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Topic: Apoprotein

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	Surfactant apoprotein A modulates interleukin-8 and monocyte chemotactic peptide-1 production -- Meloni et al. 19 (6): ...
		Effect of purified human surfactant apoprotein A on interleukin-8 and monocyte chemotactic peptide-1 release from human monocytes and rat type-II lung cells
		Rat type-II cell supernantants cultured for 72 h in the absence (type-II control) or presence of endotoxin free surfactant apoprotein A (ef-SP-A).
		Effect of modified surfactant apoprotein A on the release of interleukin-8 from human monocytes
	erj.ersjournals.com /cgi/content/full/19/6/1128 (3493 words)

	Med-Lib - Medical Online Library - English Articles - Oxford Textbook of Surgery - The pathobiology of atherosclerosis
		Apoproteins are divided into classes A, B, C, D, and E, and are further divided into subclasses (Table 3) 165.
		Apoprotein B accounts for 90 per cent of the protein of low-density lipoproteins and is a major protein of chylomicrons and very-low-density lipoproteins.
		Apoprotein CII activates the lipoprotein lipase of adipose tissue, while apoprotein E is involved with recognition of the remnant particle by the liver.
	med-lib.ru /english/oxford/pathob_ather.shtml (3431 words)

	Defective HDL particle uptake in ob/ob hepatocytes causes decreased recycling, degradation, and selective lipid uptake ...
		Apoproteins were seen to be localized in a juxtanuclear compartment in wild-type cells, which was reduced in ob/ob cells.
		Apoproteins in hepatocytes from leptin-treated ob/ob mice were localized in a similar pattern as seen in wild-type mice, i.e., juxtanuclear location.
		The degradation of HDL apoproteins in ob/ob hepatocytes was
	www.jci.org /cgi/content/full/105/2/151 (6317 words)

	Intracellular metabolism of the apoproteins of pulmonary surfactant in rat lung -- King and Martin 48 (5): 812 -- ...
		Intracellular metabolism of the apoproteins of pulmonary surfactant in rat lung
		(apoprotein B) apoproteins of surfactant and of the radioactive palmitate
		Apoprotein B is not secreted by type II cells with the same time course as
	jap.physiology.org /cgi/content/abstract/48/5/812 (296 words)

	The Heme and Chlorophyll Biosynthetic Pathways
		An apoprotein moves to that location in the unfolded state, picks up a complement of MV Chl a and/or MV Chl b, and undergoes appropriate folding.
		Apoproteins destined to some of the biosynthesis subcenters may possess specific signals for specific Chl biosynthetic enzymes peculiar to that subcenter, such as 4-vinyl reductases, formyl synthetases or Chl a and Chl b synthetases.
		Once an apoprotein formed in the cytoplasm or in the plastid reaches its biosynthesis subcenter destination and its signal is split off, it binds nascent Chl formed via one or more biosynthetic routes.
	www.vlpbp.org /pathw.html (3845 words)

	Implications of a Developmental-Stage-Dependent Thylakoid-Bound Protease in the Stabilization of the Light-Harvesting ...
		The LHCII apoprotein was isolated according to the method of Burke et al.
		Assay mixtures had 40 µg of thylakoid protein and 8 µg of exogenous LHCII apoprotein and were incubated at 37°C for 30 min.
		LHCII apoprotein in thylakoids is resistant to exogenous proteases
	www.plantphysiol.org /cgi/content/full/117/3/961 (5689 words)

	Modulation of Opsin Apoprotein Activity by Retinal. DARK ACTIVITY OF RHODOPSIN FORMED AT LOW TEMPERATURE -- Surya and ...
		decays to the opsin apoprotein and free all-trans-retinal.
		Opsin is able to activate transducin and is a form of the receptor that has low activity (5).
		The ability of the apoprotein to activate transducin in a light-independent manner is a potential source of transduction noise
	www.jbc.org /cgi/content/full/272/35/21745 (4384 words)

	The Heart Disease Breakthrough
		Apoprotein E Isoform is an actual test of the gene determining the activity of the LDL receptor that attaches to the apoproteins found on various lipid particles.
		The Apoprotein E 3/3 (about 62% of the population) person may have a modestly beneficial response to a low fat diet, but also, may have no response.
		The Apoprotein E 2/2 (1% of the population) person should never be placed on a low fat diet.
	www.theantiagingdoctor.com /hrtdisbrk.htm (4588 words)

	[No title]
		Endogenous PhyA apoprotein was visualized by immunolabeling cryosections of pea tissue, using PhyA apoprotein-deficient mutants as negative controls.
		In apical hook cells of etiolated seedlings, PhyA apoprotein immunolabeling was distributed diffusely in the cytosol.
		The results from this study indicated that the light-induced intracellular location of PhyA apoprotein was wavelength dependent and implied that this was important for PhyA activity.
	home.cc.umanitoba.ca /~umpradh0/39.768/P3/P3.html (1175 words)

	SVIBOR - Project code: 3-01-148
		In distinction from aterogenic LDL (low-density-lipoprotein) particle, with its main component apoprotein B (apo B), HDL (high-density-lipoprotein) particle, with its main component apoprotein A1 (apo A1), is protective (antiaterogenic).
		Lp (a) consists of apoprotein (a), apoprotein B and LDL particle.
		It was planned to investigate possible correlation of a certain apoprotein groups (apo A1, apo B, apo (a)), as well as Lp (a), with the development of blood vessel atherosclerotic alterations.
	www.mzos.hr /svibor/3/01/148/proj_e.htm (706 words)

	Bioluminescence and Secondary Structure Properties of Aequorin Mutants Produced for Site-Specific Conjugation and ...
		The apoprotein of aequorin binds an imidazopyrazine compound (coelenterazine) and molecular oxygen to form a stable photoprotein complex.
		A bioluminescence emission study was performed to determine if the mutant proteins had retained the same flash-type emission characteristics of native aequorin and to compare the mutants containing a specifically placed cysteine residue with mutant S (Figure 2).
		Since the apoprotein contains only a single serine residue (position 5 in the polypeptide chain) that is not part of a critical region within the protein, replacement of this serine with cysteine was the only conservative mutation possible.
	pubs.acs.org /cgi-bin/jtextd?bcches/11/i01/html/bc9900800.html (4483 words)

	Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat -- Mahley and Holcombe ...
		Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat -- Mahley and Holcombe 18 (3): 314 -- Journal of Lipid Research
		Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat
		of the arginine-rich apoprotein in the plasma and various ultracentrifugal
	www.jlr.org /cgi/content/abstract/18/3/314 (341 words)

	NEJM -- Apoprotein A-I synthesis in normal intestinal mucosa and in Tangier disease
		To determine whether human small intestine synthesizes apoA-I, the major apoprotein of plasma high-density lipoproteins, we used immunofluorescence technics and monospecific antiserums to visualize apoA-I within intestinal epithelial cells from four normal subjects and one patient with Tangier disease.
		Normal plasma chylomicrons contained apoB, apoE and the C peptides but not apoA-I. The patient's chylomicrons contained ap0A-I. Normal and Tangier-disease intestinal-mucosa cells increase their content of apoA-I during chylomicron formation and subsequently contribute to plasma apoA-I levels.
		The low levels of apoA-I in Tangier disease are not due to a failure of intestinal synthesis but might be due to abnormal metabolism of chylomicron apoproteins.
	content.nejm.org /cgi/content/abstract/299/26/1424 (390 words)

	Le Magazine, May 2006 - Report: New Blood Test Better Predicts Heart Attack Risk
		It can be measured directly as LDL particle number by the nuclear magnetic resonance spectroscopy method or indirectly as apoprotein B, which is a more widely available method.
		Apoprotein B is the major protein particle of LDL, with a single protein per LDL particle.
		Apoprotein B thus provides a “count” of LDL particles.
	www.lef.org /magazine/mag2006/may2006_report_heart_02.htm (1517 words)

	Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization -- Heeren ...
		Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization -- Heeren et al.
		The data are given in ng of apoprotein recycling/mg of cell protein and represent the mean ± S.D. of five (A) and four (B) independent experiments with duplicate samples.
		The fractions containing TRL (fractions 21 and 22), LDL (fractions 16-18), HDL (fractions 7-11), and the lipid-free bottom (fractions 1-4) are indicated and were identified by their respective density and cholesterol content.
	www.jbc.org /cgi/content/full/278/16/14370 (5422 words)

	POLYMORPHISM IN APOPROTEIN-CIII GENE
		It appears to modulate the activity of lipoprotein lipase by inhibiting the apoprotein CII-induced activation of this enzyme.
		Studies on transgenic mice reveal that the level of expression of apo-CIII is proportional to triglyceride levels in mice and suggest a regulatory role of this protein in the metabolism of triglycerides.
		Wick U, Witt E, Engel W. Restriction fragment length polymorphisms at the apoprotein genes AI, CIII and B-100 and in the 5' flanking region of the insulin gene as possible markers of coronary heart disease.
	www.kfshrc.edu.sa /annals/193/97-324.html (3044 words)

	Heme - Wikipedia, the free encyclopedia
		Heme B is the most abundant heme; both hemoglobin and myoglobin are examples of oxygen transport proteins that contain heme B and the peroxidase family of enzymes also contain heme B. The COX-1 and COX-2 enzymes (cyclooxygenase) of recent fame, also contain heme B at one of two active sites.
		Generally, heme B is attached to the surrounding protein matrix (known as the apoprotein) through a single coordination bond between the heme iron and an amino acid side-chain.
		Heme A differs from heme B in that a methyl side chain at ring position 8 is oxidized into a formyl group, and one of the vinyl side chains, at ring position 2, has been replaced by an isoprenoid chain.
	en.wikipedia.org /wiki/Heme (1330 words)

	Cholesterol Absorption and Metabolism and LDL Kinetics in Healthy Men With Different Apoprotein E Phenotypes and ...
		Plot shows apoprotein (apo) E phenotypes, LDL receptor gene Pvu II genotypes [closed circles=P-P- (n=24); open circles=P-P+ (n=13); shaded circles=P+P+ (n=3)], and cholesterol absorption efficiency in a random male population.
		Serum LDL cholesterol and cholesterol absorption efficiency are influenced by apoprotein B and E polymorphism and by the presence of the FH-Helsinki mutation of the LDL receptor gene in familial hypercholesterolemia.
		Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype.
	atvb.ahajournals.org /cgi/content/full/15/2/208 (3893 words)

	Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E -- Hirano ...
		Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E -- Hirano et al.
		Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E
		Apoprotein (apo) C-III plays an important role in the development of hypertriglyceridemia by inhibiting triglyceride (TG)
	ajpendo.physiology.org /cgi/content/abstract/281/4/E665 (285 words)

	Tissue Factor Regulates Plasminogen Binding and Activation -- Fan et al. 91 (6): 1987 -- Blood
		Contribution of TF apoprotein and phospholipids to plasminogen activation.
		immobilized fragment of recombinant TF apoprotein comprising the
		Immunohistochemical colocalization of TF apoprotein and plasminogen in human atherosclerotic coronary artery.
	www.bloodjournal.org /cgi/content/full/91/6/1987 (6216 words)

	Medical Dictionary: Apoprotein E deficiency - WrongDiagnosis.com - WrongDiagnosis.com
		Apoprotein E deficiency: A rather uncommon form of familial hyperlipemia characterized by the presence of lipoproteins of abnormal composition.
		The main abnormal lipoproteins are called beta-VLDL and have a different apoprotein content and a higher proportion of cholesterol relative to triglyceride than normal VLDL.
		Terms that may be interchangeable with Apoprotein E deficiency:
	www.wrongdiagnosis.com /medical/apoprotein_e_deficiency_printer.htm (118 words)

	Pulmonary alveolar proteinosis. Staining for surfactant apoprotein in alveolar proteinosis and in conditions simulating ...
		Staining for surfactant apoprotein in alveolar proteinosis and in conditions simulating it -- Singh et al.
		Staining for surfactant apoprotein in alveolar proteinosis and in conditions simulating it
		apoprotein, whereas the staining was focal in patients with other primary
	www.chestjournal.org /cgi/content/abstract/83/1/82 (401 words)

	[No title]
		(384aa) 3 TMS, N-term is IN 5690.m00243photosystem ii p680 chlorophyll a apoprotein (cp-47 protein).
		(384aa) 3 TMS, N-term is IN 3387.m00319photosystem ii p680 chlorophyll a apoprotein (cp-47 protein)-relatedo_sativachr_6P0417D053387
		(384aa) 3 TMS, N-term is IN 4672.m00106photosystem ii p680 chlorophyll a apoprotein (cp-47 protein).
	www.cbs.umn.edu /rice/osprotdb/fam78.htm (86 words)

	Lipoproteins
		differ in the ratio of protein to lipids, and in the particular apoproteins and lipids that they contain, as summarized in Table 12-6 p.
		MTP facilitates transfer of lipids to apoprotein B-100 while B-100 is being translocated into the ER lumen during translation.
		Whereas VLDL contains 5 different apoprotein types (B-100, C-I, C-II, C-III, and E), only one protein, apoprotein B-100, is associated with the surface monolayer of LDL.
	www.rpi.edu /dept/bcbp/molbiochem/MBWeb/mb2/part1/lipoprot.htm (1727 words)

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