromatase) which metabolize testosterone, and a transport protein, androgen-binding protein (ABP). In addition, we are studying several other gene products which have been identified as indispensable for normal spermatogenesis, but their relationship to testosterone and apoptosis is less obvious. Our studies are aided by the successful development of a transgenic mouse model which produces very high amounts of ABP and shows a progressive defect in spermatogenesis. www-cellbio.med.unc.edu /petrusz/petrusz.htm   (558 words)

Differential regulation of testicular transferrin and androgen-binding protein secretion in primary cultures of rat ...   (Site not responding. Last check: 2007-10-30) Differential regulation of testicular transferrin and androgen-binding protein secretion in primary cultures of rat Sertoli cells. Specific RIAs for rat transferrin (rTF) and androgen-binding protein (rABP) were used to determine whether the secretion of these proteins was coordinately regulated in the Sertoli cell under a variety of conditions. The age of the animal at the time of preparation of cells for culture had a strong effect on the pattern of rTF and rABP secretion in vitro; however, the effects of animal age, time in culture, and medium supplementation differed for the two proteins. www.arclab.org /medlineupdates/abstract_3079703.html   (271 words)

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