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| | Tricyclic antidepressant - Wikipedia, the free encyclopedia |
 | | Tricyclic antidepressants are used in numerous applications; mainly indicated for the treatment of clinical depression, pain, nocturnal enuresis, and ADHD, but they have also been used successfully for headache, bulimia nervosa, interstitial cystitis, irritable bowel syndrome, narcolepsy, persistent hiccups, pathological crying or laughing, smoking cessation, as an adjunct in schizophrenia, and in ciguatera poisoning. |
 | | These newer antidepressants are thought to have fewer side effects and are also thought to be less effective if used in a suicide attempt, as the treatment and lethal doses (see therapeutic index) are farther apart than with the tricyclic antidepressants. |
 | | Tricyclic antidepressants are highly protein bound and have a large volume of distribution; therefore removal of these compounds from the blood with hemodialysis, hemoperfusion or other techniques are unlikely to be of any significant benefit. |
| en.wikipedia.org /wiki/Tricyclic_antidepressant (1817 words) |
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