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Topic: Autoantibody

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	Previous Autoantibody Targets of the Month
		Autoantibodies may develop to these molecules as well; however, there is less clarity about the role that these autoantibodies may play in exacerbating atherosclerosis.
		Autoantibodies to the small proteins associated with this molecule are often measured together and one of them is a specific marker for an important disease.
		Autoantibodies to the other ribonucleoproteins (colored yellow and which vary, depending on the type of complex) are associated with SLE as well as other autoimmune disorders.
	www.aacc.org /AACC/members/divisions/immunology/antibody.htm (3111 words)

	Autoantibody - Wikipedia, the free encyclopedia
		An autoantibody is a protein manufactured by the immune system that is directed against one or more of the host's own proteins.
		Many autoimmune diseases in humans, most notably lupus erythematosus, are caused by such autoantibodies.
		Note: the sensitivity and specificity of various autoantibodies for a particular disease is different for different diseases.
	en.wikipedia.org /wiki/Autoantibody (111 words)

	Genetic Linkage of IgG Autoantibody Production in Relation to Lupus Nephritis in New Zealand Hybrid Mice -- Vyse et al. ...
		We focused on autoantibodies that have been previously implicated in the pathogenesis of nephritis, including IgG autoantibodies to dsDNA, histone, chromatin and ssDNA and autoantibodies to gp70 in the form of gp70 IC (2, 17, 21, 22).
		Backcross mice with autoantibody levels below the lower horizontal bar were assigned a low/ negative phenotype with respect to the autoantibody measured, whereas mice with autoantibody levels above the upper horizontal bar were assigned a high autoantibody phenotype.
		Linkage between genotype and autoantibody phenotype, as determined by extreme phenotype analysis, are shown in mice at 7 mo of age (Table II A), and for peak autoantibody values (Table II B).
	www.jci.org /cgi/content/full/98/8/1762 (6713 words)

	[No title] (Site not responding. Last check: 2007-10-17)
		Assays for Autoantibodies The present invention is concerned with assays for screening a sample of body fluid for autoantibodies to various antigens.
		In first and second screening methods, and first and second kits, according to the present invention, in the presence of an autoantibody or autoantibodies being screened for in a sample of body fluid, generally binding of the autoantibody or autoantibodies with the antigen precludes binding of the latter with immobilised antibody.
		In the presence of autoantibody or autoantibodies, substantially no colour change can be seen, or some colour change can be seen due to non-immobilised antibody binding to antigen in competition with autoantibody and antigen binding whereby antigen bound to non-immobilised antibody can also bind to immobilised antibody giving a colour change.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=00/25137.000504&ELEMENT_SET=DECL (7695 words)

	Autoantibody to growth hormone in a patient with myasthenia gravis -- Okada et al. 127 (3): 533 -- Journal of ...
		Autoantibody to growth hormone in a patient with myasthenia gravis -- Okada et al.
		Autoantibody to growth hormone in a patient with myasthenia gravis
		An autoantibody to GH was detected in the serum from a patient with myasthenia gravis (MG) who had never been prescribed GH.
	joe.endocrinology-journals.org /cgi/content/abstract/127/3/533 (142 words)

	Ovid: Njoku: Anesth Analg, Volume 94(2).February 2002.243-249
		In addition, autoantibodies reacting with P450 2E1 are significantly elevated in the sera of 45%–70% of patients diagnosed with halothane hepatitis, whereas control subjects did not demonstrate increased levels of these autoantibodies (10,11).
		To determine whether differences in the autoantibody levels could be explained in terms of the baseline characteristics of each group, these characteristics were examined for both pediatric and general anesthesiologists.
		To determine whether differences in the autoantibody levels of pediatric and general anesthesiology groups were statistically different because of predictor variables, two separate multiple regression models were constructed (17).
	www.uic.edu /com/mcas/auto-antibodies.html (4211 words)

	[No title] (Site not responding. Last check: 2007-10-17)
		The amount of TPO autoantibodies present in a sample is determined by the amount of label detected bound to the TPO autoantibody through the second TPO molecule and simultaneously bound to the first modified TPO molecule.
		Accordingly, in light of this unexpected problem, it would be desirable to have a TPO autoantibody sandwich antigen assay that utilizes liquid reagents in which all of the liquid reagents are stable for a period of time which allows for their use on an automated diagnostic assay instrument.
		The thyroid peroxidase autoantibody is bound at a first site to the thyroid peroxidase autoantibody first specific binding partenr and bound at a second site to the thyroid peroxidase autoantibody specific binding partner adjacent to a solid support.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=00/31535.000602&ELEMENT_SET=DECL (4028 words)

	Archives of Environmental Health: Autoantibody responses of individuals in an oil sands development community (Site not responding. Last check: 2007-10-17)
		Of interest, the study group had higher titers of autoantibodies, with 9 at 1:160, 6 at 1:320, 8 at 1:640, 3 at 1:1280, and 1 at 1:5120, whereas all three positives in the control group had titers of 1:160, which is the lowest dilution that defines a positive test.
		In this study, we found that the frequency of a positive autoantibody test in the group living near the oil sands development was comparable with that of the control group.
		Although higher autoantibody titers are more likely to be seen in disease states, (14) we did not find an associated increase in disease prevalence.
	www.findarticles.com /p/articles/mi_m0907/is_3_59/ai_n15874599 (1251 words)

	[No title] (Site not responding. Last check: 2007-10-17)
		Autoantibody profiling may serve purposes including classification of individual patients and subsets of patients based on their 'autoantibody fingerprint', examination of epitope spreading and antibody isotype usage, discovery and characterization of candidate autoantigens, and tailoring antigen-specific therapy.
		Autoantibody profiling using antigen microarray technology does not provide direct information about the specificity of the T cells that mediate autoimmunity.
		We believe the specificity of the autoantibody response is predictive of the specificity of the overall autoimmune response at the level of whole autoantigens.
	www.mult-sclerosis.org /news/Jul2002/FullTextAutoantibodyProfilingForAutoimmuneDisease.html (2992 words)

	News - Autoantibody Positive Gestational Hyperglycaemic Women Need Insulin More Often
		The researchers from the University of Turin and the Hospital of Asti, assessed the prevalence of beta-cell autoantibodies in women with gestational diabetes and impaired glucose tolerance.
		Autoantibody positivity was 8.9% in patients with diabetes, 17.9% in patients with impaired tolerance and 0.3% in patients with normoglycaemia.
		Hyperglycaemic patients with autoantibodies had lower body mass index, smaller waist measurements, less weight gain at the time of the screening test and a lower percentage of previous pregnancies than hyperglycaemic patients who did not have autoantibodies.
	www.docguide.com /news/content.nsf/news/8525697700573E1885256CAB002497D6 (425 words)

	Glutamic Acid Decarboxylase (GAD) Autoantibody
		Autoantibodies can be detected in many cases prior to the onset of glucose intolerance.
		autoantibodies are often markedly elevated in patients with the stiff-person syndrome (also referred to as stiff-man syndrome), a condition that is associated with fluctuating stiffness and paroxysmal spasms of the trunk and legs.
		and ICA512(IA-2) Autoantibodies in Organ and Nonorgan-Specific Autoimmune Diseases Confers High Specificity for Insulin-Dependent Diabetes Mellitus,” J Autoimmun, 1998, 11(1):1-10.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/sr016400.htm (484 words)

	Serum samples of patients with rheumatoid arthritis contain a specific autoantibody to "denatured" aldolase A in the ...
		The reactivity of anti-aldolase A autoantibody in RA serum to the denatured and native aldolase A was examined by the competitive
		A in the circulation and that of anti-aldolase A autoantibody
		Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex.
	ard.bmjjournals.com /cgi/content/full/58/3/169 (3708 words)

	Arthritis Research & Therapy \| Full text \| Autoantibody profiling for the study and treatment of autoimmune disease
		We are utilizing our 'myelin proteome' arrays to characterize the autoantibody response in EAE serum, multiple sclerosis patient serum and cerebral spinal fluid, and to guide selection of antigen-specific therapies in relapsing EAE [22].
		Furthermore, in T-cell-mediated IDDM, the presence of combinations of autoantibodies against at least two islet antigens, including insulin, glutamic acid decarboxylase, and IA-2, are diagnostic for or predictive of future development of IDDM [23].
		Intermolecular and intramolecular epitope spreading of the autoreactive B-cell response is associated with progression to overt clinical disease in human and murine SLE [24,25] and in IDDM [23].
	arthritis-research.com /content/4/5/290 (3102 words)

	Serological Diagnosis of Idiopathic Pulmonary Alveolar Proteinosis -- KITAMURA et al. 162 (2): 658 -- American Journal ...
		The autoantibody was eluted from the latex beads by
		the subclasses of the autoantibody, the membrane was incubated
		the autoantibody to be a mixture of IgG
	ajrccm.atsjournals.org /cgi/content/full/162/2/658 (3802 words)

	Cause and pathophysiology of chronic ITP (Site not responding. Last check: 2007-10-17)
		In most patients, the autoantibody binds to an antigen on one of the protein complexes (a complex is a combination of two or more proteins) on the platelet surface.
		Platelet destruction in chronic ITP is due to either: (1) antibody binding to a platelet autoantigen(s) followed by phagocytosis of the platelets by white blood cells (neutrophils or monocytes) or (2) binding of cytotoxic T lymphocytes to platelets followed by release of toxins causing platelet death.
		There is experimental evidence to show that autoantibody can suppress platelet production; studies have not been done, thus far, to evaluate the role of cytotoxic T lymphocytes.
	www.scripps.edu /itp/cause.html (663 words)

	Exacerbation of Autoantibody-Mediated Hemolytic Anemia by Viral Infection -- Meite et al. 74 (13): 6045 -- The Journal ...
		Hematocrit was measured at different times after injection of 2 mg of antierythrocyte autoantibody in groups of four or five uninfected BALB/c mice or in animals also infected with LDV.
		This effect of LDV infection on autoantibody pathogenicity was transient, as shown in Fig.
		Liver sections were prepared from control mice (a) and from mice 4 days after administration of 2 mg of the 34-3C antibody alone (b), LDV alone (c), or the 34-3C antibody and LDV (d).
	jvi.asm.org /cgi/content/full/74/13/6045 (2820 words)

	News - Prolonged Treatment With Infliximab Causes Autoantibody Formation
		Prolonged treatment with infliximab typically results in autoantibody formation, which is correlated with a greater number of infusions and a higher total dose of infliximab infused, new research suggests.
		In early reports, the formation of autoantibodies was noted in a small number of patients; however, the extent of autoantibody formation and the association with treatment efficacy and adverse effects have not been fully evaluated.
		New autoantibody formation was associated with both a greater number of infusions (P =.015) and a higher total dose of infliximab infused (P =.047).
	www.docguide.com /news/content.nsf/news/8525697700573E1885256E1C0038E452 (553 words)

	Pharmalicensing.com
		The invention relates to compositions and methods for detecting autoantibodies against an extracellular form of protein kinase A (ECPKA) in a biological sample for the diagnosis of cancer.
		ECPKA is secreted from cancer cells which then elicits the formation of serum autoantibodies which can serve as a cancer diagnostic and prognostic marker.
		The present invention demonstrates that the sera presence of autoantibody directed against ECPKA is highly correlative of cancer.
	pharmalicensing.com /licensing/displicopp/3153 (296 words)

	Pathogenic Autoantibody Interactions in Lupus Nephritis (Site not responding. Last check: 2007-10-17)
		In the investigation of pathogenic lupus autoantibodies, a subset of monoclonal anti-DNA IgG was identified, that penetrate cellular and nuclear membranes and localize within nuclei in vivo.
		In the investigation of pathogenic lupus autoantibodies, a subset of monoclonal anti-DNA IgG derived from lupus-prone mice, that penetrate cellular and nuclear membranes and localize within nuclei in vivo was identified.
		Madaio, M.P.: B cells and autoantibodies in the pathogenesis of lupus nephritis.
	renal2.med.upenn.edu /RehdWeb/madaiores.html (1929 words)

	Maternal Autoantibody Triggers De Novo T Cell-Mediated Neonatal Autoimmune Disease -- Setiady et al. 170 (9): 4656 -- ...
		and interestingly, the disease was not elicited by autoantibody
		IgG autoantibody response to distant ZP3 epitopes (24).
		Rapid induction of autoantibodies by endogenous ovarian antigens and activated T cells: implication in autoimmune disease pathogenesis and B cell tolerance.
	www.jimmunol.org /cgi/content/full/170/9/4656 (6576 words)

	Autoantibody Profiles and Neurological Correlations of Thymoma -- Vernino and Lennon 10 (21): 7270 -- Clinical Cancer ... (Site not responding. Last check: 2007-10-17)
		Williams CL, Hay JE, Huiatt TW, Lennon VA. Paraneoplastic IgG striational autoantibodies produced by clonal thymic B cells and in serum of patients with myasthenia gravis and thymoma react with titin.
		Ryanodine receptor autoantibodies in myasthenia gravis patients with a thymoma.
		ASM Press Washington, DC Walikonis JE, Lennon VA. Radioimmunoassay for glutamic acid decarboxylase (GAD65) autoantibodies as a diagnostic aid for stiff-man syndrome and a correlate of susceptibility to type 1 diabetes mellitus.
	clincancerres.aacrjournals.org /cgi/content/full/10/21/7270 (3011 words)

	Increased Autoantibody Titers Against Epitopes of Oxidized LDL in LDL Receptor—Deficient Mice With Increased ... (Site not responding. Last check: 2007-10-17)
		Autoantibodies of the IgG, IgA, and IgM type in the plasma of LDL receptor–deficient mice fed the high-fat (n=8) or low-fact control (n=8) diet for 167 days.
		Apoprotein E–deficient mice are a model of lipoprotein oxidation in atherogenesis: demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.
		Autoantibodies against modified low-density lipoprotein: nonlipid factor of blood plasma that stimulates foam cell formation.
	atvb.ahajournals.org /cgi/content/full/15/10/1569 (5746 words)

	Autoantibody Responses to Carbohydrate Epitopes in Endometriosis -- YEAMAN et al. 955 (1): 174 -- Annals of the New ...
		Autoantibody Responses to Carbohydrate Epitopes in Endometriosis -- YEAMAN et al.
		Autoantibody responses to endometrial and serum antigens are
		that this glycotope is involved in the autoantibody response.
	www.annalsnyas.org /cgi/content/abstract/955/1/174 (334 words)

	Molecular Characterization of Virus-induced Autoantibody Responses -- Ludewig et al. 200 (5): 637 -- The Journal of ...
		Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice.
		Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin.
		Autoantibody to DNA binding protein B as a novel serologic marker in systemic sclerosis.
	www.jem.org /cgi/content/full/200/5/637 (3910 words)

	Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine ...
		Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect -- Bleeker et al.
		Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect
		Anti-idiotypic suppression of autoantibodies to factor VIII (antihaemophilic factor) by high-dose intravenous gammaglobulin.
	www.bloodjournal.org /cgi/content/full/98/10/3136 (4934 words)

	Stratification of Type 1 Diabetes Risk on the Basis of Islet Autoantibody Characteristics -- Achenbach et al. 53 (2): ...
		Autoantibody subclass and epitope reactivities in 180 autoantibody-positive first-degree relatives of patients with type 1 diabetes.
		For each autoantibody, the prevalences of IgG subclasses other than IgG1 (A) and the prevalences of autoantibodies to multiple epitopes or IA-2ß epitopes (B) were significantly associated with autoantibody titer, which is represented as quartiles of positive titers from lowest (1st) to highest (4th) quartile.
		in the absence of autoantibodies to GAD or insulin.
	diabetes.diabetesjournals.org /cgi/content/full/53/2/384 (4815 words)

	Prediction of Autoantibody Positivity and Progression to Type 1 Diabetes: Diabetes Autoimmunity Study in the Young ...
		Autoantibody profiles of three individuals followed in DAISY representing transient, persistent, and prediabetics.
		The expression of ICA and the biochemical autoantibodies GAA,
		Ziegler A-G, Hummel M, Schenker M, Bonifacio E 1999 Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.
	jcem.endojournals.org /cgi/content/full/89/8/3896 (4159 words)

	Anti-Calpastatin Autoantibody Detection Elisa available from Research Diagnostics Inc
		Autoantibodies reactive against human calpastatin were detected by screening a cDNA expression library with the serum of a patient with the history of venous thrombosis and suspected antiphospholipid syndrome.
		By testing further sera it could be shown that >90% of calpastatin autoantibodies, detected by Western blotting against calpastatin, react with the C-terminal peptide of the protein.
		Furthermore an increased incidence of calpastatin autoantibodies was found for a subgroup of patients with rheumatoid arthritis (7).
	www.researchd.com /rdikits/calpaskt.htm (1105 words)

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