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Topic: Anti-thymocyte globulin

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Anti-thymocyte globulin - Wikipedia, the free encyclopedia Anti-thymocyte globulin (ATG) is an infusion of rabbit-derived antibodies against human T cells which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia. Anti-IL-2Rα receptor antibodies such as basiliximab and daclizumab are increasingly being used in place of ATG as an induction therapy, as they do not cause cytokine release syndrome and (theoretically) improving the development of tolerance. ATG is associated with cytokine release syndrome when it is used, and in the longer term may increase the risk of post-transplant lymphoproliferative disorder as well as (theoretically) impairing the development of immunological tolerance. en.wikipedia.org /wiki/Anti-thymocyte_globulin   (206 words)

AA&MDSIF - Glossary Terms ATG (anti-thymocyte globulin) or ALG (anti-lymphocyte globulin) are immunosuppressive agents used for the treatment of aplastic anemia patients. ATG is made by immunizing horses with thymic lymphocytes (thymocytes) obtained from the thymus or from the thoracic duct. ATG is given into a vein (intravenous, IV) while the patient is in the hospital, usually over four days (4-24 hours a day). www.aplastic.org /aplastic/glossary_terms.php?id=8   (849 words)

AA&MDSIF - Immunosuppressive Therapy ATG and cyclosoprine, which are standard in the treatment of aplastic anemia, are classified as pregnancy category C drugs, which means that they can be used when needed during pregnancy though their safety has not been officially proven. However, if the drug together with ATG were to be responsible for the long-term survival of a whole group of patients who would not have otherwise survived, then it might have the appearance of increasing the number of cases of progression to clonal disease, simply by increasing the number of patients at risk. Cyclosporine and ATG are the standard of care for severe aplastic anemia. www.aplastic.org /aplastic/information__hope/ask_the_experts/qa_library/immunosuppressive_th   (2649 words)

Globulin - Hepatitis A Immune globulin traveller's health prevention against Standard treatment with horse antithymocyte globulin (h-ATG), cyclosporine (CsA), and corticosteroids is effective, but patients often relapse. globulin, any of a large family of proteins of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Gamma globulins are a class of proteins in the blood, identified by their position after serum protein electrophoresis. siteslinks.com /q/globulin.htm   (391 words)

An Evaluation of Anti-thymocyte Globulin, rabbit (Thymoglobulin‚) Anti-thymocyte globulin (rabbit), Thymoglobulin® is a purified, pasteurized, gamma immune globulin, obtained by immunization of rabbits with human thymocytes. Anti-thymocyte globulin, equine (Atgam®) was the only commercially available polyconal product in the United States until recently when Anti-thymocyte globulin, rabbit (Thymoglobulin®) was approved by the Food and Drug Administration. Mechanisms of immunosuppression induced by antithymocyte globulins and OKT3. acc-www.bsd.uchicago.edu /drug/Bulletins/N0899.html   (2846 words)

Hepatitis C virus genotypes and the influence of the induction of immunosuppression with anti-thymocyte globulin (ATG) on chronic hepatitis in renal graft recipients. Hepatitis C virus genotypes and the influence of the induction of immunosuppression with anti-thymocyte globulin (ATG) on chronic hepatitis in renal graft recipients. Anti-thymocyte globulin (ATG) is supposed to increase viral replication and liver dysfunction in chronically infected renal graft recipients. From 726 renal graft recipients, 104 patients, with a mean follow up of 3.9 +/- 2.9 years, were anti-HCV+ by ELISA II. www.aegis.com /aidsline/1999/feb/A9920995.html   (502 words)

Polyclonal Anti-T-Cell Therapy for Type 1 Diabetes Mellitus of Recent Onset ATG was administered as an initial bolus of 9 mg/kg followed by 3 consecutive doses of 3 mg/kg. In 2 subjects from the ATG group and in none in the placebo group, complete remission of clinical diabetes was achieved (from 3 to 7 months after study entry in one and from 11 months for more than 24 months in the other). ATG administration caused a rise in body temperature in all treated subjects and exceeded 38°C in 7 of them. www.soc-bdr.org /content/e4/e887/volRdsVolumes888/issRdsIssues1020/chpRdsChapters1296/strRdsArticles1312/index_en.html?showfulltext=1   (4581 words)

MEdIC - Anti-Thymocyte Globulin ATG is purified animal serum that reacts against specific cells of the human immune system. ATG is made by first purifying these cells from normal blood. Most people who are given ATG do not develop anaphylaxis, but almost everybody develops less serious side effects because of their bodies' reaction to the horse proteins. medic.med.uth.tmc.edu /ptnt/00001044.htm   (1215 words)

140.doc Since the anti-adhesive activity in vitro correlates with graft survival in vivo it is an attractive explanation for the prolonged immunosuppression. Compared to therapeutic approaches using monoclonal antibodies against single adhesion molecules the multiple specificities of ATGs may be of additional benefit. Thereby the adhesion cascade can be interrupted at the activation step even a considerable time after the application of the drug when the ATG content in plasma is levelling off. www.kenes.com /immuno5/abstracts/140.doc   (257 words)

anti-thymocyte globulin. Toyota Index. aprotinin apidra apo-ferrous gluconate anti-thymocyte globulin aspirin and methocarbamol anti-thymocyte globulin rabbit apo-nitrofurantoin aralast asacol apo-trimip aspirin anti-thymocyte globulin apo-piroxicam antivenin pit viper apo-sulfamethoxazole apo-keto-e apo-dipyridamole sc anturane anti-tuss ascarel antispas aspergum aspirin and pravastatin anti-thymocyte globulin apo-hydro apo-alpraz apo-clonazepam antivenin micrurus fulvius aplisol injection artria s r apo-baclofen arava apo-verap arthrisin apo-hydroxyzine antivenin crotalidae polyvalent articulose-l a ascomp with codeine no 3 apo-amitriptyline apo-ampi aristocort r apo-amoxi arm-a-med metaproterenol apo-naproxen apo-ibuprofen arthrotec 75 aredia for injection apo-minocycline anti-thymocyte globulin aphrodyne arthritis strength bc powder arthritis pain ascriptin apo-erythro e-c apokyn injection anzemet injection aphthasol apo-c apo-clorazepateapo-cloxi artane sequels aristocort c apo-perphenazine arixtra aranesp for injection apo-flurazepam aranesp apomorphine hydrochloride arcoxia - etoricoxib apo-metoclop apo-salvent arthrotec tablets apo-flurbiprofen anti-thymocyte globulin aspirin free anacin maximum strength gel caplets aprepitant antivenin sea snake arthritis strength bufferin aricept odt aplisol arthropan anti-thymocyte globulin apo-sulin apo-guanethidine apo-erythro-es apo-triazide drph.home.sapo.pt /section900/anti-thymocyte-globulin.html   (144 words)

In vivo T cell depletion with pretransplant anti-thymocyte globulin reduces graft-versus-host disease without increasing relapse in good risk myeloid leukemia patients after stem cell transplantation from matched related donors ATG as part of the conditioning regimen leads to a significant reduction in GVHD without increase of relapse in patients with myeloid leukemia after stem cell transplantation from HLA-related donors. One graft failure was observed in the non-ATG and none in the ATG group. The 5-year probability of relapse was 5% in the ATG and 15% in the non-ATG group (NS). www.nature.com /bmt/journal/v29/n8/abs/1703530a.html   (358 words)

Atgam Online, Description, Chemistry, Ingredients - Lymphocyte immune globulin - RxList Monographs lymphocyte immune globulin, anti-thymocyte globulin [equine] sterile solution It is the purified, concentrated, and sterile gamma globulin, primarily monomeric IgG, from hyperimmune serum of horses immunized with human thymus lymphocytes. Each milliliter of ATGAM contains 50 mg of horse gamma globulin stabilized in 0.3 molar glycine to a pH of approximately 6.8. www.rxlist.com /cgi/generic/atgam.htm   (261 words)

Abstract In summary, infusion of ATG induced remarkable changes in both inflammatory and protein C pathways in human subjects. Considerable early APC clearance with concomitant renal neutrophil and monocyte activation was observed upon reperfusion in the grafts that were transplanted into ATG-receiving recipients. In group A, a systemic APC elevation coincided with ATG administration between pre-operative [136 (80–171)%] and pre-reperfusion [231 (82–823)%] samples. www.blackwellpublishing.com /isth2005/abstract.asp?id=47532   (278 words)

FDA Grants Orphan Drug Status To Thymoglobulin (Anti-Thymocyte Globulin) For Myelodysplastic Syndrome Thymoglobulin (anti-thymocyte globulin (rabbit)) was introduced to the US market in 1999 for the treatment of renal transplant acute rejection, and according to IMS data has since captured the top spot in US immunosuppressive antibody therapies. Thymoglobulin is a pasteurized anti-thymocyte rabbit immunoglobulin indicated for the treatment of renal transplant acute rejection, in conjunction with concomitant immunosuppression. FREMONT, CA -- September 19, 2000 -- SangStat, The Transplant Company® announced that Thymoglobulin® (Anti-thymocyte Globulin, (Rabbit)) has been granted orphan drug designation for the treatment of Myelodysplastic Syndrome (MDS) by the U.S. Food and Drug Administration (FDA). www.docguide.com /dg.nsf/PrintPrint/8FD3BCE380FE28788525695F004A964F   (596 words)

Canada Gazette Anti-thymocyte globulin (equine- and rabbit-sourced) is used to reduce the immune response in patients who have received skin, cardiac, liver, or bone-marrow transplants. Anti-thymocyte globulin will be administered as an adjunct to other immunosuppressant therapy to delay the onset of the first rejection episode of a transplant. Because of this, the safe use of anti-thymocyte globulin requires individualized instructions and direct practitioner supervision. canadagazette.gc.ca /partI/2004/20041002/html/regle2-e.html   (1805 words)

ATG, Cincinnati Children's Hospital Medical Center ATG (Anti-thymocyte globulin or Atgam) is a medicine used prevent rejection in different types of transplantation, treatment of graft versus host disease and in certain patients with aplastic anemia. This is because this drug may cause low blood pressure, especially during the infusion. Your child will also receive medication to prevent other side effects of ATG during the infusion. www.cincinnatichildrens.org /health/info/medication/a-e/atg.htm?view=content   (264 words)

Monitoring anti-thymocyte globulin (ATG) in bone marrow recipients The present study was undertaken to acquire a rationale for clinical dose adjustment of anti-thymocyte globulin (ATG) to improve cost effectiveness and safety of graft-versus-host disease prophylaxis. Monitoring anti-thymocyte globulin (ATG) in bone marrow recipients The concentration of rabbit ATG in the serum of 12 patients was measured by ELISA and by the inhibitory effect on phytohaemagglutinin-induced blastogenesis. www.nature.com /cgi-taf/DynaPage.taf?file=/bmt/journal/v23/n8/abs/1701645a.html   (230 words)

Coverage Issues Manual-Section 45-Supplies & Drugs At present, lymphocyte immune globulin preparations are not recommended to replace conventional immunosuppressive drugs, but to supplement them and to be used as alternatives to elevated or accelerated dosing with conventional immunosuppressive agents. The lymphocyte immune globulin preparations are biologic drugs not previously approved or licensed for use in the management of renal allograft rejection. A number of other lymphocyte immune globulin products of equine, lapine, and murine origin are currently under investigation for their potential usefulness in controlling allograft rejections in human transplantation. www.cms.hhs.gov /manuals/06_cim/ci45.asp   (5078 words)

National Cancer Institute - Clinical Trials (PDQ®) Cohorts of 15 patients receive adjusted doses of anti-thymocyte globulin to determine the optimal dose at which Epstein-Barr virus (EBV) activation and GVHD are reduced. This is a dose-escalation study of anti-thymocyte globulin. Determine the incidence of acute graft-vs-host disease (GVHD) requiring therapy in patients with myelodysplastic syndromes or myeloproliferative disorders treated with busulfan, cyclophosphamide, and anti-thymocyte globulin prior to transplantation with filgrastim (G-CSF)-mobilized peripheral blood stem cells (or bone marrow) from related or unrelated donors. www.cancer.gov /clinicaltrials/FHCRC-1723   (520 words)

Anti-thymocyte globulin induced thrombocytopenia -- Lazarchick et al. 20 (6): 373 -- Annals of Clinical and Laboratory Science Anti-thymocyte globulin is strongly reactive with platelets as measured by flow cytometric analysis. This reactivity appears to be independent of human leukocyte antigen (HLA) phenotype, is dose-dependent with saturation of platelet binding sites readily achieved with concentrations of horse anti-thymocyte globulin (ATG) at 0.25 mg per ml, and cannot be blocked with human anti-PLA1 antibody nor with heat-aggregated human IgG. Anti-thymocyte globulin induced thrombocytopenia -- Lazarchick et al. www.annclinlabsci.org /cgi/content/abstract/20/6/373   (141 words)

Anti-lymphocyte globulin It is less commonly used than the similar anti-thymocyte globulin (ATG), and like ATG it is associated with cytokine release syndrome in the short term and an increased risk of post-transplant lymphoproliferative disorder in the long term. Anti-lymphocyte globulin (ALG) is an infusion of horse-derived antibodies against human T cells which is used in the treatment of acute rejection in organ transplantation, especially in kidney transplants. ALG is more likely to cause side effects than ATG, but is safer than OKT3. www.worldhistory.com /wiki/A/Anti-lymphocyte-globulin.htm   (160 words)

:: Arab Society Of Nephrology and Renal Transplantation :: ANTIBODIES AND ANTI THYMOCYTE GLOBULIN IN RENAL TRANSPLANTATION - ATG group and 2 in anti IL-2 Rab group. Induction therapy with anti IL-2 Rab and ATG are equally effective in preventing AR and www.asnrt.org /CNE/CNE_Details.asp?CNE_ID=13   (13267 words)

Contemporary Issues in Transplantation: Delayed Graft Function -- Clinical Implications and Case Management. Anti-thymocyte globulin (rabbit) has not been approved by the FDA for this use in the United States. Bloom has indicated that he will include the discussion of anti-thymocyte globulin (rabbit) for intra-operative administration to prevent delayed graft function. Brayman has indicated that he will include the discussion of anti-thymocyte globulin (rabbit) for intra-operative administration to prevent delayed graft function. www.hdcn.com /symp/00asnsatg/dgraftfx.htm   (1004 words)

Pilot study of anti-thymocyte globulin plus mycophenolate mofetil in recent-onset diffuse scleroderma -- Stratton et al. 40 (1): 84 -- Rheumatology Rabbit anti-human lymphocyte globulin (ATG) is a polyclonal A biological anti-lymphocyte effect of ATG therapy was observed ATG therapy was associated with the development of a severe rheumatology.oxfordjournals.org /cgi/content/full/40/1/84   (2188 words)

S096632749980028.abstract.en Serum samples were obtained from 148 patients participating in a multicentre, double-blind randomized phase III trial comparing Atgam (Pharmacia Upjohn, horse anti-thymocyte globulin) with Thymoglobulin (SangStat Medical Corporation, rabbit anti-thymocyte globulin). While it is generally accepted that blocking anti-idiotypic antibodies can decrease the efficacy of retreatment with mouse monoclonal antibody preparations, sensitization levels and subsequent effects on treatment efficacy are less clear for polyclonal preparations. Recipients of a first or second renal allograft undergoing biopsy proven acute rejection were randomized to treatment with Atgam or Thymoglobulin. www.elsevier.com /cdweb/journals/09663274/articles/7/2/S096632749980028.abstract.en   (220 words)

FDA Approves Thymoglobulin To Prevent Acute Kidney Rejection A polyclonal antibody, Thymoglobulin successfully reversed acute organ rejection in 78 percent of kidney transplant patients in a pivotal Phase III clinical trial of 163 patients, compared with 67.5 percent for patients treated with Pharmacia and Upjohn's Atgam(R) (immune globulin, anti-thymocyte globulin [equine]). MENLO PARK, CA -- Jan. 5, 1999 -- The United States Food and Drug Administration has approved SangStat's Thymoglobulin(R) (anti-thymocyte globulin, [rabbit]), a new drug that could prevent organ loss in kidney transplant recipients experiencing acute rejection. Thymoglobulin-treated patients had a graft survival of 83 percent and patient survival of 93 percent one year later. www.docguide.com /dg.nsf/PrintPrint/5EB6EB79A15A2779852566F0006F1F38   (637 words)

Anti-thymocyte Globulin (Systemic) Information and Resources Online at The Drug Database - Find Useful Articles and Websites on Anti-thymocyte Globulin (Systemic) Right Now. The effect of anti-thymocyte globulin (rabbit) on the white blood cells may also reduce the... Phase II Pilot Study of Cyclophosphamide and Rabbit Anti-Thymocyte Globulin as Salvage Therapy in Patients With Diffuse Systemic Sclerosis. MedlinePlus Drug Information: Drugs beginning with An-Az Systemic) Anti-thymocyte Globulin (Rabbit) (Systemic... www.thedrugdatabase.com /directory/A/Anti-thymocyte_Globulin__(Systemic)   (306 words)

Protocols - General Clinical Research Center at the University of Minnesota d) Induction immunotherapy is provided anti-thymocyte globulin therapy from day-2 to +2 post-transplant, equivalent to four standard anti-thymocyte globulin doses. C) study drug administration is replaced with the no-diabetogenic immunosupressant mycophenolate mofetil, either initially at the time of transplant or at one month post-transplant. www.gcrc.umn.edu /gcrc/proto.php?p681   (605 words)

ASCO - Browse by Meeting - Impact of molecular (mol) HLA typing and anti-thymocyte globulin (ATG) on nonmyeloablative (NMA) unrelated donor bone marrow transplants (BMT) Addition of horse anti-thymocyte globulin and corticosteroids to methotrexate and cyclosporine (or tacrolimus) does not change the rates of acute graft-vs-host disease, early infections, relapses, or survival in unrelated bone marrow transplantation Impact of molecular (mol) HLA typing and anti-thymocyte globulin (ATG) on nonmyeloablative (NMA) unrelated donor bone marrow transplants (BMT) ATG improved engraftment rate in Flu/Cy pts and trended toward reducing the risk of grade II-IV aGvHD in the Flu/Mel pts. www.oncology.com /ac/1,1003,_12-002702-00_18-0023-00_19-00102927,00.asp   (840 words)

Business Wire: SangStat and Pasteur Merieux Connaught Receive ... @ HighBeam Research THYMOGLOBULIN is a pasteurized, rabbit anti-human thymocyte immunoglobulin which induces immunosuppression as a result of T-cell depletion. SangStat and Pasteur Merieux Connaught Receive THYMOGLOBULIN -- anti-thymocyte globulin, rabbit -- PLA Complete Review Letter From FDA; Pre-Approval Site Inspection Completed. THYMOGLOBULIN is manufactured and marketed outside North America by IMTIX, the Pasteur Merieux Connaught transplantation division. www.highbeam.com /library/doc0.asp?DOCID=1G1:20182786&refid=ip_encyclopedia_hf   (979 words)

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