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Topic: Antidiabetic

Related Topics

Sulfonylurea

Acarbose

Diabetes mellitus

Pioglitazone

Rosiglitazone

Metformin

Thiazolidinedione

Pharmacology

Gabapentin

Endocrine

Bartlett Arboretum and Gardens

	BioMed Central \| Full text \| Antidiabetic and renoprotective effects of the chloroform extract of Terminaliachebula ...
		Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz.
		Although the fruits are known for their antidiabetic properties, the whole powder of dried ripe fruits is also being widely used for the control of diabetes.
		For the study of antidiabetic agents, streptozotocin-induced hyperglycemia in rodents is considered to be a good preliminary screening model and is widely used [24].
	www.biomedcentral.com /1472-6882/6/17 (2917 words)

	Drug Information: Antidiabetic Agents, Sulfonylurea (Systemic) (Print Version)
		Sulfonylurea antidiabetic agents (also known as sulfonylureas) are used to treat a certain type of diabetes mellitus (sugar diabetes) called type 2 diabetes.
		Oral antidiabetic medicines do not help diabetic patients who have type 1 diabetes because these patients cannot produce or release insulin from their pancreas gland.
		The use of sulfonylurea antidiabetic agents has been reported, but not proven in all studies, to increase the risk of death from heart and blood vessel disease.
	www.nlm.nih.gov /medlineplus/print/druginfo/uspdi/202742.html (4868 words)

	Antidiabetic Agents - Page 2
		The effectiveness of oral antidiabetic therapy is lower for those who have had type 2 diabetes for more than 10 years or who take more than 20 units of insulin a day.
		Antidiabetic agents are most effective in treating type 2 diabetes when they are used as part of a comprehensive physician-prescribed management plan.
		In addition to antidiabetic agents, medications are being developed to treat or prevent diabetic complications such as diseases of the kidneys, nerves and eyes.
	diabetes.healthcentersonline.com /diabetesdrugtreatments/antidiabeticagents2.cfm (752 words)

	Antidiabetic drugs (Site not responding. Last check: 2007-10-30)
		Antidiabetic drugs are medicines that help control blood sugar levels in people with diabetes mellitus (sugar diabetes).
		Antidiabetic drugs may be subdivided into six groups: insulin, sufonylureas, alpha-glucosidase inhibitors, biguanides, meglitinides, and thiazolidinediones.
		Dosage must be highly individualized for all antidiabetic agents and is based on blood glucose levels which must be taken regularly.
	www.healthatoz.com /healthatoz/Atoz/ency/antidiabetic_drugs.jsp (1850 words)

	Howstuffworks "Glipizide: A Profile of an Antidiabetic Drug"
		Glipizide is used in the treatment of type 2 diabetes mellitus (sometimes called non-insulin-dependent, or adult-onset, diabetes) that cannot be managed by control of diet alone.
		People with diabetes who are taking oral antidiabetic medication may need to be switched to insulin if they develop diabetic coma, have a severe infection, are scheduled for major surgery, or become pregnant.
		Antidiabetic medications can increase the effects of warfarin, which can lead to bleeding complications.
	health.howstuffworks.com /define-glipizide.htm (1046 words)

	Natural Products Industry Insider - The Antidiabetic Activity of Aloe Vera
		However, it is not uncommon for people with Type II diabetes to require medication to stimulate the pancreas to produce more insulin, decrease the amount of glucose made by the liver, slow the absorption of starches in the diet, or take a combination of medications to control blood sugar.
		In a human clinical trial conducted at the Mahidol University of Bangkok, Thailand, 72 patients with high fasting blood sugar and typical diabetic curve of glucose tolerance who had never been treated with hypoglycemic drugs were selected to participate in the study.
		At Mahidol University, a second trial with Aloe vera was conducted to determine the effect of aloe treatment in patients unresponsive to glibenclamide, an antidiabetic medication used to lower blood sugar levels by stimulating the production and release of insulin from the pancreas.
	www.naturalproductsinsider.com /articles/491ingredient03.html (1906 words)

	HighBeam Encyclopedia - antidiabetic drug (Site not responding. Last check: 2007-10-30)
		ANTIDIABETIC DRUG [antidiabetic drug] any of several drugs that control blood sugar level in the treatment of diabetes.
		Starlix(R) Approved For Use in Combination with Popular Thiazolidinedione Class of Antidiabetic Drugs; Combination Therapy with a Thiazolidinedione Provides New Option For Controlling and Maintaining Blood Sugar Levels in Type 2 Diabetes.
		New Oral Antidiabetic May Change Treatment Paradigm for Patients With Type 2 Diabetes.
	www.encyclopedia.com /html/a1/antidiab.asp (226 words)

	Antidiabetic effects of an oral administration of Lactobacillus casei in a non-insulin-dependent diabetes mellitus ...
		Antidiabetic effects of an oral administration of Lactobacillus casei in a non-insulin-dependent diabetes mellitus (NIDDM) model using KK-Ay mice.
		The antidiabetic effects of Lactobacillus casei (LC) on a non-insulin-dependent diabetes mellitus (NIDDM) model, KK-Ay mice, were investigated.
		The oral administration of LC to male 4-week-old KK-Ay mice, or raising the mice on a 0.05% LC-containing diet significantly decreased the plasma glucose at 8 to 10 weeks of age compared with the control group.
	www.aegis.com /aidsline/1997/dec/M97C0952.html (446 words)

	Antidiabetic drugs Encyclopedia of Medicine - Find Articles
		Antidiabetic drugs do not cure diabetes, but they do help keep the condition under control and reduce the risk of serious complications.
		Children who have not reached puberty may be particularly sensitive to the effects of insulin and are more likely to have their blood sugar levels drop too low.
		Anyone who has ever had unusual or allergic reactions to any antidiabetic medicines, sulfonamides (sulfa drugs), or thiazide diuretics (a type of water pill) should let his or her physician know before taking antidiabetic medicines again.
	www.findarticles.com /p/articles/mi_g2601/is_0001/ai_2601000101 (952 words)

	A Review of Oral Antidiabetic Agents
		Finally, compared to other oral antidiabetic medications, the sulfonylureas are the least expensive.
		Oral antidiabetic agents can be used alone or in combination to provide effective therapy for type 2 diabetes.
		When selecting an oral antidiabetic agent, the effects on glucose, lipids, adverse reaction profile, and route of elimination should be considered.
	www.clevelandclinicmeded.com /medical_info/pharmacy/MayJune2001/oral_antidiabetic.htm (1325 words)

	Bristol-Myers Squibb Files New Drug Application for Novel Oral Antidiabetic Drug
		This innovative fixed combination drug works by targeting two of the main causes of type 2 diabetes and may provide a new treatment option for the more than 14 million patients who cannot adequately manage their condition with diet and exercise alone.
		Glucophage, which is also marketed in the United States by Bristol-Myers Squibb, is a member of a class of drugs known as biguanides and helps to lower blood sugar levels by improving insulin sensitivity and by decreasing glucose production by the liver and glucose absorption in the intestine.
		Based on the results of this research, Bristol-Myers Squibb is seeking approval of the new drug for use as an initial therapy for patients with type 2 diabetes who are unable to control their condition with diet and exercise alone.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/09-30-1999/0001033352&EDATE= (739 words)

	Evaluation of Antidiabetic Activity of Ginkgo Biloba in Streptozotocin Induced Diabetic Rats
		The objective of the study was to evaluate the antidiabetic activity of Ginkgo biloba and to probe into its mechanism of action.
		The antidiabetic activity of Ginkgo biloba may be attributed to its antioxidant activity without having a role in metal ion mediated lipid peroxidation.
		Therefore, the present study was carried out to evaluate the antidiabetic activity of Ginkgo biloba in STZ induced diabetes and to probe into the mechanism of its antidiabetic property.
	ijpt.iums.ac.ir /v4n1/050401016.htm (2477 words)

	Texas Medicaid, Vendor Drug Program, Oral Antidiabetic Agents
		There is no basis for limiting the duration of oral antidiabetic therapy.
		Dosage requirements for oral antidiabetic agents may increase when thiazides are administered concurrently.
		Blood glucose levels should be monitored in patients maintained on the oral antidiabetic-thiazide diuretic drug combination as oral antidiabetic dosage adjustments may be necessary.
	www.hhsc.state.tx.us /HCF/vdp/Criteria/antidiab.html (1085 words)

	Synthesis and Biological Activity of Aminoguanidine and Diaminoguanidine Analogues of the Antidiabetic/Antiobesity ...
		The corresponding aminoguanidine analogue 2 was recently discovered to retain the antidiabetic activity of 1 while being markedly less susceptible to creatine-like metabolism, suggesting that it should have less potential to accumulate in muscle.
		Further structural modification of 2 was undertaken to investigate whether the antidiabetic potency could be augmented while maintaining resistance to creatine-like metabolism.
		However, the simple regioisomeric aminoguanidinoacetic acid 9 and diaminoguanidinoacetic acid analogue 7 were found to be equipotent to 2, leading eventually to the discovery of the significantly more potent diaminoguanidinoacetic acid regioisomers 52 and 53.
	pubs.acs.org /cgi-bin/abstract.cgi/jmcmar/2001/44/i08/abs/jm000094n.html (335 words)

	Commercial Perspectives: Diabetes - Type 2 Epidemic Driving Aggressive Therapy
		Despite increasing maturity and a high level of genericization, the global antidiabetic market experienced growth of 5.8% from 2001 to 2002, achieving sales of nearly $12.4 billion.
		Due to escalating rates of obesity and the aging population, type 2 diabetes is an emerging epidemic; Datamonitor estimates there will be 48.1m diabetics in the seven major markets in 2011.
		Although insulin is the oldest class of antidiabetic, the greater proportion of type 2 diabetics treated with insulin has ensured continued growth.
	www.marketresearch.com /researchindex/941758.html (438 words)

	New Oral Antidiabetic May Change Treatment Paradigm for Patients With Type 2 Diabetes
		The study demonstrates that patients who were placed on first-line therapy with a new oral antidiabetic achieved superior blood sugar control as compared with patients who were placed on single agent therapy with the most widely prescribed oral antidiabetic agents, metformin hydrochloride tablets (Glucophage(R)) or glyburide.
		The Phase III study examines the benefits of a novel oral antidiabetic that combines the two leading oral antidiabetic agents -- metformin and glyburide -- in a single pill, as a first line therapy for patients who cannot manage their condition with diet and exercise alone.
		In many cases, the required dose was lower than the doses of single agent glyburide or metformin, two commonly prescribed antidiabetics." The Phase III trial was designed to assess the efficacy of two fixed combination glyburide/metformin tablet dosages as first line therapy.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/06-12-2000/0001240684&EDATE= (460 words)

	Howstuffworks "Metformin: A Profile of an Antidiabetic Drug"
		Metformin is used for the treatment of the form of diabetes mellitus that most commonly appears in adulthood -- known as type 2 or non-insulin-dependent diabetes -- and that cannot be managed by exercise and dietary therapy alone.
		Metformin helps to control sugar in the blood by making the body more sensitive to insulin and by reducing the amount of sugar produced by the body.
		Metformin can be used alone or with other antidiabetic medications (such as sulfonylureas or insulin).
	health.howstuffworks.com /define-metformin.htm (967 words)

	Synthesis and Biological Activity of Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid: ...
		In an effort to identify novel entities that maintain antidiabetic potency without susceptibility to creatine-like metabolism, an analogue program was undertaken to explore the effects of various structural modifications, including homologation, simple substitution, single atom mutations, and bioisosteric replacements for the guanidine and carboxylic acid.
		Overall, the scope of activity encompassed by the set of new analogues proved to be exceedingly narrow.
		Furthermore, in vitro studies demonstrated that 69 is markedly less susceptible to phosphorylation by creatine kinase than the lead 1, suggesting that it should have less potential for accumulation in muscle tissue than 1.
	pubs.acs.org /cgi-bin/abstract.cgi/jmcmar/2001/44/i08/abs/jm000095f.html (284 words)

	Newer Oral Antidiabetic Agents (Site not responding. Last check: 2007-10-30)
		This is partly due to limitations of currently available modalities of treatment, and partly due to patient's non-compliance with prescribed antidiabetic medications as well as with diet and exercise prescriptions.
		Despite simultaneous research on oral antidiabetic agents having different mechanisms of action in order to overcome the deficiencies of currently available antidiabetic medication, only glimeperide, repaglinide, thiazolidenediones, and acarbose have been introduced for routine use.
		Antidiabetic and anti-obesity effects of a highly selective 3 adrenoreceptor agonist (CL 316,243).
	www.indegene.com /End/FeatArt/indEndFeatArt3.html (3279 words)

	Pharmacokinetics of Troglitazone, an Antidiabetic Agent: Prediction of In Vivo Stereoselective Sulfation and ...
		Pharmacokinetics of Troglitazone, an Antidiabetic Agent: Prediction of In Vivo Stereoselective Sulfation and Glucuronidation from In Vitro Data -- Izumi et al.
		Kutt, H. and Fouts, J. Diphenylhydantoin metabolism by rat liver microsomes and some of the effects of drug or chemical pretreatment on diphenylhydantoin metabolism by rat liver microsomal preparations.
		Synthesis, identification, and antidiabetic activity of the glucuronide of CS-045.
	jpet.aspetjournals.org /cgi/content/full/280/3/1392 (4342 words)

	Antidiabetic, Antidiabetic Agent
		Ipriflavone may increase the effects of antidiabetics which may cause hypoglycemia.
		Vitamin E improves the response to insulin, which may cause hypoglycemia if used with antidiabetic agents.
		Antidiabetic drugs interfere with the activity of enzymes containing CoQ10.
	www.naturdoctor.com /Chapters/Drugs/Antidiabetic.html (677 words)

	Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones -- Chao et ...
		Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones -- Chao et al.
		Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
		An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).
	www.jci.org /cgi/content/full/106/10/1221 (5165 words)

	IngentaConnect Comparison of pioglitazone with other antidiabetic drugs for asso... (Site not responding. Last check: 2007-10-30)
		Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone
		The aim of this study was to assess the incidence of liver failure in association with antidiabetic treatment using pioglitazone vs. other oral antidiabetic medications.
		Pioglitazone therapy was not associated with an increased risk of liver failure at 2 years relative to other oral antidiabetic therapies.
	www.ingentaconnect.com /content/bsc/dom/2005/00000007/00000002/art00006 (398 words)

	Antidiabetic drugs and heart failure risk in patients with type 2 diabetes in the U.K. primary care setting (NDEI.ORG)
		Antidiabetic drugs and heart failure risk in patients with type 2 diabetes in the U.K. primary care setting (NDEI.ORG)
		Maru S, Koch GG, Stender M, Clark D, Gibowski L, Petri H, White AD, Simpson RJ, Jr OBJECTIVE: To assess the effects of antidiabetic drugs on the risk of heart failure in patients with type 2 diabetes.
		Antidiabetic drugs and heart failure risk in patients with type 2 diabetes in the U.K. primary care setting.
	www.ndei.org /v2/website/litalerts/article.cfm?Article_ID=1255 (366 words)

	PRESS RELEASE First Clinical Trial to Demonstrate Colesevelam HCl Plus Stable Oral Antidiabetic Medication Improves ... (Site not responding. Last check: 2007-10-30)
		PARSIPPANY, NJ -- (MARKET WIRE) -- June 10, 2006 -- The first data to demonstrate the effect of WelChol® (colesevelam hydrochloride) on glucose lowering was presented today at The American Diabetes Association's (ADA) 66th Annual Scientific Sessions in Washington, DC.
		The Glucose Lowering Effect Of WelChol Study (GLOWS) examined the ability of a bile acid sequestrant, colesevelam HCl, to improve glycemic control in addition to a patient's current oral antidiabetic therapy.
		Addition of WelChol did not cause weight gain, a typical side effect of glucose-lowering therapies, and did not cause increased incidence of hypoglycemia.
	www.marketwire.com /mw/release_html_b1?release_id=134706&tsource=3 (1024 words)

	Rapid Increase in the Use of Oral Antidiabetic Drugs in the United States, 1990-2001 -- Wysowski et al. 26 (6): 1852 -- ...
		Rapid Increase in the Use of Oral Antidiabetic Drugs in the United States, 1990-2001 -- Wysowski et al.
		Rapid Increase in the Use of Oral Antidiabetic Drugs in the United States, 1990–2001
		This period was marked by an increase in the
	care.diabetesjournals.org /cgi/content/abstract/26/6/1852 (312 words)

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