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| | Harvard Gazette: Newly identified gene linked to brain development |
 | | Depicted are MRI images of the brains of patients with bilateral frontoparietal polymicrogyria (BFPP), a recessive genetic disorder characterized by mental retardation, gait difficulty, language impairment, and seizures. |
 | | Bilateral frontoparietal polymicrogyria (BFPP), a recessive genetic disorder characterized by mental retardation, gait difficulty, language impairment, and seizures, results in severely abnormal architecture of the brain's frontal lobes, as well as milder involvement of parietal and posterior parts of the cerebral cortex. |
 | | In this new study, lead author Xianhua Piao and colleagues used magnetic resonance imaging (MRI) to identify BFPP patients, and then used linkage analysis, homozygosity mapping, and candidate gene analysis to identify the BFPP gene as GPR56, located on an area of chromosome 16. |
| www.news.harvard.edu /gazette/daily/0403/25-brain.html (635 words) |
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