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Topic: Anticoagulant

	Anticoagulant Information ~ APSFA
		Anticoagulants are medications that slow down the body’s ability to make blood clots.
		Anticoagulants are available in the following forms: intravenous, injections under the skin, and pills.
		Anticoagulants can be used to treat of prevent several medical conditions.
	www.apsfa.org /anticoagulants.htm (805 words)

	Anticoagulant-Antidote Pairing For Heart - Heart Disease and other cardiovascular conditions on MedicineNet.com
		The pairing of an anticoagulant and its antidote would allow the fine-tuning of anti-coagulants given during various procedures, including heart-bypass surgery, angioplasty and even kidney dialysis.
		Anticoagulants are generally used to prevent blood clots in heart patients.
		In this Phase I trial, the anticoagulant thinned the blood as expected and the antidote reversed this process, also as expected.
	www.medicinenet.com /script/main/art.asp?articlekey=77513 (660 words)

	Highbeam Encyclopedia - Search Results for anticoagulant (Site not responding. Last check: )
		anticoagulants Compounds that prevent or slow the process of blood clotting or coagulation, either in samples of blood taken for analysis or in the body.
		A polysaccharide, heparin is found in the human body and occurs in greatest concentration in the tissues surrounding the capillaries of the lungs and the liver.
		The effect of anticoagulant therapy in primary and anorectic drug-induced pulmonary hypertension.
	www.encyclopedia.com /SearchResults.aspx?Q=anticoagulant (840 words)

	PPM2 Anticoagulant and Thrombolytic Drugs
		Oral anticoagulants are primarily used in the long-term management of patients who have a thromboembolic disorder such as deep vein thrombosis or atrial fibrillation and patients who have an artificial heart valve.
		The dosage of oral anticoagulants to be given is based on the patient’s prothrombin time (PT). This measurement is determined by drawing a blood sample, adding a tissue thromboplastin preparation to initiate coagulation in it, and comparing the in vitro clotting time in the sample with that in a standardized control preparation.
		Heparin anticoagulation may be rapidly reversed with protamine sulfate, given at a ration of 1 mg per 100 units of estimated heparin reserve (the amount of heparin thought to remain in the body).
	faculty.washington.edu /alexbert/MEDEX/Spring/PPM2AnticoagulantThrombolytic.htm (5871 words)

	Anticoagulant rodenticides (EHC 175, 1995)
		It was concluded that for all four anticoagulants the reductions of KO and K are the target reactions for inhibition.
		The presence of anticoagulants (brodifacoum, bromadiolone or diphacinone) in serum or liver was confirmed by HPLC or GC/MS.
		Of the anticoagulant rodenticide enquiries, 202 pertained to warfarin and 136 to "superwarfarin" compounds (Persson, 1994).
	www.inchem.org /documents/ehc/ehc/ehc175.htm (13705 words)

	Anticoagulant definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms
		Oral anticoagulants such as warfarin and dicumarol -- which act by inhibiting the liver's production of vitamin K dependent factors crucial to clotting.
		Anticoagulant solutions are also used for the preservation of stored whole blood and blood fractions.
		Anticoagulants are also used to keep laboratory blood specimens from clotting.
	www.medterms.com /script/main/art.asp?articlekey=11022 (329 words)

	Rat Poison
		Anticoagulant rodenticides do not produce signs of poisoning for several days after the toxic dose has been consumed.
		In cases of poisoning one would expect symptoms to be nearly immediate but in the case of anticoagulant rodenticide poisoning, it takes several days to deplete Vitamin K. After that, even the smallest of jostles and traumas can lead to life-threatening bleeds.
		While anticoagulant rodenticide poisoning is a life-threatening event, at least there is an antidote readily available.
	www.marvistavet.com /html/body_rat_poison.html (1212 words)

	MedlinePlus Drug Information: Anticoagulants (Systemic) (Site not responding. Last check: )
		Anticoagulants decrease the clotting ability of the blood and therefore help to prevent harmful clots from forming in the blood vessels.
		Your doctor may suggest that you take a different anticoagulant that is less likely to harm the fetus or the newborn infant during all or part of your pregnancy.
		Anticoagulants may also cause severe bleeding in the mother if taken soon after the baby is born.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202050.html (2282 words)

	Anticoagulant Rodenticide Toxicosis in the Dog and Cat (Site not responding. Last check: )
		Anticoagulant rodenticides exert their effect by inducing a secondary vitamin K-dependent coagulopathy leading to uncontrollable hemorrhage and death.
		Anticoagulant rodenticide toxicosis is a potentially fatal condition, but it may be treated successfully if the diagnosis is made quickly and appropriate therapy is instituted.
		Because anticoagulant rodenticides do not block activated (functional or carboxylated) circulating clotting factors, there is a lag of approximately 12-24 hours between ingestion of the offending compound and the onset of clinical signs of bleeding.
	www.vet.uga.edu /vpp/clerk/Harrell/index.htm (2490 words)

	s000407d - Antiphospholipid Syndrome and Lupus Anticoagulant
		The presence of lupus anticoagulants was assessed with an: integrated assay using hexagonal phase phospholipids.
		Abstract: We have studied target platelet antigens in 22 patients with lupus anticoagulants and a primary antiphospholipid: syndrome in order to determine whether any specificities of platelet autoantibodies are correlated with: thromboembolism, and if these antibodies cross-react with phospholipids, which would suggest their role in the: development of thromboembolic disease.
		Abstract: Lupus anticoagulants and anticardiolipin antibodies have been strongly associated with the risk of thrombosis,: recurrent fetal loss, thrombocytopenia, and a number of other clinical manifestations that together have been referred to: as the antiphospholipid syndrome.
	www.emory.edu /WHSCL/grady/amreport/litsrch99/s000407d.html (4569 words)

	LONG ACTING ANTICOAGULANT RODENTICIDES (Site not responding. Last check: )
		The dose of vitamin K and the duration of treatment depends on the type of anticoagulant ingested and the response of the individual animal.
		Ingestion of anticoagulant rodenticidescontinues to be a common cause of poisoning in small animals.
		These vary in the amount needed to cause poisoning, and the duration of effect (which is directly related to the duration of treatment). The older, first generation anticoagulants, the coumarins (warfarin and fumarin), and pindone and valone (indanediones), usually require multiple ingestions and depress the amounts of clotting factors for seven to ten days.
	www.addl.purdue.edu /newsletters/1995/rodent.shtml (530 words)

	Lupus Anticoagulant Reflex
		The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood.
		The qualitative detection of lupus anticoagulants in plasma.
		Lupus anticoagulants are nonspecific antibodies that extend the clotting time of phospholipid-dependent clotting assays such as the aPTT.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/cf000400.htm (691 words)

	anticoagulant. The Columbia Encyclopedia, Sixth Edition. 2001-05
		The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitamin).
		Another anticoagulant, heparin, is a polysaccharide (see carbohydrate) found naturally in many cells.
		Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients.
	www.bartleby.com /65/an/anticoag.html (220 words)

	Anticoagulant Rodenticides
		The term superwarfarin refers to a group of compounds, second-generation anticoagulants, which are extremely long-acting.
		Regardless of their classification, all anticoagulants work by inhibiting the generation of an active form of vitamin K1 via inhibition of vitamin K1 reductases.
		Breckenridge, A., et al: A study of the relationship between the pharmacokinetics and pharmacodynamics of the 4-hydroxycoumarin anticoagulants warfarin, difenacoum and brodifacoum in the rabbit.
	www.iowapoison.com /index.asp?pageID=150 (2860 words)

	Anticoagulant Therapy-Argatroban
		Argatroban is indicated as an anticoagulant for prophylaxis or treatment of thrombosis in patients with HIT.
		Argatroban is indicated in patients with or at risk for HIT undergoing percutaneous coronary intervention (PCI).
		It is an effective alternative anticoagulant to heparin in HIT patients.
	argatroban.com (254 words)

	anticoagulant - What is definition of the term - anticoagulant ? (Site not responding. Last check: )
		A group of pharmaceuticals called anticoagulants can be used in vivo as a medication for thrombotic disorders.
		Anticoagulants are given to people to stop thrombosis (blood clotting inappropriately in the blood vessels).
		The oral anticoagulants are a class of pharmaceuticals that act by antagonizing the effects of vitamin K. It is important to note that they take at least 48 to 72 hours for the anticoagulant effect to develop fully.
	www.linguasphere.org /dictionary/n-3230-anticoagulant.html (259 words)

	Anticoagulant and antiplatelet drugs (Site not responding. Last check: )
		Anticoagulants are drugs used to prevent clot formation or to prevent a clot that has formed from enlarging.
		People who are taking anticoagulant drugs should tell all physicians, dentists, pharmacists, and other medical professionals who provide medical treatments or services to them that they are taking such a medication.
		Thrombin inhibitors are one type of anticoagulant medication, used to help prevent formation of harmful blood clots in the body by blocking the activity of thrombin.
	www.healthatoz.com /healthatoz/Atoz/ency/anticoagulant_and_antiplatelet_drugs.jsp (1758 words)

	Billing guidelines for anticoagulant monitoring ACP Observer Jul/Aug 00
		Payment for anticoagulant monitoring-related services is considered part of the payment for an evaluation and management (E/M) service.
		Anticoagulant monitoring services that are bundled into payment for an E/M service include interpreting test results, evaluating the patient and adjusting dosages.
		A physician may choose to personally relay the results if he or she needs to evaluate the patient and adjust the anticoagulant drug dosage.
	www.acponline.org /journals/news/jul-aug00/billingguides.htm (640 words)

	Lupus Anticoagulant - New Treatments, January 2, 2007
		It is a relatively common syndrome, often known as the antiphospholipid syndrome or lupus anticoagulant syndrome.
		Generally if the anticoagulant is of sufficient titer it will not correct with a mixing study with normal plasma.
		This anticoagulation should be continued for at least six months and it may be very important to continue it for a longer time depending on the status of the patient.
	www.ccspublishing.com /journals_6a/lupus_anticoagulant.htm (2162 words)

	A Professional Program of the Temple University School of Pharmacy
		Patients who are chronic heavy drinkers may experience an increase in warfarin metabolism, thereby potentially decreasing warfarin’s anticoagulant effect.
		However, the enhanced anticoagulant effect of warfarin seen at the initiation of phenytoin therapy may be due to phenytoin displacement of protein bound warfarin.
		Wort is an enzyme inducer, it may enhance the hepatic metabolism of warfarin, thereby decreasing its anticoagulant effect.
	www.temple.edu /pharmacy/ce_mancano.htm (5859 words)

	Medcyclopaedia - Anticoagulant
		The anticoagulant effect may be drug-specific as with Heparin or Warfarin (and similar drugs) or more unspecific.
		Specific anticoagulant effects may be controlled and adjusted according to the biological effect.
		All contrast media may cause unspecific inhibition of clotting in vitro, more with ionic contrast media but, to a smaller extent, also with non-ionic low-osmolar contrast media.
	www.medcyclopaedia.com /Home/library/glossaries/anticoagulant.aspx (519 words)

	Lupus Anticoagulant Profile (Site not responding. Last check: )
		Chronic lupus anticoagulant is associated with a 30% risk of venous thromboembolic disease or arterial thrombosis, including stroke and myocardial infarction.
		The lupus anticoagulant* profile is a series of assays based on the PTT-LA and the DRVVT with follow-up mixing studies and neutralization stages.
		A positive lupus anticoagulant* profile should be repeated on a new specimen after 8-10 weeks to determine if the inhibitor is transient or chronic.
	peir.path.uab.edu /coag/article_3.shtml (171 words)

	Anti-Phospholipid Antibodies (Lupus Anticoagulant)
		In general, to diagnose the syndrome, a positive blood test to either the lupus anticoagulant or the anticardiolipin antibody on two separate occasions at least 8 weeks apart is needed.
		Statistically significant associations were shown between lupus anticoagulant positivity and previous pregnancy loss (odds ratio [OR], 4.8; 95% confidence intervals [CI], 1.0 to 23.6; P =.05) and between anticardiolipin antibody positivity and previous pregnancy loss (OR, 20.0; 95% CI, 1.3 to 97.0; P =.01).
		Distribution of lupus anticoagulant and anticardiolipin antibody isotypes in a population with antiphospholipid syndrome.
	www.thedoctorsdoctor.com /diseases/antiphospholipid_antibody.htm (5584 words)

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