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Topic: Antiphospholipid syndrome

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	Antiphospholipid syndrome - Wikipedia, the free encyclopedia
		Antiphospholipid syndrome (or antiphospholipid antibody syndrome) is a disorder of coagulation which causes thrombosis in both arteries and veins, as well as recurrent miscarriage.
		Antiphospholipid syndrome is tested for in the laboratory by using a minimum of two coagulation tests that are phospholipid sensitive.
		Antiphospholipid syndrome is an autoimmune disease, in which antibodies react against anionic phospholipids on cell membranes.
	en.wikipedia.org /wiki/Antiphospholipid_syndrome (692 words)

	Antiphospholipid Syndrome (Site not responding. Last check: 2007-10-13)
		The antiphospholipid antibody syndrome, also known as Hughes Syndrome, is a disorder characterized by multiple different antibodies that are associated with both arterial and venous thrombosis (clots).
		The antiphospholipid antibody syndrome is an autoimmune phenomenon.
		The role of the antiphospholipid antibody syndrome in both arterial and venous thrombotic disorders is an active area of clinical research.
	www-admin.med.uiuc.edu /hematology/PtAPS.htm (0 words)

	Antiphospholipid Syndrome
		Antiphospholipid Syndrome is a disorder in which the blood clotting system begins to form blood clots in the veins or arteries without obvious reason.
		The symptoms of Antiphospholipid Syndrome include blood clots (thromboses) in leg or arm veins and/or arteries; blood clots which travel to the lungs (pulmonary emboli); sudden loss of vision; occasional episodes of numbness, tingling, or weakness in the face or limbs; stroke; seizures; and recurrent miscarriages.
		Treatment of Antiphospholipid Syndrome is generally tailored for each patient depending on his or her degree of symptoms.
	www.med.umich.edu /1libr/aha/umantiphos.htm (0 words)

	Sneddon Syndrome
		We suggest that the association of pre-perinatal distress, Sneddon syndrome and arylsulfatase A pseudodeficiency is responsible for the diffuse impairment of cerebral white matter, never reported in Sneddon syndrome and similar to described cases of delayed posthypoxic demyelination and arylsulfatase A pseudodeficiency.
		Sneddon's syndrome is a rare clinical entity first described in 1965 and characterized by typical skin lesions (livedo reticularis) and cerebrovascular lesions occurring at early age.
		Sneddon syndrome is characterized by the association of livedo reticularis and cerebral ischemic arterial events (stroke or transient ischemic attack).
	www.thedoctorsdoctor.com /diseases/sneddon_syndrome.htm (0 words)

	Child Health Library - High-Risk Pregnancy - Antiphospholipid Syndrome (aPL)
		Antiphospholipid syndrome is an autoimmune disease in which the body produces large amounts of antiphospholipid antibodies.
		Antiphospholipid syndrome was only defined in recent years and is sometimes called Hughes syndrome, or sticky blood syndrome.
		Antiphospholipid syndrome is often difficult to diagnose, however, blood tests for antibodies including lupus and anticardiolipin may aid in the diagnosis.
	www.chp.edu /greystone/hrpregnant/autoapl.php (0 words)

	MERSI Ocular Immunology and Uveitis Foundation\| Medical Professionals \| Articles \| Case Reports
		Antiphospholipid syndrome is defined as the presence of antiphospholipid antibodies, arterial or venous thrombosis, recurrent spontaneous abortions, and thrombocytopenia.
		The diagnosis of antiphospholipid syndrome is based on the presence of antiphospholipid antibodies - anticardiolipin antibodies and lupus anticoagulant.
		Antiphospholipid antibodies in the aethiology of ischaemic optic neuropathy.
	www.uveitis.org /medical/articles/case/antiphospholipid_syndrome.html (0 words)

	Antiphospholipid Syndrome (Phospholipid Antibody Syndrome or Hughes Syndrome) Causes, Diagnosis, Symptoms, and ... (Site not responding. Last check: 2007-10-13)
		The antiphospholipid syndrome is a disorder of the immune system that is characterized by excessive clotting of blood and/or certain complications of pregnancy (premature miscarriages, unexplained fetal death, or premature birth) and the presence of antiphospholipid antibodies (cardiolipin or lupus anticoagulant antibodies) in the blood.
		Harmless antiphospholipid antibodies can be detected in the blood for a brief period occasionally in association with a wide variety of conditions, including bacterial, viral (hepatitis, HIV), and parasite (malaria) infections.
		Antiphospholipid antibodies have also been detected in over half of patients with the immune disease systemic lupus erythematosus.
	www.medicinenet.com /antiphospholipid_syndrome/article.htm (0 words)

	Antiphospholipid Syndrome
		It has been reported that antiphospholipid antibodies are found among young, apparently healthy individuals at a prevalence of 1 to 5% for both anticardiolipin antibodies and the lupus anticoagulant (Petri et al.).
		Several theories exist in an attempt to explain the cellular and molecular mechanisms by which antiphospholipid antibodies promote thrombosis: activated endothelial cells, oxidant-mediated injury to the vascular endothelium, direct interference in the phospholipid mediated regulation of coagulation and a mechanism similar to the paradoxical thrombosis of heparin induced thrombocytopenia (Levine et al.).
		Antiphospholipid Syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1000 patients.
	www.amc.edu /amr/archives/200210/review02.html (0 words)

	s000410b - Antiphospholipid Syndrome
		Thrombosis in the: antiphospholipid syndrome is due to disruption of the annexin shield by antiphospholipid (and cofactor) antibodies: which results in the increased exposure of thrombogenic phospholipids.
		Abstract: The antiphospholipid syndrome is defined as the association between the presence of antiphospholipid antibodies,: detected as anticardiolipin antibodies and/or lupus anticoagulant, and a history of either arterial or venous thrombosis: and/or recurrent pregnancy loss.
		Abstract: The antiphospholipid syndrome is an illness characterized by recurrent venous or arterial thrombosis, recurrent fetal: loss, and thrombocytopenia.
	www.emory.edu /WHSCL/grady/amreport/litsrch99/s000410b.html (0 words)

	s000816c - Antiphospholipid Syndrome, INR Goal
		Several studies suggest that the presence of an antiphospholipid syndrome in patients with SLE conveys a worse prognosis.
		The use of interleukin-3 in animal models of the syndrome has been shown to be effective in the prevention of fetal loss, and this therapeutic modality appears promising, particularly because of its recognized low frequency of side effects in therapeutic trials in humans.
		The antiphospholipid syndrome was primary in 51 patients (73%) and secondary to systemic lupus erythematosus in 14 patients (20%) and to chronic idiopathic thrombocytopenic purpura in 5 patients (7%).
	www.emory.edu /WHSCL/grady/amreport/litsrch00/s000816c.html (0 words)

	THE CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME (CAPS) (Site not responding. Last check: 2007-10-13)
		Asherson RA, Piette J-C. The Catastrophic Antiphospholipid Syndrome in 1996.
		Antiphospholipid antibodies in HIV infection and SLE with or without anti-phospholipid syndrome; comparisons of phospholipid specificity, avidity and reactivity with beta2-GPI.
		Piette J-C, Amour Z, Foucher-Lavergne A : ìCatastrophicî diagnosis of the antiphospholipid syndrome.
	www.rheuma21st.com /archives/cutting_asherson_caps.html (0 words)

	Antiphospholipid syndrome - WrongDiagnosis.com
		Antiphospholipid syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Antiphospholipid syndrome, or a subtype of Antiphospholipid syndrome, affects less than 200,000 people in the US population.
		With a diagnosis of Antiphospholipid syndrome, it is also important to consider whether there is an underlying condition causing Antiphospholipid syndrome.
	www.wrongdiagnosis.com /a/antiphospholipid_syndrome/intro.htm (0 words)

	Antiphospholipid Antibodies - Lupus Foundation of America, Inc.
		It is not necessary to have lupus to have the Antiphospholipid Antibody Syndrome.
		If the woman has antiphospholipid antibodies and is pregnant for the first time, or has had normal pregnancies in the past, no treatment may be advised.
		Pregnancies in women with antiphospholipid antibodies are considered to be "high risk pregnancies." It is necessary for the obstetrician/gynecologist to work closely with the rheumatologist or other physician who evaluates a woman with miscarriages for antiphospholipid antibodies.
	www.lupus.org /education/brochures/antiphos02.html (0 words)

	Arthritis Research Campaign \| Antiphospholipid Syndrome (Site not responding. Last check: 2007-10-13)
		Antiphospholipid syndrome (APS) is a disorder in which the blood has a tendency to clot too quickly ('sticky blood' syndrome).
		The presence of the antiphospholipid antibodies is particularly important during pregnancy, where the 'sticky' blood is unable to cross the smallest blood vessels in the afterbirth (placenta), so causing miscarriage.
		This is because harmless antiphospholipid antibodies can be detected in the blood for brief periods, occasionally in association with a wide variety of conditions, including infections and certain drugs (e.g.
	www.arc.org.uk /about_arth/booklets/6059/6059.htm (0 words)

	antiphospholipid syndrome and pregnancy
		antiphospholipid syndrome and pregnancy, antiphospholipid antibody syndrome, antiphospholipid syndrome treatment, cure for antiphospholipid syndrome, natural treatment for antiphospholipid syndrome, herbal antiphospholipid syndrome remedy, treatment for antiphospholipid syndrome, natural cure for antiphospholipid syndrome, herbal medicine for antiphospholipid syndrome
		Miscarriages in antiphospholipid syndrome usually occur in the second or third trimester (week 12 or later), but can sometimes occur in the first trimester.
		There are patients with antiphospholipid syndrome who have successful pregnancies without treatment, though there is a higher risk of complications towards the end of pregnancy, including pre-eclampsia, intrauterine growth retardation (slowing down of the baby's growth in the uterus), and premature delivery.
	www.drraomd.com /diseaseindex/h_hughes_syndrome.htm (0 words)

	Antiphospholipid Syndrome
		syndrome, the persistence, isotype, and titer of the autoantibodies
		syndrome is the cause of a newly diagnosed thrombosis.
		Bleeding and recurrent thrombosis in definite antiphospholipid syndrome: analysis of a series of 66 patients treated with oral anticoagulation to a target international normalized ratio of 3.5.
	www.medical-journals.com /r03239.htm (0 words)

	Antiphospholipid Syndrome
		The treatment of patients with anticardiolipin syndrome has substantially evolved since they were discovered to be clinically important in the mid-1980s.
		Each manifestation of the antiphospholipid syndrome, and each individual patient with the condition, is treated uniquely.
		Because many of the features of illness with anticardiolipin syndrome are associated with an abnormal grouping of normal blood clotting elements (platelets), treatment is often directed toward preventing clotting by thinning the blood.
	www.virtualbloodcentre.com /diseases.asp?did=468 (0 words)

	The antiphospholipid syndrome (Hughes' syndrome)
		Women with antiphospholipid syndrome are at increased risk of miscarriage.
		They may also perform tests to look for damage caused by antiphospholipid syndrome, which could include other blood tests, echocardiogram (ultrasound scan of the heart), and MRI scans.
		Patients with antiphospholipid syndrome who have recurrent miscarriages can also be treated, but not with warfarin as it has the potential to cause foetal abnormality if given during pregnancy.
	www.netdoctor.co.uk /diseases/facts/antiphospholipid.htm (0 words)

	BBC - Health - Conditions - Antiphospholipid syndrome (Site not responding. Last check: 2007-10-13)
		Hughes syndrome (sticky blood syndrome or, more technically, antiphospholipid syndrome) is an important cause of blood clotting problems and accounts for as many as one in five cases of recurrent miscarriage.
		Hughes syndrome may be to blame in some cases of economy class syndrome, which has lead to the deaths of young people travelling on long-haul flights.
		Women with the syndrome are at increased risk of miscarriage because the 'sticky blood' can't get through the delicate small blood vessels to the baby growing in the womb.
	www.bbc.co.uk /health/conditions/antiphospholipid1.shtml (0 words)

	Antiphospholipid Antibody Syndrome @ HEMEX.com
		ANTIPHOSPHOLIPID ANTIBODY SYNDROME (APS) is a term used to describe the association between recurrent clinical events such as thrombosis (arterial or venous), thrombocytopenia, or fetal loss and the presence of a persistent antiphospholipid antibody
		Antiphospholipid antibodies are a family of related but distinct autoimmune and alloimmune immunoglobulins (IgG, IgM, IgA, or mixtures) that are directed against the anionic phospholipids contained in the membranes of cells
		Antiphospholipid antibodies are detected by using two different testing techniques, clotting tests and enzyme-linked immunoassay system (ELISA) procedures which measures specific phospholipid antibodies.
	www.hemex.com /testmenus/aps.htm (0 words)

	Antiphospholipid syndrome: an overview -- Hanly 168 (13): 1675 -- Canadian Medical Association Journal
		Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: a "lupus procoagulant" phenomenon.
		Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus-derived peptide cause thrombosis and activation of endothelial cells in vivo.
		Relapsing catastrophic antiphospholipid antibody syndrome: a mimic for thrombotic thrombocytopenic purpura?
	www.cmaj.ca /cgi/content/full/168/13/1675 (0 words)

	Antiphospholipid syndrome - Patient UK
		Antiphospholipid syndrome - Patient UK PatientPlus articles are written for doctors and so the language can be technical.
		The antiphospholipid syndrome is a disorder with recurrent arterial and venous thrombosis, pregnancy loss and possibly
		Catastrophic antiphospholipid syndrome (CAPS) is a serious and often fatal manifestation characterized by multiple organ infarctions over a period of days to weeks.
	www.patient.co.uk /showdoc/40024537 (0 words)

	Antiphospholipid Syndrome Glossary of Terms with Definitions on MedicineNet.com
		The following are health and medical definitions of terms that appear in the Antiphospholipid Syndrome article.
		Annexin V: Annexin V is the cause of a syndrome called the antiphospholipid antibody syndrome with abnormal blood clotting.
		Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease.
	www.medicinenet.com /antiphospholipid_syndrome/glossary.htm (0 words)

	Antiphospholipid Syndrome MEDSTUDENTS-RHEUMATOLOGY
		The antiphospholipid syndrome is defined as a clinical disorder with recurrent arterial and venous thrombotic events, pregnancy wastage and/or thrombocytopenia in the presence of the lupus anticoagulant and/or moderate to high positive anticardiolipin test.
		Association of antiphospholipid antibodies with renal vein thrombosis, Addison’s disease, gut ischemia, Budd-Chiari syndrome, thrombocytopenia, autoimune hemolytic anemia, idiopathic thrombocytopenic purpura, cardiac valve abnormalities (insufficiency mitral and aortic) and Libman-Sacks endocarditis have all been described.
		Both lupus anticoagulant and anticardiolipin antibody are associated with each of the clinical manifestations of the antiphospholipid syndrome.
	www.medstudents.com.br /reumat/reumat2.htm (0 words)

	Antiphospholipid Syndrome
		Morbidity and mortality rates associated with the catastrophic Antiphospholipid syndrome are high.
		In view of the noninflammatory nature of the condition and the presence of autoantibodies, therapy with anticoagulation and plasmapheresis is recommended.
		Presence of antiphospholipid antibodies does not necessarily indicate an increased risk for thrombosis.
	www.neuroland.com /cvd/aps.htm (0 words)

	NEJM -- The Antiphospholipid Syndrome (Site not responding. Last check: 2007-10-13)
		Colonic ulcers in propylthiouracil induced vasculitis with secondary antiphospholipid syndrome.
		Prospective observational study of antiphospholipid antibodies in acute lung injury and acute respiratory distress syndrome: comparison with catastrophic antiphospholipid syndrome.
		The prevalence of coeliac disease antibodies in patients with the antiphospholipid syndrome.
	content.nejm.org /cgi/content/short/346/10/752 (0 words)

	TIGC - The Antiphospholipid Syndrome
		The antiphospholipid syndrome (APS) is increasingly recognized as an important clinical disorder, but one which has engendered confusion in both its clinical and laboratory aspects.
		As APS is not a hereditary condition, antiphospholipid antibody tests are not indicated in the work up of familial hypercoagulability.
		Crowther MA et al., A comparison of two intensities of warfarin for the prevention o frecurrent thrombosis in patients with the antiphospholipid syndrome.
	www.tigc.org /eguidelines/antiphoslipid04.htm (0 words)

	Thrombosis and the Antiphospholipid Syndrome -- Ortel 2005 (1): 462 -- Hematology
		-glycoprotein 1 in the diagnosis of antiphospholipid syndrome.
		Antiphospholipid antibodies are a risk factor for early renal allograft failure.
		Antiphospholipid syndrome in patients with systemic lupus erythematosus treated by autologous hematopoietic stem cell transplantation.
	www.asheducationbook.org /cgi/content/full/2005/1/462 (0 words)

	Mycoplasma penetrans Bacteremia and Primary Antiphospholipid Syndrome
		Antiphospholipid syndrome (APS), first described in 1983 to 1986, is characterized by a wide variety of hemocytopenic and vaso-occlusive manifestations and is associated with antibodies directed against negatively charged phospholipids.
		The factor(s) causing production of the antiphospholipid antibodies in primary antiphospholipid syndrome (PAPS) remain unidentified (2).
		pneumoniae infection and the presence of antiphospholipid antibodies (12).
	www.cdc.gov /ncidod/eid/vol5no1/yanez.htm (0 words)

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