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Topic: Apolipoproteins

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Apolipoprotein B

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	CiteULike: Immunoturbidimetric assays of apolipoproteins A, AI, AII, and B in serum. (Site not responding. Last check: 2007-11-06)
		CiteULike: Immunoturbidimetric assays of apolipoproteins A, AI, AII, and B in serum.
		Immunoturbidimetric assays of apolipoproteins A, AI, AII, and B in serum.
		Reference intervals for the four apolipoproteins were determined by using sera from 193 apparently healthy individuals.
	www.citeulike.org /user/biblio24/article/803722 (267 words)

	Apolipoprotein - Wikipedia, the free encyclopedia
		Apolipoproteins are a class of apoproteins, which are proteins that depend on the presence of other small molecules, or cofactors, to function.
		Thus, apolipoproteins are the protein constituents of lipoproteins, which also consist of phospholipids, triacylglycerols, cholesterol, and cholesterol esters.
		Apolipoprotein synthesis is affected by the addition of Nicotinic Acid (a form of the vitamine niacin).
	en.wikipedia.org /wiki/Apolipoprotein (401 words)

	Process for the manufacture of apolipoproteins from human blood plasma or serum - Patent 5089602 (Site not responding. Last check: 2007-11-06)
		The process according to claim 1, wherein the apolipoprotein containing phase is brought to a higher concentration of apolipoproteins by membrane filtration, lyophilization, precipitation at pH 5 to 6, or by addition of a lower aliphatic alcohol, a water-soluble salt or a polymeric substance, or by adsorption to and elution from a solid carrier material.
		Apolipoproteins prepared according to the present method may be used for the prophylaxis and therapy of cardiovascular diseases or for the manufacture of pharmaceutical preparations used for this purpose.
		The residue was mixed with 10 g of apolipoprotein dissolved in 10 L of phosphate buffer and 930 g of sodium cholate; the mixture was incubated for 30 minutes at 24.degree.
	www.freepatentsonline.com /5089602.html (4342 words)

	CiteULike: Measurement of apolipoproteins B and A by radial immunodiffusion: methodological assessment and clinical ... (Site not responding. Last check: 2007-11-06)
		Measurement of apolipoproteins B and A by radial immunodiffusion: methodological assessment and clinical applications.
		The clinical evaluation of apolipoproteins is of interest in order to characterize the risk profile for ischemic heart disease both in normolipidemic and hyperlipidemic subjects.
		In this work several methodological questions concerning the measurement of plasma apolipoproteins B and A by radial immunodiffusion have been addressed; the results show that this method is particularly reliable for the apo B assay.
	www.citeulike.org /user/biblio24/article/803733 (367 words)

	Reference Materials for the Standardization of the Apolipoproteins A
		Until recently, the large-scale introduction of apolipoprotein measurement was hampered by the lack of reference materials and methods which resulted in the use of different calibration methods and a lack of comparability of results (27, 28).
		Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Québec Cardiovascular Study.
		Apolipoprotein B and apolipoprotein A-I as predictors of coronary artery disease.
	www.ifcc.org /ejifcc/vol13no3/130301003.htm (3289 words)

	Exploiting the Vascular Protective Effects of High-Density Lipoprotein and its Apolipoproteins: An Idea Whose Time for ...
		encoded by exon 4 of the apolipoprotein A-I gene.
		the regression of aortic atheromatosis in cholesterol-fed apolipoprotein
		efflux to apolipoprotein A-I/HDL or increasing the hepatic uptake
	circ.ahajournals.org /cgi/content/full/104/20/2498 (3939 words)

	Research Interests Lipoproteins (Site not responding. Last check: 2007-11-06)
		Apolipoproteins modulate all those processes by means of their lipid-binding ability, rate and extent of binding, and their structure.
		Therefore, the molecular properties of the apolipoproteins define the physiological role of lipoproteins and the homeostasis of the lipid metabolism, in general.
		A full understanding of the driving forces that control binding, and the identification and characterization of the functional domains of the apolipoproteins is necessary to understand the physiology and pathology of the metabolic pathways where apolipoproteins are involved.
	opbs.okstate.edu /~soulages/projects.htm (356 words)

	Apolipoproteins better than cholesterol for predicting cardiovascular disease?
		The authors comment how the results of four large prospective studies have shown that apolipoprotein B is superior to total cholesterol or LDL cholesterol to predict the risk of vascular disease.
		Based on their review of results from large statin trials apolipoproteins are also thought to be more sensitive markers than LDL cholesterol for people using statins.
		However, data now suggest that values of apolipoprotein B and the apolipoprotein B/apolipoprotein A-1 ratio are more sensitive indices of risk of vascular disease-and are more robust predictors of future vascular events for patients on statin therapy-than concentrations of LDL cholesterol, non-HDL cholesterol, or the LDL/HDL cholesterol ratio.
	www.eurekalert.org /pub_releases/2003-02/l-abt022603.php (324 words)

	Stability of Plasma Total Cholesterol, Triglycerides, and Apolipoproteins B and A-I During the Early Postmortem Period
		The stability of plasma lipids and apolipoproteins during the early postmortem period was studied by taking four duplicate blood samples from eight cadavers 2, 6, 12, and 24 h after death.
		The bodies were kept at +4°C. The plasma samples were analyzed for total cholesterol (TC), triglycerides (TG), apolipoprotein B (apo B), and apolipoprotein A-I (apo A-I).
		The results indicate that unpredictable fluctuations occur in plasma lipid and apolipoprotein values within 24 h after death, and they should be interpreted cautiously if the samples have been taken after a prolonged postmortem period.
	www.astm.org /DIGITAL_LIBRARY/JOURNALS/FORENSIC/PAGES/1419.htm (512 words)

	Focus On... Apolipoproteins
		In recent years, researchers have focused on the apolipoprotein component of Lp(a) and have found that these lipid-protein complexes are independently associated with atherosclerosis, thrombosis, and CAD.
		Other lipid and apolipoprotein components vary considerably in the LDL complex, but they all interact to maintain the apo B molecule in a specific spatial orientation for receptor binding.
		Apolipoprotein E (apoE) is another lipid-protein complex that plays a role in the pathogenesis of heart disease.
	members.aol.com /mysty1/apolipo.html (2001 words)

	MedlinePlus Medical Encyclopedia: Apolipoprotein B100
		Apolipoprotein B100 measures the amount of apolipoprotein B100 (apoB100) in the blood.
		Apolipoproteins are proteins on the surface of the lipoprotein complex that bind to specific enzymes or transport proteins on the cell membranes -- this directs the lipoprotein to the proper site of metabolism.
		Apolipoprotein levels can be measured directly, unlike HDL and LDL measurements, which are indirect.
	www.nlm.nih.gov /medlineplus/ency/article/003502.htm (621 words)

	VLDL, Apolipoproteins B, CIII, and E, and Risk of Recurrent Coronary Events in the Cholesterol and Recurrent Events ... (Site not responding. Last check: 2007-11-06)
		Logistic discriminant analysis of lipids and apolipoproteins in a population of coronary bypass patients and the significance of apolipoproteins C-III and E. Atherosclerosis.
		Apolipoproteins C-III and E in apoB- and non-apoB-containing lipoproteins in two populations at contrasting risk for myocardial infarction: the ECTIM study.
		Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia.
	www.circ.ahajournals.org /cgi/content/full/102/16/1886 (4258 words)

	Coronary Heart Disease Prediction From Lipoprotein Cholesterol Levels, Triglycerides, Lipoprotein(a), Apolipoproteins ... (Site not responding. Last check: 2007-11-06)
		Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease: the ARIC Study.
		Quantitation of plasma apolipoproteins in the primary and secondary prevention of coronary artery disease.
		Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Quebec Cardiovascular Study.
	circ.ahajournals.org /cgi/content/full/104/10/1108 (4289 words)

	Protein Folding in the Boston University's Department of Physiology and Biophysics (Site not responding. Last check: 2007-11-06)
		Exchangeable apolipoproteins are soluble protein components of lipoproteins that mediate cholesterol transport and metabolism and play crucial roles in the pathogenesis of atherosclerosis and several other major human disorders, including amyloidosis.
		This distinct adaptability is key to apolipoproteins functions and is attributed to re-folding and re-packing of the constituent amphipathic alpha-helices.
		Our laboratory is interested in elucidating the details of chaperone-assisted folding of apolipoprotein B (apoB) whose correct folding involves its assembly with lipids to form very low density lipoprotein (VLDL), the precursors of low density lipoproteins (LDL).
	biophysics.bumc.bu.edu /researchfacility/proteinfolding (559 words)

	Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during ...
		Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development -- Babin et al.
		Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development
		Apolipoprotein E (apoE) is associated with several classes of plasma lipoproteins and mediates uptake of lipoproteins through
	www.pnas.org /cgi/content/full/94/16/8622 (3699 words)

	Segregation Analysis of Apolipoproteins A-1 and B-100 Measured Before and After an Exercise Training Program : The ... (Site not responding. Last check: 2007-11-06)
		Inheritance of plasma apolipoprotein B levels in families of patients undergoing coronary arteriography at an early age.
		Genetic determination of high-density lipoprotein-cholesterol and apolipoprotein A-1 plasma levels in a family study of cardiac catheterization patterns.
		Linkage and segregation analyses of apolipoprotein A1 and B, and lipoprotein cholesterol levels in a large pedigree with excess coronary heart disease: the Bogalusa heart study.
	atvb.ahajournals.org /cgi/content/full/20/3/807 (4247 words)

	McGill Centre for Studies in Aging
		Apolipoprotein C-I expression in the brain in Alzheimer’s disease (2002).
		(2003) Apolipoprotein E and cholesterol metabolism in the pathophysiology and treatment of of Alzheimer’s disease.
		Apolipoprotein E: “A novel therapeutic target for the treatment of Alzheimer’s disease.
	www.aging.mcgill.ca /pub.htm (7201 words)

	Amazon.com: Apolipoprotein E polymorphism is related to plasma lipids and apolipoproteins in Mexican adolescents. : An ... (Site not responding. Last check: 2007-11-06)
		Amazon.com: Apolipoprotein E polymorphism is related to plasma lipids and apolipoproteins in Mexican adolescents.
		Apolipoprotein E polymorphism is related to plasma lipids and apolipoproteins in Mexican adolescents.
		Apolipoprotein E (apoE protein; APOE gene) in conjunction with apolipoprotein B (apoB) plays an important physiological role in the regulation of overall cholesterol homeostasis and concentration of lipoproteins in plasma (Mahley 1988; Rall and Mahley 1992).
	www.amazon.com /exec/obidos/tg/detail/-/B000973HZE?v=glance (296 words)

	TOTAL CHOLESTEROL:HDL RATIO IS VALIDATED AS A POWERFUL MI PREDICTOR - Journal Watch (General)
		Levels of a number of lipoproteins and apolipoproteins have been found to predict the risk of myocardial infarction, but few large studies have used multivariate techniques to evaluate each marker independently of the others.
		The apolipoproteins and the HDL subfractions had little independent predictive power in the multivariate analysis once the total cholesterol:HDL ratio was considered.
		Stampfer MJ et al A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction N Engl J Med 1991 Aug 8; 325:373-381.
	general-medicine.jwatch.org /cgi/content/full/1991/813/1 (268 words)

	HDL Apolipoproteins and ABCA1: Partners in the Removal of Excess Cellular Cholesterol -- Oram 23 (5): 720 -- ... (Site not responding. Last check: 2007-11-06)
		Effects of enrichment of fibroblasts with unesterified cholesterol on the efflux of cellular lipids to apolipoprotein A-I. J Biol Chem.
		Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway.
		Apolipoprotein binding to protruding membrane domains during removal of excess cellular cholesterol.
	atvb.ahajournals.org /cgi/content/full/23/5/720 (5190 words)

	Apolipoproteins A-I and A-II are potentially important effectors of innate immunity in the teleost fish Cyprinus carpio ... (Site not responding. Last check: 2007-11-06)
		Apolipoproteins A-I and A-II are potentially important effectors of innate immunity in the teleost fish Cyprinus carpio -- Concha et al.
		Apolipoproteins A-I and A-II are potentially important effectors of innate immunity in the teleost fish Cyprinus carpio
		Srinivas, R.V., Venkatachalapathi, Y.V., Rui, Z., Owens, R.J., Gupta, K.B., Srinivas, S.K., Anantharamaiah, G.M., Segrest, J.P. and Compans, R.W. (1991) Inhibition of virus-induced cell fusion by apolipoprotein A-I and its amphipathic peptide analogs.
	content.febsjournal.org /cgi/content/full/271/14/2984 (4044 words)

	Quantitation of Plasma Apolipoproteins in the Primary and Secondary Prevention of Coronary Artery Disease -- Rader et ...
		The role of apolipoprotein E and lipoprotein receptors in modulating the in vivo metabolism of apolipoprotein B-containing lipoproteins in humans.
		Apolipoprotein A-I deficiency due to a codon 84 nonsense mutation of the apolipoprotein A-I gene.
		Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease.
	www.annals.org /cgi/content/full/120/12/1012 (8929 words)

	Are apolipoproteins the key to heart attack risk? - Swedish Medical Center, Seattle, Washington (Site not responding. Last check: 2007-11-06)
		They were trying to determine if levels of apolipoprotein B (apoB) and apolipoprotein A-1 (apoA-1) are better predictors of fatal heart attack than high LDL cholesterol, high triglycerides, and low HDL cholesterol.
		High apolipoprotein B, low apolipoprotein A-1, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study.
		Apolipoproteins B and A-1 as predictors of risk of coronary artery disease.
	www.swedish.org /17824.cfm (817 words)

	NEJM -- A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction
		The independent contributions of subfractions of high-density lipoprotein (HDL) cholesterol (HDL2 and HDL3) and apolipoproteins in predicting the risk of myocardial infarction are unclear.
		The levels of total cholesterol and apolipoprotein B-100 were significantly associated with an increased risk of myocardial infarction (data on levels of low-density lipoprotein cholesterol were unavailable).
		However, the levels of HDL subfractions and apolipoproteins did not add significantly to the value of a multivariate model that included the ratio of total to HDL cholesterol in predicting myocardial infarction, whereas that ratio remained a significant independent predictor of risk.
	content.nejm.org /cgi/content/abstract/325/6/373 (3451 words)

	Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a) -- Hartgens et al. 38 (3): 253 -- ...
		Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a) -- Hartgens et al.
		Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a)
		apolipoprotein B (Apo-B), and lipoprotein (a) (Lp(a)) were determined.
	bjsm.bmjjournals.com /cgi/content/abstract/38/3/253 (439 words)

	Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein -- Pankhurst et ...
		of apolipoproteins occurred (26, 28), as characterized by decreasing
		Data are shown as percent of total apolipoprotein peak area and represent means ± SE of three separate experiments.
		Secondary radicals derived from chloramines of apolipoprotein B-100 contribute to HOCl-induced lipid peroxidation of low-density lipoproteins.
	www.jlr.org /cgi/content/full/44/2/349 (4240 words)

	Monoclonal Antibodies, Polyclonal Antibodies, Antigens, Apolipoproteins - Product Category
		Apolipoproteins are mostly formed in the liver and intestine, and play an important role in the production and transport of cholesterol around the body.
		There are at least nine types of apolipoproteins, including apo A-1, apo B and apo E. Each type bonds with cholesterol in the blood - either the protective cholesterol, known as High Density Lipoproteins (HDL), or the more harmful cholesterol, Low Density Lipoproteins (LDL).
		Levels of different apolipoproteins are linked to differing risks of coronary heart disease, diabetes or stroke.
	www.amsbio.com /ProdCat.aspx?CatID=Apolipoproteins (138 words)

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