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| | HERSHKO, AVRAM - CIRS |
 | | Pr Hershko and his laboratory are focussing on the biochemical mechanisms involved in the degradation of two important cell cycle regulators: cyclin B, the major mitotic cyclin, and the CDK inhibitor p27, whose degradation is required for the transition of cells from quiescence to the proliferating stage. |
 | | Sudakin V., Ganoth D., Dahan A., Heller H., Hershko J., Luca F.C., Ruderman J.V. and Hershko A. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. |
 | | Carrano A., Eytan E., Hershko A. and Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. |
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