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Topic: BRCA1

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	BRCA1 - Breast cancer 1, early onset - Cancer GeneticsWeb
		Somatic mutations in the BRCA1 gene in chinese sporadic breast and ovarian cancer.
		Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.
		BRCA1 gene mutations in sporadic ovarian carcinomas: detection by PCR and reverse allele-specific oligonucleotide hybridization.
	www.cancerindex.org /geneweb/BRCA1.htm (902 words)

	BRCA1 and BRCA2 Hereditary Breast/Ovarian Cancer
		BRCA1 cancer-predisposing mutations is therefore unclear, but recent studies suggest that it is probably not better than that for women without such mutations.
		BRCA1 mutations in the general population is estimated to be between 1/500 and 1/1000.
		BRCA1 may occur in other populations, but may not be identified by the more commonly used PCR-based mutation screening approaches, such as mutation scanning, protein truncation testing (PTT), and direct sequencing.
	www.geneclinics.org /profiles/brca1/details.html (4288 words)

	National Cancer Institute - Genetic Testing for BRCA1 and BRCA2
		Inherited alterations in the genes called BRCA1 and BRCA2 (short for breast cancer 1 and breast cancer 2) are involved in many cases of hereditary breast and ovarian cancer.
		The likelihood that breast and/or ovarian cancer is associated with BRCA1 or BRCA2 is highest in families with a history of multiple cases of breast cancer, cases of both breast and ovarian cancer, one or more family members with two primary cancers (original tumors at different sites), or an Ashkenazi (Eastern European) Jewish background.
		BRCA1 mutations and breast cancer in the general population: Analyses in women before age 35 years and in women before age 45 years with first-degree family history.
	www.cancer.gov /cancertopics/factsheet/Risk/BRCA (4185 words)

	Breast Cancer Genes (BRCA1 and 2)
		By the age of 70, the estimated risk of breast cancer among carriers was 56 percent (95 percent confidence interval, 40 to 73 percent); of ovarian cancer, 16 percent (95 percent confidence interval, 6 to 28 percent); and of prostate cancer, 16 percent (95 percent confidence interval, 4 to 30 percent).
		The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation analysis in 237 families, each with at least four cases of breast cancer, collected by the Breast Cancer Linkage Consortium.
		BRCA1 and BRCA2 carriers are at increased risk for both breast and ovarian cancer, but estimates of lifetime risk vary widely, suggesting their penetrance is modified by other genetic and/or environmental factors.
	www.thedoctorsdoctor.com /labtests/brca_genes.htm (8801 words)

	NIH Press Release-NIH Animal Model Uncovers a Role of BRCA1-Associated Breast Tumor Formation - 04/29/1999
		Scientists have known that mutations of BRCA1 are involved in the development of these cancers but had not been able to identify specifically how alterations in BRCA1 affected the timing and process of tumor development.
		When BRCA1 alone was deleted from mammary glands, 5 of 23 of the experimental mice developed tumors over one year.
		Mutations in the BRCA1 gene are found in 90 percent of women who have inherited both breast and ovarian cancer, and in about 50 percent of women with inherited breast cancer alone.
	www.nih.gov /news/pr/apr99/niddk-29.htm (740 words)

	BRCA1 Mutations in Taiwanese with Epithelial Ovarian Carcinoma and Sporadic Primary Serous Peritoneal Carcinoma -- Wang ...
		BRCA1 Mutations in Taiwanese with Epithelial Ovarian Carcinoma and Sporadic Primary Serous Peritoneal Carcinoma -- Wang et al.
		BRCA1 Mutations in Taiwanese with Epithelial Ovarian Carcinoma and Sporadic Primary Serous Peritoneal Carcinoma
		Somatic mutations in the BRCA1 gene in sporadic ovarian tumors.
	jjco.oxfordjournals.org /cgi/content/full/30/8/343 (3465 words)

	Collaboration of Brca1 and Chk2 in tumorigenesis -- McPherson et al. 18 (10): 1144 -- Genes and Development
		Tumorigenesis in the absence of BRCA1 is facilitated
		The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse embryo.
		BRCA1 is a component of the RNA polymerase II holoenzyme.
	www.genesdev.org /cgi/content/full/18/10/1144 (3818 words)

	genome.gov \| BRCA1/BRCA2 Study FAQ
		In 1995 scientists from the National Institutes of Health (NIH) discovered that a particular alteration in the breast cancer gene called BRCA1 was present in 1 percent of the general Jewish population.
		Because family history is the strongest single predictor of a woman's chance of developing breast cancer, researchers turned to cancer-prone families - those with a high incidence of cancer in several generations - to find specific inherited gene alterations that are passed on from one generation to the next.
		Supported previous studies testing the frequency of three BRCA1 and BRCA2 alterations in the general Jewish population: The frequencies reported in the current study are consistent with those previously reported for the general Jewish population.
	www.genome.gov /10000940 (2628 words)

	BRCA1 - Genetics Home Reference
		The BRCA1 gene belongs to a class of genes known as tumor suppressor genes.
		The protein made by the BRCA1 gene is directly involved in the repair of damaged DNA.
		The BRCA1 gene is located on the long (q) arm of chromosome 17 at position 21.
	ghr.nlm.nih.gov /ghr/gene/brca1;jsessionid=E30B2E1111CE23D0F5C5B17A83BE4C62 (747 words)

	BRCA1 GENE GENE PRODUCT
		In contrast to the prevailing idea that the BRCA1 gene product may be a transcription factor and thus may reside in the nuclei of cells, the protein was found in the cytoplasm of cells.
		Regardless of the tissue of origin, a dot pattern of nuclear staining was observed in the nuclei of all human cell lines that were examined.
		Since the localization of the BRCA1 protein seems to differ based on the antibody and the method of fixation that is being used, the true intracellular localization of the protein remains to be shown.
	www.bioscience.org /news/scientis/breast.htm (474 words)

	Molecular Analysis of BRCA1 Function
		The BRCA1 gene was isolated two years ago, which allows for study of the BRCA1 protein that the gene encodes.
		I have shown that the BRCA1 protein may be a transcription factor, which is a type of protein that regulates how much of certain other proteins are made.
		A potential link between the transcriptional regulatory function of BRCA1 and its role in response to DNA damage was made by other groups which demonstrated that some proteins within the p53 tumor suppression pathway were regulated by BRCA1.
	www.cbcrp.org /research/PageGrantPrintPage.asp?grant_id=182 (634 words)

	Functions of BRCA1 and BRCA2 in the biological response to DNA damage -- Venkitaraman 114 (20): 3591 -- Journal of Cell ...
		BRCA1 and BRCA2 co-localise in mitotic and meiotic cells (Chen et al., 1998a)
		The precise role of BRCA1 in these events is unclear, but it is likely to have multiple functions in DNA damage responses.
		There is accumulating evidence that BRCA1 performs multiple functions in the cellular response to DNA damage through its interactions with different protein partners.
	jcs.biologists.org /cgi/content/full/114/20/3591 (6290 words)

	BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during ...
		BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair -- Morris and Solomon 13 (8): 807 -- Human Molecular Genetics
		Conjugated ubiquitin colocalizes with BRCA1 in S-phase and in hydroxyurea-induced foci
		Conjugated ubiquitin colocalizes with BRCA1 in S-phase and in hydroxyurea (HU)-induced foci.
	hmg.oxfordjournals.org /cgi/content/full/13/8/807 (5690 words)

	CGN - Modifiers of Penetrance in BRCA1 and BRCA2 (Site not responding. Last check: 2007-09-19)
		Women who carry germline mutations in BRCA1 or BRCA2 (BRCA1/2) have an elevated lifetime risk of developing breast or ovarian cancer.
		However, there is substantial variability in penetrance estimates of these mutations, and age of first breast cancer diagnosis among mutation carriers, even within the same family.
		Study participants are evaluated for BRCA1 and BRCA2 status.
	epi.grants.cancer.gov /CGN/studies/modifiers.html (336 words)

	Extracellular Matrix Enhances Heregulin-Dependent BRCA1 Phosphorylation and Suppresses BRCA1 Expression through Its C ... (Site not responding. Last check: 2007-09-19)
		caused a significant decrease in BRCA1 mRNA expression that
		truncated BRCA1, was not affected by either LAM or CL4.
		of BRCA1 from HCC-1937 cells was observed in response to HRG.
	mcb.asm.org /cgi/content/abstract/23/2/579 (595 words)

	BRCA1 regulates p53-dependent gene expression -- Ouchi et al. 95 (5): 2302 -- Proceedings of the National Academy of ...
		BRCA1 was isolated as a candidate for the familial breast and ovarian cancer susceptibility gene (8), and encodes a 220-kDa
		Lanes: 1 and 3, vector; 2 and 4, BRCA1.
		Of mice and (wo)men: genotype-phenotype correlations in BRCA1
	www.pnas.org /cgi/content/full/95/5/2302 (4468 words)

	Regulation of BRCA1 Phosphorylation by Interaction with Protein Phosphatase 1{alpha} -- Liu et al. 62 (22): 6357 -- ...
		BRCA1 is hyperphosphorylated after DNA damage (11, 17).
		BRCA1 is hyperphosphorylated in response to DNA damage (11, 17)
		of BRCA1 is associated with the centrosome during mitosis (12).
	cancerres.aacrjournals.org /cgi/content/full/62/22/6357 (3057 words)

	NEJM -- Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations
		Background Data concerning the efficacy of bilateral prophylactic oophorectomy for reducing the risk of gynecologic cancer in women with BRCA1 or BRCA2 mutations are limited.
		Methods A total of 551 women with disease-associated germ-line BRCA1 or BRCA2 mutations were identified from registries and studied for the occurrence of ovarian and breast cancer.
		Of 99 women who underwent bilateral prophylactic oophorectomy and who were studied to determine the risk of breast cancer, breast cancer developed in 21 (21.2 percent), as compared with 60 (42.3 percent) in the control group (hazard ratio, 0.47; 95 percent confidence interval, 0.29 to 0.77).
	content.nejm.org /cgi/content/abstract/NEJMoa012158v1 (2378 words)

	Genomics\|HuGENet\|eJournal\|Breast cancer, tamoxifen, BRCA1 & BRCA2
		Based on this result for BRCA1 carriers, the authors clarify that it is unclear whether tamoxifen use at a younger age would reduce breast cancer incidence among healthy women who have BRCA1 mutations.
		Currently, screening the general population for BRCA1 and BRCA2 mutations for breast cancer is not recommended (1).
		In the context of studies that examine the treatment of breast cancer and identify BRCA1 and BRCA2 mutations as susceptibility genes, King et al.
	www.cdc.gov /genomics/hugenet/ejournal/tamoxBRC.htm (617 words)

	BRCA1 at a branch point -- Parvin 98 (11): 5952 -- Proceedings of the National Academy of Sciences
		The role for BRCA1 in the maintenance in the genome was first suggested by experiments in which cells were stained by using
		The BRCA1 foci colocalize with Rad51 or with Rad50
		BRCA1 has also been found associated with the MRN complex (4).
	www.pnas.org /cgi/content/full/98/11/5952 (2101 words)

	JAMA -- Abstract: Frequency of Breast Cancer Attributable to BRCA1 in a Population-Based Series of American Women, ... (Site not responding. Last check: 2007-09-19)
		JAMA -- Abstract: Frequency of Breast Cancer Attributable to BRCA1 in a Population-Based Series of American Women, March 25, 1998, Newman et al.
		Conclusions.— These data suggest that in the general US population, widespread screening of BRCA1 is not warranted.
		BRCA1 is associated with the centrosome during mitosis
	jama.ama-assn.org /cgi/content/abstract/279/12/915 (1082 words)

	Estrogens, BRCA1, and Breast Cancer -- Hilakivi-Clarke 60 (18): 4993 -- Cancer Research
		cancer (76, 77, 78), and Brca1 is up-regulated at puberty (26).
		Spillman M., Bowcock A. BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen.
		Chen Y., Farmer A., Chen C-F., Jones D., Chen P-L., Lee W-H. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.
	cancerres.aacrjournals.org /cgi/content/full/60/18/4993 (8206 words)

	BRCA1/2 Genetic Testing in the Community Setting -- Chen et al. 20 (22): 4485 -- Journal of Clinical Oncology (Site not responding. Last check: 2007-09-19)
		BRCA1 AND BRCA2, the high-penetrance genes for hereditary cancers
		Syrjakoski K, Vahteristo P, Eerola H, et al: Population-based study of BRCA1 and BRCA2 mutations in 1035 unselected Finnish breast cancer patients.
		Meijers-Heijboer EJ, Verhoog LC, Brekelmans CT, et al: Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation.
	www.jco.org /cgi/content/full/20/22/4485 (4623 words)

	World's largest population study on BRCA1/2
		The largest population study ever done into the risk of cancer in families that fulfil the criteria for BRCA1 and BRCA2 mutation testing has confirmed that breast and ovarian cancers are the major concerns for geneticists and doctors counselling families.
		It has also verified that families eligible for BRCA1/2 mutation testing are at increased risk of pancreatic, prostate and stomach cancers.
		Risk of cancer at sites other than the breast in Swedish families eligible for BRCA1 or BRCA2 mutation testing.
	www.eurekalert.org /pub_releases/2004-11/esfm-wlp111204.php (635 words)

	SNP's linked from GeneView (Site not responding. Last check: 2007-09-19)
		SNP's are linked from Locus BRCA1 via the following methods:
		Lys [K] Variations in genomic region of BRCA1
		This is will turn off the view of snp in Contig Annotation.
	www.ncbi.nlm.nih.gov /SNP/snp_ref.cgi?locusId=672 (49 words)

	Genatlas sheet
		two evolutionarily conserved noncoding sequences (CNS1 and 2) in intron 2, 5 kb downstream of the core BRCA1 promoter, having differential transcriptional regulatory activity in epithelial cell lines
		transactivating CDKN1B,may be a mechanism for BRCA1 growth inhibition
		potentiated by binding JUNB to one of the transactivation domain of BRCA1
	www.dsi.univ-paris5.fr /genatlas/fiche.php?symbol=BRCA1 (378 words)

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