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Topic: Aplasia

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	other alopecias - aplasia cutis congenita
		Aplasia cutis congenita is a developmental inherited defect and may occur at any time from the embryonic stage to very early childhood.
		Aplasia cutis congenita presenting as a familial triad of atrophic alopecia, ocular defects and a peculiar scarring tendency of the skin.
		Aplasia cutis congenita complicated by sagittal sinus hemorrhage.
	www.keratin.com /af/af006.shtml (712 words)

	eMedicine - Aplasia Cutis Congenita : Article by Mark A Crowe, MD (Site not responding. Last check: 2007-10-20)
		Background: Aplasia cutis congenita (ACC) is part of a heterogenous group of disorders first reported by Cordon in 1767 and is characterized by the absence of a portion of skin in a localized or widespread area at birth.
		Triplet areas of aplasia cutis congenita are common in infants with trisomy 13.
		Kelly BJ, Samolitis NJ, Xie DL, Skidmore RA: Aplasia cutis congenita of the trunk with fetus papyraceus.
	www.emedicine.com /derm/topic32.htm (3621 words)

	DermAtlas: Online Dermatology Image Library dermatology image,aplasia cutis congenita,malformation, ... (Site not responding. Last check: 2007-10-20)
		Aplasia cutis congenita (ACC) reflects a spectrum of cutaneous and subcutaneous tissue defects.
		This limited form of aplasia cutis congenita must be distinguished from traumatic ulceration from scalp electrode placement in the perinatal time period and congenital or neonatal herpes simplex infection.
		Areas of skin aplasia generally heal well, albeit with scarring, and infection — with the exception of extensive scalp ACC — is not usually a problem.
	dermatlas.med.jhmi.edu /derm/result.cfm?Diagnosis=231 (878 words)

	Aplasia Cutis Congenita
		Aplasia Cutis Congenita is a rare disorder that may be inherited as an autosomal dominant or autosomal recessive trait.
		Aplasia Cutis Congenita-Gastrointestinal is a rare disorder inherited as an autosomal recessive trait.
		This disorder is characterized by extensive Aplasia Cutis Congenita and the absence of a normal opening in the canal that goes from below the mouth to the stomach (esophagus), the tube-shaped part of the stomach, and/or the short part of the small intestine that joins the stomach (duodenum).
	hw.healthdialog.com /kbase/nord/nord901.htm (1480 words)

	Dentoskeletal Features Associated with Unilateral or Bilateral Palatal Displacement of Maxillary Canines
		Unilateral PDC was significantly associated with aplasia of upper lateral incisors, whereas bilateral PDC was associated with aplasia of third molars.
		One of the aims of the present study was to verify clinically the possible role of the size anomaly or aplasia of the upper lateral incisors as a local factor in the etiopathogenesis of PDC according to the so-called guidance theory.
		Finally, the existence of a significant reciprocal association between aplasia of the lateral incisor on one side of the upper dental arch and small-sized lateral incisor on the opposite side of the arch in the same subjects was corroborated.
	www.arabmedmag.com /issue-31-07-2004/dentistry/main03.htm (3963 words)

	Mullerian Aplasia
		Mullerian Aplasia is a rare birth defect characterized by the absence of the uterus, the cervix, and the upper part of the vagina at birth (congenital).
		Affected individuals are females with Mullerian Aplasia; renal abnormalities including absent (agenic) and/or improperly placed (ectopic) kidney(s); and abnormalities of the spinal cord, ribs, and/or arms due to improper development (dysplasia) of part of the embryo (cervicothoracic somite).
		For women with Mullerian Aplasia who also have absent (agenic) or improperly located (ectopic) kidneys, medical management and treatment is based upon the specifics of their case.
	hw.healthdialog.com /kbase/nord/nord1018.htm (2602 words)

	Is Pure Red-Cell Aplasia Linked to All Epo Products or Just Eprex?
		The diagnosis of pure red-cell aplasia was based on the characteristic appearance of the bone marrow and circulating blood.
		In all the patients studied, the red-cell aplasia was caused by an immune reaction against the therapeutic epo.
		Although the incidence of red-cell aplasia is low enough that it will probably not affect overall sales of epo, a problem with Eprex manufacturing could significantly benefit Amgen, especially with physicians offered the new choice of using Aranesp.
	www.bioportfolio.com /news/btech_021802_1.htm (1625 words)

	Pure Red Cell Aplasia - New Treatments, January 15, 2005 (Site not responding. Last check: 2007-10-20)
		Clinical features of pure red cell aplasia include anemia, reticulocytopenia, and an absence or paucity of recognizable red cell precursors in marrow.
		Pure red cell aplasia relatively frequent in chronic lymphocytic leukemia.
		About two-thirds of patients with pure red cell aplasia respond to some form of immunosuppression: steroids, azathioprine, cyclophosphamide, and 6-mercaptopurine first line; also ATG and cyclosporine.
	www.ccspublishing.com /journals5a/pure_red_cell_aplasia.htm (334 words)

	The Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins (Site not responding. Last check: 2007-10-20)
		Aplasia means less blood cells are made in the bone marrow.
		This condition is called "neutropenia" and is one part of "aplasia" or low blood cells.
		This condition is also called "thrombocytopenia" and is one part of "aplasia" or low blood cells.
	www.hopkinskimmelcancercenter.org /kpr/pted-a-patients-guide-to-aplasia.cfm (1328 words)

	Welcome to the TEF / Vater® Web Site!
		Radial aplasia is a birth defect of one of the two bones in the lower arm.
		So the diagnosis of radial aplasia means the radial bone in the arm did not grow.
		Radial aplasia and radial dysplasia are very common birth defects in the VATER association.
	www.tefvater.org /radialdir/aplasia.html (1574 words)

	Radial Aplasia and Distraction
		The degree of radial aplasia is related to the degree and time of insult to the developing fetus.
		Premature closure of the ulna physis presumably from the centralization procedure at a young age was responsible for the inability of the affected forearm to keep up with growth.
		The current treatment for radial aplasia is centralization of the carpus on the distal ulna.
	www.limblength.com /pubs/articles/radial/radial.htm (3619 words)

	Aplasia cutis congenita. DermNet NZ
		Aplasia cutis (sometimes called ‘aplasia cutis congenita’) is a condition where a newborn child is missing skin from certain areas.
		Membranous aplasia cutis is the term used when there is an underlying flat, white membrane, which overlies a defect in the skull.
		Aplasia cutis affecting the limbs may be associated with the death of a twin fetus (papyreous fetus)
	www.dermnetnz.org /lesions/aplasia-cutis.html (289 words)

	Donor Leukocyte Infusion for Leukemic Relapse After Allogeneic Marrow Transplantation: Lack of Residual Donor ...
		No aplasia occurred in these patients after DLI, whereas in the two patients with exclusively recipient hematopoiesis severe aplasia lasting for 5 and 13 weeks necessitated hematopoietic stem cell support.
		However, there is evidence that patients with acute leukemia who received donor leukocytes in chemotherapy-induced remission or with CML in cytogenetic relapse are less prone to aplasia than patients in advanced stage of CML or in relapse of acute leukemia.
		donor cells, prolonged aplasia must be expected and an early infusion of donor BM or PB stem cells seems to be necessary to reduce DLI-associated morbidity and mortality.
	www.bloodjournal.org /cgi/content/full/89/9/3113 (3783 words)

	Dorlands Medical Dictionary
		Michel's aplasia, lack of development of the inner ear, which causes Michel's deafness.
		It occurs as either a primary chronic form (congenital hypoplastic anemia), in chronic forms secondary to immune disorders, or in an acute form that is self-limited and associated with drugs or infection.
		thymic aplasia, absence of the thymus gland, as in DiGeorge's syndrome.
	www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_a_53zPzhtm (1754 words)

	MURCS Association
		This rare disorder is characterized by the absence of the cervix, uterus, and upper part of the vagina (Mullerian Aplasia); kidney (renal) abnormalities; and/or malformations of the arms, ribs, and/or portions of the spinal column.
		In almost all cases, affected females exhibit Mullerian Aplasia, which is characterized by the absence of the uterus, the cervix, and the upper part of the vagina at birth (congenital).
		The diagnosis of MURCS Association may be confirmed when Mullerian Aplasia is found to occur in association with absence (agenesis) and/or improper placement (ectopia) of the kidneys, abnormalities of upper vertebrae in the spinal column, and/or malformations of the ribs and/or arms.
	hw.healthdialog.com /kbase/nord/nord1059.htm (2936 words)

	Ear, Nose & Throat Journal: Concomitant vagal neurofibroma and aplasia of the internal carotid artery in ...
		To our knowledge, this is the first report in the literature of these two disorders occurring in the same patient and the first report of an ICA aplasia in a patient with neurofibromatosis type 1.
		When symptoms are present, they are caused by cerebrovascular insufficiency, compression of the brain by vessels that were dilated to compensate for the absence of the ICA, or the presence of an aneurysm.
		Aside from the presence of the mass, she was asymptomatic, except for the minimal motor deficit in her right upper extremity.
	www.findarticles.com /p/articles/mi_m0BUM/is_10_80/ai_80193513 (1427 words)

	Unilateral Semicircular Canal Aplasia in Goldenhar's Syndrome -- Lemmerling et al. 21 (7): 1334 -- American Journal of ...
		dysplasia) and unilateral aplasia of all semicircular canals
		labyrinth with unilateral aplasia of the semicircular canals
		The observation of unilateral semicircular canal aplasia in
	www.ajnr.org /cgi/content/full/21/7/1334 (1385 words)

	Pure Red Cell Aplasia
		Background: Pure red cell aplasia (PRCA) describes a condition in which there is a near absence of red blood cell precursors in bone marrow, while megakaryocytes and white blood cell precursors usually are present at normal levels.
		Freedman MH: Pure red cell aplasia in childhood and adolescence: pathogenesis and approaches to diagnosis.
		Handgretinger R, Geiselhart A, Moris A: Pure red-cell aplasia associated with clonal expansion of granular lymphocytes expressing killer-cell inhibitory receptors.
	thymoma.de /prca.htm (5337 words)

	References (Site not responding. Last check: 2007-10-20)
		Fisher M, Schneider R. Aplasia cutis congenita in three successive generations.
		Epidermolisis bulosa y aplasia cutis congénita (Sindrome de Bart).
		Sybert V. Aplasia cutis congenita: a report of 12 new families and review of the literature.
	www.medscape.com /content/2003/00/46/18/461827/461827_ref.html (175 words)

	Journal of Bone and Joint Surgery: Radial dysplasia with localised cutis aplasia congenita (Site not responding. Last check: 2007-10-20)
		The cutis aplasia was diagnosed at birth in all cases, but the radial dysplasia was not recognised until presentation to our orthopaedic department between the ages of 5 and 10 years.
		Radial dysplasia describes a spectrum of osseous, musculotendinous, and neurovascular dysplasias of the pre-axial border of the upper limb, and is the most common form of longitudinal deficiency.
		Cutis aplasia congenita involves an ulcerated area lacking in normal skin formation, present at birth.
	www.findarticles.com /p/articles/mi_qa3767/is_200301/ai_n9209412 (388 words)

	Australasian Hair and Wool Research Society (Site not responding. Last check: 2007-10-20)
		Aplasia cutis congenita (ACC) is a congenital anomaly seen in 0.03% of live births.
		Aplasia cutis congenita may present at birth as a sharply circumscribed ulcer with a red
		aplasia includes the dura with lysis of the underlying skull.
	www.alopecia.com.au /alopecia/CB.nsf/0/AAC6E95E7FA540B6CA2568E0007782B7?OpenDocument (775 words)

	Zidovudine-induced pure red cell aplasia.
		We experienced a case of pure red cell aplasia induced by AZT.
		These results highly suggest that the AZT have caused pure red cell aplasia to this patient.
		Conclusion: Accordingly, physicians have to pay attention to the occurrence of pure red cell aplasia as well as megaloblastic anemia when treating HIV-infected patients with AZT.
	www.aegis.com /aidsline/1997/jan/M9715982.html (434 words)

	TheFetus.net - Aplasia cutis congenita -Steven Van Calenbergh, Ingrid Witters, Paul Casaer and Frank Van Calenbergh
		This is a case of antenatally detected aplasia cutis congenita.
		Aplasia cutis congenita is a developmental defect characterized by the absence of skin either localized or widespread.
		The most commonly involved region is the scalp, however multiple locations can be affected.
	www.thefetus.net /page.php?id=1446 (205 words)

	Bioline International Official Site (site up-dated regularly)
		Primary acquired pure red cell aplasia is a rare occurrence in childhood.
		All possible investigations were done to exclude secondary causes of pure red cell aplasia.
		Acquired pure red cell aplasia (PRCA) is a disease characterised by normocytic, normochromic anaemia, low haematocrit, reticulocytopaenia and selective erythroid hypoplasia.
	www.bioline.org.br /request?jp02011 (1166 words)

	eMedicine - Pure Red Cell Aplasia : Article by Paul Schick, MD
		Background: Pure red cell aplasia (PRCA) describes a condition in which RBC precursors in bone marrow are nearly absent, while megakaryocytes and WBC precursors are usually present at normal levels.
		Handgretinger R, Geiselhart A, Moris A, et al: Pure red-cell aplasia associated with clonal expansion of granular lymphocytes expressing killer-cell inhibitory receptors.
		Isomoto H, Fukuda Y, Bando Y, et al: Pure red cell aplasia associated with parvovirus B19 infection in a patient with ulcerative colitis.
	www.emedicine.com /med/topic1967.htm (6084 words)

	Reversible zidovudine-induced pure red-cell aplasia.
		In five of these 10 patients the mean cell volume did not increase but remained within the normal range.
		In all five patients the anaemia resolved on discontinuation of the drug and in three that were re-challenged, the anaemia recurred.
		Zidovudine-induced anaemia has usually been reported as macrocytic and megaloblastic, but in our experience erythroid aplasia appears to be a major cause of anaemia occurring within the first 3 months of treatment.
	www.aegis.com /aidsline/1989/aug/M8980191.html (382 words)

	Aplasia Cutis Congenita
		It is possible that the main title of the report Aplasia Cutis Congenita is not the name you expected.
		Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
		Aplasia Cutis Congenita is a rare disorder with a complicated pattern of inheritance.
	my.webmd.com /hw/raising_a_family/nord901.asp (408 words)

	Anemia Management News - RenalWEB Dialysis Nephrology Kidney Discussion Boards
		The Canadian PRCA Focus Group found that Eprex lacking human serum albumin and administered subcutaneously was associated with the greatest risk of PRCA (26.9 case per 100,000 patient-years of exposure).
		May 31, 2004 - Immunosuppressive therapy appears to accelerate recovery from pure red cell aplasia induced by recombinant human erythropoietin treatment among patients with anaemia related to chronic kidney disease, according to the findings of a retrospective study appearing in Lancet.
		Such labeling changes might indicate aplasia has been seen in kidney failure patients who have received injections of the drug, but rarely with those receiving intravenous infusions.
	www.renalweb.com /ubb/Forum15/HTML/000398.html (1273 words)

	Low-dose cyclosporin therapy for recombinant erythropoietin-induced pure red-cell aplasia -- Duffield et al. 19 (2): ...
		Pure red-cell aplasia (PRCA) is an uncommon condition.
		Treatment of refractory pure red cell aplasia with cyclosporine A: disappearance of IgG inhibitor associated with clinical response.
		Lacy MQ, Kurtin PJ, Tefferi A. Pure red cell aplasia: association with large granular lymphocyte leukemia and the prognostic value of cytogenetic abnormalities.
	ndt.oxfordjournals.org /cgi/content/full/19/2/479 (1114 words)

	Treatment of cervical aplasia by a graft of peritoneum (Site not responding. Last check: 2007-10-20)
		Objective:To evaluate efficacy of a graft of peritoneum for cervical aplasia.
		This patient had congenital absence of upper two third of vagina and cervical aplasia.
		This report presents a new technique using a graft of peritioneum which was successful in treatment of two such cases.
	royaninstitute.org /seminar01/SeAwAbs-09.htm (226 words)

	NEJM -- Pure Red-Cell Aplasia and Antierythropoietin Antibodies in Patients Treated with Recombinant Erythropoietin
		Asari, A., Gokal, R. Pure Red Cell Aplasia Secondary to Epoetin alpha Responding to Darbepoetin Alpha in a Patient on Peritoneal Dialysis.
		Schonholzer, C., Keusch, G., Nigg, L., Robert, D., Wauters, J.-P. High prevalence in Switzerland of pure red-cell aplasia due to anti-erythropoietin antibodies in chronic dialysis patients: report of five cases.
		Autoantibodies against granulocyte-macrophage colony stimulating factor and interleukin-3 are rare in patients with Felty's syndrome.
	content.nejm.org /cgi/content/short/346/7/469 (1421 words)

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