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Arecoline - Health Encyclopedia Arecoline is a stimulant which acts on the parasympathetic nervous system to induce a range of different effects including a heightened sense of awareness as well as increased salivation, heart rate, blood pressure, body temperature and intestinal function. Regional brain metabolic responsivity to the muscarinic cholinergic agonist arecoline is similar in young and aged Fischer-344 rats. Arecoline is a parasympathetic agent and increases the tonus and the mobility of smooth muscle resulting in the purgation of E. Retrieved from "http://www.steadyhealth.com/encyclopedia/Arecoline" www.steadyhealth.com /encyclopedia/Arecoline   (143 words)

Betel Nut : by Ray Sahelian, M.D., Benefits of Betel Nut The plant extract was subjected to activity-directed fractionation and all resultant fractions showed atropine-sensitive spasmogenicity in rabbit jejunum and also AChE inhibitory effect at doses similar to that for the parent crude extract, the ethyl acetate fraction being slightly less potent. Some of the known constituents of betel nut, including arecoline, were tested for the possible inhibitory effect on AChE, none were found active. In study 2, 15 Indian men received gels delivering 0 or 10 mg arecoline after consuming a 2.5 MJ meal, and the same protocol was then applied as in study 1. www.raysahelian.com /betelnut.html   (1564 words)

BETEL-ARECA Arecoline modulates the activity of matrix metalloproteinases, their tissue inhibitors and lysyl oxidase, which leads to the accumulation of collagen in the fibroblasts of the oral mucosa. In mice, arecoline was genotoxic to early spermatids and it increased the frequency of abnormal sperm. Arecoline and other areca-nut alkaloids gave positive responses in most bacterial mutagenicity assays, and induced chromosomal aberrations, micronucleus formation and sister chromatid exchange in mammalian cells, both in vitro and in vivo. www.inchem.org /documents/iarc/vol85/85-01-betel-areca.html   (3382 words)

Interaction of 2H arecoline with SH group and other biomolecules,Bhide SV, Shivapurkar NM: Indian Journal of ... : In an attempt to understand the mechanism of action of arecoline at molecular level, interaction of 3H arecoline with DNA, RNA, Protein in glutathione was studied in Swiss mice. Among all these fractions maximum specific activity was observed in glutathione fraction and next to it in DNA fraction Significantly high radioactivity was observed in all the fractions under study at 10 minutes indicating possibility of interaction with intact arecoline. Further, pretreatment of sulfhydryl reaction reagents decreased the specific activity of protein in mice injected with 3H arecoline. www.ijp-online.com /article.asp?issn=0253-7613;year=1983;volume=15;issue=4;spage=255;epage=260;aulast=Bhide;type=0   (169 words)

MEDLINE Search on Medscape.com The areca alkaloids comprise arecoline, arecaidine, guvacoline, and guvacine. Arecoline inhibits catecholamine release from perfused rat adrenal gland. Arecoline, the main areca alkaloid in betel quid (BQ), is reported to have cytotoxic, genotoxic, and mutagenic effects in various cells. search.medscape.com /medline-search?queryText=Arecoline   (468 words)

Arecoline at AllExperts Arecoline is a natural organic compound which is an alkaloid found in betel nuts from the betel palm (Areca catechu). Arecoline is the primary active ingredient responsible for the central nervous system affects which are roughly comparable to those of nicotine, which has a similar chemical structure. Arecoline is known to be an agonist of muscarinic receptors, which is believed to be the primary cause of its sympathetic effects. en.allexperts.com /e/a/ar/arecoline.htm   (213 words)

details   (Site not responding. Last check: ) Arecoline, a major areca nut alkaloid, is considered to be the most important etiologic factor in the areca nut. At a concentration higher than 50 microg/ml, arecoline was shown to be cytotoxic to human buccal fibroblasts in a dose-dependent manner by the alamar blue dye colorimetric assay (P<0.05). Arecoline at a concentration of 50 microg/ml caused about 30% of cell death over the 24 h incubation period. cmbi.bjmu.edu.cn /ChinaPaper/details.asp?PubMedID=11545236   (331 words)

SSR 2005   (Site not responding. Last check: ) Arecoline is one of the major ingredients in betel nut extract. However, it is important to investigate the effect of arecoline during the processes of establishment of pregnancy. Therefore, we suggested that arecoline, the major content of betel nut, inhibits the growth implanting mouse embryos in vitro and the results indicated that arecoline may exerts poisonous effects on implanting embryos in vivo. abstracts.co.allenpress.com /pweb/ssr2005/document/?ID=47825   (340 words)

details   (Site not responding. Last check: ) Arecoline, the most abundant betel alkaloid, is considered the most important etiologic factor in betel nuts. In order to elucidate the potential toxicological implications of interactions of arecoline and peroxynitrite (a reaction product of cigarette smoking), cell viability, and cellular levels of glutathione (GSH) were investigated, using cultured human buccal mucosal fibroblasts. At a concentration higher than 0.8 mM, arecoline was cytotoxic to buccal mucosal fibroblasts in a concentration- and time-dependent manner. cmbi.bjmu.edu.cn /ChinaPaper/details.asp?PubMedID=11137310   (238 words)

Prenatal exposure to arecoline (areca nut alkaloid) and birth outcomes -- García-Algar et al. 90 (3): F276 -- ... Prenatal exposure to arecoline (areca nut alkaloid) and birth outcomes -- García-Algar et al. Prenatal exposure to arecoline (areca nut alkaloid) and birth outcomes that chronic exposure of the fetus to arecoline (the principal fn.bmjjournals.com /cgi/content/abstract/90/3/F276   (179 words)

Devices and methods for treating memory impairment - Patent 4765985 For example, arecoline and its derivatives are administered at a rate of 0.1 to 10 mg/hr, preferably 0.5 to 5 mg/hr. Arecoline in pH 10 buffer (99.9% dissociation to the free base) yielded partition coefficients of 0.756 and 0.654 for concentrations of 1.0M and 0.01 M, respectively. Ten grams of arecoline HBr was dissolved in a minimal quantity (approximately 25 ml) of water and adjusted to pH 10 with saturated KOH in a separatory funnel. www.freepatentsonline.com /4765985.html   (3189 words)

Areca Nut Arecoline Hydrobromide, a commercial salt, is a stronger stimulant to the salivary glands than Pilocarpine and a more energetic laxative than Eserine. Of the Arecoline Hydrobromide, for colic in horses, 1 to 1 1/2 grains. Of the Arecoline Hydrobromide, for human use, 1/15 to 1/10 grains. www.nisbett.com /herbs/a/areca056.html   (454 words)

[No title]   (Site not responding. Last check: ) Arecoline, a major betel nut alkaloid, was found to be a cytotoxic agent to human gingival fibroblasts & betel quid chewers might be more susceptible to destruction of the periodontium and less responsive to a regeneration procedures during periodontal therapy. Arecoline, a major component of the particular alkaloid in betel nuts, was found to be cytotoxic to human gingival fibroblasts at a concentration higher than 50 micrograms/ml by depleting intracellular thiols and inhibiting mitochondrial activity. Arecoline obtained from Areca Catechu L.,induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.)& prevented by muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.)& S-(-)-ET-126 (0.01 microg per mouse i.c.v.), which is mediated by activation of central M1 muscarinic receptors. www.herbmed.org /members/serv/bridgeport/?getpg=http://www.herbmed.org/members/herbtemplates/subcategory.asp?varHerb_ID=199   (5991 words)

Acta Pharmacologica Sinica Therefore, the present study was designed to investigate the effects of arecoline on catecholamine secretion in an isolated perfused model of the rat adrenal gland, and to clarify its mechanism of action. In contrast to arecoline exposure, exposure of the adrenal gland to nicotine (30 µmol/L) for 60 min initially enhanced the ACh-evoked CA secretory responses. It seems that this inhibitory effect of arecoline may be mediated by blocking calcium influx into the rat adrenal medullary chromaffin cells without the inhibition of Ca release from the cytoplasmic calcium store. www.chinaphar.com /1671-4083/27/71.htm   (4499 words)

The GAR-3 Muscarinic Receptor Cooperates With Calcium Signals to Regulate Muscle Contraction in the Caenorhabditis ... worms are exposed to arecoline, a muscarinic agonist. mutations in the gpb-2 gene are hypersensitive to arecoline: arecoline for 24 hr were categorized as "severely stuffed" (the pharyngeal lumen is distended with bacteria to its fully open position), "partially stuffed" (bacteria have accumulated in the pharynx but the lumen is not fully open), or "not stuffed." (D) EPG recordings from wild-type and gpb-2(ad541) worms exposed to 5 m www.genetics.org /cgi/content/full/167/2/633   (5541 words)

The Fate of Areca from Abuse to Loss? The main purpose of chewing the betel nut is to extract out the alkaloids, of which the dominant one is arecoline (related alkaloids present in smaller quantities are arecaidine, guvacoline, and guvacine) a process aided by the added lime (1). The carcinogenic agents in the betel quid are thought to be at least three of the constituents: arecoline, arecaidine, and safrole. Arecoline and arecaidine from the nut may be promoters for other carcinogens (especially N-nitroso compounds with which they can combine); the areca alkaloids also contribute to changes in the oral mucosa that lead to the other detrimental oral effects. www.itmonline.org /arts/areca.htm   (2833 words)

Prenatal exposure to arecoline (areca nut alkaloid) and birth outcomes -- García-Algar et al. 90 (3): F276 -- ... Prenatal exposure to arecoline (areca nut alkaloid) and birth outcomes -- García-Algar et al. Prenatal exposure to arecoline (areca nut alkaloid) and birth outcomes Arecoline concentration was determined in meconium to assess fn.bmj.com /cgi/content/full/90/3/F276   (751 words)

Wholesale Betel Nuts, Areca catechu and additives Traditionally about ¼ of a whole betel nut would be put inside one leaf along with a pinch of lime and a little Gambir flavoring, the whole quid would be put into the mouth and chewed swallowing all the juices that were released. Arecoline, a volatile oil is released from the nut by saliva and lime. Interesting enough, Arecoline is in the same cholinergic alkaloids group as muscarine which is found in the Fly Agaric mushroom!! www.wholesaleshamanicherbs.com /betel-nut-additives.htm   (378 words)

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