| | USC Center for Vascular Care |
 | | This accumulation is called atherosclerosis, or “hardening of the arteries.” As the atherosclerotic process of the lower extremity arteries increases, the arteries become narrowed or blocked, causing blood flow to decrease. |
 | | When claudication is used as an indicator of lower extremity arterial disease, estimates are that 2% of the population aged 40 to 60 years and 6% older than 70 years of age are affected. |
 | | Although the mechanism by which smoking causes or worsens atherosclerosis is unclear, it is known that the degree of damage to the arterial wall lining is directly related to the amount of tobacco used. |
| www.surgery.usc.edu /divisions/vas/legpainandlowerextremityarterialdisease.html (2251 words) |