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Topic: Avram Hershko


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  Avram Hershko
Avram Hershko was born in 1937, in Karcag, Hungary.
Hershko is a Distinguished Professor at the Unit of Biochemistry, the Rappaport Faculty of Medicine at the Technion (Israel Institute of Technology) in Haifa, Israel.
Hershko, A., Ciechanover, A., Heller, H., Haas, A. L., and Rose, I. (1980) Proposed role of ATP in protein breakdown: conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis.
www.jewishvirtuallibrary.org /jsource/biography/Hershko.html   (323 words)

  
 Hershko, Avram - MSN Encarta
Hershko, Avram, born in 1937, Hungarian-born Israeli biochemist and cowinner of the 2004 Nobel Prize in chemistry for his role in discovering the process by which cells apply a molecular “tag” to certain proteins, marking them for destruction.
When Hershko and his colleagues began their research in the 1970s, many scientists had studied the process by which cells assemble the hundred thousand or so different proteins that fulfill many vital cellular functions.
Hershko and Ciechanover, who was then his graduate student, decided to study a question that had puzzled biochemists since the 1950s: why the breakdown of a cell’s own proteins require energy on the part of the cell, when other forms of protein degradation do not consume the cell’s energy.
encarta.msn.com /encyclopedia_701711820/Hershko_Avram.html   (691 words)

  
 Canadian Jewish News   (Site not responding. Last check: 2007-11-02)
Avram Hershko, one of the three winners of this year’s Nobel Prize in chemistry, owes his life to a random event that occurred in Hungary during the Holocaust in 1944.
Hershko, an Israeli who shares the award with two other scientists, Aaron Ciechanover of Israel and Irwin Rose of the United States, was to have been transported to that infamous death camp in Poland with his mother, Shoshana, and older brother, Chaim.
Hershko, the first Israeli, along with Ciechanover, to win a Nobel Prize in science, was not at his home on Mount Carmel on Sukkot when the Royal Swedish Academy of Sciences called to inform him that he was one of the winners.
www.cjnews.com /viewarticle.asp?id=4680   (1131 words)

  
 February 1996
F., Hershko, A. and Pagano, M. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
Golan, A., Yudkovsky, Y. and  Hershko, A. The cyclin-ubiquitin ligase activity of the cyclosome/APC is jointly activated by protein kinases Cdk1/cyclin B and Plk.
Hershko, A. Mechanisms and regulation of the degradation of cyclin B. Phil.
pard.technion.ac.il /archives/presseng/Html/CV-Hershko_20041.Html   (1852 words)

  
 israelinsider: Culture: Two Israelis share in Nobel Prize for chemistry   (Site not responding. Last check: 2007-11-02)
Aaron Ciechanover, 57, Avram Hershko, 67 - the first Israelis to win a chemistry prize - and Irwin Rose, 78, were honored by the Royal Swedish Academy of Sciences for their work in the 1980s that discovered one of the cell's most important cyclical processes, regulated protein degradation.
Hershko was born in the small town of Karcag in Hungary in 1937.
Hershko was appointed a member of the Israel Academy of Sciences in 2000 and in 2003 was elected a member of the National Academy of Sciences of the United States.
web.israelinsider.com /Articles/Culture/4228.htm   (1363 words)

  
 MBL :: Inside the MBL :: News :: Publications / Databases
Hershko, a professor of biochemistry at the Technion-Israel Institute of Technology in Haifa, Israel, is a long-time member of the MBL family.
Hershko shares this year’s chemistry prize with Aaron Ciechanover, also of the Technion, and Irwin Rose, an MBL Embryology course alumnus and researcher at the University of California, Irvine.
Hershko is collaborating with fellow MBL summer investigators Yosef Gruenbaum of Hebrew University of Jerusalem, Robert Palazzo, and Robert Goldman.
www.mbl.edu /inside/what/news/publications/labnotes/2004/04_fall01.html   (858 words)

  
 Professor Avram Hershko, Professor Aaron Ciechanover
Professors Aaron Ciechanover (1947-) and Avram Hershko (1937-) share the 2004 Nobel Prize for Chemistry with Professor Irwin Rose (USA) for contributing "ground-breaking knowledge" in "discoveries of ubiquitin-related protein degeneration" (The "Ubiquitin System"), identifying the staged process in cells to be marked for destruction - as published in 1978 and pursued in the 1980s.
Both are recipients of the Israel prize: Hershko in 1994 (Biochemistry and Medicine) and Ciechanover in 2003.
Professor Hershko was born in Hungary in 1937.
www.jafi.org.il /education/actual/nobel.html   (606 words)

  
 [No title]   (Site not responding. Last check: 2007-11-02)
Hershko and Varshavsky stand out in their seminal contributions to the discovery of both the mechanism and the functions of ubiquitin-dependent proteolysis.
Professor Avram Hershko was the first to recognize that the covalent attachment of a small protein, later found to be ubiquitin, plays a role in ATP-dependent proteolysis.
The discovery by Hershko and Varshavsky that ubiquitin-dependent proteolysis is a fundamental regulatory process, impacts on virtually all aspects of modern biology.
www.wolffund.org.il /full.asp?id=102   (266 words)

  
 Eszter’s Blog » Blog Archive » “Hungarian” Nobel Prize winners
The rest of the Hershko family, Hershko’s mother and his brother and himself were taken to a ghetto first in their home town in Karcag, then to a larger concentration in Szolnok, in central Hungary.
The Hershko family was among the lucky ones and were sent to a distribution camp of Strasshof near Vienna.
Hershko had started the work almost a decade before; Ciechanover was initially his doctoral student; Rose was a recognized researcher of enzymes when he and Hershko met and Hersho and Ciechanover spent some time in Rose’s laboratory in Philadelphia.
www.esztersblog.com /?p=37   (1592 words)

  
 Avram Hershko - Wikipedia, the free encyclopedia
Avram Hershko (Hungarian: Herskó Ferenc) (born December 31, 1937) is an Israeli biologist.
Hershko, A., Ciechanover, A., and Rose, I.A. (1979) "Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP".
Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system.
en.wikipedia.org /wiki/Avram_Hershko   (403 words)

  
 Hungarian-born Avram Hershko wins Nobel Prize for Chemistry - 15-10-2004 - Radio Prague
One of this year's Nobel Prize winners in chemistry is Avram Hershko - an Israeli scientist born in Hungary.
Hershko was born in 1937 and was seven years old when he and his family were taken by Hungarian gendarmes to a ghetto and from one ghetto to another and where then directed to Auschwitz.
"Hershko's father was a teacher in the Jewish school in Korzo, which was a town of about 25,000 people with a one thousand strong Jewish population.
www.radio.cz /en/article/59244   (634 words)

  
 Massry prize awarded to Hershko and Varshavsky   (Site not responding. Last check: 2007-11-02)
Biochemists Avram Hershko and Alexander Varsh-avsky recently re-ceived the 2001 Massry Prize for their groundbreaking research on regulated protein degradation.
The award recipients created the field of regulated protein degradation, discovered the role of the degradative components called "the ubiquitin system," described the intraceIlular structures they comprise, and elaborated the precise rules that govern how, where and when a specific protein molecule is subjected to regulated degradation, according to a release from the foundation.
It also noted that the pioneering work of Hershko and Varshavsky laid the groundwork for the discoveries that the ubiquitin system plays a central role in the cell cycle, cell growth and differentiation, regulation of DNA replication, nerve cell connections and even acquisition of memory.
www.usc.edu /hsc/info/pr/1vol7/726/massry.html   (269 words)

  
 HERSHKO, AVRAM - CIRS
Pr Hershko and his laboratory are focussing on the biochemical mechanisms involved in the degradation of two important cell cycle regulators: cyclin B, the major mitotic cyclin, and the CDK inhibitor p27, whose degradation is required for the transition of cells from quiescence to the proliferating stage.
Sudakin V., Ganoth D., Dahan A., Heller H., Hershko J., Luca F.C., Ruderman J.V. and Hershko A. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.
Carrano A., Eytan E., Hershko A. and Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.
www.cirs.net /Chercheurs/chercheurs1.php?id=664   (537 words)

  
 Biomol - Biomolecules for Research Success
Aaron Ciechanover, Avram Hershko and Irwin Rose went against the stream and at the beginning of the 1980s discovered one of the cell's most important cyclical processes, regulated protein degradation.
Aaron Ciechanover, Avram Hershko and Irwin Rose have brought us to realise that the cell functions as a highly-efficient checking station where proteins are built up and broken down at a furious rate.
The degradation is not indiscriminate but takes place through a process that is controlled in detail so that the proteins to be broken down at any given moment are given a molecular label, a ‘kiss of death', to be dramatic.
www.proteasome.com /news/news-nobelprize2004.htm   (575 words)

  
 Marine Biological Laboratory summer investigator wins Nobel Prize in Chemistry
By 1989, MBL scientists had developed a means of studying cyclins and the cell cycle in the test tube using the eggs of local surf clams as models.
Today Hershko is studying that ubiquitin ligating complex in both clam eggs and cultured human cells in hopes of learning even more about cell division in general and cancer more specifically.
At the MBL, Hershko is also leading an effort to sequence some of the surf clam's active genes-an effort, Hershko says, that is vital to the future of his research.
www.eurekalert.org /pub_releases/2004-10/mbl-mbl100604.php   (792 words)

  
 NYU Today
Avram Hershko, distinguished professor at the Technion-Israel Institute of Technology and adjunct professor of pathology at NYU School of Medicine, has been awarded the 2004 Nobel Prize in Chemistry.
Hershko shares the Nobel Prize with two collaborators for discovering and elucidating in the 1980’s the process of ubiquitin-mediated protein degradation in eukaryotic cells.
As part of their continuing collaboration, Hershko intends to expand his involvement with both students and post-doctoral fellows at the School of Medicine.
www.nyu.edu /nyutoday/archives/18/03/PageOneStories/hershko.html   (293 words)

  
 Technion Scientists to Receive Nobel Prize Dec. 10 at Stockholm Ceremony
Avram Hershko and Aaron Ciechanover of the Technion Faculty of Medicine became the first Israelis ever to win the Nobel Prize in science.
Avram Hershko and Dr. Irwin A. Rose — is open to the public.
Both Hershko and Ciechanover pointed to the important role of the American Technion Society in their Nobel Prize-winning research.
www.ats.org /news.php?id=109   (508 words)

  
 Columbia News ::: Louisa Gross Horwitz Prize Awarded to Researchers Avram Hershko and Alexander Varshavsky for Work on ...
Columbia University awarded this year's Louisa Gross Horwitz Prize to Dr. Avram Hershko, Distinguished Professor at the Technion-Israel Institute of Technology, and Dr. Alexander Varshavsky, Howard and Gwen Laurie Smits Professor of Cell Biology at California Institute of Technology.
Hershko was the first to identify the process through which ubiquitin interacts with its intended targets, identifying the biochemical pathway that marks proteins for destruction and showing that three enzymes work in sequence to successfully complete this task.
The prize was named for the mother of Columbia benefactor S. Gross Horwitz, who was the daughter of former AMA president and surgery textbook author Dr. Samuel David Gross.
www.columbia.edu /cu/news/01/12/horwitz_prize.html   (520 words)

  
 Tragac: avram   (Site not responding. Last check: 2007-11-02)
Avram and Bobby both share a love of the melodic, the soulful,...
It may be that Avram Davidson never realized that he was too brilliant in too many ways...
Avram needs someone to take over sound editing when he leaves in three weeks.
www.tragac.com /avram.html   (206 words)

  
 The Gairdner Foundation
Avram Hershko, Ph.D. " For the discovery of the ubiquitin system of intracellular protein degradation and its many functions in the cell.
Hershko has pursued his research on intracellular proteolysis at the Technion, where he was appointed Associate Professor in 1972, Professor in 1980 and Distinquished Professor in 1998.
Hershko was awarded the Weizmann Prize in 1987 and the Israel Prize in 1994.
www.gairdner.org /winners1999.html   (1542 words)

  
 JewishJournal.com
The Israeli winners, Avram Hershko and Aaron Ciechanover of the Technion in Haifa, shared the $1.35 million prize in chemistry with Irwin A. Rose, professor emeritus at UC Irvine.
They were recognized for their research on the regulatory process taking place inside human cells, a discovery leading to the development of drugs against cancer and degenerative diseases.
Ciechanover, in turn, became Hershko’s graduate student and over the next 19 years, the two Israelis spent the summers at Rose’s lab at the Fox Chase Cancer Center in Philadelphia.
www.jewishjournal.com /home/preview.php?id=13091   (727 words)

  
 University of Chicago Hospitals: Alumnus Irwin Rose receives 2004 Nobel Prize in chemistry
Many of the studies that led to the Prize were done when Hershko and Ciechanover took sabbatical leave and worked with Rose in Philadelphia, the Foundation said in a statement.
Rose, Ciechanover and Hershko "went against the stream," according to the press release, and discovered how cells break proteins down.
Beginning in 1978, they began to show that the cell functions as a "highly-efficient checking station where proteins are built up and broken down at a furious rate," according to the release.
www.uchospitals.edu /news/2004/20041107-rose.html   (622 words)

  
 2001 Louisa Gross Horwitz prize awarded to ubiquitin system researchers Avram Hershko and Alexander Varshavsky
Columbia University will award this year's Louisa Gross Horwitz Prize to Dr. Avram Hershko, Distinguished Professor at the Technion-Israel Institute of Technology, and Dr. Alexander Varshavsky, Howard and Gwen Laurie Smits Professor of Cell Biology at California Institute of Technology.
Hershko and Varshavsky, plays a fundamental part in this process.
Hershko and Varshavsky have been recognized for these groundbreaking achievements.
www.eurekalert.org /pub_releases/2001-12/cuco-2lg121101.php   (503 words)

  
 RedOrbit - Science - Three Scientists Share Chemistry Prize
STOCKHOLM, Sweden: Israelis Aaron Ciechanover and Avram Hershko and American Irwin Rose won the 2004 Nobel Prize in chemistry yesterday for their work in discovering a process that lets cells destroy unwanted proteins.
Ciechanover, 57, Hershko, 67, and Irwin Rose, 78, were honoured by the Royal Swedish Academy of Sciences for their work in the 1980s that discovered one of the cell's most important cyclical processes, regulated protein degradation.
Rose is a specialist at the department of physiology and biophysics at the college of medicine at the University of California-Irvine.
www.redorbit.com /news/display?id=91875   (564 words)

  
 Pressmeddelande: Nobelpriset i kemi 2004
Aaron Ciechanover, Avram Hershko och Irwin Rose gick mot strömmen och upptäckte i början av 1980-talet ett av cellens viktigaste kretslopp, den reglerade proteinnedbrytningen.
Aaron Ciechanover, Avram Hershko och Irwin Rose har fått oss att inse att cellen fungerar som en högeffektiv kontrollstation där proteiner byggs upp och bryts ner i ett rasande tempo.
Avram Hershko, född 1937 (67 år) i Karcag, Ungern (israelisk medborgare).
uk.geocities.com /chemystry111_rer/press-sv.html   (452 words)

  
 NYU > Office of Public Affairs > NYU School of Medicine Adjunct Faculty Member, Avram Hershko, Awarded Nobel ...
Avram Hershko, M.D., Ph.D., Distinguished Professor at the Technion-Israel Institute of Technology, and Adjunct Professor of Pathology at NYU School of Medicine, has been awarded the 2004 Nobel Prize in Chemistry.
Since 1998, Dr. Hershko has collaborated with Michele Pagano, M.D., Associate Professor of Pathology at NYU School of Medicine, spending several months a year doing research in Dr. Pagano’s laboratory.
As part of their continuing collaboration, Dr. Hershko intends to expand his involvement with both students and post-doctoral fellows at the School of Medicine.
www.nyu.edu /public.affairs/releases/detail/30   (362 words)

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