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Topic: Autocrine

Related Topics

Autocrine signalling

Autocrine agent

Paracrine signalling

Paracrine agent

Leukotriene

Prostaglandin

Histamine

Somatostatin

Smooth muscle

Thromboxane

Myocardial infarction

Paracrine

	Autocrine signalling - Wikipedia, the free encyclopedia
		Autocrine signalling is a form of signalling in which a cell secretes a chemical messenger (called the autocrine agent) that signals the same cell.
		An example of an autocrine agent is the cytokine interleukin-1 in monocytes.
		When this is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it.
	en.wikipedia.org /wiki/Autocrine_signalling (189 words)

	Autocrine loops with positive feedback enable context-dependent cell signaling -- Shvartsman et al. 282 (3): C545 -- ...
		A: bistability as a basis of memory effects in autocrine loops with positive feedback: steady levels of intracellular signaling activity in a model autocrine loop were computed as a function of (steady) exogenous stimulus.
		Autocrine loop in the "on" state (A) converts transient external perturbation (B) to a long-lasting and dynamic transient of the intracellular signaling (C).
		Autocrine loop is interrupted when the cell has a low number of surface receptors (D) or when the endogenous ligands are captured by components of the cellular microenvironment (E).
	ajpcell.physiology.org /cgi/content/full/282/3/C545 (5859 words)

	Localization of Autocrine Motility Factor Receptor to Caveolae and Clathrin-independent Internalization of Its Ligand ...
		Benlimame, N., Simard, D., and Nabi, I.R. Autocrine motility factor receptor is a marker for a distinct tubular membrane organelle.
		Nabi, I.R., Watanabe, H., and Raz, A. Autocrine motility factor and its receptor: role in cell locomotion and metastasis.
		Silletti, S., Paku, S., and Raz, A. Tumor autocrine motility factor responses are mediated through cell contact and focal adhesion rearrangement in the absence of new tyrosine phosphorylation in metastatic cells.
	www.molbiolcell.org /cgi/content/full/9/7/1773 (6170 words)

	Novel roles of the autocrine motility factor/phosphoglucose isomerase in tumor malignancy -- Yanagawa et al. 11 (4): ...
		Benlimame N, Le PU and Nabi IR 1998 Localization of autocrine motility factor receptor to caveolae and clathrin-independent internalization of its ligand to smooth endoplasmic reticulum.
		Funasaka T, Haga A, Raz A and Nagase H 2001 Tumor autocrine motility factor is an angiogenic factor that stimulates endothelial cell motility.
		Le PU, Benlimame N, Lagana A, Raz A and Nabi IR 2000 Clathrin-mediated endocytosis and recycling of autocrine motility factor receptor to fibronectin fibrils is a limiting factor for NIH-3T3 cell motility.
	erc.endocrinology-journals.org /cgi/content/full/11/4/749 (5189 words)

	Self-Organization of Polarized Cell Signaling via Autocrine Circuits: Computational Model Analysis — Portal
		Autocrine cells both produce signalling modelcules and respond to them.
		A cell releases EGFR ligands into its environment, and a fraction of the released ligand is recaptured by the receptors at the cell surface.
		Model siumulations supported the hypothesis that autocrine EGFR siganlling circuits could contribute to the generation and/or maintainance of intrinsic cell spatial polarity, possibly realted to migration as ell as tissue organisation.
	www.cellml.org /models/maly_wiley_lauffenburger_2004_version01 (456 words)

	Oncogenic Transformation of Human Mammary Epithelial Cells by Autocrine Human Growth Hormone -- Zhu et al. 65 (1): 317 ...
		Autocrine hGH stimulation of anchorage-independent growth in immortalized human mammary epithelial cells is JAK2 dependent.
		Autocrine stimulation of human mammary carcinoma cell proliferation by human growth hormone.
		Autocrine human growth hormone inhibits placental transforming growth factor-beta gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells.
	cancerres.aacrjournals.org /cgi/content/full/65/1/317 (4648 words)

	Autocrine FGF-2 Is Responsible for the Cell Density-Dependent Susceptibility to Apoptosis of HUVEC : A Role of a ...
		Autocrine FGF-2 Is Responsible for the Cell Density-Dependent Susceptibility to Apoptosis of HUVEC : A Role of a Calpain Inhibitor-Sensitive Mechanism -- Kinoshita and Shimokado 19 (10): 2323 -- Arteriosclerosis, Thrombosis, and Vascular Biology
		Autocrine FGF-2 Is Responsible for the Cell Density–Dependent Susceptibility to Apoptosis of HUVEC
		Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.
	atvb.ahajournals.org /cgi/content/full/19/10/2323 (4645 words)

	ApoE-mediated cholesterol efflux from macrophages: separation of autocrine and paracrine effects -- Dove et al. 288 ...
		Theoretical basis for the separation of autocrine and paracrine effects of apolipoprotein E (apoE) on cholesterol efflux.
		Effects that occur solely in the juxtacellular space are independent of the extracellular distribution volume and are autocrine.
		Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized.
	ajpcell.physiology.org /cgi/content/full/288/3/C586 (3695 words)

	Autocrine Growth of Epstein-Barr Virus-Positive Gastric Carcinoma Cells Mediated by an Epstein-Barr Virus-Encoded Small ...
		Autocrine Growth of Epstein-Barr Virus-Positive Gastric Carcinoma Cells Mediated by an Epstein-Barr Virus-Encoded Small RNA.
		Although it is not known whether IGF-I is the sole determinant of GC development, what we have shown here is that EBER-induced IGF-I acts as an autocrine growth factor in GC cells, and EBV-positive GC biopsies consistently express IGF-I. In previous articles, we reported that EBER contributes oncogenically to Burkitt’s lymphoma (16, 17, 23).
		Moreover, it induces IL-10 expression and secreted IL-10 acts as an autocrine growth factor for Burkitt’s lymphoma (16).
	www.euchromatin.org /Iwakiri01.htm (3527 words)

	Autocrine, Mitogenic Pheromone Receptor Loop of the Ciliate Euplotes raikovi: Pheromone-Induced Receptor ...
		Autocrine, Mitogenic Pheromone Receptor Loop of the Ciliate Euplotes raikovi: Pheromone-Induced Receptor Internalization -- Vallesi et al.
		Autocrine, Mitogenic Pheromone Receptor Loop of the Ciliate Euplotes raikovi: Pheromone-Induced Receptor Internalization
		Autocrine mitogenic activity of pheromones produced by the protozoan ciliate Euplotes raikovi.
	ec.asm.org /cgi/content/full/4/7/1221 (4716 words)

	Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission ...
		Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias -- Dias et al.
		Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias
		Autocrine and Paracrine VEGF/VEGFR2 Signaling Pathways Are Essential for Leukemic Cell Growth.
	www.pnas.org /cgi/content/full/98/19/10857 (4369 words)

	Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct ...
		Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes.
		Inhibition of both paracrine and autocrine VEGF/VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias.
		Angiogenic growth factors: autocrine and paracrine regulation of survival in hematologic malignancies.
	www.bloodjournal.org /cgi/content/full/103/10/3883 (5523 words)

	Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration -- ...
		Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration -- Maheshwari et al.
		The observation that autocrine EGF-stimulated migration of the
		Autocrine regulation of membrane transforming growth factor-a cleavage.
	www.jcb.org /cgi/content/full/155/7/1123 (4050 words)

	Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys -- Schwiebert et al. ...
		Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys -- Schwiebert et al.
		Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys
		ATP and its metabolites are potent autocrine agonists that act extracellularly within tissues to affect epithelial function.
	ajprenal.physiology.org /cgi/content/full/282/4/F763 (7721 words)

	Autocrine/Paracrine Mechanisms in Human Hematopoiesis -- Janowska-Wieczorek et al. 19 (2): 99 -- Stem Cells
		In vivo models for studying the role of autocrine or paracrine growth factors in hematologic malignancies.
		Evidence for internal autocrine regulation of growth in acute myeloblastic leukemia cells.
		Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-ß1 is a cycle-independent effect and influences their hematopoietic potential.
	stemcells.alphamedpress.org /cgi/content/full/19/2/99 (3946 words)

	Autocrine growth inhibition by transforming growth factor {beta}-1 (TGF{beta}-1) in human neuroendocrine tumour cells ... (Site not responding. Last check: 2007-10-20)
		Autocrine growth inhibition by transforming growth factor {beta}-1 (TGF{beta}-1) in human neuroendocrine tumour cells -- Wimmel et al.
		Autocrine growth inhibition by transforming growth factor ß-1 (TGFß-1) in human neuroendocrine tumour cells
		Transforming growth factor beta 1 (TGF beta 1) is an autocrine positive regulator of colon carcinoma U9 cells in vivo as shown by transfection of a TGF beta 1 antisense expression plasmid.
	gut.bmjjournals.com /cgi/content/full/52/9/1308 (4594 words)

	Vascular Smooth Muscle Growth: Autocrine Growth Mechanisms -- Berk 81 (3): 999 -- Physiological Reviews
		suggesting a role as an endogenous autocrine factor (315).
		Stimulation of PDGF expression is among the most common autocrine VSMC growth mechanisms (265, 267).
		Both IL-1 (17.5 kDa) and IL-6 (20.5 kDa) have been reported to have autocrine growth effects on VSMC (136, 254).
	physrev.physiology.org /cgi/content/full/81/3/999 (9308 words)

	Autocrine Hepatocyte Growth Factor Provides a Local Mechanism for Promoting Axonal Growth -- Yang et al. 18 (20): 8369 ...
		Autocrine growth factors have previously been demonstrated to be important for neuronal survival (Acheson et al., 1995
		Such an HGF autocrine loop is apparently not limited to this later stage of sympathetic neuron development.
		It is as yet unknown whether such an autocrine HGF loop occurs in other neurons.
	www.jneurosci.org /cgi/content/full/18/20/8369 (9713 words)

	Autocrine Transforming Growth Factor {beta} Suppresses Telomerase Activity and Transcription of Human Telomerase ...
		Autocrine Transforming Growth Factor {beta} Suppresses Telomerase Activity and Transcription of Human Telomerase Reverse Transcriptase in Human Cancer Cells -- Yang et al.
		Autocrine Transforming Growth Factor ß Suppresses Telomerase Activity and Transcription of Human Telomerase Reverse Transcriptase in Human Cancer Cells
		The total radioactivity of all PCR-amplified telomeric bands and the IC band in each lane was quantified separately with a PhosphorImager, and the relative telomerase activity was calculated according to the manufacturer’s instructions and plotted in B for HCT116 cells and in D for MCF-7 cells.
	cgd.aacrjournals.org /cgi/content/full/12/2/119 (6424 words)

	Multiple Distinct Signal Pathways, Including an Autocrine Neurotrophic Mechanism, Contribute to the Survival-Promoting ...
		autocrine mechanism contributes to the survival of depolarized
		Davies AM (1996) Paracrine and autocrine actions of neurotrophic factors.
		Hegarty JL, Kay AR, Green SH (1997) Trophic support of cultured spiral ganglion neurons by depolarization exceeds and is additive with that by neurotrophins or cAMP, and requires e
	www.jneurosci.org /cgi/content/full/21/7/2256 (7970 words)

	Self-Organization of Polarized Cell Signaling via Autocrine Circuits: Computational Model Analysis -- Maly et al. 86 ...
		On the abscissa axis is the concentration of EGFR ligand in the medium far from the autocrine cell.
		The solid and broken curves are the steady-state fractions of activated, ligand-bound forms of EGFR at the opposite poles of the cell.
		Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration.
	www.biophysj.org /cgi/content/full/86/1/10 (6477 words)

	Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced ...
		Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis -- Frassanito et al.
		Villunger A, Egle A, Kos M, Hittmair A, Maly K, Greil R. Constituents of autocrine IL-6 loops in myeloma cell lines and their targeting for suppression of neoplastic growth by antibody strategies.
		Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma.
	www.bloodjournal.org /cgi/content/full/97/2/483 (4758 words)

	Neutralization of Autocrine Transforming Growth Factor-{beta} in Human Cord Blood CD34+CD38-Lin- Cells Promotes ...
		of autocrine and paracrine TGF-ß1 to HSC differentiation.
		Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells.J Immunol 2002;168:755–762.
		Ploemacher RE, van Soest PL, Boudewijn A. Autocrine transforming growth factor beta 1 blocks colony formation and progenitor cell generation by hemopoietic stem cells stimulated with steel factor.
	stemcells.alphamedpress.org /cgi/content/full/21/5/557 (4401 words)

	TGF-{beta} autocrine loop regulates cell growth and myogenic differentiation in human rhabdomyosarcoma cells -- ...
		TGF-{beta} autocrine loop regulates cell growth and myogenic differentiation in human rhabdomyosarcoma cells -- BOUCHÉ et al.
		Autocrine loops are often involved in regulating proliferation
		autocrine loop is likely operating in these cells.
	www.fasebj.org /cgi/content/full/14/9/1147 (6584 words)

	Autocrine Activation of the IGF-I Signaling Pathway in Mesangial Cells Isolated From Diabetic NOD Mice -- Tack et al. ...
		Autocrine Activation of the IGF-I Signaling Pathway in Mesangial Cells Isolated From Diabetic NOD Mice -- Tack et al.
		Autocrine Activation of the IGF-I Signaling Pathway in Mesangial Cells Isolated From Diabetic NOD Mice
		of autocrine IGF-I with a neutralizing antibody decreased the
	diabetes.diabetesjournals.org /cgi/content/full/51/1/182 (4029 words)

	Autocrine Motility Factor Signaling Enhances Pancreatic Cancer Metastasis -- Tsutsumi et al. 10 (22): 7775 -- Clinical ...
		Funasaka T, Haga A, Raz A, Nagase H. Tumor autocrine motility factor is an angiogenic factor that stimulates endothelial cell motility.
		Funasaka T, Haga A, Raz A, Nagase H. Autocrine motility factor secreted by tumor cells upregulates vascular endothelial growth factor receptor (Flt-1) expression in endothelial cells.
		Niizeki H, Kobayashi M, Horiuchi I, et al Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells.
	clincancerres.aacrjournals.org /cgi/content/full/10/22/7775 (4769 words)

	The oncogenic potential of autocrine human growth hormone in breast cancer -- Waters and Conway-Campbell 101 (42): ... (Site not responding. Last check: 2007-10-20)
		The oncogenic potential of autocrine human growth hormone in breast cancer -- Waters and Conway-Campbell 101 (42): 14992 -- Proceedings of the National Academy of Sciences
		Autocrine GH could thus act within the nucleus to regulate
		autocrine prolactin decreases the proliferation of breast cancer
	www.pnas.org /cgi/content/full/101/42/14992 (1751 words)

	Induction of a Negative Autocrine Loop by Expression of Sst2 Somatostatin Receptor in NIH 3T3 Cells -- Rauly et al. 97 ... (Site not responding. Last check: 2007-10-20)
		Induction of a Negative Autocrine Loop by Expression of Sst2 Somatostatin Receptor in NIH 3T3 Cells -- Rauly et al.
		Induction of a Negative Autocrine Loop by Expression of Sst2 Somatostatin Receptor in NIH 3T3 Cells
		Yamada (1989) Somatostatin receptors on canine fundic D-cells: evidence for autocrine regulation of gastric somatostatin.
	www.jci.org /cgi/content/full/97/8/1874 (6420 words)

	Spatial Range of Autocrine Signaling: Modeling and Computational Analysis -- Shvartsman et al. 81 (4): 1854 -- ...
		Autocrine loops formed by growth factors and their receptors have been identified in a large number of developmental, physiological,
		of autocrine cells to recapture the endogenous ligand and the
		autocrine signaling enables autocrine cells to perceive a broad
	www.biophysj.org /cgi/content/abstract/81/4/1854 (518 words)

	Autocrine Regulation of Single Pancreatic {beta}-Cell Survival -- Navarro-Tableros et al. 53 (8): 2018 -- Diabetes (Site not responding. Last check: 2007-10-20)
		Autocrine Regulation of Single Pancreatic {beta}-Cell Survival -- Navarro-Tableros et al.
		Trophic autocrine effects of insulin and NGF on ß-cell survival.
		Inhibition of autocrine regulation of ß-cells increases cell death.
	diabetes.diabetesjournals.org /cgi/content/full/53/8/2018 (3780 words)

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