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Topic: Antiarrhythmic agent

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	Antiarrhythmic agent - Wikipedia, the free encyclopedia
		Antiarrhythmic agents are a group of pharmaceuticals that are used to suppress fast rhythms of the heart (cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.
		Antiarrhythmic agents may be considered the first-line therapy in the prevention of sudden death in certain forms of structural heart disease, and failure of these agents to suppress arrhythmias may lead to implantation of an implantable cardioverter-defibrillator (ICD).
		Class Ic agents are indicated for life-threatening ventricular tachycardia or ventricular fibrillation, and for the treatment of refractory supraventricular tachycardia (ie: atrial fibrillation).
	en.wikipedia.org /wiki/Antiarrhythmic_agent (1295 words)

	Flecainide - Wikipedia, the free encyclopedia
		Flecainide acetate is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
		It is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation (episodic irregular heartbeat originating in the upper chamber of the heart), paroxysmal supraventricular tachycardia (episodic rapid but regular heartbeat originating in the atrium), and ventricular tachycardia (rapid rhythms of the lower chambers of the heart).
		As with all other antiarrhythmic agents, there is a risk of proarrhythmia associated with the use of flecainide.
	en.wikipedia.org /wiki/Flecainide (1638 words)

	Antiarrhythmic drugs - The Doctors Lounge(TM)
		While the use of antiarrhythmic agents to suppress atrial arrhythmias (atrial fibrillation and atrial flutter) is still in practice, it is unclear whether suppression of atrial arrhythmias will prolong life 1,2.
		The antiarrhythmic agents are classified based on what portion of the action potential they directly affect, and which ion channels of the cardiac myocyte they interact with.
		Class Ic agents are indicated for life-threatening ventricular tachycardiac or ventricular fibrillation, and for the treatment of refractory supraventricular tachycardia (ie: atrial fibrillation).
	www.thedoctorslounge.net /cardiology/drugs/antiarrhythmic (869 words)

	Society of Cardiovascular Anesthesiologists
		Intravenous (IV) antiarrhythmic agents are commonly used as adjuncts to DC cardioversion during cardiopulmonary resuscitation.
		IV amiodarone is an antiarrhythmic agent with a broad pharmacologic spectrum that includes beta receptor, alpha receptor, and sodium, calcium, and potassium channel antagonism.
		Given that nearly 50% of cardiac-related deaths result from arrhythmias, there is a surprising paucity of prospective clinical data evaluating the efficacy of antiarrhythmic agents for sustained VT and VF.
	www.scahq.org /sca3/newsletters/nov_res.shtml (1667 words)

	RSD1000: A Novel Antiarrhythmic Agent with Increased Potency under Acidic and High-Potassium Conditions -- Yong et al. ...
		Antiarrhythmic activity of RSD1000 against ischaemia-induced arrhythmias is shown as number of animals (x) in group (n) having PVC, VT, VF, and/or fatal or irreversible ventricular fibrillation (irrv VF).
		Abraham S, Beatch GN, MacLeod BA and Walker MJ (1989) Antiarrhythmic properties of tetrodotoxin against occlusion-induced arrhythmias in the rat: A novel approach to the study of the antiarrhythmic effects of ventricular sodium channel blockade.
		Kupersmith J (1979) Electrophysiological and antiarrhythmic effects of lidocaine in canine acute myocardial ischemia.
	jpet.aspetjournals.org /cgi/content/full/289/1/236 (5488 words)

	[No title]
		Amiodarone, sotalol and ibutilide are class III antiarrhythmic agents which have been investigated for their effectiveness in the conversion of atrial fibrillation and atrial flutter to normal sinus rhythm.
		Class III antiarrhythmics prolong the refractory period of atrial and ventricular myocardium, the AV node, and the His-Purkinje conduction system by increasing the action potential duration.
		Use of class Ia or other class III antiarrhythmic agents during or four hours post-infusion of ibutilide is not recommended due to additive effects in prolonging the refractory period.
	www.courses.ahc.umn.edu /pharmacy/5822/GPamiod.html (2024 words)

	Body
		Amiodarone (Cordarone®) — is an antiarrhythmic agent (class III) widely used for acute (intravenous) and chronic (tablets) treatment of both ventricular and supraventricular arrhythmias.
		Antiarrhythmic agents — Medications for the prevention or termination of arrhythmias.
		See Antiarrhythmic Agent Class I. ECG (electrocardiogram or EKG) — A record of the electric activity of the heart from the body’s surface.
	www.txai.org /edu/glossary/glossary.htm (2508 words)

	Mexiletine: a new type I antiarrhythmic agent -- Schrader and Bauman 20 (4): 255 -- The Annals of Pharmacotherapy
		Mexiletine is a type I antiarrhythmic drug that is structurally similar to lidocaine.
		When mexiletine is combined with other antiarrhythmic agents, a significantly higher percentage of patients with this difficult arrhythmia have a good response.
		Mexiletine is a potentially important addition to the existing antiarrhythmic drugs currently available, but its place in the clinical setting and in therapeutic drug monitoring is not well defined at this time.
	www.theannals.com /cgi/content/abstract/20/4/255 (226 words)

	A guide to recently approved cardiovascular medications - Patient Care
		Indication Dofetilide, a class III antiarrhythmic agent, is effective in converting AF and atrial flutter to normal sinus rhythm (30% success rate) and in maintaining normal sinus rhythm (60%-70% success rate).
		This is an advantage over other antiarrhythmic agents, such as flecainide, encainide, and moricizine (class 1C agents), and sotalol (another class III agent), which all increased mortality when compared with placebo.
		Because it is a relatively weak lipid-lowering agent as monotherapy, it should be used primarily in patients with mild dyslipidemia, or in conjunction with more powerful agents when monotherapy is inadequate to attain lipid goals.
	www.patientcareonline.com /patcare/article/articleDetail.jsp?id=119752 (2359 words)

	Dofetilide: A New Class III Antiarrhythmic
		It is different from other class III antiarrhythmics in that it exhibits selective potassium channel blockade, with no effect on the conduction system.
		Other agents that should be avoided are those that prolong the QT interval, such as phenothiazines, cisapride, bepridil, tricyclic antidepressants, erythromycin, and class I (e.g., quinidine, procainamide, lidocaine, flecainide) and class III antiarrhythmic agents.
		Lastly, agents that cause hypokalemia or hypomagnesemia, such as diuretics, should also be used with caution.
	clevelandclinicmeded.com /medical_info/pharmacy/septoct2000/pharm.htm (908 words)

	Mechanisms of Action of Antiarrhythmic Agent Bertosamil on hKv1.5 Channels and Outward Potassium Current in Human ...
		Bertosamil is a structural analog of tedisamil, a new bradycardic class III antiarrhythmic agent with potential therapeutic
		Singh BN (1999) Current antiarrhythmic drugs: an overview of mechanisms of action and potential clinical utility.
		Tessier S, Rucker-Martin C, Mace L, Coraboeuf E, Mercadier JJ and Hatem SN (1997) The antiarrhythmic agent bertosamil induces inactivation of the sustained outward K+ current in human atrial myocytes.
	jpet.aspetjournals.org /cgi/content/full/300/2/612 (5843 words)

	(Print Version) Arrhythmia (Cardiac) Page 2 (Site not responding. Last check: 2007-11-06)
		The use of magnesium as an antiarrhythmic agent in ventricular and supraventricular arrhythmias is a matter of an increasing but still controversial discussion during recent years.
		We investigated the antiarrhythmic effect of magnesium sulfate administered to critically ill patients with cardiac arrhythmias and reduced iMg2+ as determined using the ion-selective electrode.
		Some of the mechanisms suggested to explain the antiarrhythmic action of fish oils include the incorporation and modification of cell membrane structure by (n-3) polyunsaturated fatty acids, their direct effect on calcium channels and cardiomyocytes and their role in eicosanoid metabolism.
	www.lef.org /protocols/abstracts/abstr-txt/t-abstr-012a.html (5443 words)

	MedForumsLive.com - propafenone, Rythmol (Site not responding. Last check: 2007-11-06)
		The primary mechanism of action is blocking channels which transport sodium across cell borders, which prolongs the beginning of the phase during which heart muscle cells become electrically stimulated (action potential).
		Propafenone slows conduction throughout the heart and is referred to as a type IC antiarrhythmic.
		PRESCRIBED FOR: Propafenone is an antiarrhythmic agent and is only approved for use in patients with life-threatening ventricular arrhythmias, such as ventricular tachycardia.
	www.medforumslive.com /drugs/p/propafenone.html (456 words)

	Myocardial infarction: class of antiarrhythmic agent affects mortality.
		Myocardial infarction: class of antiarrhythmic agent affects mortality.
		Patients given class II antiarrhythmics (beta-blockers) are less likely to die than those given a control (NNT = 85 at unknown).
		McAlister FA, and Teo KK: Antiarrhythmic therapies for the prevention of sudden cardiac death.
	www.eboncall.org /CATs/500.htm (191 words)

	HighBeam Research: Library Search: Results (Site not responding. Last check: 2007-11-06)
		Cardiology Marketing approval was recently granted for dofetilide, a pure class III antiarrhythmic agent and is anticipated this year for azimilide, a similar agent.
		Indication Dofetilide, a class III antiarrhythmic agent, is effective in...
		Agents that are proarrhythmic, such as dofetilide, or agents that are contraindicated in...
	highbeam.com /library/search.asp?q=Dofetilide&refid=healthcyclopedia (495 words)

	[No title] (Site not responding. Last check: 2007-11-06)
		Review Questions on Antiarrhythmic Drugs Cardiac arrhythmias are disorders of heart rate and rhythm which may arise from changes in 1) automaticity of pacemaker cells and/or 2) conduction of the impulse through the heart.
		The antiarrhythmic agents are divided into 4 classes based on mechanisms:
		Miscellaneous adenosine magnesium chloride Amiodarone is a Class III antiarrhythmic agent approved for refractory life treatening ventricular arrhythmias.
	www.kumc.edu /research/medicine/pharmacology/CAI/webCAI/blk2/ab85.wbc (1215 words)

	Clinical Trial: Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE) (Site not responding. Last check: 2007-11-06)
		Pharmacological therapy with anti-arrhythmic agents either alone or in combination with selection guided by the results of continuous electrocardiographic monitoring or electrophysiologic studies is often the initial step.
		The agent was released as an oral agent for the treatment of ventricular fibrillation in the United States by the FDA.
		A total of 113 patients were randomized to amiodarone and 115 patients to conventional therapy with other antiarrhythmic agents which included procainamide, quinidine, disopyramide, tocainide, mexiletine, encainide, flecainide, propafenone, moricizine, or combination therapy in that order.
	clinicaltrials.gov /ct/show/NCT00000464?order=36 (664 words)

	Antiarrhythmic Drug Target Choices and Screening -- Sanguinetti and Bennett 93 (6): 491 -- Circulation Research
		antiarrhythmic agent in use, yet it is one of the least selective.
		Antiarrhythmic and antifibrillatory actions of the levo- and dextrorotary isomers of sotalol.
		Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel blocking drugs.
	circres.ahajournals.org /cgi/content/full/93/6/491 (6276 words)

	Proarrhythmia of Azimilide and Other Class III Antiarrhythmic Agents in the Adrenergically Stimulated Rabbit -- Brooks ...
		the ED, SVT occurred with all agents; dofetilide caused VF in 1 of 12 rabbits.
		Efficacy of the class III antiarrhythmic agent azimilide in rodent models of ventricular arrhythmia.
		Arrhythmogenic effects of antiarrhythmic drugs: A study of 506 patients treated for ventricular tachycardia or fibrillation.
	www.ebmonline.org /cgi/content/full/223/2/183 (3151 words)

	Amiodarone: Reevaluation of an Old Drug -- Podrid 122 (9): 689 -- Annals of Internal Medicine
		Clinical efficacy of amiodarone as an antiarrhythmic agent.
		Significance of ventricular arrhythmias in idiopathic dilated cardiomyopathy.
		Prospective evaluation of a discriminant function for prediction of recurrent symptomatic ventricular tachycardia or ventricular fibrillation in coronary artery disease patients receiving amiodarone and having inducible ventricular tachycardia at electrophysiologic study.
	www.annals.org /cgi/content/full/122/9/689 (8220 words)

	[No title] (Site not responding. Last check: 2007-11-06)
		Class III antiarrhythmic drugs, especially amiodarone (a broad-spectrum antiarrhythmic agent), have gained popularity for use in clinical practice in recent years.
		These agents are effective for the management of various types of cardiac arrhythmias both atrial and ventricular in origin.Class III antiarrhythmic drugs may interact with other drugs by two major processes: pharmacodynamic and pharmacokinetic interactions.
		Pharmacokinetic interactions can result from the interference of drug absorption, metabolism and/or elimination of the object drug by the precipitant drug.Among the class III antiarrhythmic drugs, amiodarone has been reported to be involved in a significant number of drug interactions.
	www.cis.upenn.edu /~mamandel/Annotators/cyp/set03/pm12692891.cyp (329 words)

	Effects of the antiarrhythmic agent tedisamil on cardiac potassium currents in humans
		Effects of the antiarrhythmic agent tedisamil on cardiac potassium currents in humans
		Tedisamil is a new antiarrhythmic drug with predominantly class III action.
		The aim of the present study was to investigate the effects of the compound on potassium currents in human cardiac myocytes isolated from either right atrial appendages or explanted left ventricles.
	www.pulsus.com /europe/02_01/rav2_ed.htm (238 words)

	Pharmacokinetic and tolerance evaluation of actisomide, a new antiarrhythmic agent, in healthy volunteers -- Malesker ...
		Pharmacokinetic and tolerance evaluation of actisomide, a new antiarrhythmic agent, in healthy volunteers -- Malesker et al.
		Pharmacokinetic and tolerance evaluation of actisomide, a new antiarrhythmic agent, in healthy volunteers
		Sr Sketch MH The pharmacokinetics and tolerance of actisomide (SC-36602) were determined following intravenous doses of 2.1, 4.2, and 8.4 mg/kg infused over five hours.
	www.theannals.com /cgi/content/abstract/25/3/231 (255 words)

	Amiodarone \| ENIOSSA.COM - Drugs and Medications Directory (Site not responding. Last check: 2007-11-06)
		Amiodarone (Cordarone) is a complex antiarrhythmic agent with multiple electrophysiologic effects, unusual pharmacokinetics, and numerous potentially harmful drug interactions and adverse effects.
		Amiodarone is approved for use in the secondary prevention of life-threatening ventricular arrhythmias.
		In a meta-analysis of 18 RCTs, amiodarone was similar to other antiarrhythmic drugs in its ability to convert patients to normal sinus rhythm (72.1 percent for amiodarone compared with 71.9 percent for other antiarrhythmic drugs).
	fentanyl.eniossa.com /A/Amiodarone.html (1520 words)

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