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Topic: BK channel

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	BK channel
		BK channels are essential for key physiological processes.
		BK channels are important for the behavioral effects of ethanol in the worm C. elegans [[1]].
		In addition, BK channels carry a unique transmembrane domain that appears to mediate the interaction with a family of modulatory tissue specific (beta) subunits, and also a unique large intracellular domain that is thought to act as a sensor for the intracellular Ca2+ concentration (see the image below).
	www.mrsci.com /Neuroscience/BK_channel.php (208 words)

	BK channel - Wikipedia, the free encyclopedia
		BK channels are important for very high concentration (> 100 mM) behavioral effects of ethanol in the worm C.
		A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans.
		Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel.
	en.wikipedia.org /wiki/BK_channel (276 words)

	InterPro: IPR003929 Calcium-activated BK potassium channel, alpha subunit
		InterPro IPR003929 Calcium-activated BK potassium channel, alpha subunit
		channels are involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes [ 6 ].
		BK channels (also referred to as maxi-K channels) are widely expressed in the body, being found in glandular tissue, smooth and skeletal muscle, as well as in neural tissues.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR003929 (3586 words)

	Richard W. Aldrich
		Ion channels are also important for the generation and regulation of the heartbeat, for contraction of muscles, and for the release of hormones in the bloodstream.
		The gating of BK channels by both calcium and voltage provides a convenient system to study both ligand- and voltage-dependent gating in the same protein, and to examine their interaction.
		BK channels composed of the pore-forming α subunit and the smooth muscle–specific β1 subunit play an important role in controlling membrane potential and contractility of urinary bladder smooth muscle.
	www.hhmi.org /research/investigators/aldrich.html (1054 words)

	Ion Channels
		Ion channels are the key proteins of cell membranes responsible for all the diversity in electrical signaling found in nerve and muscle cells, and virtually every living cell.
		BK channels are expressed among a wide variety of cells including almost all nerve cells, muscle cells, and endocrine cells.
		subunits of a channel, and not from auxiliary
	www.elysium.wustl.edu /cllab/home.htm (1033 words)

	BioMed Central \| Full text \| Increased large conductance calcium-activated potassium (BK) channel expression ...
		In this manuscript, we have exploited quantitative real-time RT-PCR Taqman™ analysis of BK channel splice variants [27] to test the hypothesis that alternative splicing of the STREX exon is regulated during development of different regions of the murine CNS.
		The contribution of BK channels to the regulation of CNS function is critically dependent upon cell type, subcellular localisation, intrinsic BK channel kinetic properties, calcium- and voltage sensitivities, and regulation by diverse cellular signalling pathways.
		While determination of the functional consequence of BK channel mRNA splicing during development remains to be fully explored in vertebrates [20], the developmental upregulation in total BK mRNA expression is in accordance with several functional and molecular studies [9-13,15,16,20].
	www.biomedcentral.com /1471-213X/6/37 (4864 words)

	B-Line BK Channel
		B-Line's new BK Channel is designed to facilitate field installations by providing convenient measurement markings.
		The channel has small "tick" marks on 1 1/2" centers and a longer indicator on every 6" increment.
		BK Channel is available in both (12) and (14) gauge so that the strength of the channel can match the application.
	www.b-line.com /whatsnew/wn_110.asp (257 words)

	Potassium channel - Wikipedia, the free encyclopedia
		Some potassium channels are voltage-gated ion channels that open or close in response to changes in the transmembrane voltage.
		The pore-forming subunits of potassium channels have a homo- or heterotetrameric arrangement.
		Potassium channels found in bacteria are amongst the most studied of ion channels, in terms of their molecular structure.
	en.wikipedia.org /wiki/Potassium_channel (384 words)

	Bovine Versus Rat Adrenal Chromaffin Cells: Big Differences in BK Potassium Channel Properties -- Lovell et al. 83 (6): ...
		BK channels are defined by the synergistic effects of submembrane calcium and membrane depolarization on channel activation,
		The rate of BK channel activation and deactivation may be critical in chromaffin cell repetitive firing.
		Inactivating BK channels in rat chromaffin cells may arise from heteromultimeric assembly of distinct inactivation-competent and non-inactivating subunits.
	jn.physiology.org /cgi/content/full/83/6/3277 (6211 words)

	Elevated Blood Pressure Linked to Primary Hyperaldosteronism and Impaired Vasodilation in BK Channel-Deficient Mice -- ...
		(WT) and BK mice with the hybrid SV129/C57BL6
		puncture from WT and BK mice euthanized by inhalation
		Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype.
	circ.ahajournals.org /cgi/content/full/112/1/60 (4879 words)

	Fast BK-Type Channel Mediates the Ca2+-Activated K+ Current in Crayfish Muscle -- Araque and Buño 82 (4): 1655 ...
		Channel open probability increased and the channel tended to open at briefer delays from pulse onset.
		channel in baso-lateral acinar cell membranes of mammalian salivary glands.
		channel in the apical membrane of rabbit proximal convoluted tubule in primary culture.
	jn.physiology.org /cgi/content/full/82/4/1655 (4054 words)

	The {beta}1 subunit of the Ca2+-sensitive K+ channel protects against hypertension -- Nelson and Bonev 113 (7): 955 -- ...
		The BK channel ß1 subunit gene is associated with human baroreflex and blood pressure regulation.
		Spontaneous transient outward currents arise from microdomains where BK channels are exposed to a mean Ca concentration on the order of 10 µM during a Ca spark.
		Acute activation of Maxi-K channels (hSlo) by estradiol binding to the ß subunit.
	www.jci.org /cgi/content/full/113/7/955 (1603 words)

	Bilayer Thickness Modulates the Conductance of the BK Channel in Model Membranes -- Yuan et al. 86 (6): 3620 -- ...
		The conductance of the BK channel was evaluated in reconstituted
		conductance of the BK channel in the presence of SPM is not
		The BK channel protein is an integral protein spanning the lipid
	www.biophysj.org /cgi/content/full/86/6/3620 (7551 words)

	The BK Channel: Protective or Detrimental in Genetic Hypertension? -- Clapp and Jabr 93 (10): 893 -- Circulation ...
		BK channels are typically composed of four pore-forming
		Downregulation of the BK channel ß1 subunit in genetic hypertension.
		channels is increased in basilar artery during chronic hypertension.
	circres.ahajournals.org /cgi/content/full/93/10/893 (1775 words)

	Ca2+-binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activation -- ...
		Ca2+-binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activation -- Bian et al.
		binding to the BK channel protein and the mechanism by which Ca binding is coupled to channel opening are poorly understood.
		Dslo and D5N5 mutant BK channels were expressed in HEK293 cells and characterized by patch clamp analysis in inside-out patches.
	www.pnas.org /cgi/content/full/98/8/4776 (4858 words)

	Ca2+-Dependent Gating Mechanisms for dSlo, a Large-Conductance Ca2+-Activated K+ (BK) Channel -- Moss et al. 76 (6): ...
		The Ca -dependent gating mechanism of cloned BK channels from Drosophila (dSlo) was studied.
		Channels H23 and H21 are indicated by the open circle and open square, respectively.
		In terms of Schemes 1 and 3, this increase for the native skeletal muscle BK channel arises because increasing Ca
	www.biophysj.org /cgi/content/full/76/6/3099 (8718 words)

	Modulation of BK channel calcium affinity by differential phosphorylation in developing ovine basilar artery myocytes ...
		Modulation of BK channel calcium affinity by differential phosphorylation in developing ovine basilar artery myocytes -- Lin et al.
		BK channels from adult and fetus exhibited similar voltage-activation
		However, voltage-activation curves of native fetal BK channels shifted significantly to the left of those of the adult,
	ajpheart.physiology.org /cgi/content/abstract/291/2/H732 (309 words)

	Divalent Cation Sensitivity of BK Channel Activation Supports the Existence of Three Distinct Binding Sites -- Zeng et ...
		channel and demonstration of its presence in the human BK channel.
		Inactivation of BK channels mediated by the N-terminus of the ß3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade.
		Gating properties conferred on BK channels by the ß3b auxiliary subunit in the absence of its NH and COOH termini.
	www.jgp.org /cgi/content/full/125/3/273 (7939 words)

	Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK channel of K+-deficient rats -- TRICARICO et ...
		Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK channel of K+-deficient rats -- TRICARICO et al.
		Structure-activity relationships of the carbonic anhydrase (CA) inhibitors as BK channel agonists.
		Activation of BK channels by CA inhibitors is caused by interaction of the drugs (in the presence of internal Ca ions) with receptor site/s located in the spatial vicinity of the Ca binding site.
	www.fasebj.org /cgi/content/short/18/6/760 (1086 words)

	InterPro: IPR003091 Voltage-dependent potassium channel
		O35173 Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1)
		Three-dimensional structure of the S4-S5 segment of the Shaker potassium channel.
		Liu Y.S. Sompornpisut P. Perozo E. Structure of the KcsA channel intracellular gate in the open state.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR003091 (3383 words)

	Erectile dysfunction in mice lacking the large-conductance calcium-activated potassium (BK) channel -- Werner et al. ...
		Erectile dysfunction in mice lacking the large-conductance calcium-activated potassium (BK) channel -- Werner et al.
		BK channels in the corpus cavernosum utilizing a knock-out mouse
		function, and loss of the BK channel leads to erectile dysfunction.
	jp.physoc.org /cgi/content/abstract/567/2/545 (376 words)

	Summary of NCEDC Products
		The NC and BK networks span northern California, while localized networks focus on the Gesyers, the Hayward Fault, and Parkfield.
		Data from the Hayward fault stations are folded into the BDSN and NCSN, while data from the HRSN and Calpine/Unocal Geysers network are not.
		In particular, the mini-Plate Boundary Observatory Project is a deployment of strain meters, borehole seismometers, and continuous GPS.
	www.ncedc.org /ncedc/ncedc.summary.html (325 words)

	Pituitary Control of BK Potassium Channel Function and Intrinsic Firing Properties of Adrenal Chromaffin Cells -- ...
		Pituitary Control of BK Potassium Channel Function and Intrinsic Firing Properties of Adrenal Chromaffin Cells -- Lovell and McCobb 21 (10): 3429 -- Journal of Neuroscience
		A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel {alpha}-subunits
		Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase
	www.jneurosci.org /cgi/content/abstract/21/10/3429 (619 words)

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