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	National MS Society \| Avonex (Interferon beta-1a) (Site not responding. Last check: 2007-10-13)
		Avonex is approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients with relapsing forms of MS to slow the accumulation of physical disability and decrease the frequency of clinical exacerbations.
		Avonex is to be used with caution in individuals with a seizure disorder.
		Because of the potential of Avonex to affect the functioning of the liver and thyroid gland, and to cause a drop in the levels of white blood cells, red blood cells, and platelets in a person's system, periodic blood tests are recommended.
	www.nationalmssociety.org /Meds-InterferonBeta1aAvo.asp (1101 words)

	Interferon beta-1a - Wikipedia, the free encyclopedia
		Avonex is a a once a week intramuscular injection using a 27 gauge needle (thicker than Rebif).
		Avonex was approved in USA in 1996, and in Europe in 1997, and is registered in more than 80 countries worldwide.
		Biogen Idec markets Avonex in two formulations: the original powder form, which requires the patient to reconstitute it before administration; and a newer pre-reconstituted "liquid Avonex" syringe kit.
	en.wikipedia.org /wiki/Avonex (763 words)

	MSWorld-Resource Center-News-FDA Approves Prefilled Syringe for MS Therapy, Avonex (Site not responding. Last check: 2007-10-13)
		As with the current form of Avonex, the new formulation will be indicated to slow the progression of disability and reduce the frequency of relapses in relapsing forms of MS, including people who have experienced a first clinical episode and who have brain scans consistent with MS.
		Avonex, which is administered by intramuscular injection, should be used with caution in patients with depression or other mood disorders and in patients with seizure disorders.
		Avonex is the leading treatment for relapsing forms of multiple sclerosis worldwide, with more than 120,000 patients on therapy.
	www.msworld.org /Resource_Center/med_info/n03avonexprefill.htm (460 words)

	Avonex - multiple sclerosis encyclopaedia
		Avonex is a form of beta interferon known as interferon beta-1a.
		Avonex is the same substance as Rebif but administered differently (30 mcg, intra-muscularly, once a week as against 22 mcg or 44 mcg, sub-cutaneously, 3 times a week for Rebif).
		Avonex is usually given in the large muscles of the thigh, upper arm, or hip.
	www.mult-sclerosis.org /Avonex.html (900 words)

	RemedyFind: patient ratings of Avonex for Multiple Sclerosis (Site not responding. Last check: 2007-10-13)
		Avonex (Interferon beta-1a) is a genetically modified beta interferon produced in mammalian cells.
		Avonex and Rebif are made up of exactly the same amino acids (major components of proteins) that are created by the body.
		Avonex (Interferon beta-1a) and the other interferon medications, Rebif (Interferon beta-1a) and Betaseron etc. (Interferon beta-1b), along with Copaxone (Glatiramer acetate), a synthetic protein that simulates myelin basic protein, make up the so-called “CRAB” therapies for MS.
	remedyfind.com /rm-1110-Avonex.asp (903 words)

	MS Society of Australia - MS information - Avonex
		Clinical trials found that avonex® (interferon beta -1a) has a significant beneficial effect in people with relapsing-remitting multiple sclerosis by reducing the accumulation of permanent physical disability, exacerbation frequency and disease activity measured by gadolinium-enhanced lesions on brain magnetic resonance images (MRI).
		Avonex® is a weekly intramuscular injection (into the muscle), which you or a chosen person is taught to give.
		Avonex® cannot be taken by mouth, as it is a protein and therefore digested (broken down) by gastric juices in the stomach.
	www.msaustralia.org.au /msinformation/avonex.htm (1763 words)

	Interferon beta-1a, Avonex, Biogen, Inc - Package Insert
		AVONEX® is formulated as a sterile, white to off-white lyophilized powder for intramuscular injection after reconstitution with supplied diluent (Sterile Water for Injection, USP).
		AVONEX® (Interferon beta-1a) is indicated for the treatment of patients with relapsing forms of multiple sclerosis to slow the accumulation of physical disability and decrease the frequency of clinical exacerbations.
		AVONEX® has also been evaluated in 290 patients with diseases other than multiple sclerosis, primarily chronic viral hepatitis B and C, in which the doses studied ranged from 15 mcg to 75 mcg, given SC, 3 times a week, for up to 6 months.
	www.fda.gov /cder/foi/label/2003/ifnbbio013103LB.htm (4738 words)

	Avonex (Interferon Beta-1a) Slows Progression In Secondary Multiple Sclerosis (Site not responding. Last check: 2007-10-13)
		Treatment with Avonex reduced the progression of disability of secondary progressive MS by 27 percent versus treatment with placebo.
		The primary objective was to determine whether weekly treatment with Avonex (60 mcg) is effective in slowing the progression of secondary progressive MS, as determined by the multiple sclerosis functional composite endpoint (MSFC).
		It was launched first in the U.S. in 1996 for the treatment of relapsing forms of MS to slow the accumulation of physical disability and decrease the frequency of clinical exacerbations.
	www.pslgroup.com /dg/1EFD5A.htm (407 words)

	Multiple Sclerosis Foundation Forum - avonex (joe)
		Avonex® (interferon beta-1a) has been shown to slow the rate of progression of disability in relapsing-remitting MS.
		Avonex is given as weekly intramuscular injection at a lower dose than Betaseron or Rebif.
		Avonex is indicated for the treatment of relapsing-remitting MS.
	www.msfacts.org /dcforum/DCForumID2/3116.html (987 words)

	Multiple Sclerosis Drug Avonex Approved for First Attack
		What is approved: The FDA has expanded its approval for the drug Avonex to include the treatment of people who experience their first multiple sclerosis (MS) attack, as confirmed by an MRI (magnetic resonance imaging) scan of the brain.
		Avonex (interferon beta-1a) is the first treatment to be approved for use in people who have had only one attack and whose MRI scans indicate MS as the likely cause.
		Precautions: Avonex should be used with caution in people with depression and other mood disorders or those with seizure disorders.
	my.webmd.com /content/article/60/67174 (339 words)

	Avonex (Site not responding. Last check: 2007-10-13)
		The population-based surveillance study was conducted to evaluate the efficacy and safety of Avonex and Betaseron in RRMS patients.
		Avonex had a 47 percent reduction in the risk of experiencing cognitive deterioration versus patients who were treated with placebo.
		AVONEX is the only MS therapy proven to be effective in people who have experienced a first attack and have MRI features consistent with MS.
	www.friendswithms.com /avonex.htm (3603 words)

	Evidence of the effectiveness of Avonex - BrainTalk Communities (Site not responding. Last check: 2007-10-13)
		In a separate analysis of the CHAMPS clinical trial, Avonex demonstrated a statistically significant benefit on "optic neuritis, brainstem-cerebellar syndromes, and spinal cord syndromes", so the benefit of Avonex was not limited to particular subgroups of those with MS.
		Those on Avonex enjoyed a statistically significant benefit on measures of information processing and learning/memory, and there was a beneficial trend -- which did not reach statistical significance -- on visuospatial measures and problem solving, but no benefit was detected on measures of verbal ability and attention span.
		The original Avonex patients from the pivotal FDA trial were followed for 8 years, and the amount of brain atrophy was significantly correlated with disability.
	brain.hastypastry.net /forums/showthread.php?t=18467 (2210 words)

	Avonex discussions (experiences, side effects, dosages, etc...) (Site not responding. Last check: 2007-10-13)
		Avonex is given intra-muscularly with a 1 1/4 inch long needle...
		I took avonex for about a year and a half and it was hell in an...
		She was not at all like this before using the Avonex, and has not had this problem since going off of it...
	drugtalk.com /avonex?p=3 (4785 words)

	Kline & Specter - Avonex Lawyer
		The multiple sclerosis drug Avonex may cause liver failure, according to a warning issued March 16, 2005 by the manufacturer, Biogen Idec Inc., and the U.S. Food and Drug Administration.
		Avonex has been on the market since 1996 and was used by about 130,000 patients.
		The warning about Avonex came just weeks after a newer Biogen drug used to treat multiple sclerosis, Tysabri, was suspended from the market after reports that the medication may have caused a rare brain disease in two patients, one of whom died.
	www.klinespecter.com /avonex.html (399 words)

	FDA Approves Labeling Change for Biogen's Avonex (Interferon Beta-1a) to Indicate Lower Occurrence of Neutralizing ...
		Recent studies with multiple sclerosis patients given AVONEX for at least 1 year showed the presence of neutralizing antibodies at the rate of 5 percent (13 of 261 patients).
		AVONEX should be used with caution in people with depression and people with seizure disorders.
		Headquartered in Cambridge, MA, the Company's revenues are generated from worldwide sales of AVONEX for treatment of relapsing forms of multiple sclerosis, and from the sales by licensees of a number of products.
	www.docguide.com /dg.nsf/PrintPrint/2448EFCF744E5E1385256C7100537916 (641 words)

	avonex drug information, avonex side effects
		Avonex was introduced to the market on May 17, 1996 as treatment for relapsing remitting multiple...
		Avonex is a medication manufactured by a biotechnological process from one of the naturally-occurring...
		Avonex, manufactured by Biogen, is a form of beta interferon (interferon beta, IFN-b) used to...
	www.drugs.com /drug/avonex (562 words)

	MSWorld-Resource Center-News-AAN: Avonex Slows Disability Progression In SPMS (Site not responding. Last check: 2007-10-13)
		The data, from a phase III study reported at the 53rd Annual Meeting of the American Academy of Neurology (AAN), showed that patients with secondary progressive MS who were treated with Avonex had a 40 percent decrease in the progression of disability compared to patients who received a placebo.
		Subjects were randomized to treatment with Avonex 60 µg or placebo by weekly intramuscular injection.
		In addition to a decrease in the median disability progression favoring Avonex, Avonex-treated patients had a 33 percent decrease in the disease relapse rate.
	msworld.org /Resource_Center/med_info/n01avonexspms2.htm (354 words)

	Avonex Information from Drugs.com
		Interferon beta-1a is a specific interferon used in the treatment of relapsing multiple sclerosis to slow the development of physical disability and to decrease the frequency of exacerbations.
		Avonex is in the FDA pregnancy category C. This means that it is not known whether Avonex will harm an unborn baby.
		The Avonex formulation of interferon beta-1a is used as an intramuscular (into the muscle) injection.
	www.drugs.com /avonex.html (1415 words)

	MSWorld Forums - steriods for avonex side effects (Site not responding. Last check: 2007-10-13)
		My philosophy is that since you are already taking Avonex which already causes side effects (some more serious than others) you shouldn't be giving your body a double whammy with steroid use if you can help it.
		I also take half the Avonex injection, because the side effects are so bad for me. I am doing much better on the half dose and working my way up to three quarters.
		I did start Avonex with a steroid for the first week or so but then was taken off, (thank God) Hope all goes well with everybody.
	www.msworldboards.org /vbulletin/archive/index.php/t-27691.html (1653 words)

	Liver Injury Warning for MS Drug Avonex
		Some of the cases occurred in Avonex users who were also taking other drugs that could cause liver problems, says the Biogen letter.
		Avonex is used to help treat MS symptoms.
		Avonex was the first drug to get approval for those patients.
	www.webmd.com /content/article/102/106608.htm (424 words)

	Avonex - MSNews \| Tysabri + Avonex 2 Year Data Published
		Avonex and Chronic MS The reason for starting Avonex was the fact I was being taken off Imuran.
		Treatment with Avonex, Rebif, or Betaseron may delay or reduce the chance of Avonex and Betaseron are effective at slowing the progression of cognitive
		Compared to Avonex alone, the data show 24% reduction in the risk of disability progression and a sustained 56% reduction in relapse rate.
	linkhighway.com /?q=avonex (431 words)

	Avonex, abc drugs of Multiple Sclerosis
		Interferon beta-1a (Avonex®) is for injection into a muscle.
		It may be given by a health-care professional in a hospital or clinic setting.
		The manufacturer of Avonex® offers free information to patients and their health care partners.
	www.pychealth.com /msandopcs.html (440 words)

	News Search: avonex (Site not responding. Last check: 2007-10-13)
		News on Avonex continually updated from thousands of sources around the net.
		Two types of beta interferon (Avonex and Betaferon) have been subsidised since 2000.
		BIOGEN: The Avonex program will be phased out for patients who qualify for Part D as of Dec. 31.
	www.topix.net /search?q=avonex (287 words)

	Avonex Dear Doctor Letter
		We encourage you to prescribe lyophilized AVONEX for your new patients instead of prefilled syringes until this situation is resolved.
		Nevertheless, until the manufacturing issue is fully resolved, some liquid AVONEX syringes released for distribution may contain increased levels of aggregates.
		This has the potential for immunogenicity-related events such as those listed in the AVONEX package insert including allergic reactions, anaphylaxis, dyspnea, orolingual edema, skin rash and/or urticaria or increased incidence of neutralizing antibodies which may result in decreased efficacy.
	www.fda.gov /cder/drug/shortages/avonexltr.htm (401 words)

	Newly Approved Drug Therapies (10): Avonex (Interferon Beta 1-A), Biogen
		Avonex is used for treatment of relapsing forms of multiple sclerosis.
		It is the first drug to have proven, in a blinded clinical trial, that it slows the progression of disability as well as reduces the frequency of exacerbations.
		In addition, subjects receiving Avonex in the trial experienced 32% fewer exacerbations of the disease than subjects on placebo.
	www.centerwatch.com /patient/drugs/dru10.html (272 words)

	National MS Society \| Avonex Labeling Change (Site not responding. Last check: 2007-10-13)
		It was announced last week that the U.S. FDA has issued a product safety alert about Avonex (interferon beta-1a), and the drug's distributor, Biogen Idec, has issued a letter to healthcare professionals about changes in its labeling that better reflect the risk of liver injury.
		The new wording suggests that before prescribing Avonex, doctors should consider the potential risk of Avonex if it will be used with other drugs or products (such as alcohol) that are known to be toxic to the liver.
		The FDA labeling for each of the three interferon beta medications used in MS (Avonex and Rebif, which are both interferon beta-1a and Betaseron, which is interferon beta-1b) includes recommendations for periodic liver function testing.
	www.nationalmssociety.org /clinup-Avonex.asp (415 words)

	Biogen Introduces the Avonex Alliance
		The Avonex Alliance will provide people with MS, as well as their care partners, with new support tools they can use to further enhance the AVONEX treatment experience," said Jim Tobin, President and Chief Executive Officer of Biogen.
		Members of The Avonex Alliance who are using AVONEX will also receive materials to support therapy, such as a video in which AVONEX users share their experiences with therapy, and a voucher for free extra injection supplies, such as needles and syringes, to supplement materials already provided with each package of AVONEX.
		The Company's revenues are generated from U.S. and European sales of AVONEX (interferon beta-1a) for treatment of relapsing forms of multiple sclerosis, and from the worldwide sales by licensees of a number of products, including alpha interferon and hepatitis B vaccines and diagnostic products.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/112862&EDATE= (390 words)

	Suicide, Depression, Liver Toxicity with Avonex – FDA Warning DrugIntel (Site not responding. Last check: 2007-10-13)
		Approved May 17, 1996, Avonex represents a bold step forward in treating the autoimmune disease Multiple Sclerosis.
		Avonex, Interferon, Multiple Sclerosis Medication, Avonex Deaths, Avonex Litigation, Prescription Drug Avonex, Avonex Side Effects, Avonex Expert Witness, Avonex Lawsuits, Avonex Liver.
		Multiple Sclerosis Drug Avonex is linked to Depression, Suicide, Liver injury; FDA Biogen modify label.
	www.drugintel.com /drugs/avonex.htm (159 words)

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