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Topic: Antiretroviral


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In the News (Mon 28 May 12)

  
  Taking antiretroviral drugs for HIV infection
Your willingness and ability to follow your antiretroviral therapy schedule exactly as prescribed is essential for successful treatment of your HIV infection.
You should not start antiretroviral therapy until you have considered the benefits and risks of treatment and discussed all the issues with your doctor.
When antiretroviral drugs are not taken exactly as prescribed, the effectiveness of the drug is decreased and drug resistance is more likely to occur.
www.webmd.com /hiv-aids/taking-antiretroviral-drugs-for-hiv-infection   (1546 words)

  
  HIV Medicine 2006 | Antiretroviral therapy in children
Several factors have to be considered when giving antiretroviral drugs to children: children may already have been exposed to AZT and other drugs in utero, the pharmacokinetics of the drugs are age-dependent and children require special attention to help with adherence.
Without antiretroviral therapy there is a bimodal natural course of vertical HIV infection: in 10-25 % of the children, rapid progression with AIDS-defining symptoms and lethal complications is observed within the first year of life.
Sometimes a brief period of hospitalization at the start of antiretroviral therapy is useful to educate the patient and access the tolerability of the treatment regimen.
www.hivmedicine.com /textbook/ped.htm   (5694 words)

  
  Antiretroviral drug - Wikipedia, the free encyclopedia
Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV.
Combinations of antiretrovirals are subject to positive and negative synergies, which limits the number of useful combinations.
Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.
en.wikipedia.org /wiki/Antiretroviral_drug   (2744 words)

  
 WHO | Antiretroviral therapy for HIV infection in adults and adolescents: towards universal access
Antiretroviral therapy for HIV infection in adults and adolescents: towards universal access
This publication is intended to serve as a reference tool for countries with limited resources as they develop or revise national guidelines for the use of ART in adults and postpubertal adolescents (see Annex 9 for pubertal Tanner staging; prepubertal adolescents should follow the WHO paediatric guidelines).
Cost-effectiveness is not explicitly considered as part of the recommendations, although the realities of human resources, health system infrastructures and socioeconomic issues should be taken into account when the recommendations are being adapted to regional and country programmes.
www.who.int /hiv/pub/guidelines/adult/en/index.html   (289 words)

  
 Antiretroviral drugs
Antiretroviral agents are virustatic agents which block steps in the replication of the virus.
The optimum combinations of antiretroviral drugs have not been determined, nor is there agreement on the stage of infection at which to start treatment.
Fifty percent of patients who fail antiretroviral therapy are resistant to one class of drug.
www.healthatoz.com /healthatoz/Atoz/ency/antiretroviral_drugs.jsp   (1327 words)

  
 CIGNA - Taking antiretroviral drugs for HIV infection   (Site not responding. Last check: )
Highly active antiretroviral therapy (HAART) is the use of 3 or more antiretroviral drugs to treat the HIV infection.
The antiretroviral therapy drugs will not control the virus replication as effectively or protect the immune system.
When antiretroviral drugs are not taken exactly as prescribed, the effectiveness of the drug is decreased and drug resistance is more likely to occur.
www.cigna.com /healthinfo/tm6476.html   (1516 words)

  
 Overview of Antiretroviral Therapy
Each of the antiretroviral drugs used in combination therapy regimens should always be taken according to optimum schedules and dosages, and under the conditions specified for maximal drug absorption.
The available antiretroviral drugs are limited in number and mechanism of action, and cross-resistance between specific drugs has been documented.
Antiretroviral regimens should be changed in the event of intolerance, non-adherence, or failure.
www.hivdent.org /seatecover.htm   (4035 words)

  
 USAID Health: HIV/AIDS, Technical Areas, Care and Support, Antiretroviral Therapy
Antiretroviral drugs have been used extensively in the developed world for a number of years to improve the quality of life and extend the life of those infected with HIV.
Antiretroviral drugs are one aspect of a comprehensive care and support program that includes meeting the medical, psychological, socioeconomic, and legal needs of those affected by HIV/AIDS.
In addition to the importance of antiretroviral drugs for treatment of HIV infection, specific antiretroviral drugs are key to preventing transmission of HIV from infected mothers to their children.
www.usaid.gov /our_work/global_health/aids/TechAreas/caresupport/arvfactsheet.html   (1295 words)

  
 Starting antiretroviral treatment
The antiretroviral HIV drugs that are currently available can improve the quality of life of someone infected with HIV, helping them to stay well much longer than they otherwise would.
Depending on the age of the child, adult supervision is usually needed to ensure the medication is taken consistently and correctly.
There are more antiretroviral drugs available for adults than there are for children because of the way some of them react negatively with a growing child's immune system.
www.avert.org /starttrt.htm   (1675 words)

  
 The Body: Antiretroviral Therapy in Children
Moreover, intragestational antiretroviral therapy with ZDV, as established by ACTG 076, has reduced the transmission rate from mothers to their infants by two thirds.
If one is, of necessity, already prescribing combination antiretroviral therapy for pediatric patient without the benefit of hard data on the efficacy of these drugs in younger patients, perhaps it is only a small leap to experiment with a new class of compounds such as the protease inhibitors.
Effect of antiretroviral combination therapy (zidovudine/didanosine or zidovudine/lamivudine) on quantitative plasma human immunodeficiency virus-ribonucleic acid in children and adolescents infected with human immunodeficiency virus.
www.thebody.com /hivnews/newsline/aug97/child.html   (2770 words)

  
 NIH Guidance for Addressing the Provision of Antiretroviral Treatment for Trial Participants Following their Completion ...
Does the antiretroviral treatment identified for post-trial provision have to be the same regimen that the participant received during the trial?
HIV antiretroviral treatment trials that are subject to the provisions outlined in this document are defined as clinical trials conducted in developing countries where antiretroviral medications are provided to enrolled subjects in order to assess the safety and efficacy of HIV antiretroviral treatment regimens.
The Principal Investigator is encouraged, however, to include sources for the provision of antiretroviral treatment in the U.S. that are available to trial participants at the conclusion of their participation in the trial.
grants.nih.gov /grants/policy/antiretroviral/QandA.htm   (1963 words)

  
 Antiretroviral Therapy — Improving Quality Of Life In Hiv Positive Children Pediatric Oncall
The availability of an increasing number of antiretroviral agents have lead to improvement in quality of life, reduction of HIV-related morbidity and mortality with restoration and preservation of immunologic functions.
Antiretroviral regimens are complex, have serious side effects, post difficulty with adherence and carry serious potential consequences from the development of viral resistance because of non-adherance to the drug or sub-optimal levels of antiretroviral agents.
Antiretroviral therapy in children is recommended in patients who are in CDC class B or C with severe immuno suppression.
www.pediatriconcall.com /fordoctor/casereports/antiretroviral.asp   (607 words)

  
 Antiretroviral therapy
HIV is an uncommon type of virus called a retrovirus, and drugs developed to disrupt the action of HIV are known as antiretrovirals or ARVs.
Moreover, the health infrastructure required to deliver antiretroviral therapy is lacking in many places, and only a tiny minority of the estimated six million people in need of ARVs in resource-poor countries are receiving treatment.
In 2003, UNAIDS and WHO launched a campaign—the '3 by 5' Initiative—aimed at ensuring that at least 3 million of these people have access to antiretroviral therapy by 2005.
www.unaids.org /en/Issues/Prevention_treatment/antiretroviral_therapy.asp   (201 words)

  
 Antiretroviral Drugs -- HIV Drugs
Antiretroviral regimens are complex, have serious side effects, pose difficulty with adherence, and carry serious potential consequences from the development of viral resistance because of nonadherence to the drug regimen or suboptimal levels of antiretroviral agents.
Treatment interruptions (aka "drug holidays") where the antiretrovirals drugs are discontinued are also being studied as a method by which the sensitivity of HIV to the antiretroviral drugs can be increased by changing the selection pressure back from the drugs to being the human immune system again.
Third antiretroviral to be approved by FDA, on Jun 19, 1992 as a monotherapy and again in 1996 for use in combination with AZT.
www.edinformatics.com /biotechnology/antiretroviral_drugs.htm   (2925 words)

  
 GENESIS OF AIDS :: BASIC :: TREATMENT - Antiretroviral
Antiretroviral treatment usually elongates the lifespan of an HIV positive person, it involves the use of certain drugs called antiretroviral drugs (sometimes called anti-HIV drugs or HIV antiviral drugs).
It is however, being recommended that a minimum of three antiretroviral drugs should be taken at a time for effective action, in what is know as the Highly Active Antiretroviral Therapy (HAART or combination therapy).
Antiretroviral drugs are generally being classified into various groups according to their actions and how they work.
library.thinkquest.org /04oct/00924/antiretroviral.html   (396 words)

  
 [No title]
Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents.
Antiretroviral Therapy in Adults and Adolescents - December 2006
Pocket reference card for clinicians on antiretrovirals used in the treatment of HIV infection in adults and adolescents.
www.aidsinfo.nih.gov /Guidelines/GuidelineDetail.aspx?MenuItem=Guidelines&Search=Off&GuidelineID=7&ClassID=1   (246 words)

  
 Antiretroviral
United Pharmacies has a selection of antiretroviral medications which are used in the treatment of HIV/AIDS and can prolong your good health and life expectancy.
Generic Zidovudine is indicated for the treatment of HIV infection when antiretroviral therapy is warranted.
Dinex EC in combination with other antiretroviral agents is indicated for the treatment of HIV-1 infection.
www.unitedpharmacies.com /Antiretroviral_page_1_c_19.html   (372 words)

  
 Diarrhea and Reduced Levels of Antiretroviral Drugs: Improvement with Glutamine or Alanyl-glutamine
The effects of therapy with glutamine and alanyl-glutamine on diarrhea and antiretroviral drug levels in patients with AIDS were examined in a randomized, double-blinded, placebo-controlled study in northeast Brazil.
Patients with AIDS and with diarrhea and/or wasting were randomized into 4 groups to determine the efficacy of glutamine or high- or low-dose alanyl-glutamine given for 7 days, compared with isonitrogenous glycine given to control subjects.
Antiretroviral drug resistance mutations were common in all groups.
www.hivandhepatitis.com /recent/toxicities/diarrhea/070704_g.html   (225 words)

  
 The Hopkins HIV Report: Update on Antiretroviral Therapy: Report from the 4th Conference on Retroviruses and ...   (Site not responding. Last check: )
One of the most important lessons we learned at this meeting is that the viral nadir achieved after starting antiretroviral therapy is a stronger predictor of the durability of response than either baseline viral load or the magnitude of decline [Kempf et al., Abstract 373].
It is a function not only of the potency of the regimen, but also of the prior antiretroviral experience of the patients and of the convenience and tolerability of the combination [Richman, Abstract S53].
In her review of new developments in antiretroviral therapy, Ann Collier closed with a quotation from Voltaire: "Perfection is attained by slow degrees.
www.thebody.com /jh/hivrept/mar97/Antivir.html   (2080 words)

  
 WHO | Antiretroviral Therapy (ART)
When antiretroviral drugs are given in combination, HIV replication and immune deterioration can be delayed, and survival and quality of life improved.
Without access to antiretroviral therapy, people living with HIV/AIDS cannot attain the fullest possible physical and mental health and cannot play their fullest role as actors in the fight against the epidemic, because their life expectancy will be too short.
Selection of ARV treatment regimens for programmes and individual patients should consider: potency, frequency of dosage, side effects, maintenance of future treatment options, the anticipated adherence of the patient population to a regimen, need for storage, concurrent conditions, the potential for resistant viral strains, and cost and access.
www.who.int /hiv/topics/arv/en/index.html   (988 words)

  
 NGC - NGC Summary
Antiretroviral drug resistance testing is recommended prior to initiation of therapy in all treatment-naïve children.
Antiretroviral therapy regimens must be individually tailored to the adolescent, as those with perinatal exposure generally have a very different clinical course and treatment history than those who acquired HIV during adolescence.
Antiretroviral regimens should be chosen based on treatment history and drug resistance testing to optimize antiretroviral drug potency in the second regimen.
www.guideline.gov /summary/summary.aspx?doc_id=9928&nbr=5323&ss=6&xl=999   (9931 words)

  
 Treatment of HIV Infection, NIAID Fact Sheet
Hence, antiretroviral drugs provide a way for the immune system to remain intact and effective, thereby improve the quality and duration of life for people with HIV.
The current recommended regimen involves taking several antiretroviral drugs each day from at least two different classes, some of which may require fasting and cause unpleasant side effects such as nausea and vomiting.
In addition, researchers are studying the long-term metabolic effects of various antiretroviral regimens in pregnant women and their infants and in HIV-infected children and adolescents.
www.niaid.nih.gov /factsheets/treat-hiv.htm   (1442 words)

  
 Leukine Extends Duration Of Antiretroviral Therapy In AIDS Patients   (Site not responding. Last check: )
Physicians were permitted to change antiretroviral therapy to manage the patient's viral load.
Among 115 patients with viral loads less than 30,000 copies/ml, 81 percent of the Leukine patients were able to remain on the same antiretroviral regimen and maintain baseline level of viral suppression throughout the duration of the study as compared to 62 percent of the patients receiving placebo.
One is a lack of patient adherence to the strict dosing regimens of antiretroviral drugs.
www.pslgroup.com /dg/fb492.htm   (802 words)

  
 FHI - Antiretroviral Therapy
Antiretroviral therapy (ART) has made a dramatic impact on the quality of life of people living with HIV/AIDS by decreasing the associated morbidity and mortality.
It is now a challenge to continue to advocate for decreased prices of these drugs and increased health service capacity to optimize their sustained, safe and effective use.
Combining at least three drugs from the various classes of ARVs into a "cocktail" typically produces a dramatic reduction in viral load (the level of virus in the blood) and prevents further immune damage.
www.fhi.org /en/Topics/Topics_Antiretroviral_Therapy.htm   (454 words)

  
 WHO | Antiretroviral Therapy
Important: addendum to 2006 WHO guidelines on "Antiretroviral therapy for HIV infection in adults and adolescents".
Standard antiretroviral therapy (ART) consists of the use of at least three antiretroviral (ARV) drugs to maximally suppress the HIV virus and stop the progression of HIV disease.
WHO has released a revised version of the guidelines on "Antiretroviral therapy for HIV infection in adults and adolescents: towards universal access Recommendations for a public health approach" in August 2006.
www.who.int /hiv/treatment/en   (493 words)

  
 Antiretroviral Therapy - Guidelines - HIV: health and medical information about HIV and AIDS   (Site not responding. Last check: )
Nowhere is this more evident than in the guidelines for when to start antiretroviral therapy for HIV.
Details of the most recent guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents can be found at www.hivatis.org.
Additionally, many people have an even greater concern that antiretroviral therapy may be contributing to certain body changes that have been described, such as sunken cheeks, thinning of the arms and legs, and an increase in waist size.
www.medicinenet.com /script/main/art.asp?articlekey=16494   (543 words)

  
 HIV Report November 2000 - Antiretroviral News from ICAAC 2000   (Site not responding. Last check: )
Similarly, suppression was seen in 88% of those with 0-5 selected PI mutations, 57% of those with 6-7 mutations, and 17% of those with 8-10 mutations.
LPV/RTV will be the only new antiretroviral agent approved by the FDA this year, and it clearly represents an important addition to our armamentarium.
The HAVANNA trial was a randomized, multicenter trial in which 326 participants with viral loads >1000 c/mL on a stable antiretroviral regimen for at least six months were first randomized to either a genotype test or standard of care arm [Tural, et al.
www.hopkins-aids.edu /publications/report/nov00_6.html   (3450 words)

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