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Topic: Atorvastatin

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	the Drug Monitor - Atorvastatin (Lipitor) - Nasr Anaizi, PhD
		Atorvastatin is contraindicated in active liver disease or unexplained persistent elevations of serum transaminases.
		Atorvastatin therapy should be temporarily withheld or discontinued in any patient with an acute, serious condition suggestive of a myopathy or having a risk factor predisposing to the development of renal failure secondary to rhabdomyolysis (severe acute infection, hypotension, major surgery, trauma, severe metabolic / endocrine disorders, and poorly controlled tonic-clonic seizure disorder, etc).
		Atorvastatin may be the most useful statin in the treatment of patients with homozygous familial hypercholesterolemia who may require pheresis in addition to drug therapy.
	www.thedrugmonitor.com /lipitor.html (2115 words)

	Atorvastatin -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-11-06)
		Atorvastatin inhibits a rate-determining (Any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions) enzyme located in hepatic tissue used in cholesterol synthesis, which lowers the amount of cholesterol produced.
		Atorvastatin is available as (An oral drug (trade name Lipitor) that is effective in lowering triglycerides; potent in reducing LDL cholesterol because higher doses can be given) Lipitor in tablet form (10, 20, 40 or 80 mg) for oral administration.
		Atorvastatin is a competitive (A substance that retards or stops an activity) inhibitor of (A liver enzyme that is responsible for producing cholesterol) HMG-CoA reductase.
	www.absoluteastronomy.com /encyclopedia/a/at/atorvastatin.htm (506 words)

	Lipitor Indications, Dosage, Storage, Stability - Atorvastatin - RxList Monographs
		Atorvastatin is indicated as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson Types IIa and IIb).
		The dosage of atorvastatin in patients with homozygous FH is 10 to 80 mg daily.
		Atorvastatin may be used in combination with a bile acid binding resin for additive effect.
	www.rxlist.com /cgi/generic/atorvastatin_ids.htm (727 words)

	Lipitor Online, Description, Chemistry, Ingredients - Atorvastatin - RxList Monographs
		Atorvastatin is an inhibitor of 3 hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.
		Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below.
		Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, slightly soluble in ethanol, and freely soluble in methanol.
	www.rxlist.com /cgi/generic/atorvastatin.htm (173 words)

	atorvastatin - [Medication]
		Atorvastatin is used to reduce the amounts of LDL (bad) cholesterol, total cholesterol, triglycerides (another type of fat), and apolipoprotein B (a protein needed to make cholesterol) in your blood.
		Atorvastatin is in the FDA pregnancy category X. This means that atorvastatin is known to cause birth defects if it is taken during pregnancy.
		Atorvastatin may need to be taken on a long-term basis for the treatment of high cholesterol.
	www.peacehealth.org /kbase/multum/d04105a1.htm (1327 words)

	Atorvastatin Better than Simvastatin for Achieving Total Cholesterol Targets (Site not responding. Last check: 2007-11-06)
		The maximum dose of atorvastatin was 80mg, while the maximum approved dose of simvastatin at the time of the study was 40mg supplemented if necessary with 4g of cholestyramine.
		Atorvastatin has been shown in clinical studies to produce reductions in LDL-C in patients with elevated cholesterol of 39 percent to 60 percent across the dose range of 10mg to 80mg.
		Atorvastatin is indicated as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and TG and to increase HDL-C levels in patients with primary hypercholesterolemia and mixed dyslipidemia.
	www.pslgroup.com /dg/1cc806.htm (924 words)

	Mosby's Drug Consult Top 200
		Atorvastatin calcium is effective in a wide variety of patient populations with hypercholesterolemia, with and without hypertriglyceridemia, in men and women, and in the elderly.
		Atorvastatin therapy should be temporarily withheld or discontinued in any patient with an acute, serious condition suggestive of a myopathy or having a risk factor predisposing to the development of renal failure secondary to rhabdomyolysis (e.g., severe acute infection, hypotension, major surgery, trauma, severe metabolic, endocrine and electrolyte disorders, and uncontrolled seizures).
		Atorvastatin calcium should be administered to women of child-bearing potential only when such patients are highly unlikely to conceive and have been informed of the potential hazards.
	www.mosbysdrugconsult.com /DrugConsult/Top_200/Drugs/e3318.html (5697 words)

	amlodipine and atorvastatin - Connecticut (Site not responding. Last check: 2007-11-06)
		Amlodipine and atorvastatin are used together to treat high blood pressure or angina (chest pain) that occurs together with elevated levels of cholesterol or triglycerides.
		Amlodipine and atorvastatin is in the FDA pregnancy category X. This means that amlodipine and atorvastatin is known to cause birth defects if it is taken during pregnancy.
		Symptoms of an overdose of amlodipine and atorvastatin are not known.
	www.saintfranciscare.com /19809.cfm (1518 words)

	Amlodipine/Atorvastatin (Caduet)
		Atorvastatin inhibits HMG-CoA reductase, which is the rate limiting enzyme in the liver that converts HMG-CoA to mevalonate, a precursor of cholesterol.
		Amlodipine is converted to inactive metabolites (90%) in the liver, while atorvastatin is hepatically metabolized via the CYP3A4 enzyme into active metabolites, which is responsible for 70% of the circulating inhibitory activity of HMG-CoA reductase.
		Atorvastatin is a known CYP3A4 inhibitor, thus increased effects occur with concurrent administration of cyclosporine, fibrates, niacin, erythromycin, and azole antifungals.
	uuhsc.utah.edu /pharmacy/bulletins/caduet.html (736 words)

	Lipitor Side Effects & Drug Interactions - Atorvastatin - USA Today (Site not responding. Last check: 2007-11-06)
		Atorvastatin plasma concentrations and LDL-C reduction were not altered by coadministration of cimetidine.
		Coadministration of atorvastatin and an oral contraceptive increased AUC values for norethindrone and ethinyl estradiol by approximately 30% and 20%.
		Atorvastatin had no clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment.
	www.healthscout.com /rxdetail/68/2/2/main.html (622 words)

	Atorvastatin (Site not responding. Last check: 2007-11-06)
		Atorvastatin blocks the action of an enzyme required for the manufacture of cholesterol, thereby interfering with its formation.
		By lowering the amount of cholesterol in the liver cells, atorvastatin increases the formation of receptors for LDL, and thereby reduces blood levels of total and LDL cholesterol.
		Because atorvastatin has potential side effects, it is important that you maintain a recommended healthy diet and cooperate with other treatments your doctor may suggest.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,665,00.html (564 words)

	Clinical Significance of the Atorvastatin-Clopidogrel Drug-Drug Interaction * Response -- Lau et al. 110 (6): e66 -- ... (Site not responding. Last check: 2007-11-06)
		Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes.
		Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug–drug interaction.
		Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction.
	circ.ahajournals.org /cgi/content/full/110/6/e66 (838 words)

	MedlinePlus Drug Information: Atorvastatin
		Atorvastatin is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood.
		Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins).
		Atorvastatin comes as a tablet to take by mouth.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a600045.html (774 words)

	ADA: Atorvastatin May Lower LDL And Triglycerides In Type 2 Diabetics (Site not responding. Last check: 2007-11-06)
		Atorvastatin 10 mg and 80 mg significantly lowered triglyceride levels by 25 percent and 35 percent respectively versus 10 percent in the placebo group.
		Atorvastatin has been shown in clinical studies to produce reductions in LDL-C of 39 percent to 60 percent across the dose range of 10 mg to 80 mg in patients with elevated cholesterol.
		Trials assessing the effect of atorvastatin on atherosclerosis and cardiovascular morbidity and mortality are also underway.
	www.pslgroup.com /dg/1FF056.htm (666 words)

	University of Miami School of Medicine - Glossary - atorvastatin
		Atorvastatin may be used in pregnancy if the physician feels that its benefits outweigh the potential risks.
		Therefore, the physician must decide whether to instruct a pregnant woman to continue taking atorvastatin and nursing if the benefits of treatment are judged to outweigh the potential risks, or to discontinue either nursing or atorvastatin if the potential risks are judged to outweigh the benefits.
		Atorvastatin should be used with caution in patients with alcohol or other liver diseases.
	www.med.miami.edu /glossary/art.asp?ArticleKey=776 (586 words)

	Atorvastatin - Patient UK
		Atorvastatin is used to lower levels of cholesterol and other lipids (fats) in the blood.
		Atorvastatin may help prevent medical problems caused by cholesterol and fats building up in blood vessels, such as heart disease and other problems.
		Women of childbearing age should not take atorvastatin unless they are using an effective contraceptive, which should be continued for at least one month after stopping treatment.
	www.patient.co.uk /showdoc/30002620 (809 words)

	Atorvastatin, Lipitor
		Atorvastatin is a member of the HMG-CoA reductase inhibitor family of drugs that blocks the body’s production of cholesterol.
		A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption.
		Atorvastatin in the treatment of primary hypercholesterolemia and mixed dyslipidemias.
	www.truestarhealth.com /Notes/healthnotes.asp?ContentID=1090009 (771 words)

	Atorvastatin
		The next day, the patient reinstituted by himself atorvastatin and colchicine, and he was readmitted to the hospital 4 days later because of diseminated petechiae.
		Chemically atorvastatin, a single stereoisomer of a pyrrole derivative, is different from other statins.1,3 The fact that thrombocytopenia was not caused in this patient while on simvastatin suggests that this adverse reaction was not an effect of HMG-CoA-reductase inhibition, but an idiosyncratic reaction to atorvastatin or to one of its metabolites.
		Consequently, for a patient with such a reaction to atorvastatin and for whom the lipid-lowering effects of an HMG-CoA-reductase inhibitor are necessary, other statins could be cautiously used.
	www.itppeople.com /atorvastatin.htm (471 words)

	Healthopedia.com Drugs Information - Atorvastatin : Before Using (Lipitor)
		Atorvastatin may cause birth defects or other problems in the baby if taken during pregnancy.
		However, blood levels of atorvastatin tend to be higher in older people than they do in younger adults.
		Niacin (nicotinic acid) in lipid-lowering doses—Use of these medicines with atorvastatin may increase the risk of developing muscle problems (causing the release of muscle pigment into the urine) that may lead to kidney failure
	www.healthopedia.com /drugs/detailed/atorvastatin/before-using.html (797 words)

	Atorvastatin
		Atorvastatin should be taken once a day, with or without food.
		It is especially important to check with your doctor before combining Atorvastatin with antacids, colestipol, cyclosporine, digoxin, erythromycin, fluconazole, gemfibrozil, itraconazole, ketoconazole, niacin, or oral contraceptives.
		Store Atorvastatin at room temperature in a tightly closed container, away from heat and light.
	www.health-net.info /atorvastatin.html (184 words)

	Atorvastatin - Drugs & Vitamins - Drug Library - DrugDigest
		Atorvastatin can help lower blood cholesterol for patients who are at risk of getting heart disease or a stroke.
		Atorvastatin can be taken at anytime of the day with or without food.
		Atorvastatin is only part of a total cholesterol-lowering program.
	www.drugdigest.org /DD/DVH/Uses/0,3915,55\|Atorvastatin,00.html (649 words)

	Newly Approved Drug Therapies (847): Caduet (amlodipine/atorvastatin ), Pfizer
		Subjects received once daily treatment with eight dose combinations of amlodipine and atorvastatin (5/10, 10/10, 5/20, 10/20, 5/40, 10/40, 5/80, or 10/80mg), amlodipine alone (5 mg or 10 mg), atorvastatin alone (10 mg, 20 mg, 40 mg, or 80 mg) or placebo.
		Atorvastatin, a HMGCoA reductase inhibitor indicated for lowering cholesterol, is the active ingredient in Lipitor (Pfizer).
		Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMGCoA reductase and cholesterol synthesis in the liver and by increasing the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDL.
	www.centerwatch.com /patient/drugs/dru847.html (599 words)

	VitaminShoppe.com - Health Guide - Atorvastatin
		lovastatin (a drug closely related to atorvastatin) or with atorvastatin itself may cause muscle disorders (myopathy) that can become serious (rhabdomyolysis).
		There is one case report of a woman developing severe muscle damage from simvastatin (a drug similar to atorvastatin) after she began eating one grapefruit per day.
		Although there have been no reports of a grapefruit–atorvastatin interaction, to be on the safe side, people taking atorvastatin should not eat grapefruit or drink grapefruit juice.
	www.vitaminshoppe.com /learning/healthguide/healthguide_content.jhtml?Category=Drug&title=Atorvastatin&relativePath=/content/healthnotes/Drug/Atorvastatin.htm (1085 words)

	REVERSAL: Atorvastatin halts atheroma progression (Site not responding. Last check: 2007-11-06)
		We strongly believe that consideration of more intensive treatment with 80-mg atorvastatin is now warranted in secondary prevention, particularly for patients at high risk of morbid events," he said.
		The primary end point was percent change in atheroma volume, which showed a 2.7% significant increase in the pravastatin group and a 0.4% nonsignificant reduction in the atorvastatin group.
		Nissen suggested that the superior reduction in CRP with atorvastatin might have contributed to its better effect on atheroma.
	www.clevelandclinic.org /heartcenter/pub/news/archive/2003/reversal11_13.asp (1544 words)

	The Seattle Times: Health: Heart-disease drugs show promise in fighting other ailments
		In January, she added atorvastatin, a drug not known for MS treatment — but along with other "statins" widely recognized for its ability to lower cholesterol.
		Rheumatoid arthritis: Scientists at the University of Glasgow, Scotland, reported that patients who took atorvastatin had a "modest" decrease in inflammation stemming from arthritis, compared with patients given placebos.
		The 116 patients in the study were assessed for disease severity, including pain and the number of swollen joints.
	seattletimes.nwsource.com /html/health/2001973144_healthstatin07.html (1794 words)

	MedlinePlus Drug Information: Atorvastatin (Systemic) (Site not responding. Last check: 2007-11-06)
		Atorvastatin (a-TOR-va-stat-in) is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood.
		Atorvastatin belongs to the group of medicines called 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors.
		Niacin may increase atorvastatin's adverse effects on muscle, which can lead to serious kidney problems.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/203635.html (1485 words)

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