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Topic: Aubrey de Grey

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  Aubrey de Grey - Wikipedia, the free encyclopedia
Aubrey de Grey (D.O.B April 20, 1963) is a biomedical gerontologist and bioinformatician at the Department of Genetics, University of Cambridge, England.
De Grey is Editor-in-Chief of the Rejuvenation Research journal, which deals with topics related to engineered negligible senescence.
De Grey believes that once dramatic life extension of already middle-aged mice has been achieved, a large amount of funding will be diverted to this kind of research, which would accelerate progress in doing the same for humans.
en.wikipedia.org /wiki/Aubrey_de_Grey   (654 words)

 Engineered negligible senescence - Wikipedia, the free encyclopedia
De Grey describes an "escape velocity" of life extension, when advances in senescence treatment come rapidly enough to save the lives of the oldest beneficiaries of the previous treatments.
De Grey claims that the goals work together to eliminate known causes of human senescence, are concrete, seem achievable, and are considered feasible by experts in the applicable fields.
De Grey believes that once this objective has been achieved in mice, a large amount of funding will be diverted to this kind of research, which would accelerate progress.
en.wikipedia.org /wiki/Engineered_negligible_senescence   (1308 words)

 Vue Weekly : Articles
De Grey is bringing his radical views on aging to the University of Alberta on Tuesday (February 15), where he will discuss the potential benefits of medical intervention in the aging process within our lifetime.
De Grey’s theory is reasonably simple: aging in humans, he says, is caused by molecular and cellular damage that accumulates in the body over time, the end result of the basic processes, like digestion, that keep us alive.
But de Grey believes that by using stem-cell manipulation, he can limit the accumulation of these by-products without affecting the processes themselves, which are beneficial to the body.
www.vueweekly.com /articles/default.aspx?i=1543   (923 words)

 Mike Linksvayer » Aubrey de Grey at Stanford   (Site not responding. Last check: 2007-11-07)
I was prepared to understand very little, but de Grey only spoke for awhile on one of his proposed solutions to one of the seven types of damage–extracellular junk.
Later de Grey said that this idea is the easiest to explain to non-specialists and that the others that he has personally worked on would have required far longer to introduce than the hour lecture format allowed.
de Grey is attempting to jump start anti-aging interventions with the Methuselah Mouse Prize[s] for extending the lifespan of mice, inspired by the X Prize.
gondwanaland.com /mlog/2005/06/12/de-grey-stanford   (933 words)

 Encyclopedia: Aubrey de Grey   (Site not responding. Last check: 2007-11-07)
Aubrey de Grey File history Legend: (cur) = this is the current file, (del) = delete this old version, (rev) = revert to this old version.
Rejuvenation Research is an authoritative peer-reviewed journal that publishes leading work on the implementation of rejuvenation therapies in the laboratory and eventually in the clinic, as well as basic research relevant to the further elucidation of what such therapies must do at the molecular and cellular level in order...
Aubrey de Grey is a theoretical biogerontologist at Cambridge University.
www.nationmaster.com /encyclopedia/Aubrey-de-Grey   (1528 words)

 John Hawks Anthropology Weblog : Prove Aubrey de Grey is a nut, win $20,000
Aubrey de Grey is a well-known futurist, with a twist.
Aubrey de Grey is a man of ideas, and he has set himself toward the goal of transforming the basis of what it means to be human.
De Grey lists seven basic causes, and argues that there likely aren't any more to be found, since no new ones have emerged in over twenty years.
johnhawks.net /weblog/topics/senescence/de_grey_challenge_2005.html   (705 words)

 Methuselah Mouse Man - Aubrey de Grey is helping humans live forever, whether or not he's a real biologist. By ...
Whether de Grey is a genius or a kook—MIT's no-nonsense Technology Review argued the latter, in a cover story and a bitchy editorial in February—he's the best thing to happen to aging research in a decade, since Cynthia Kenyon proved that tweaking the genes of roundworms made them live twice as long as usual.
De Grey's premise seems sober enough: Aging, he says, is a set of mechanical processes that happen inside and around our cells, causing them to eventually die one by one.
Before de Grey got interested in longevity, he was a computer programmer, a capacity in which his beard seems pretty normal.
www.slate.com /id/2115015/device/html40/workarea/3   (1537 words)

 The Impact of Emerging Technologies: Do You Want to Live Forever? - Technology Review
De Grey began reading the relevant literature in late 1995 and after only a few months had learned so much that he was able to explain previously unidentified ­influences affecting mutations in mitochondria, the intracellular structures that release energy from certain chemical processes necessary to cell function.
As he surveyed the literature, de Grey reached the conclusion that there are seven distinct ingredients in the aging process, and that emerging understanding of molecular biology shows promise of one day providing appropriate technologies by which each of them might be manipulated—“perturbed,” in the jargon of biologists.
De Grey has documented his contributions in the scientific literature, publishing scores of articles in an impressive array of journals, including those of the quality of Trends in Biotechnology and Annals of the New York Academy of Sciences, as well as contributing commentary and letters to other publications like Science and Biogerontology.
www.technologyreview.com /articles/05/02/issue/feature_aging.asp   (934 words)

 The Chronicle: 10/28/2005: The Man Who Would Murder Death
de Grey was on sabbatical from her position as a professor of genetics at the University of California at San Diego.
de Grey would like her to quit, but she's been a smoker since she was a teenager and believes that nicotine is necessary to kick-start her brain.
de Grey "drinks too much beer" and that even though he's just in his early 40s "the signs of decay are strongly marked on his face." He also called the potential social consequences of extending life indefinitely "terrible" and wrote that Mr.
chronicle.com /free/v52/i10/10a01401.htm   (3433 words)

 WCCO-TV - Minnesota's Breaking News, Video, Weather, Traffic and Sports: Scientist Ponders Eternal Youth   (Site not responding. Last check: 2007-11-07)
De Grey has identified the biological processes he thinks are responsible for aging, including the mutations that cause cancer and the gradual buildup of useless, toxic junk.
De Grey says that not all of the conditions that cause our bodies to age can be avoided or prevented…yet.
De Grey acknowledges that some people will say those 100,000 lives lost a day are just in the nature of things.
wcco.com /health/health_story_001195918.html   (1744 words)

 Telegraph | Health | 'I can make you live to be 1,000'
Aubrey de Grey's wife is 60 years old, but he promises to get her up to 1,000.
De Grey reckons he needs £1 billion over the next 10 years to produce "escape velocity": average age will be extended by a few decades to begin with, but further advances will be made, so that the potential age of a human being can be ratcheted all the way up to a thousand and beyond.
Which is why de Grey has devised the Methuselah Mouse competition – which will be won by the first mouse (normal maximum age, three) to achieve the grand old age of five.
www.telegraph.co.uk /health/main.jhtml?xml=/health/2005/02/16/hage16.xml&sSheet=/health/2005/02/16/ixhright.html   (688 words)

 Fight Aging!: Aubrey de Grey in Fortune Magazine   (Site not responding. Last check: 2007-11-07)
But de Grey has emerged as one of the boldest thinkers and organizers in the science of aging, whose ideas have begun to influence a whole generation of biologists, even as they make rapid strides toward understanding that universal curse.
Aubrey de Grey's first big bold stroke, engineered in concert with the indefatigable Dave Gobel, is the Methuselah Mouse Prize.
De Grey believes that mounting a high-profile campaign to arrest aging in mice would rivet public attention on the huge promise of anti-aging research, making it politically tenable to put in serious money.
www.fightaging.org /archives/000133.php   (1429 words)

 Sentient Developments: Another Technology Review attack on Aubrey de Grey   (Site not responding. Last check: 2007-11-07)
In his waking life, de Grey is the ­com­puter support to a research team; he dresses like a shabby graduate student and affects Rip Van Winkle’s beard; he has no children; he has few interests outside the science of biogeron­tology; he drinks too much beer.
Immortality might be okay for de Grey, but an entire world of the same superagenarians thinking the same kinds of thoughts forever would be terrible.
de Grey a "troll" it was of course a literary
sentientdevelopments.blogspot.com /2005/01/another-technology-review-attack-on.html   (816 words)

 Life Extension Daily News   (Site not responding. Last check: 2007-11-07)
Cambridge University biogerontologist Dr. Aubrey de Grey reckons "we have a 50-50 chance of developing a human rejuvenation therapy that works." His timetable calls for 10 years to prove the scheme works for mice, and another five years to apply the techniques to humans.
De Grey and his supporters believe that genetic engineering, stem cell research, and other technologies offer opportunities to "correct" the body's ills.
If this DNA could be copied into the cell nuclei, de Grey argues, they would be far better protected, slowing the aging process by half.
www.lef.org /news/LefDailyNews.htm?NewsID=1259&Section=AGING   (521 words)

 Methuselah Mouse Prize - Wikipedia, the free encyclopedia
The prize is named after Methuselah, a patriarch in the Bible said to have reached 969 years of age.
Cambridge biogerontologist Aubrey de Grey is co-founder (with David Gobel) and chief scientist of the project.
From his biogerontology work, De Grey believes there are seven root causes of cellular aging, or as he puts it, "the set of accumulated side effects from metabolism that eventually kills us,"[1] all of which are reversible.
www.wikipedia.org /wiki/Methuselah_mouse_contest   (566 words)

 FuturePundit: Aubrey De Grey: We Could Triple Mouse Lives In 10 Years
In an interview with the MIT Technology Review biogerontologist Aubrey de Grey states that treatments that would tripe mouse life expectancy could be developed within 10 years.
Aubrey advocates use of an animal model to demonstrate that rejuvenation therapies could be developed for humans and he has founded the Methuselah Mouse Foundation to provide awards to scientists who break new records in mouse longevity.
My Aging Reversal archive has many other posts about Aubrey's views on why we can reverse aging within the lifetimes of many people who are currently alive and why we ought to try much harder to do the research that will let us reverse aging.
www.futurepundit.com /archives/002042.html   (2098 words)

 Betterhumans > Interview   (Site not responding. Last check: 2007-11-07)
ADG: The way to cure aging is to rejuvenate tissues, not to try to slow down their deterioration.
ADG: Well, each of the seven treatments listed above has its own obstacles, but none of them is obviously incredibly hard except targeted gene therapy and there has been quite a bit of progress even on that in recent years.
ADG: The Methuselah Mouse project (visit project home page) is my way of breaking the fatalism logjam by making life-extension research on mice more interesting to the public.
www.betterhumans.com /Interviews/Interview/tabid/111/Interview/845/Default.aspx   (3137 words)

 The Chronicle of Higher Education: Colloquy Transcript
Aubrey de Grey believes that some people alive right now could live to be 1,000 years old.
Aubrey de Grey holds a Ph.D. in biology from the University of Cambridge.
Dr. De Grey: You make a good many public predictions both about the prospects of scientific success and the possibilities of increased life spans.
chronicle.com /colloquy/2005/11/forever   (2523 words)

 ImmInst.org -> Where Is Thy Sting? - quote by Aubrey de Grey
Aubrey, he has been a strong advocate in the fight against death.
Aubrey hopes to bridge the gap between theory and application in anti-aging from an engineer's perspective.
Aubrey was instrumental in setting up the Methuselah Mouse Project.
www.imminst.org /forum?s=&act=ST&f=69&t=1559&st=0   (3661 words)

 Aubrey de Grey   (Site not responding. Last check: 2007-11-07)
Aubrey de Grey (born 1963) is a pioneering biogerontologist at the Universityof Cambridge in England who is currently working to expedite the development of atrue cure for human aging, a medical goal he refers to as engineered negligible senescence.
Prior to his work as a biologist, de Grey was formally trained in computer science —a discipline that provided him with insight into thehuman aging problem and cellular biology in particular.
De Grey's current work at Cambridge centers around a detailed plan called Strategies for Engineered NegligibleSenescence (SENS) which is aimed at preventing age-related physical and cognitive decline.
www.therfcc.org /aubrey-de-grey-128008.html   (206 words)

 The Longevity Meme -- pointing the way to a longer, healthier life
This PDF-format article on Aubrey de Grey and his Strategies for Engineered Negligible Senescence appeared in the Winter edition of Advances in Orthomolecular Research.
de Grey earned his doctorate with a seminal work that overthrew previous thought on the role of mitochondria (the cellular 'power plants') in aging.
But he eventually realized that even a solution to the problem of age-associated mitochondrial mutations would not lead to a final solution to the ongoing, seemingly-inevitable theft of health, dignity, and life by the aging process." His currently proposed solution took a few more years to gel into its present form.
www.longevitymeme.org /news/view_news_item.cfm?news_id=1360   (261 words)

 The Impact of Emerging Technologies: Debating Immortality - Technology Review
What follows is a letter to de Grey by Richard Miller, a professor of pathology at the University of Michigan and a well-known biogerontologist.
De Grey has challenged gerontologists to debate the merits of the SENS program, and has expressed his opinion that we are now at or near a historical "cusp"; those born after the cusp will be able to stay alive and youthful by adherence to the SENS strategy.
Although de Grey's assertions have enjoyed wide circulation in the lay press, at scientific meetings, and in your own journal, it is fair to say that many experienced gerontologists still remain somewhat skeptical about his claims.
www.techreview.com /BioTech-Genomics/wtr_15936,312,p1.html   (454 words)

 Popular Science on Aubrey de Grey: The Prophet of Immortality :: AO   (Site not responding. Last check: 2007-11-07)
Aubrey de Grey proposes to tinker with the essential biochemical pathways that drive the aging process.
In de Grey time, the 400-year span between Shakespeare's England and today would be but the blink of an eye.
Aubrey de Grey should understand that there is harmful radioactivity in the atmosphere and this could pose problem for his theory.
www.alwayson-network.com /comments.php?id=7424_0_5_0_C   (760 words)

 BBC NEWS | UK | 'We will be able to live to 1,000'
Aubrey de Grey: "The first person to live to 1,000 might be 60 already"
Ageing is a physical phenomenon happening to our bodies, so at some point in the future, as medicine becomes more and more powerful, we will inevitably be able to address ageing just as effectively as we address many diseases today.
Aubrey de Grey leads the SENS project at Cambridge University and also runs the Methuselah Mouse prize for extending age in mice.
news.bbc.co.uk /1/hi/uk/4003063.stm   (961 words)

 Anti-Aging Medicine & Science Blog: Aubrey de Grey On 60 Minutes Soon
de Grey describes SENS best in his opening paragraph on the SENS website: "SENS is a detailed plan for curing human aging.
de Grey is not an armchair general in this war on aging.
This volume focuses squarely on the fact that, as a result of a wide range of advances over recent years, increasingly many specialists studying the biology of aging are revising their traditional view that mammalian aging will remain essentially immutable for many decades to come.
anti-ageing.us /2005/09/aubrey-de-grey-on-60-minutes-soon.html   (1191 words)

 NEXT05 - exit habit. Conference News
We’re very pleased to announce that Aubrey de Grey, Jason Tester, Norbert A. Streitz and Stefan Andrén will be joining us for EXIT HABIT.
Aubrey de Grey is a pioneering biogerontologist at the University of Cambridge who’s working to develop a true cure for human aging.
According to Dr. de Grey, we already have the knowledge we need to prevent – even reverse – the physical and mental effects of aging as we know it: finding a cure for old age is a question of the right interdisciplinary and goal-oriented approach.
www.next2005.dk /2005/en/conferencenews.html   (663 words)

 CNN.com - Extended life spans 'within reach' - May 16, 2005
During 2005 de Grey enjoyed extensive media coverage, triggering belated analysis of SENS by top biogerontologists goaded by the media's dissatisfaction with the absence of such critiques.
Most acknowledged that it could indeed, possibly, work in mice in a few decades -- though de Grey's projected timeframe of just one decade was generally rejected.
But with $100 million per year guaranteed for 10 years, de Grey mobilized the relevant biomedical communities toward the single-minded goal of making already middle-aged mice live much longer healthy lives.
www.cnn.com /2005/HEALTH/05/12/visionary.degrey   (630 words)

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