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Topic: Apolipoprotein B

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Apolipoprotein B

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	NEJM -- Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with ...
		NEJM -- Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with cerebrotendinous xanthomatosis.
		Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with cerebrotendinous xanthomatosis.
		Apolipoprotein AIV and apolipoprotein E concentrations were comparable to those in controls, and apolipoprotein AII was considerably decreased.
	content.nejm.org /cgi/content/abstract/316/20/1233 (461 words)

	Apolipoprotein Assessment
		When apo A-1, apo B, lipids, and lipoprotein cholesterol were measured in school-aged children (mean age of 10 years), apo A-1 and apo B levels were associated with a history of myocardial infarction in their parents.
		Maciejko has suggested apo B levels are helpful in differentiating primary causes of hypertriglyceridemia, provided that secondary causes (diabetes, alcohol ingestion, uremia, acromegaly, emotional stress or stress from acute illness, and certain drugs such as estrogen or beta blockers) have been ruled out.
		Apo B measurements will also provide laboratory evidence of hyperapobetalipoproteinemia with excess apo B, whereas apo B deficiency states are found in abetalipoproteinemia, hypobetalipoproteinemia, familial hypobetalipoproteinemia with chylomicronemia, and abetalipoproteinemia with normotriglyceridemia.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/sc002200.htm (857 words)

	Reagents for enzyme immunoassay for apolipoprotein B - Patent 4722893
		In view of the fact that apolipoprotein B, as the major apoprotein component of LDL, represents as much as about 98% of the total apoprotein contents of LDL, the present inventors contemplated measuring apolipoprotein B concentration accurately and on a mass measurement basis to provide a marker as to the atherogenesity of LDL concentration.
		That is, the peroxidase-labeled Fab' is bound to the apolipoprotein B which is in bond with the IgG on the polystyrene ball.
		The apolipoprotein B is prepared by refining LDL (low-density lipoprotein) fractionated by centrifugation from human serum, further refinement being carried out by such method as dialysis or column chromatography.
	www.freepatentsonline.com /4722893.html (3484 words)

	Apo B (Site not responding. Last check: 2007-11-02)
		The Apo B Test is designed for the quantitative measurement of apolipoprotein B in human plasma.
		During a 30 minute incubation, the monoclonal antibody binds to either the immobilized apo B or to the soluble apo B, hence the notion of competitive binding.
		Expected values for apo B in male subjects are reported to be 108 +/- 33 mg/dl for individuals free of coronary artery disease (CAD), and 131 +/- 37 for subjects with angiographically documented premature CAD.
	www.exocell.com /apoB.html (242 words)

	Apolipoprotein B antibody (ab13993) datasheet (Site not responding. Last check: 2007-11-02)
		If Apolipoprotein B antibody (ab13993) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund.
		Apolipoprotein B consists of a single polypeptide chain with a molecular weight of 549 kDa and is mostly synthesised in the liver.
		Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis.
	www.abcam.com /?datasheet=13993 (335 words)

	Apolipoprotein B gene polymorphisms and serum lipids: meta-analysis of the role of genetic variation in responsiveness ...
		Apolipoprotein B gene variants are involved in the determination of serum cholesterol levels: a study in normo- and hyperlipidaemic individuals.
		Apolipoprotein B signal peptide insertion/deletion polymorphism is associated with Ag epitopes and involved in the determination of serum triglyceride levels.
		Apolipoprotein B gene DNA polymorphisms are associated with macro- and microangiopathy in non-insulin-dependent diabetes mellitus.
	www.ajcn.org /cgi/content/full/71/3/713 (5866 words)

	Reference Materials for the Standardization of the Apolipoproteins A
		Until recently, the large-scale introduction of apolipoprotein measurement was hampered by the lack of reference materials and methods which resulted in the use of different calibration methods and a lack of comparability of results (27, 28).
		Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Québec Cardiovascular Study.
		Apolipoprotein B and apolipoprotein A-I as predictors of coronary artery disease.
	www.ifcc.org /ejifcc/vol13no3/130301003.htm (3289 words)

	Clinical Trial: Hyperapo B and Coronary Heart Disease
		To determine the role of apolipoprotein B and apolipoprotein A1 in the etiology of coronary artery disease.
		Hyperapo B is a phenotype defined as elevated plasma level of the major apoprotein B of low density lipoproteins in the presence of a normal plasma level of low density lipoprotein cholesterol.
		To determine if apolipoprotein B and apolipoprotein A levels aggregated in families and to determine if hyperapo B and hypoalphalipoproteinemia segregated as Mendelian traits, genetic analysis was conducted in the 200 index cases and the 900 first degree relatives.
	clinicaltrials.gov /show/NCT00005168 (995 words)

	HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: A potential mechanism for protease ...
		Thus murine models of apolipoprotein B biogenesis are currently inadequate to fully address production of these lipoproteins in vivo, particularly with regard to the subcellular events that lead to degradation of ApoB in response to lipid status.
		b, RTV-mediated alterations in neutral-lipid synthesis in mouse hepatocytes in the presence or absence of OA.
		The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70.
	www.nature.com /nm/journal/v7/n12/full/nm1201-1327.html (3678 words)

	Association of an Apolipoprotein B Gene Marker With Essential Hypertension -- Frossard et al. 33 (4): 1052 -- ... (Site not responding. Last check: 2007-11-02)
		Ye P, Chen B, Wang S. The association of polymorphisms at a VNTR locus 3' to the apolipoprotein B gene with coronary heart disease in Chinese population.
		Variation of apolipoprotein B gene is associated with myocardial infarction and lipoprotein levels in Danes.
		Association of mutations in the apolipoprotein B gene with hypercholesterolemia and the risk of ischemic heart disease.
	hyper.ahajournals.org /cgi/content/full/33/4/1052 (2812 words)

	A Truncated Species of Apolipoprotein B (B-38.7) in a Patient With Homozygous Hypobetalipoproteinemia Associated With ... (Site not responding. Last check: 2007-11-02)
		Apolipoprotein B-38.9 does not associate with apo (a) and forms two distinct HDL density particle populations that are larger than HDL.
		Apo B gene nonsense and splicing mutations in a compound heterozygote for familial hypobetalipoproteinemia.
		Apolipoprotein B-32: a new truncated mutant of human apolipoprotein B capable of forming particles in the low density lipoprotein range.
	atvb.ahajournals.org /cgi/content/full/18/8/1330 (3145 words)

	APOLIPOPROTEIN B
		LDL and its major protein, apolipoprotein B, play an essential role in lipid transport and metabolism.
		Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG Co A reductase.
		Apo B may be important in the genesis of atherosclerosis and its quantitation useful in the evaluation of patients at risk for or having coronary atherosclerosis (CAD).
	www.mgh.org /lab/CATALOG/TESTS/988.HTM (87 words)

	Plasma Apolipoprotein B-48, Hepatic Apolipoprotein B mRNA Editing and Apolipoprotein B mRNA Editing Catalytic Subunit-1 ... (Site not responding. Last check: 2007-11-02)
		Percentage of hepatic apolipoprotein B (apoB) mRNA editing in zinc-adequate (ZA), zinc-deficient (ZD) and zinc-replenished (ZDA) rats as determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and subsequent primer extension analysis.
		Hepatic apolipoprotein B (apoB) mRNA abundance in zinc-adequate (ZA), zinc-deficient (ZD) and zinc-replenished (ZDA) rats.
		Hepatic apolipoprotein B mRNA editing catalytic subunit 1 (apobec-1) mRNA abundance in zinc-adequate (ZA), zinc-deficient (ZD) and zinc-replenished (ZDA) rats.
	www.nutrition.org /cgi/content/full/129/10/1855 (4927 words)

	Insights into Apolipoprotein B Biology from Transgenic and Gene-Targeted Mice -- Véniant et al. 129 (2): 451 -- ... (Site not responding. Last check: 2007-11-02)
		Callow M. J., Rubin E. Site-specific mutagenesis demonstrates that cysteine 4326 of apolipoprotein B is required for covalent linkage with apolipoprotein(a) in vivo.
		Apolipoprotein B mRNA editing in 12 different mammalian specieshepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins.
		Nielsen L. B., Véniant M., Hamilton R. L., Borén J., Wong J. S., Tam C., Flynn L., Gunn M. D., Sanan D., Goldberg I., Young S. The genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heartindications that the heart has capacity to synthesize and secrete lipoproteins.
	www.nutrition.org /cgi/content/full/129/2/451S (3963 words)

	Clinical Trial: Epidemiology of Genetic Factors in Lipid Metabolism
		The apolipoprotein B and apolipoprotein E genes were selected because of their central role in lipid metabolism and interaction with dietary factors.
		Data collected from these families permitted the partitioning of the effects of the apolipoprotein B and E genes from the overall polygenetic and phenotypic variance of the measured lipids, lipoproteins, and apolipoproteins.
		A determination was made of the effects of apolipoprotein E and B genes, disease status, age, and their interactions on fasting and postprandial lipid metabolism.
	clinicaltrials.gov /show/NCT00005214 (1134 words)

	The apolipoprotein B R3531C mutation: characteristics of 24 subjects from 9 kindreds -- Pullinger et al. 40 (2): 318 -- ...
		The apolipoprotein B R3531C mutation: characteristics of 24 subjects from 9 kindreds -- Pullinger et al.
		B: Detection of novel conserved mutations, N3542N and T3540T in fragment I. C: Analysis of fragment III during screening of patients with LDL of low binding affinity revealed only the presence of the Q3405E polymorphism.
		R3531C Mutation in the Apolipoprotein B Gene Is Not Sufficient to Cause Hypercholesterolemia
	www.jlr.org /cgi/content/full/40/2/318 (4997 words)

	The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay (Site not responding. Last check: 2007-11-02)
		The antibiotic leptomycin B is a potent inhibitor of exportin 1-mediated nuclear export pathways and is used to dissect protein export processes (Wolff et al., 1997).
		Lau PP, Xiong WJ, Zhu HJ, Chen SH and Chan L (1991) Apolipoprotein B mRNA editing is an intranuclear event that occurs posttranscriptionally coincident with splicing and polyadenylation.
		Wolff B, Sanglier J-J and Wang Y (1997) Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA.
	www.nature.com /emboj/journal/v22/n15/full/7590779a.html (7771 words)

	Apolipoprotein B and AI distributions in the United States, 1988—1991: results of the National Health and Nutrition ... (Site not responding. Last check: 2007-11-02)
		B in the three ethnic groups are shown in Fig.
		Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease.
		Measurement of apolipoprotein B in plasma from hyperlipidemic subjects treated with cholestyramine or placebo: differential effects of storage at -70 °C. Clin Chem 1989;35:380-383.
	www.clinchem.org /cgi/content/full/43/12/2364 (8120 words)

	Palmitoylation of Apolipoprotein B Is Required for Proper Intracellular Sorting and Transport of Cholesteroyl Esters ...
		Palmitoylation of Apolipoprotein B Is Required for Proper Intracellular Sorting and Transport of Cholesteroyl Esters and Triglycerides -- Zhao et al.
		Apolipoprotein B (apoB) is an essential component of chylomicrons, very low density lipoproteins, and low density lipoproteins.
		Wang, C., Hobman, T.C., and Brindley, D.N. Degradation of apolipoprotein B in cultured rat hepatocytes occurs in a postendoplasmic reticulum compartment.
	www.molbiolcell.org /cgi/content/full/11/2/721 (7801 words)

	[No title]
		Elevated plasma levels of low density lipoprotein (LDL) and apolipoprotein B (apo B) are associated with a higher risk for atherosclerosis and coronary heart disease, a leading cause of mortality in the industrialized world.
		Apo B is the mandatory constituent of LDL particles.
		We have recently shown that the responsiveness of plasma apo B levels to dietary omega-3 fatty acids is genetically regulated in congenic human apo B mouse strains.
	cpmcnet.columbia.edu /dept/medicine/huangcv.html (795 words)

	Studies on the Translocation of the Amino Terminus of Apolipoprotein B into the Endoplasmic Reticulum -- Pease et al. ...
		Apolipoprotein (apo) B is either co-translationally assembled into lipoproteins, or becomes associated with the membrane of the endoplasmic reticulum (ER) and is subsequently degraded.
		Apolipoprotein B in the Rough Endoplasmic Reticulum: Translation, Translocation and the Initiation of Lipoprotein Assembly
		Intracellular Translocation and Stability of Apolipoprotein B Are Inversely Proportional to the Length of the Nascent Polypeptide
	www.jbc.org /cgi/content/abstract/270/13/7261 (624 words)

	Can Measurement of Apolipoprotein B Replace the Lipid Profile in the Follow-up of Patients with Lipoprotein Disorders? ...
		B to associate physically with triglycerides in the liver and
		mutations truncate apo B early in its sequence (2).
		B that arises from overproduction of apo B
	www.clinchem.org /cgi/content/full/48/3/401 (1561 words)

	FBR Resource Guide: Apolipoprotein B (APO B) (Site not responding. Last check: 2007-11-02)
		Apo B is the major protein associated with low density lipoprotein.
		Apo B is useful in evaluating coronary heart disease (CHD) risk and in monitoring treatment when CHD and/or high levels of apo B have been established.
		Apo B is also measured as part of the Protein profile/immunoassay (IA), Block I, and Block III.
	www.fbr.org /publications/resguide/rg-t_apob.html (130 words)

	Streptozotocin-induced diabetes in human apolipoprotein B transgenic mice: effects on lipoproteins and atherosclerosis ...
		Streptozotocin-induced diabetes in human apolipoprotein B transgenic mice: effects on lipoproteins and atherosclerosis -- Kako et al.
		Streptozotocin-induced diabetes in human apolipoprotein B transgenic mice: effects on lipoproteins and atherosclerosis
		Apolipoprotein CIII-induced hypertriglyceridemia is not mediated by effects on apolipoprotein E. Clin.
	www.jlr.org /cgi/content/full/40/12/2185 (5994 words)

	Apolipoprotein B antibody [069-04] (ab17778) datasheet (Site not responding. Last check: 2007-11-02)
		If Apolipoprotein B antibody [069-04] (ab17778) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund.
		Normal plasma apolipoprotein B levels are around 800mg/L. Alternative names for Apolipoprotein B antibody [069-04] (ab17778)
		Simultaneous quantification by double rocket immunoelectrophoresis of apolipoproteins A-I and B in blood spotted on filter paper.
	www.abcam.com /?datasheet=17778 (381 words)

	Apolipoprotein B mRNA-Editing Protein Induces Hepatocellular Carcinoma and Dysplasia in Transgenic Animals -- Yamanaka ...
		Apolipoprotein B mRNA-Editing Protein Induces Hepatocellular Carcinoma and Dysplasia in Transgenic Animals -- Yamanaka et al.
		Apolipoprotein B mRNA-Editing Protein Induces Hepatocellular Carcinoma and Dysplasia in Transgenic Animals
		Apolipoprotein (apo-) B mRNA editing is the deamination of cytidine that creates a new termination codon and produces a truncated version of apo-B (apo-B48).
	www.pnas.org /cgi/content/abstract/92/18/8483 (1550 words)

	Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion ...
		Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage -- Ihara et al.
		of apolipoprotein B, leading to the generation of fatty liver.
		Characterization of human apolipoprotein B100 oligosaccharides in LDL subfractions derived from normal and hyperlipidemic plasma: deficiency of {alpha}-N-acetylneuraminyllactosyl-ceramide in light and small dense LDL particles
	www.pnas.org /cgi/content/abstract/95/5/2526 (603 words)

	Lipids Online Slides: b, risk, Quebec Cardiovascular Study, diabetes
		High apo B was associated with CHD, and the presence of both high apo B and small, dense LDL was associated with a marked increase in CHD risk.
		One interpretation of these findings is that concomitant interventions should be used both to lower apo B, such as with a statin, and to improve LDL particle size, such as with fibrates or high-dose statins.
		However, another interpretation is that if apo B is reduced to less than 120 mg/dL, LDL particle size no longer has an effect, perhaps because if there are few enough apo B-containing particles, it may not matter how atherogenic these particles are.
	www.lipidsonline.org /slides/slide01.cfm?q=b&dpg=31 (223 words)

	Targeted Disruption of the Mouse apobec-1 Gene Abolishes Apolipoprotein B mRNA Editing and Eliminates Apolipoprotein ...
		Targeted Disruption of the Mouse apobec-1 Gene Abolishes Apolipoprotein B mRNA Editing and Eliminates Apolipoprotein B48 -- Hirano et al.
		Apolipoprotein B mRNA Editing and the Reduction in Synthesis and Secretion of the Atherogenic Risk Factor, Apolipoprotein B100 Can Be Effectively Targeted through TAT-Mediated Protein Transduction
		Tissue-specific Inhibition of Apolipoprotein B mRNA Editing in the Liver by Adenovirus-mediated Transfer of a Dominant Negative Mutant APOBEC-1 Leads to Increased Low Density Lipoprotein in Mice
	www.jbc.org /cgi/content/abstract/271/17/9887 (919 words)

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