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Topic: Azathioprine

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	Azathioprine - Wikipedia, the free encyclopedia
		Azathioprine is a chemotherapy drug, now rarely used for chemotherapy but more for immunosuppression in organ transplantation, autoimmune disease such as rheumatoid arthritis or inflammatory bowel disease such as Crohn's disease.
		Azathioprine acts to inhibit purine synthesis necessary for the proliferation of cells, especially leukocytes and lymphocytes.
		Mycophenolate mofetil is increasingly being used in place of azathioprine in organ transplantation as it is associated with less bone marrow suppression, fewer opportunistic infections and a lower incidence of acute rejection.
	en.wikipedia.org /wiki/Azathioprine (680 words)

	Azathioprine
		Azathioprine is such a medication, though it is important to realize that it can have some of its own adverse side effects in some individuals.
		Azathioprine disrupts the synthesis of DNA and RNA.
		Azathioprine is typically started once a day and then tapered to every other day use and is almost always started in conjunction with other immune suppressive agents.
	www.marvistavet.com /html/body_azathioprine.html (637 words)

	Azathioprine (PIM 053)
		Azathioprine is a chemical analogue of the physiologic purines and is of synthetic origin.
		Azathioprine is used as an adjunct for the prevention of the rejection of kidney allografts.
		Azathioprine was resumed again at 50 mg daily and subsequently to 100 mg daily without further suppression of WBC and the patient survived (Carney et al, 1974).
	www.inchem.org /documents/pims/pharm/azathiop.htm (4402 words)

	MedlinePlus Drug Information: Azathioprine
		Azathioprine is used with other medications to prevent rejection of kidney transplants.
		If you are taking azathioprine to prevent kidney transplant rejection, your doctor may start you on a high dose and decrease your dose gradually as your body adjusts to the transplant.
		Azathioprine is also used to treat ulcerative colitis (a condition in which sores develop in the intestine causing pain and diarrhea).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682167.html (967 words)

	IMURAN® (azathioprine)
		Azathioprine is chemically 6-[ (1 - m e t h y l - 4 - n i t r o - 1H- i m i d a z o l - 5 - y l) t h i o ] -1H-purine.
		Azathioprine or its metabolites are transferred at low levels, both transplacentally and in breast milk.29,30,31 Because of the potential for tumorigenicity shown for azathioprine, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
		The mutagenicity of azathioprine in mice, Drosophila Melanogaster and Neurospora Crassa.
	www.transplantbuddies.org /library/drugs/full/azathio.html (3687 words)

	Pharmacogenomic and Metabolite Markers for Patients with Inflammatory Bowel Disease Treated with Azathioprine (6-MP)
		Azathioprine, which is a prodrug of 6-mercaptopurine (6-MP), is considered an effective immunosuppressive treatment of inflammatory bowel disease, particularly in patients with steroid-resistant disease.
		Azathioprine is converted to 6-mercaptopurine in vivo, where it is subsequently metabolized to two active metabolites: either 6-thioguanine nucleotides (6-TG) by the enzyme IMPDH, or to 6-methyl-mecaptopurine ribonucleotides (6-MMRP) by the enzyme TPMT.
		Azathioprine is typically given orally, but in some cases, it may be initially given intravenously in order to accelerate its onset of action.
	www.regence.com /trgmedpol/lab/lab27.html (2085 words)

	Imuran Online, Description, Chemistry, Ingredients - Azathioprine - RxList Monographs
		Azathioprine is insoluble in water, but may be dissolved with addition of one molar equivalent of alkali.
		The sodium salt of azathioprine is sufficiently soluble to make a 10 mg/mL water solution which is stable for 24 hours at 59º to 77º F (15º to 25º C).
		Azathioprine is stable in solution at neutral or acid pH but hydrolysis to mercaptopurine occurs in excess sodium hydroxide (0.1N), especially on warming.
	www.rxlist.com /cgi/generic/azathioprine.htm (232 words)

	All about azathioprine. News azathioprine for severe eczema.
		It azathioprine azathioprine, muscles in the bladder to help azathioprine, problems of urgency and frequent azathioprine The azathioprine is obvious azathioprine, to azathioprine, The philosophy transposes azathioprine azathioprine, principle of azathioprine discredits the outstanding azathioprine, Alcohol may further lower blood pressure and increase drowsiness azathioprine, dizziness while azathioprine, azathioprine azathioprine captopril.
		In non-insulin-dependent diabetes azathioprine for severe eczema, not been azathioprine for severe eczema established to be azathioprine for severe eczema suppression of the life.
		Before azathioprine for severe eczema, azathioprine for severe eczema, a azathioprine for severe eczema time it was necessary to tell, azathioprine for severe eczema clearing displays a postmodernism on elements.
	rx.150m.com /azathioprine (222 words)

	Arthritis Research Campaign \| Drugs for Arthritis: Azathioprine (Site not responding. Last check: 2007-10-13)
		Azathioprine is used in the treatment of several different types of rheumatic disease, including rheumatoid arthritis and systemic lupus erythematosus (SLE).
		Because azathioprine can affect the blood count (one of the effects is that fewer blood cells are made) and can sometimes cause liver problems, your doctor will arrange for you to have a blood test before you start treatment and then regular blood checks while on azathioprine.
		Azathioprine may be prescribed along with other drugs in treating your condition.
	www.arc.org.uk /about_arth/infosheets/6243/6243.htm (801 words)

	MedlinePlus Drug Information: Azathioprine (Systemic) (Site not responding. Last check: 2007-10-13)
		Azathioprine may also be used for other conditions as determined by your doctor.
		Even though azathioprine may cause side effects that could be very serious, remember that it may be required to treat your medical problem.
		Although there is no specific information comparing use of azathioprine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202077.html (2050 words)

	Facts About Autoimmune Myasthenia Gravis
		Azathioprine is an immunosuppressive medication that decreases the actions of the body’s immune system.
		Azathioprine is available in a generic formulation or as the brand name, Imuran®.
		Since azathioprine is a strong medicine, the doctor and patient must consider its risks and benefits.
	www.myasthenia.org /information/Azathioprine.htm (1006 words)

	Patient Education - Azathioprine
		Azathioprine is used to treat many inflammatory conditions, such as rheumatoid arthritis, systemic lupus erythematosus (lupus), vasculitis and inflammatory bowel disease.
		Azathioprine counters this by interfering with deoxyribonucleic acid (DNA) synthesis, which prevents cells (including those in the immune system) from dividing.
		Less often, azathioprine has been associated with liver test abnormalities, hepatitis (inflammation of the liver), or pancreatitis (inflammation of the pancreas gland behind the stomach that can cause abdominal pain).
	www.rheumatology.org /public/factsheets/azathioprine.asp?aud=pat (577 words)

	azathioprine (Imuran) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		Azathioprine is used to suppress the immune system in patients who have had kidney transplants.
		Azathioprine is also used for the treatment of severe, active rheumatoid arthritis.
		Because azathioprine's toxicity increases when taken with the gout medication allopurinol (Zyloprim), its dose is reduced with simultaneous use.
	www.medicinenet.com /Art.asp?li=MNI&ag=Y&ArticleKey=764 (592 words)

	Rheum Info \| Medical Information \| Patient Azathioprine Information Sheet \| Imuran Information Sheet (Site not responding. Last check: 2007-10-13)
		Azathioprine is an immunosuppressive medication (suppresses the immune system).
		Azathioprine is used to treat Systemic Lupus Erythematosus and many other types of arthritis and rheumatic disease.
		Blood Counts - Azathioprine can cause a drop in the numbers of red blood cells (which carry oxygen), white blood cells (which are needed to fight infection) and platelets (which help to stop bleeding).
	rheumbook.com /rheum_info/med_info/AZATHIOPRINE_INFORMATION_SHEET.HTM (559 words)

	Azathioprine (Imuran®) - PetPlace.com (Site not responding. Last check: 2007-10-13)
		Azathioprine is used to suppress cells involved in
		Azathioprine is related to other anticancer agents and should be always kept out of reach of children and other pets in the household.
		Azathioprine often is administered in combination with other drugs, most often corticosteroids (cortisone-like drugs) such as prednisone.
	www.petplace.com /drug-library/azathioprine-imuran/page1.aspx (632 words)

	Azathioprine for rheumatoid arthritis
		Azathioprine is an immunosuppressive medication, which means that it decreases the action of your body's immune system.
		Azathioprine and other immunosuppressive medications may be more toxic than other DMARDs, such as methotrexate, and should be used only under the supervision of a specialist in rheumatic disease (rheumatologist) who is familiar with their side effects.
		Azathioprine should not be used by pregnant women or women of childbearing age who are not using reliable contraception.
	www.webmd.com /hw/rheumatoid_arthritis/uh1166.asp (423 words)

	Clinical Trial: Imuran (Azathioprine) Dose-Ranging Study in Crohn's Disease
		The purpose of this study is to identify an optimal weight based dose of azathioprine that is safe and effective in the treatment of subjects with active Crohn’s disease requiring treatment with corticosteroids, and for maintaining remission in those subjects.
		Azathioprine is often used to treat patients with steroid resistant or dependent Crohn’s disease.
		Azathioprine is used as a steroid sparing agent, as treatment for active, inflammatory disease, for maintenance of remission, as therapy for perforating disease (fistulae), and for specific extraintestinal manifestations.
	www.clinicaltrials.gov /ct/gui/show/NCT00098111 (965 words)

	Psoriatic Arthritis Treatment: Azathioprine
		Azathioprine is also an immunosuppressive agent used in the tranplantation program.
		Azathioprine may also suppress the bone marrow and is associated with an increased risk of infection.
		When starting azathioprine patients should have a blood test done at one week to assure that they have not reduced their white blood cell count.
	www.psoriaticarthritisguide.ca /treatment/azathioprine.html (298 words)

	Azathioprine: Facts and details from Encyclopedia Topic (Site not responding. Last check: 2007-10-13)
		Azathioprine was first introduced into clinical practice by Sir Roy Calne, EHandler: no quick summary.
		Azathioprine acts to inhibit purine synthesis necessary for the proliferation of cells, EHandler: no quick summary.
		Bone marrow suppression is a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine....
	www.absoluteastronomy.com /encyclopedia/a/az/azathioprine.htm (985 words)

	All about azathioprine. (Site not responding. Last check: 2007-10-13)
		Although its exact mechanism of action in rheumatoid azathioprine arthritis is not known, its effect in suppressing the immune system appears to decrease the activity of this illness.
		Azathioprine is also used for the treatment of severe, active azathioprine rheumatoid arthritis.
		In New Zealand azathioprine is azathioprine for severe eczema available as 50mg tablets or as an injection, trade name Imuran®, Azamun® or Thioprine®.
	azathioprine.blogspot.com (155 words)

	Azathioprine
		Azathioprine has been used since the mid-1960’s to treat rheumatoid arthritis and systemic lupus erythematosus.
		Azathioprine is a pill that is sold under the brand name of Imuran.
		However, after azathioprine gets into the blood stream, it is changed by the liver to a chemical called “6-mercaptopurine” (also called “6-MP”).
	www.midwestarthritis.com /html/azathioprine.htm (749 words)

	Azathioprine (Site not responding. Last check: 2007-10-13)
		Azathioprine is an immunosuppressive medicine that prevents organ rejection by interfering with the body's normal immune response.
		Although not a treatment for rejection, azathioprine can prevent the body's refusal of the organ by interfering with the growth of white blood cells.
		Azathioprine is generally taken in the form of tablets, but also is available as an injection.
	clevelandclinic.org /health/health-info/docs/0900/0945.asp?...&src=news (738 words)

	CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes -- Tiede et ...
		The average percentage of azathioprine- and 6-MP–specific apoptosis (induction of annexin-positive, propidium iodide–negative cells compared with untreated cells indicated by fl sections of bars, induction of annexin-positive, propidium iodide–positive cells compared with untreated cells indicated by white sections) ± SEM is shown in the lower panel.
		Successful azathioprine treatment associated with low-level gut inflammation was characterized by a high number of apoptotic cells (shown at low [d] and high [g] magnification) as compared with control patients with low-level gut inflammation not receiving azathioprine (c and f).
		Azathioprine and 6-MP treatment had little effect on Rac1 protein levels, whereas vav levels were increased in cellular extracts.
	www.jci.org /cgi/content/full/111/8/1133 (7707 words)

	Azathioprine
		Azathioprine is used to prevent organ rejection following kidney transplant and to treat severe cases of
		The highest blood folic acid level was observed in an individual who had not taken azathioprine for two years.
		For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb.
	www.gianteagle.com /healthnotes/Drug/Azathioprine.htm (367 words)

	The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review -- Fraser et al. 50 (4): ...
		Figure 1 Cox regression analysis of the proportion of patients remaining in remission during azathioprine treatment related to diagnosis of inflammatory bowel disease (324 patients).
		Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease.
		Azathioprine in inflammatory bowel disease: an 8-year study of response predictors.
	gut.bmjjournals.com /cgi/content/full/50/4/485 (3222 words)

	Azathioprine - Compare Prices and Buy Azathioprine online at HQ-RX.com.
		We investigate the prices on Azathioprine, conditions of sale and client-service of online pharmacies in the Internet for more than 5 years.
		After pressing the button, you are redirect on the online form, where it is necessary to confirm the choice of Azathioprine and enter the personal data, address and information of your credit card.
		The prescription on Azathioprine is not required at this pharmacy.
	www.hq-rx.com /drugs/Azathioprine.htm (315 words)

	Azathioprine - Drugs & Vitamins - Drug Library - DrugDigest
		Azathioprine reduces unwanted immune responses and helps to prevent rejection in patients who receive organ transplants.
		The response of the immune system may contribute to arthritis, and azathioprine helps to treat severe rheumatoid arthritis.
		It is better not to have any vaccinations while you are taking azathioprine.
	www.drugdigest.org /DD/DVH/Uses/0,3915,59\|Azathioprine,00.html (660 words)

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