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Topic: Aromatase inhibitor

	Aromatase Inhibitor information : by Ray Sahelian, M.D.
		Aromatase Inhibitor information : by Ray Sahelian, M.D. Aromatase Inhibitors by Ray Sahelian, M.D. In premenopausal women ovaries are the major sites of estrogen production, while in postmenopausal women estrogen is produced by aromatization of ovarian and adrenal androgens in extragonadal sites, mostly in adipose tissue.
		Aromatase is a cytochrome P450 hemoprotein-containing enzyme complex that catalyzes the rate-limiting step in the conversion of androstenedione and testosterone to estrone and estradiol (E2).
		Aromatase inhibitors have been used in the treatment of selective forms of precocious puberty since the mid-1980s.
	www.raysahelian.com /aromatase.html (0 words)

	Aromatase Inhibitor
		Aromatase inhibitors are drugs used to treat breast cancer by blocking the aromatase enzyme; they are typically used in postmenopausal women.
		Typically, aromatase conversion is only a primary source of estrogen in post-menopausal women; pre-menopausal women get most of their estrogen from the ovaries; and the elimination of estrogen, stimulates their bodies to increase androgen production, which counteracts aromatase.
		Aromatase inhibitors, or AIs, are categorized as either irreversible steroid inhibitors, which form a permanent bond with armoatase, or non-steroidal inhibitors, which eliminate aromatase uptake by reversible competition.
	www.iscid.org /encyclopedia/Aromatase_Inhibitor (202 words)

	Aromatase inhibitors and Adjuvant Treatment of Breast Cancer
		One of the special aspects of aromatase inhibitors, a new class of treatment options for the adjuvant therapy of breast cancer, is that they have different safety issues than tamoxifen.
		Reflecting on how initial work with aromatase inhibitors in the treatment of metastatic disease has led to advances in adjuvant therapy, he said "A clue to the fact that these inhibitors were going to turn out to be dynamite, in the adjuvant setting, was the extraordinary increase in time-to-progression.
		The three aromatase inhibitors currently in use are: Arimidex (anastrozole) and Femara (letrozole) which are non-steroidal aromatase inhibitor, and Aromasin (exemestane) is which is a steroidal aromatase inhibitor.
	www.cancerlynx.com /aromatase.html (912 words)

	Chrysin: Is It An Effective Aromatase Inhibitor? Article
		Aromatase is the enzyme that causes the conversion of testosterone into estradiol and androstenedione into estrone.
		Aromatase levels are known to rise with age.1 This increase often causes a relative imbalance of estrogen and testosterone in men as they grow older.
		Ibrahim, A.R. and Abul-Hajj, Y.J. Aromatase inhibition by flavonoids.
	www.vrp.com /art/1208.asp (1577 words)

	Breast cancer - Wikipedia, the free encyclopedia
		Persistently increased blood levels of estrogen are associated with an increased risk of breast cancer, as are increased levels of the androgens androstenedione and testosterone (which can be directly converted by aromatase to the estrogens estrone and estradiol, respectively).
		The mainstay of breast cancer treatment is surgery when the tumor is localized, with possible adjuvant hormonal therapy (with tamoxifen or an aromatase inhibitor), chemotherapy, and/or radiotherapy.
		Aromatase inhibitors are typically given to postmenopausal women to lower the amount of estrogen in their systems
	en.wikipedia.org /wiki/Breast_cancer (5330 words)

	Aromatase Inhibitors/Estrogen Dominance
		Aromatase is an enzyme required for the conversion of androgens to estrogens.
		Aromatase inhibitors thus decrease the concentrations of estrogens in the body and are effective against tumors that depend on estrogen for growth.
		In the general population, aromatase inhibitors are used by the bodybuilding community to increase lean muscle mass and decrease body fat.
	www.annieappleseedproject.org /arindom.html (1135 words)

	washingtonpost.com: New Drug Shows Promise in Cutting Risk of Breast Cancer Recurrence
		The results were so strong that the researchers recommended that most postmenopausal women struck by breast cancer should immediately begin taking an aromatase inhibitor as soon as they are done with the standard regimen of surgery, radiation and, often, chemotherapy, instead of first going on an older drug.
		Before the development of aromatase inhibitors, women whose breast cancers were promoted by the hormone estrogen -- which is true of most -- were given tamoxifen to reduce their risk of a recurrence.
		Aromatase inhibitors block the formation of estrogen in the first place and carry none of those risks.
	www.washingtonpost.com /ac2/wp-dyn/A49564-2004Dec8?language=printer (703 words)

	Aromatase Inhibitors to Treat Breast Cancer at Fox Chase Cancer Center (Site not responding. Last check: )
		Aromatase inhibitors are a newer class of hormonal treatments for postmenopausal women.
		Aromatase inhibitors slow or stop the growth of breast cancers controlled by estrogen by lowering estrogen levels in a woman's body.
		Aromatase inhibitors are at least as effective as tamoxifen in preventing breast cancer from coming back in postmenopausal women.
	www.fccc.edu /cancer/types/breast/treatment/hormonal/aromatase.html (823 words)

	What's Next In Health - Switching to an aromatase inhibitor significantly improves breast cancer survival rates
		For breast cancer patients taking tamoxifen, switching to an aromatase inhibitor within three years significantly improves survival rates, according to a new study.
		Aromatase inhibitors, such as aminoglutethimide and anastrozole, work in a different way to lower estrogen levels.
		Recent evidence shows aromatase inhibitors used alone or in follow-up after two years of tamoxifen therapy demonstrates clear and, in some cases, improved reduction of recurrence risk.
	www.whatsnextnetwork.com /health/index.php/a/2007/02/14/switching_to_an_aromatase_inhibitor_sign (428 words)

	ACS :: Switch to Aromatase Inhibitor Better than Continuing Tamoxifen
		Aromatase inhibitors and tamoxifen are types of hormone therapy that affect estrogen, which can cause breast cancer to grow.
		That means women who have taken 2-3 years of tamoxifen should consider switching to an aromatase inhibitor for the remaining years of their treatment, he added.
		Russell, however, thinks the benefits of aromatase inhibitors are greater than the risks to bone health, even in women at high risk for bone problems, such as the elderly.
	www.cancer.org /docroot/NWS/content/NWS_1_1x_Switch_to_Aromatase_Inhibitor_Better_than_Continuing_Tamoxifen.asp (0 words)

	Endometriosis aromatase inhibitors
		Although the use of aromatase inhibitors is new in endometriosis, they have been used to treat post-menopausal women with some forms of breast cancer for nearly 10 years.
		In postmenopausal women, an aromatase inhibitor is used in combination with calcium, vitamin D and a bisphosphonate to prevent osteoporosis of the bones.
		Aromatase inhibitors — like all the hormonal treatments for endometriosis — will not improve your chance of conceiving, so they should not be used as a treatment for infertility.
	www.endometriosis.org /aromatase.html (900 words)

	New breast cancer drug promising (Site not responding. Last check: )
		Geyer added that he will likely use aromatase inhibitors more frequently as a first-line treatment, but he is not yet convinced that tamoxifen doesn't have a role there, too.
		Both tamoxifen and aromatase inhibitors interfere with the growth of tumors that are sensitive to estrogen, which comprise the majority of breast cancers.
		Brufsky, who has used aromatase inhibitors for about three years, said that doctors sometimes prescribe a year of tamoxifen to ensure that women who were approaching or just started menopause when they were diagnosed with breast cancer are truly menopausal before switching to the new drug.
	www.post-gazette.com /pg/04071/284051.stm (827 words)

	Chrysin 500 mg 180 caps - health-marketplace.com
		Aging men often have excess aromatase enzyme activity, and the result is that too much of their testosterone is "aromatized" into estrogen.
		These studies demonstrate that chrysin is a more potent inhibitor of the aromatase enzyme than phytoestrogens and other flavonoids that are known to have aromatase-inhibiting properties (299, 300).
		While this cancer preventing effect is most important for Women, inhibiting aromatase in aging men has tremendous potential for naturally suppressing excess estrogen while boosting low levels of testosterone to a youthful state.
	www.health-marketplace.com /Chrysin.htm (1163 words)

	Bone Loss Associated With Aromatase Inhibitor Therapy for Breast Cancer Confirmed: Presented at ASCO
		Although smaller studies showed this association between aromatase inhibitor use and bone loss, the link was not confirmed in a large population until now.
		The observation start-date for the aromatase inhibitor and control groups was defined as the service date of the first aromatase inhibitor claim and for the first breast cancer claim, respectively.
		Aromatase inhibitor use was associated with a relative risk (RR) ratio of 1.3 (P =.01).
	www.docguide.com /dg.nsf/PrintPrint/5F16CAA62621DD31852571830057DFB0 (520 words)

	Aromatase Inhibitors
		Aromatase inhibitors stop the enzyme called aromatase from turning androgen into estrogen, lowering the amount of estrogen produced OUTSIDE the ovaries.
		Now medical experts consider aromatase inhibitors to be the new standard of care for post-menopausal women with invasive hormone-receptor-positive breast cancer, both early and advanced-stage.
		Aromatase inhibitors are not prescribed for women who are still having menstrual periods.
	www.breastcancer.org /treatment/hormonal/aromatase_inhibitors/index.jsp (0 words)

	Aromatase Inhibitor or Tamoxifen? - Breast Cancer Forum
		Both aromatase inhibitors and herceptin have been approved for advanced disease but not in the adjuvant setting.
		There have been clinical trials of aromatase inhibitors in the adjuvant setting and the data are encouraging.
		Aromatase inhibitors do show promise in the adjuvant setting in folks who are her2 positive.
	www.medhelp.org /forums/BreastCancer/messages/600.html (811 words)

	Aromatase inhibitor definition - Medical Dictionary definitions of popular medical terms
		Aromatase inhibitor: A drug that inhibits the enzyme aromatase and by that means lowers the level of the estrogen estradiol.
		Aromatase catalyzes the conversion of testosterone (an androgen) to estradiol (an estrogen) in many tissues including the adrenal glands, ovaries, placenta, testicles, adipose (fat) tissue, and brain.
		Aromatase inhibitors are used mostly in women who have reached menopause, when the ovaries are no longer producing estrogen.
	www.medterms.com /script/main/art.asp?articlekey=20282 (0 words)

	New Hormonal Therapy - the Aromatase Inhibitors
		Still, this treatment is not curative in advanced breast cancer, but many studies were then started to test aromatase inhibitors in early stage breast cancer in hopes that it could lower recurrence and mortality in early stage breast cancer.
		The first such study to be reported was a comparison of the aromatase inhibitor anastrozole (trade name Arimidex) to tamoxifen or to a combination of the two drugs.
		The other aromatase inhibitors, letrozole (Femara) and exemestane (Aromasin) are also being tested in early stage breast cancer.
	www.cancersupportivecare.com /aromatase.html (630 words)

	ARIMIDEX (Anastrozole) British Dragon - Steroids-Shop.Net
		As an aromatase inhibitor, Arimidex's mechanism of action -- blocking conversion of aromatizable steroids to estrogen -- is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid) or tamoxifen (Nolvadex), which block estrogen receptors in some tissues, and activate estrogen receptors in others.
		In post-menopausal women, the principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues, such as adipose tissue, with further conversion of estrone to estradiol.
		Inhibition of aromatase activity is primarily due to anastrozole, the parent drug.
	www.steroids-shop.net /buyarimidexanastrozole.html (0 words)

	New class of drugs helps fight hormone-sensitive breast cancer - Cancer He@lthLINK - Yale-New Haven Hospital
		Aromatase inhibitors also do not seem to have the same degree of certain side effects as tamoxifen, most significantly, increased risk of uterine cancer, blood clotting and strokes.
		Aromatase inhibitors go beyond tamoxifen in some sense to deplete the body of estrogen, making the hormone unavailable in the body to bind to the hormone-receptor positive cells.
		Women on an aromatase inhibitor are wise to have their bone density checked every one to two years and consider taking a bone-strengthening drug if needed.
	www.ynhh.org /healthlink/cancer/cancer_3_05.html (1457 words)

	ACS :: Aromatase Inhibitor Arimidex Beats Tamoxifen in Study
		And if the cancer did return, it was after a longer period of time in women who took the aromatase inhibitor than in those who took tamoxifen.
		The panel recommended that all postmenopausal women with hormone-receptor positive breast cancer should receive an aromatase inhibitor at some point — either as initial therapy or after 2 to 5 years of treatment with tamoxifen.
		Nor is it clear how women would fare if they took an aromatase inhibitor first for some period of time, and then took tamoxifen.
	www.cancer.org /docroot/NWS/content/NWS_1_1x_Aromatase_Inhibitor_Anastrozole_Beats_Tamoxifen.asp (0 words)

	ARS \| Publication request: Fetal Exposure to An Aromatase Inhibitor Alters Secretion of Luteinizing Hormone in ...
		To examine the role of estrogen in sexual differentiation of the male ovine brain, pregnant ewes were treated with an aromatase inhibitor, to block the conversion of testosterone to estrogen.
		Five mo after castration, rams were given estrogen intramuscularly to determine whether in utero exposure to aromatase inhibitor would cause these rams to exhibit a luteinizing hormone surge, thus suggesting that defeminization of the brain had failed to occur.
		To determine whether altered basal luteinizing hormone secretion was due to an effect of the aromatase inhibitor at the level of the hypothalamus or the pituitary (specific brain regions), rams were administered gonadotropin-releasing hormone.
	www.ars.usda.gov /research/publications/publications.htm?seq_no_115=161799 (613 words)

	Patterns of Care in Medical Oncology. 2005 - Vol 2 Issue 3
		Indirect data evaluating the sequence of a nonsteroidal aromatase inhibitor to fulvestrant suggest that 25 to 30 percent of patients may benefit with that approach.
		We know that responses can be seen with either sequence — an aromatase inhibitor followed by fulvestrant or the opposite — but I believe it’s important that we determine which is superior.
		That scenario equates to the withdrawal of a nonsteroidal aromatase inhibitor and the addition of fulvestrant.
	patternsofcare.com /2005/3/endocrine.htm (1386 words)

	Medical Dictionary: Aromatase inhibitor - WrongDiagnosis.com
		Aromatase inhibitor: An agent that blocks the function of the enzyme aromatase with antineoplastic activity.
		Aromatase inhibitors belong to two classes: Type I steroidal drugs are androgen substrate analogues that bind competitively but irreversibly to the enzyme.
		Present in many tissues, aromatases are heme-containing enzymes that catalyze the adrenal conversion of cholesterol to pregnenolone and the peripheral conversion (aromatization) of androgenic precursors to estrogens.
	www.wrongdiagnosis.com /medical/aromatase_inhibitor.htm (291 words)

	Ob/Gyn \| Reproductive Endocrinology
		Aromatase inhibitors (i.e., Femara) are used for the treatment of abnormalities of ovulation in patients desiring pregnancy much the same as clomiphene citrate or tamoxifen.
		Like tamoxifen, aromatase inhibitors are being used for breast cancer and are being increasingly utilized for ovulation induction.
		The benefits in using aromatase inhibitors include avoiding the specific side effects from clomiphene citrate, lower peak estradiol values (therefore diminishing the risk of ovarian hyperstimulatin syndrome) and possibly decreasing the incidence of multiple gestations (twins or higher).
	www.med.umich.edu /obgyn/repro-endo/infertility/pted/Aromatase_Inhibitor.htm (667 words)

	Aromatase Inhibition in Male Athletes Using Anabolic-Androgenic Steroids by Author L Rea
		When we think of aromatase inhibitors we often assume that they are all the same with various levels of results…depending upon dosages.
		On the other hand, the steroidal inhibitors are rather better classified as inactivators, in that they bind to the aromatase molecule in an irreversible fashion (they hold on and do not let go).
		Aromatase inhibitors decrease the amount of circulating estrogen/estradiol and estrogen receptor antagonist keep estrogen out of the specific pituitary receptors.
	www.mesomorphosis.com /articles/rea/aromatase-inhibitors.htm (1885 words)

	Aromatase Inhibitors - National Cancer Institute
		Aromatase inhibitors (AIs) can help block the growth of these tumors by lowering the amount of estrogen in the body.
		of the body, using a substance called aromatase.
		(Posted: 03/07/2007) - Aromatase inhibitors (AIs), which interfere with the body's ability to produce the hormone estrogen, are rapidly changing the standard of treatment for breast cancer.
	www.cancer.gov /clinicaltrials/developments/aromatase-inhibitors-digest (0 words)

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