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Topic: Ascorbate


  
  DoctorYourself.com - AIDS and Vitamin C
Measurements of ascorbate in urine, saliva, or serum indicate that if sufficient doses of ascorbate are not given when a patient is ill, the body level of vitamin C drops rapidly.
When ascorbate is destroyed in the process of destroying free radicals, the vitamin C stores, particularly in the cells directly involved in the disease process, are so depleted as to cause disorders of known housekeeping functions of vitamin C. It is certain that AIDS causes this depletion.
Ascorbate may or may not block these sensitivities significantly; however, ascorbate may decrease the intensity and duration of the reaction in such a way as to make clinical discovery of the offending substance easier.
www.doctoryourself.com /aids_cathcart.html   (4722 words)

  
 CALCIUM ASCORBATE   (Site not responding. Last check: 2007-10-17)
Vitamin C (calcium ascorbate) is required for the production of collagen, a protein necessary for the formation of connective tissue in muscles, skin, bones, and cartilage.
Vitamin C (calcium ascorbate) aids in the metabolism of the amino acids phenylalanine and tyrosine by preventing the formation of potentially carcinogenic nitrosamines in the stomach.
Vitamin C (calcium ascorbate) is essential in the formation of adrenaline and is absorbed in the mucous membranes of the mouth, stomach, and upper part of the small intestine.
vitazanpro.com /id73.html   (277 words)

  
 Cardiovascular Disease As  A Form of Chronic Vitamin C Deficiency
In particular, ascorbate is known to stimulate 7-a-hydroxylase, a key enzyme in the conversion of cholesterol to bile acids and to increase the expression of LDL receptors on the cell surface.
During spring and summer seasons the ascorbate content in the diet increased significantly and mechanisms were favored that decreased the vascular deposits under the protection of increased ascorbate concentration in the vascular tissue.
Ascorbate deficiency unmasks the underlying genetic disease, aggravates the imbalance between glucose and ascorbate, decreases vascular ascorbate concentration, and thereby triggers diabetic angiopathy.
www.drlam.com /opinion/cardiovascular_disease.cfm   (4003 words)

  
 Robert Cathcart MD at orthomed.com
The dehydroascorbate formed, as ascorbate reduces free radicals and oxidizing substances, is not as toxic as the substances it reduced because the oxidizing redox potential of the dehydroascorbate is not as great as the oxidizing redox potential of the free radicals and oxidizing substances reduced.
The threshold amount could be the amount of ascorbate necessary to reduce the free radicals and other oxidants present in the inflamed tissues, establish a relatively reducing redox potential in those tissues, and reduce the SS bonds of the antigen binding ends of the antibodies.
Ascorbate would lessen the area of secondary inflammation and thereby reduce the amount of antigen presented to the B cells and therefore reduce the amount of antibodies formed.
www.orthomed.com /unprimed.htm   (6504 words)

  
 British Journal of Pharmacology - Differential effects of ascorbate on endothelium-derived hyperpolarizing factor ...   (Site not responding. Last check: 2007-10-17)
The possibility that concentration of ascorbate by the ciliary body was a prerequisite for blockade to occur was ruled out, since EDHF was still blocked when the anterior and posterior chambers were continuously flushed with Krebs solution or when both the aqueous and vitreous humour were drained.
M ascorbate into the ciliary vascular bed was required, it is possible that the blockade of EDHF arose as a result of the ability of the eye to concentrate this antioxidant.
Ascorbate at this concentration failed, however, to block EDHF in the bovine coronary artery, demonstrating that the antioxidant is not a universal inhibitor of EDHF.
www.nature.com /bjp/journal/v138/n6/full/0705143a.html   (5510 words)

  
 Doctoryourself.com - Titration
Ascorbate excreted in the urine drops markedly with stresses of any magnitude unless vitamin C is provided in large amounts.
The possibility that ascorbate might have some value in controlling the immune response at the gene level should be thoroughly investigated because there could be some basic implications in histocompatibility (graft acceptance), cancer control, and destruction of foreign invaders.
Ascorbate should be used in cancer patients to avert disorders of ascorbate deficiency in various systems of the body including the immune system.
www.doctoryourself.com /titration.html   (6580 words)

  
 [Frontiers in Bioscience 3, d1-10, January 1, 1998]
Further, DHA-induced ferricyanide reduction is saturable with regard to the extracellular DHA concentration, and parallels the intracellular ascorbate content of the cells (42, 45).
Similar estimates of ascorbate recycling capacity were determined from more recent studies in which initial rates of DHA reduction to ascorbate were measured directly in erythrocytes (16).
The ascorbate recycling capacity of erythrocytes provides ascorbate to supplement the already substantial antioxidant defenses of the cells (42), and to serve as a source of ascorbate for export into plasma, as discussed in the next section.
www.bioscience.org /1998/v3/d/may/5.htm   (989 words)

  
 Vitamin C, K6
Therefore, the levels of extracellular ascorbate should be highest during times of motor activity: this is a time when the cells are most likely producing increased levels of free radicals themselves and may need extra protection from glutamate toxicity.
The two groups that were not treated (one of the HD mice, the other, normal mice) got injections of a placebo to control for any effects that the actual injections and handling may have had on the mice.
The researchers found that HD mice treated with ascorbate performed the repetitive grooming movement less often and had increased flexibility in the maze than did untreated HD mice, suggesting that ascorbate treatment is beneficial to these mice (specifically, by acting as an antioxidant in the striatum).
www.stanford.edu /group/hopes/treatmts/antiox/k6.html   (1975 words)

  
 Magnesium Ascorbate: Vitamin C and Magnesium supplement
In Magnesium Ascorbate, the acidic Vitamin C is neutralized by the accompanying magnesium, and becomes less irritating to the stomach.
Magnesium Ascorbate is excellent for fatigue conditions, hypoglycemia and depression since magnesium is the principle driver of ATP synthesis in the cells.
Magnesium Ascorbate is a potent source of magnesium for those suffering from magnesium anemias--most teenagers and elderly are deficient in magnesium.
www.intensivenutrition.com /magnesiumascorbate.htm   (325 words)

  
 Ascorbate Depletion: A Critical Step in Nickel Carcinogenesis?   (Site not responding. Last check: 2007-10-17)
The role of ascorbate as an antioxidant molecule has been appreciated for years, but only recently ascorbate was found to play a crucial role in hydroxylation reactions that determine interactions and functioning of thousands of cellular proteins.
Numerous data indicate that ascorbate deficiency may be an underlying factor in the pathophysiology of asthma and acute respiratory distress syndrome (Kelly 1998; Kongerud et al.
Because collagen assembly greatly depends on ascorbate, the decrease in the ascorbate level during spontaneous or carcinogen-induced tumor progression could be a key factor in the ECM disorganization (Preist 1970).
ehp.niehs.nih.gov /members/2005/7605/7605.html   (8171 words)

  
 Reevaluation of Ascorbate in Cancer Treatment: Emerging Evidence, Open Minds and Serendipity -- Padayatty and Levine 19 ...
In this speculative sense, ascorbate is one of the early unorthodox
ascorbate survived 300 days longer than controls [8,9].
Amacher DE, Paillet SC: Ascorbate is detectably mutagenic in the L5178Y TK+/- cell mutation assay.
www.jacn.org /cgi/content/full/19/4/423   (1535 words)

  
 Calcium Ascorbate
Antiatherogenic, antihypercholesterolemic, Vitamin C (calcium ascorbate) is an immune booster and aids in fighting bacterial infections.
Vitamin C (calcium ascorbate) is an anti-cancerogenic, antitumorigenic, antibacterial, and promotes bone and tooth formation.
Vitamin C (calcium ascorbate) assists in the absorption of calcium, increases the effectiveness of iron and barbiturates and decreases the absorption of copper.
www.althealth.co.uk /services/info/supplements/calcium_ascorbate1.php   (560 words)

  
 Decreasing Ascorbate Intake Does Not Affect the Levels of Glutathione, Tocopherol or Retinol in the Ascorbate-Requiring ...   (Site not responding. Last check: 2007-10-17)
Decreasing Ascorbate Intake Does Not Affect the Levels of Glutathione, Tocopherol or Retinol in the Ascorbate-Requiring Osteogenic Disorder Shionogi Rats -- Smith et al.
E levels were not affected by decreasing dietary ascorbate intake.
of ascorbate may be associated with elevated glycation of hemoglobin.
www.nutrition.org /cgi/content/abstract/129/6/1229   (342 words)

  
 Ascorbate recycling in human neutrophils: Induction by bacteria -- Wang et al. 94 (25): 13816 -- Proceedings of the ...
Ascorbate is found in normal circulating human neutrophils in millimolar concentration and is accumulated by two mechanisms
Ascorbate and dehydroascorbic acid were measured as described by HPLC with coulometric electrochemical detection or by scintillation
The specific role of ascorbate recycling in neutrophil function is not certain, but there are several intriguing possibilities.
www.pnas.org /cgi/content/full/94/25/13816   (2509 words)

  
 (WO 01/82955) DEPLETION METHOD OF BLOOD PLASMA ASCORBATE   (Site not responding. Last check: 2007-10-17)
When mice were given exogenous ascorbate or its physiological precursor, L-gulono-γ-lactone, the plasma level of ascorbate was elevated substantially but immediately returned to the basal levels.
However, the circulation life of the exogenous ascorbate oxidase in the animal was successfully extended by chemical modification with methoxypolyethylene glycol.
This study suggests that the chemically modified ascorbate oxidase should find many uses in the animal studies on ascorbate since it was found to deplete plasma ascorbate even in the ascorbate-synthesizing animal in the absence of dietary control.
www.wipo.int /ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/82955.011108   (271 words)

  
 Duodenal Ascorbate Levels Are Changed in Mice with Altered Iron Metabolism -- Atanasova et al. 134 (3): 501 -- Journal ...   (Site not responding. Last check: 2007-10-17)
mouse duodenum was incubated in vitro and analyzed for ascorbate
FIGURE 1 Effect of in vitro incubation on ascorbate levels in duodenal fragments from mice exposed to hypoxia for 3 d.
ascorbate rapidly from the glucose present in the medium.
www.nutrition.org /cgi/content/full/134/3/501   (3758 words)

  
 Ascorbate (Online) by Steve Hickey , Hilary Roberts (Book) in Books > Medicine & Biotechnology > Health Science > ...
Ascorbate: The Science of Vitamin C by Mike Mesham
The people who are concerned with damaging the reputation of vitamin C are possibly the same people who advocate the use of expensive drugs, sold by big multi-national drug companies.
'Ascorbate' recommends the widespread use of Vitamin C that could cut the health service budget in half.
www.lulu.com /content/55277   (676 words)

  
 Vitamin C for IV Use
It turns out that sodium ascorbate is soluble to almost exactly a 50% concentration at room temperature.
I presume that this is good because sodium ascorbate is clear and dehydroascorbate is yellow.
I do not know if it is an acid problem (because ascorbic acid was used rather than sodium ascorbate) or whether some colleges get carried away with what other things they add to the intravenous solutions.
www.orthomed.com /civprep.htm   (763 words)

  
 Regulation and function of ascorbate peroxidase isoenzymes -- Shigeoka et al. 53 (372): 1305 -- Journal of Experimental ...
Amako K, Chen GX, Asada K. Separate assays specific for ascorbate peroxidase and guaiacol peroxidase and for the chloroplastic and cytosolic isoenzymes of ascorbate peroxidase in plants.
Ascorbate peroxidase: a prominent membrane protein in oilseed glyoxysomes.
Chen G-X, Asada K. Ascorbate peroxidase in tea leaves: occurrence of two isozymes and the differences in their enzymatic and molecular properties.
jxb.oupjournals.org /cgi/content/full/53/372/1305   (5952 words)

  
 The relationship of the urinary ascorbate metabolites to specific levels of ascorbate supplementation in the monkey -- ...
The relationship of the urinary ascorbate metabolites to specific levels of ascorbate supplementation in the monkey -- Tillotson and McGown 34 (11): 2405 -- American Journal of Clinical Nutrition
The relationship of the urinary ascorbate metabolites to specific levels of ascorbate supplementation in the monkey
monkeys fed high levels of ascorbate were 75% for ascorbate and 7% for
www.ajcn.org /cgi/content/abstract/34/11/2405   (216 words)

  
 Ascorbate-Deficient Mutants of Arabidopsis Grow in High Light Despite Chronic Photooxidative Stress -- ...
Ascorbate is found in concentrations of up to 25 m
Foyer C, Rowell J, Walker D (1983) Measurement of ascorbate content of spinach leaf protoplasts and chloroplasts during illumination.
Smirnoff N (2000b) Ascorbate biosynthesis and function in photoprotection.
www.plantphysiol.org /cgi/content/full/134/3/1163   (5068 words)

  
 Antioxidant-independent ascorbate enhancement of catecholamine-induced contractions of vascular smooth muscle -- Dillon ...
Antioxidant-independent ascorbate enhancement of catecholamine-induced contractions of vascular smooth muscle -- Dillon et al.
Ascorbate reduces the oxidation rate of catecholamines and,
Ascorbate may play a role in shock and asthma treatments
ajpheart.physiology.org /cgi/content/abstract/286/6/H2353   (302 words)

  
 TWINLAB ASCORBATE VITAMIN C POWDER 8 OZ ( VITAMIN C )   (Site not responding. Last check: 2007-10-17)
A delicious blend of high potency Vitamin C (from Calcium Ascorbate) Plus Lemon Bioflavonoids, Rose Hips, Acerola, Rutin and Heperidin.
This product dissolves instantly, naturally, without the use of artificial instantizers which are detrimental because of the high heat and materials used in their production.
As a dietary supplement, add 1 teaspoonful of Twinlab Ascorbate C to 6 fl.
www.enkueros.net /30134.html   (262 words)

  
 Intravenous Vitamin C (Ascorbate) for Cancer Treatment   (Site not responding. Last check: 2007-10-17)
Research has found that Intravenous Vitamin C administration in the form of Ascorbate was tested on nine cancer cell lines and four normal cell lines.
The effect of Ascorbate on the cells is found by a chemical reaction in which the hydrogen peroxide produced toxicity to the cells.
Mark Levine said that the anticancer effect of Ascorbate has to be tested on patients to find its efficacy and side effects, has many substances that have been shown to kill cancer cells in the lab but failed to fulfill that promise when tested in people.
www.medindia.net /news/view_news_main.asp?x=4930   (413 words)

  
 Holistic Health Encyclopedia - E   (Site not responding. Last check: 2007-10-17)
In the Ester-C manufacturing process, the vitamin C is fully reacted with an essential mineral (such as calcium), resulting in a neutral pH and a strong mineral bond.
Buffered forms of mineral ascorbates are also nonacidic; however, many are dry-blended which means that they don't react until they are in your system, causing gas accompanied by stomach and intestinal discomfort.
Increases white blood cell ascorbate levels 4 times more, is better absorbed, & is faster absorbed.
www.myholistic.com /glossary/E.php3   (7235 words)

  
 Magnesium Ascorbate   (Site not responding. Last check: 2007-10-17)
Not only is this product an excellent source of Vitamin C and Magnesium, it can also act as a digestive aid especially in cases of constipation.
SCS Intensive Nutrition's Magnesium Ascorbate is especially recommended for individuals experiencing constipation when taking SCS Intensive Nutrition's plant tannin formulas.
It provides both the essential magnesium mineral and Vitamin C for the human body.
www.doctorshealthsupply.com /intensive/magnesium_ascorbate.htm   (562 words)

  
 Calcium Ascorbate
Calcium Ascorbate Buffered Vitamin C Crystals (4 ounces)(SAVE 40% DURING OUR SOURCE NATURALS SALE!) (Mfr: Source Naturals)
Calcium Ascorbate Buffered Vitamin C Crystals (8 ounces) (SAVE 40% DURING OUR SOURCE NATURALS SALE!) (Mfr: Source Naturals)
We recommend in all cases that you consult with a trusted health care professional before taking any nutritional supplements or discontinuing any medication.
www.gaines.com /store/Minerals/CalcAsc.html   (344 words)

  
 Super Ascorbate C ( Vitamin C ), TwinLab, 2000 mg, 8 oz. powder   (Site not responding. Last check: 2007-10-17)
A delicious pure blend of Vitamin C (from five mineral ascorbates) with lemon bioflavonoids, rose hips, acerola, rutin and hesperidin.
Potassium (from potassium ascorbate) 120 mg 3 %
Directions: As a dietary supplement, add one teaspoonful or one half teaspoonful of TwinLab Super Ascorbate C to 6 fl.
www.iherb.com /superascorbate1.html   (159 words)

  
 Magnesium Ascorbate, Now Foods, Net Wt. 8 oz. (227 g)   (Site not responding. Last check: 2007-10-17)
Magnesium Ascorbate is a buffered (non-acidic) form of Vitamin C that will not contribute to gastric irritation in acid-sensitive persons.
Magnesium Ascorbate is synthesized from a combination of Ascorbic Acid and Magnesium to form Magnesium Ascorbate.
Magnesium Ascorbate is a buffered form of vitamin C which contains approximately 87% Ascorbic Acid and 7.5% Magnesium.
www.iherb.com /magascorb.html   (172 words)

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