Where results make sense

About us   |   Why use us?   |   Reviews   |   PR   |   Contact us

Lalisio - Literature Search   (Site not responding. Last check: 2007-10-29) In contrast, BMP signaling has been shown to be involved in the onset and progression of ankylosing enthesitis in spondyloarthropathies and in the induction of osteophytes in OA Antagonism of BMP signaling was therefore suggested as an attractive therapeutic principle [8,10]. That BMPs might provide a beneficial effect on joint repair can be assumed from their role in joint development [27], their induction of chondrogenic differentiation in adult mesenchymal stem cells [28,29] and their effect on cartilage formation in tissue engineering with chondrocytes [5]. It is intriguing that inhibition of BMP signalling in a papain-induced OA mouse model could prevent osteophyte formation and synovial fibrosis but at the same time increased the loss of proteoglycan from the cartilage matrix, thereby certainly promoting the damage of the joint surface [10]. www.gallileus.info /search/bmc_detail?id=ar1923   (5577 words)

Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis -- Shi et al. 280 (5): ... As morphogens, some BMP family members such as BMP-4, BMP-5, and BMP-7 are expressed during the development of embryonic lungs. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. ajplung.physiology.org /cgi/content/full/280/5/L1030   (6320 words)

Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing ... BMP-7, BMPR-IA (BMP receptor subunit), BMPR-IB, BMPR-II, and A, BMP expression in the whole bowel and brain (examined as a positive control) at E12 and E14. of transgenic mice that overexpress the BMP antagonist noggin www.jneurosci.org /cgi/content/full/24/17/4266   (8684 words)

BMPs and BMPRs in chicken ovary and effects of BMP-4 and -7 on granulosa cell proliferation and progesterone production ... Representative semiquantitative RT-PCR of mRNAs of the BMPs and BMPRs in granulosa and theca cells of the chicken ovary. Figure 5 shows the dose effect of the BMPs on F1 or F3/4 G cells. BMPs are known to induce bone cell proliferation and differentiation ajpendo.physiology.org /cgi/content/full/285/5/E973   (6183 words)

BMP-4 / BTR-T   (Site not responding. Last check: 2007-10-29) Russia's latest attempt at a tracked APC is the BMP-4/BTR-T [BMP = Boyevaya Mashina Pyekhota - Infantry Fighting Vehicle / BTR-T = Bronyetransporter-Tyazhelyy - Armored Transporter -Heavy]. The configuration is based on lessons learned in Chechnya, where very heavy losses were inflicted on thin-skinned BMPs and BTRs. In response, this heavy, more survivable APC was designed for improved service in city fighting for possible use by specialized formations trained for urban warfare. www.fas.org /man/dod-101/sys/land/row/bmp-4.htm   (137 words)

The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain ... Levels of injected BMP-4 transcripts were analyzed by Northern blot hybridization of RNA extracted from sibling embryos at the 8-cell stage. Representative embryos showing short- (+), intermediate- (++ or +++), and long-range (++++) BMP signaling, as defined in the text, and in B are illustrated. Cho, K.W. and Blitz, I.L. BMPs, Smads and metalloproteases: Extracellular and intracellular modes of negative regulation. www.genesdev.org /cgi/content/full/15/21/2797   (4282 words)

Gene Information Fujiwara T, et al 2001 reported that bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. It was hypothesized that BMPs might be the long-sought "luteinization inhibitor" in Graafian follicles during their growth and development. Comment: Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse Fujiwara T, et al. ovary.stanford.edu /4_display.html?rec=976   (1986 words)

Bone Morphogenetic Protein (BMP2, 3,4, 5 , 6, 7 & 8) antibodies from RDI Divison of Fitzgerald Industries Intl Immunohistochemistry: Tissues may be dissected from experimental animals that were fixed by vascular perfusion with 4% paraformaldehyde/PBS (pH 7.4) and followed by perfusion with a 10% sucrose solution in 0.1 M phosphate buffer (pH 7.2). BMP4 is one of nine structurally related BMPs belonging to the transforming growth factor beta (TGF-Beta) superfmaily of secreted proteins. BMPs 1 to 6 are expressed in prostatic adenocarcinoma and BMPs 1 to 5 are expressed in both benign prostatic hyperplasia and occular melanoma. www.researchd.com /miscabs/bmpab.htm   (922 words)

Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic ...   (Site not responding. Last check: 2007-10-29) E14 ES cells were induced to differentiate for 4 days with or without 1.5 ng/mL BMP-4, 10 ng/mL VEGF, or both in the serum-free medium followed by another 3 days in the presence or absence of these factors. Data are displayed as averaged percentage total EB cell population obtained from 4 (for CD45) to 5 (for Ter119) independent experiments with the corresponding SD. A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: roles of animal pole tissue in the development of ventral mesoderm. www.bloodjournal.org /cgi/content/full/95/7/2275   (6218 words)

Cleavages within the Prodomain Direct Intracellular Trafficking and Degradation of Mature Bone Morphogenetic Protein-4 ... Khokha, M.K., Hsu, D., Brunet, L.J., Dionne, M.S., and Harland, R.M. Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. McMahon, J.A., Takada, S., Zimmerman, L.B., Fan, C.M., Harland, R.M., and McMahon, A.P. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Podos, S.D., Hanson, K.K., Wang, Y.C., and Ferguson, E.L. The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis. www.molbiolcell.org /cgi/content/full/15/11/5012   (7006 words)

Molecular basis of bone morphogenetic protein-4 inhibitory action on progesterone secretion by ovine granulosa cells -- ... gene (Poncelet and Schnaper 2001) and with Smad2, 3 and 4 Monte D, DeWitte F and Hum DW 1998 Regulation of the human P450 scc gene by steroidogenic factor 1 is mediated by CBP/p300. Souza CJ, MacDougall C, Campbell BK, McNeilly AS and Baird DT 2001 The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene. jme.endocrinology-journals.org /cgi/content/full/33/3/805   (5614 words)

The Homeodomain Transcription Factor Xvent-2 Mediates Autocatalytic Regulation of BMP-4 Expression in Xenopus Embryos ... RNA, whereas co-injection with chordin or truncated BMP receptor Xvent-2 as Mediator of BMP Signaling-- We next investigated whether the observed stimulations by BMP-2/4 can also be obtained by Xvent-2. Accordingly, BMP-2 triggers the BMP signaling pathway at the www.jbc.org /cgi/content/full/275/44/34365   (5990 words)

Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen ... Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk -- Páez-Pereda et al. PDGF stimulation of GH3 cell proliferation was used as a positive control unrelated to BMP signaling. Bars represent the mean ± SE of the differences between the treated and the corresponding basal values of quadruplicates from three independent experiments. www.pnas.org /cgi/content/full/100/3/1034   (3944 words)

BMP-4 inhibits follicle-stimulating hormone secretion in ewe pituitary -- Faure et al. 186 (1): 109 -- Journal of ... BMP, BMP-15 exhibited a stimulatory effect in rodents (Otsuka and Shimasaki 2002). Glister C, Kemp CF and Knight PG 2004 Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin. Hanrahan JP, Gregan SM, Mulsant P, Mullen M, Davis GH, Powell R and Galloway SM 2004 Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries). joe.endocrinology-journals.org /cgi/content/full/186/1/109   (6129 words)

Smad1 and Smad4 Are Components of the Bone Morphogenetic Protein-4 (BMP-4)-induced Transcription Complex of the ... Smad1 and Smad5 mimic BMP-4 induction of ventral mesoderm (4, 75 (lane 1) incubated with 300 or 750 ng of full-length His-tagged Smad1 (lanes 2 and 3), Smad4 (lanes 4 and 5), or Smad3 (lanes 6 and 7). 3 and 4 with lanes 5 and 6, Fig. www.jbc.org /cgi/content/full/275/29/21827   (5812 words)

Bone Morphogenetic Protein-4 Acts as an Ovarian Follicle Survival Factor and Promotes Primordial Follicle Development ... BMP signaling leads to an increase in ovulation rate [14]. The type I BMP receptor BmprIB is essential for female reproductive function. Koster M, Plessow S, Clement JH, Lorenz A, Tiedemann H, Knochel W. Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity. www.biolreprod.org /cgi/content/full/69/4/1265   (4860 words)

Bone Anabolic Effects of Sonic/Indian Hedgehog Are Mediated By BMP-2/4-Dependent Pathways in the Neonatal Rat ... 4 C and then processed for paraffin embedding. Kameda T, Koike C, Saitoh K, Kuroiwa A, Iba H 1999 Developmental patterning in chondrocytic cultures by morphogenic gradients: BMP induces expression of Indian hedgehog and noggin. Marcelle C, Stark MR, Bronner-Fraser M 1997 Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite. endo.endojournals.org /cgi/content/full/142/2/940   (4128 words)

BMP-4 Inhibits Neural Differentiation of Murine (ResearchIndex) If your firewall is blocking outgoing connections to port 3125, you can use these links to download local copies. Abstract: Members of the transforming growth factor-# superfamily, including bone morphogenetic protein 4 (BMP-4), have been implicated as regulators of neuronal and glial differentiation. To test for a possible role of BMP-4 in early mammalian neural specification, we examined its effect on neurogenesis in aggregate cultures of mouse embryonic stem (ES) cells. citeseer.ist.psu.edu /524076.html   (188 words)

Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial ...   (Site not responding. Last check: 2007-10-29) BMP responsive element derived from the mouse Smad6 promoter. Kruppel-like Factor 4 (KLF4/GKLF) Is a target of bone morphogenetic proteins and transforming growth factor beta 1 in the regulation of vascular smooth muscle cell phenotype. In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb. circres.ahajournals.org /cgi/content/full/96/10/1053   (4645 words)

[No title] I chose the fields using: # http://www.daubnet.com/formats/BMP.html # # If you find a simple BMP image that this can't handle, I'd be interested # in seeing it, though I can't guarantee I'll update the code to make it work.. @bits; } # Read bmp to pad out to some chunksize (or 4 bytes) sub pad_bmp { my ($bmp, $chunk) = @_; $chunk = $chunk 4; my $pad = $chunk - $bmp->{_byte}%$chunk; $pad=0 if $pad==$chunk; $pad = $bmp->{_size}-$bmp->{_byte}-1 if ($bmp->{_byte}+$pad>=$bmp->{_size}); read_bmp($bmp,$pad) if $pad>0; } # Writing files sub write_file($$) { my ($bmp,$wfile) = @_; $wfile = $wfile marginalhacks.com /bin/BMP.pm   (1307 words)

BMP-4 and BMP-6 Involvement in the Osteogenic Properties of the HeLa Cell Line -- Kochanowska et al. 227 (1): 57 -- ... The first line indicates molecular weight markers; the second and fourth lines indicate 20-fold concentrated media; the third and fifthlines indicate ultrafiltrated supernatants. Electrophoresis was performed under nonreducing (lines 2 and 3) and reducing (lines 4 and 5) conditions. Cloning and sequence of bone morphogenetic protein 4 cDNA from fetal rat calvarial cell. www.ebmonline.org /cgi/content/full/227/1/57   (2794 words)

Bone Morphogenetic Protein Inhibits Ovarian Androgen Production -- Dooley et al. 85 (9): 3331 -- Journal of Clinical ... activin, and the bone morphogenetic proteins (BMPs) (4, 5, 6). Expression on BMP receptors RNA in HOTT cells. RT-PCR was performed to demonstrate the presence of the three different subtypes of BMP receptors in HOTT cells. jcem.endojournals.org /cgi/content/full/85/9/3331   (3920 words)

Bone Morphogenetic Proteins-2 and -4: Negative Growth Regulators in Adult Retinal Pigmented Epithelium -- Mathura et ... In situ hybridization with digoxigenin-labeled antisense (A, C) or sense (B, D) BMP-4 (A, B) or type II BMP receptor (C, D) riboprobes showed specific hybridization with both types of antisense probes in the RPE (A, C; large arrows), photoreceptors, cells of the inner nuclear layer, and ganglion cells. The type II BMP receptor is required for BMP signaling. One microgram RNA from primary human RPE cultures from two donors (158 and 156), a human RPE cell line (ARPE), freshly isolated human RPE cells (in situ), human retina, or cultured bovine aortic endothelial cells (BAEC) was used for RT-PCR with primers specific for human and bovine BMP-4, BMPR-II, and 16S. www.iovs.org /cgi/content/full/41/2/592   (5917 words)

Disruption of LTBP-4 function reduces TGF-{beta} activation and enhances BMP-4 signaling in the lung -- Koli et al. 167 ... Expression of BMP-4, gremlin, and BMP target genes Id1 and -2 in lung fibroblasts. Connective-tissue growth factor (CTGF) modulates cell signaling by BMP and TGF-ß. Disruption of the gene encoding the latent transforming growth factor-ß binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. www.jcb.org /cgi/content/full/167/1/123   (6214 words)

Roadmap to the BMP The following table comprises a proportional map of Plane 0, the BMP (Basic Multilingual Plane). A PDF version of this document is available for convenient printing. The Roadmap Committee maintains and updates this document as a service to the Unicode Technical Committee and to ISO/IEC JTC1/SC2/WG2. www.unicode.org /roadmaps/bmp/bmp-4-17.html   (268 words)

Sonic hedgehog Cascade Is Required for Penile Postnatal Morphogenesis, Differentiation, and Adult Homeostasis -- ... either frozen in liquid nitrogen or fixed in 4% paraformaldehyde. Penes that were fixed in 4% paraformaldehyde overnight were Roberts DJ, Johnson RL, Burke AC, Nelson CE, Morgan BA, Tabin C. Sonic hedgehog is an endodermal signal inducing BMP-4 and Hox genes during induction and regionalization of the chick hindgut. www.biolreprod.org /cgi/content/full/68/2/423   (5533 words)

Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells -- Chadwick et al. 102 (3): 906 ... Horizontal bars indicate mean percentages of positive cells ± SEMs from 9-13 independent experiments using both H1 and H9 cell lines. detection of 100% (4 of 4, Table 2). Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. www.bloodjournal.org /cgi/content/full/102/3/906   (6585 words)

Try your search on: Qwika (all wikis)

About us   |   Why use us?   |   Reviews   |   Press   |   Contact us   Copyright © 2005-2007 www.factbites.com Usage implies agreement with terms.