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Topic: Bzip domain

	The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions (Site not responding. Last check: 2007-10-15)
		Chimeras with the Fos transcription activation domain fused on the amino- and carboxy-terminal sides of the bZIP domains are indicated by diamonds and squares respectively.
		Chimeras with the Jun transcription activation domain fused on the amino- and carboxy-terminal sides of the bZIP domains are indicated by triangles and circles respectively.
		The DNA bends induced by the transcription activation domains in heterodimers formed by the chimeric proteins were deduced based on the hypothesis that they contribute to DNA bending that is independent of the bZIP domains.
	www.nature.com /emboj/journal/v16/n10/fig_tab/7590272f5.html (466 words)

	The role of helix stabilizing residues in GCN4 basic region folding and DNA binding -- Hollenbeck et al. 11 (11): 2740 ...
		GCN4 bZip domain in the absence of DNA.
		the Asp-Pro dipeptide at the N-terminus of the bZip domain stabilizes
		Landschulz, W.H., Johnson, P.F., and McKnight, S.L. The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite.
	www.proteinscience.org /cgi/content/full/11/11/2740 (4365 words)

	RF2a, a bZIP transcriptional activator of the phloem-specific rice tungro bacilliform virus promoter, functions in ...
		Figure 1 Predicted amino acid sequence and domain structure of RF2a.
		(A) Deduced amino acid sequence of RF2a is shown with the bZIP domain boxed and the three potential activation domains, the proline-rich, acidic and glutamine-rich domains, underlined.
		The RF2a bZIP domain was aligned with PosF21 (Aeschbacher et al., 1991), VSF-1 (Torres-Schumann et al., 1996) and other bZIP proteins (summarized by Hurst, 1994).
	www.nature.com /emboj/journal/v16/n17/fig_tab/7590500ft.html (1187 words)

	REPRESSION OF SHOOT GROWTH, a bZIP Transcriptional Activator, Regulates Cell Elongation by Controlling the Level of ...
		P-labeled DNA fragment corresponding to the bZIP domain of RSG.
		Yeast cells HF7c were simultaneously transformed with a plasmid expressing a GAL4 DNA binding domain fused to the bZIP domain of RSG and with plasmids expressing the GAL4 activation domain fused to the bZIP domains of the indicated RSG, VLP (a RSG-related protein), TGA1a, TAF1, GBF1, HY5, or a control vector.
		The sequence of the bZIP domain of RSG exhibited considerable
	www.plantcell.org /cgi/content/full/12/6/901 (7577 words)

	Dept. of Biochemistry Publications 1998
		Using domain deletion mutants we localized the NgCAM hemophilic binding in the Ig domains 1-4 whereas heterophilic binding to axonin-1 was localized in the Ig domains 2-4 and the third FnIII domain.
		Bispecific miniantibodies were constructed by genetically fusing the C(H)1 domain of an IgG1 to the C-terminus of a single-chain Fv fragment (scFv-425), specific for the EGF receptor, and fusing the C(L) domain of a kappa light chain to the C-terminus of a scFv specific for CD2 (scFv-M1).
		The beta-sandwich structure of immunoglobulin variable domains is characterized by a typical kink in the first strand, which allows the first part of the strand to hydrogen bond to the outer beta-sheet (away from the VH-VL interface) and the second part to the inner beta-sheet.
	www.biochem.unizh.ch /publications/1998/abstracts/pub1998.html (11187 words)

	The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions -- Kerppola ... (Site not responding. Last check: 2007-10-15)
		Furthermore, whereas the bZIP domains of Fos and Jun
		domains of Fos (FA) and Jun (JA) fused to the bZIP domains of
		Leonard, D.A., Rajaram, N. and Kerppola, T.K. Structural basis of DNA bending and oriented heterodimer binding by the bZIP domains of Fos and Jun. Proc.
	embojournal.npgjournals.com /cgi/content/full/16/10/2907 (7075 words)

	The alpha -Helical D1 Domain of the Tobacco bZIP Transcription Factor BZI-1 Interacts with the Ankyrin-repeat Protein ...
		The alpha -Helical D1 Domain of the Tobacco bZIP Transcription Factor BZI-1 Interacts with the Ankyrin-repeat Protein ANK1 and Is Important for BZI-1 Function, Both in Auxin Signaling and Pathogen Response -- Kuhlmann et al.
		The Protein Domains N, BD, and D1 Are Important for BZI-1 Transcription Factor Function in Planta-- Conserved protein domains have been defined in BZI-1-related proteins by means of amino acid (aa) homology (1).
		The BD domain is important for DNA-binding and is involved in nuclear localization.
	www.jbc.org /cgi/content/full/278/10/8786 (4620 words)

	How mammalian transcriptional repressors work -- Thiel et al. 271 (14): 2855 -- FEBS Journal (Site not responding. Last check: 2007-10-15)
		The evolutionarily conserved 60-amino acid chromo domain is a structural component of nuclear proteins involved in remodelling of the chromatin structure and serves as a versatile protein interaction module.
		The chromo domain of HP1 proteins is required for the high-affinity binding to histone H3 tails methylated on Lys9 (H3mLys9).
		The SET domain, named after the proteins Su(var)3–9, Enhancer of zeste and Trithorax, in which this domain was orginally found, is evolutionary conserved from yeast to mammals and is found in proteins that function as ‘chromatin modulators’.
	content.febsjournal.org /cgi/content/full/271/14/2855 (4547 words)

	Plant Gene Register PGR95-078 (Site not responding. Last check: 2007-10-15)
		Basic leucine zipper (bZIP) and basic helix-loop-helix (HLH) are leucine zipper-containing transcriptional regulators which have an important role in the regulation of gene expression in diverse eukaryotic species ranging from mammals to higher plants (Lamb & McKnight, 1991; Katagiri & Chua, 1992).
		Acidic domains are present in many transcriptional factors and have activation activities (Ptshne and Gann, 1990).
		The presence of the two potential leucine zipper domain in 9L implies that it may form heterodimer with other protein factors, such as bZIP and HLH classes of transcriptional factors, and regulate gene expression.
	www.tarweed.com /pgr/PGR95-078.html (827 words)

	Domain disruption and mutation of the bZIP transcription factor, MAF,associated with cataract, ocular anterior segment ...
		Domain disruption and mutation of the bZIP transcription factor, MAF,associated with cataract, ocular anterior segment dysgenesis and coloboma -- Jamieson et al.
		Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma
		domain, the cosegregation of the R288P mutation with the disease
	hmg.oupjournals.org /cgi/content/full/11/1/33 (5760 words)

	A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain -- ...
		The bZIP domain of c/ebp1 was between 26% and 50% identical and
		An "attenuator domain" is sandwiched by two distinct transactivation domains in the transcription factor C/EBP.
		Transactivation of LAP/NF-IL6 is mediated by an acidic domain in the N-terminal part of the protein.
	www.bloodjournal.org /cgi/content/full/97/9/2611 (4864 words)

	The orientation of the AP-1 heterodimer on DNA strongly affects transcriptional potency -- Chytil et al. 95 (24): 14076 ...
		The bZip domains of Fos (residues 134-200, preceded by a N-terminal Cys) and Jun (residues 258-324, preceded by a N-terminal
		domain only onto Fos, which is incapable of homodimerizing (19).
		The level of transcription activation is dependent on the strength or speed of interaction between the activation domain and the transcriptional apparatus, which is influenced by the stereochemistry of the protein-DNA complex.
	www.pnas.org /cgi/content/full/95/24/14076 (3970 words)

	The loss of circadian PAR bZip transcription factors results in epilepsy -- Gachon et al. 18 (12): 1397 -- Genes and ...
		Temporal expression of mRNAs encoding PAR bZip transcription factors and clock proteins in mouse liver and brain.
		The transcription of the pyridoxal kinase gene (Pdxk) is regulated by PAR bZip transcription factors.
		Accordingly, target genes of PAR bZip transcription factors, such as Pdxk, are expressed in a strongly circadian manner in liver and at nearly constant levels in the brain.
	www.genesdev.org /cgi/content/full/18/12/1397 (8222 words)

	An Exposed KID-Like Domain in Human T-Cell Lymphotropic Virus Type 1 Tax Is Responsible for the Recruitment of ...
		Purified Tax, GST-CREB bZip, and p300 were used in EMSAs together with a DNA probe containing the HTLV-1 21-bp repeat (A) or a CRE with nonspecific neighboring sequences (B) as detailed previously (38).
		A minor band which migrated between the 2° and 3° complexes (A, lanes 3 and 4; B, lanes 2 to 5) is due to an aggregated form of CREB bZip which possibly originated from the formation of a disulfide linkage between bZip moieties.
		The domain organization of Tax is tentatively outlined, with specific landmarks such as the protease-sensitive sites and the M22 and M47 mutations indicated.
	mcb.asm.org /cgi/content/full/18/9/5052 (8004 words)

	Characterization of Human Activating Transcription Factor 4, a Transcriptional Activator That Interacts with Multiple ...
		Because the DNA binding domain of hATF4 resides at its C terminus, deletion of this region would render the rest of the molecule
		We examined two domains: the KIX domain and the C/H3 domain.
		C/H3 region, the C-terminal region, and the HAT domain.
	www.jbc.org /cgi/content/full/272/38/24088 (5964 words)

	PPL Vol. 6, No. 2 (Site not responding. Last check: 2007-10-15)
		The conformational analyses of leucine zipper domain showed high consistency to the solution structure obtained from NMR spectroscopy [2].
		The basic domain of homodimer exhibited a Gaussian distributed inter-domain wagging motion.
		Constant wagging motion of the basic domain was proposed to "grope" for DNA major grooves to recognize a specific sequence.
	www.bentham.org /ppl/ppl6-2.html (840 words)

	FUNCTIONAL RELATIONSHIP BETWEEN AMINO ACID RESIDUES AT N- AND C-TERMINI OF DNA-BINDING REGIONS OF TRANSCRIPTION FACTORS ... (Site not responding. Last check: 2007-10-15)
		The highest correlations were observed for the pairs formed by positions 227-229 at the N-terminus and 248-251 at the C-terminus of the domain (alignment positions are numbered according to protein GCN4; Fig.
		Since the value of isoelectric point characterizes the charge of amino acids, it is reasonable to suggest that such dependence stem from the electrostatic interactions of the residues in the groups of positions considered.
		This suggestion is supported by the data on mutations in the bZIP domains of proteins CRE-BP1 and GCN4 [8].
	www.bionet.nsc.ru /bgrs/thesis/106 (1310 words)

	bZIP proteins of human gammaherpesviruses -- Sinclair 84 (8): 1941 -- Journal of General Virology
		The large fl oval represents the transactivation domain located at the N terminus.
		Francis, A. L., Gradoville, L. and Miller, G. Alteration of a single serine in the basic domain of the Epstein–Barr virus ZEBRA protein separates its functions of transcriptional activation and disruption of latency.
		Zerby, D., Chen, C. J., Poon, E., Lee, D., Shiekhattar, R. and Lieberman, P. The amino-terminal C/H1 domain of CREB binding protein mediates Zta transcriptional activation of latent Epstein–Barr virus.
	vir.sgmjournals.org /cgi/content/full/84/8/1941 (5047 words)

	AP-1 subunits: quarrel and harmony among siblings -- Hess et al. 117 (25): 5965 -- Journal of Cell Science
		The bZIP domain of Jun is shown in blue and the bZIP domain of Fos in red.
		The Jun and Fos proteins exhibit several domains, including the bZIP domain (leucine zipper plus basic domain), transactivation domains and docking sites for several kinases, such as JNK or ERK.
		JNK specifically phosphorylates serine residues within the transactivation domain of Jun at position 63 and 73 and thereby regulates its transactivation activity.
	jcs.biologists.org /cgi/content/full/117/25/5965 (5691 words)

	The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor -- Finkelstein and ...
		The basic domain and leucine repeats of the bZIP domain are double underlined, possible kinase recognition sites are single underlined, the position of the nested primer used for rapid amplification of cDNA ends is indicated by dashes, and the locations of poly(A) tracts in three independent cDNAs are indicated by carets.
		The leucine zipper domain of bZIP proteins is involved in dimerization,
		Luerssen, H., Kirik, V., Herrmann, P., and Misera, S. encodes a protein with a conserved VP1/ABI3–like B3 domain which is of functional importance for the regulation of seed maturation in Arabidopsis thaliana.
	www.plantcell.org /cgi/content/full/12/4/599 (6779 words)

	Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus.
		We report here the identification in the KSHV genome of a gene for a protein designated K-bZIP and belonging to the basic-leucine zipper (bZIP) family of transcription factors.
		K-bZIP is a homodimerizing protein of 237 amino acids with a prototypic bZIP domain at the C terminus.
		Full-length K-bZIP forms dimers with itself, and the C terminus encompassing the ZIP domain is required for this process.
	www.aegis.com /aidsline/1999/may/A9950824.html (524 words)

	Lecture 34 (Site not responding. Last check: 2007-10-15)
		DNA-binding domain interacts with specific promoter/enhancer sequence and activator domain of same protein promotes transcription
		structure and sequences of activator domains are not conserved
		Helix-turn-helix structure + extra N-terminal domain that binds major groove of DNA (Fig.
	uwp.edu /~higgs/Lect34mb.html (348 words)

	Kerppola Lab Research
		Thus, DNA recognition by some bZIP family members involves protein regions in addition to the bZIP domain.
		Heterodimers formed between different bZIP family members differ in both their DNA binding selectivity and in their interactions with other transcription factors.
		The inhibition of DNA binding and transcription activation results from a direct interaction between the zinc finger DNA binding domain of GR and the transcription activation domain of Fos.
	www.umich.edu /~hhmi/research.html (726 words)

	Thermodynamic Characterization of the Folding Coupled DNA Binding by the Monomeric Transcription Activator GCN4 Peptide ...
		Diffusion-controlled DNA recognition by an unfolded, monomeric bZIP transcription factor.
		Weiss, M. Thermal unfolding studies of a leucine zipper domain and its specific DNA complex: implications for scissor's grip recognition.
		Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA.
	www.biophysj.org /cgi/content/full/84/3/1867 (4497 words)

	Plant bZIP G-box binding factors. : Modular structure and activation mechanisms -- Sibéril et al. 268 (22): 5655 ... (Site not responding. Last check: 2007-10-15)
		Metallo, S.J. and Schepartz, A. (1997) Certain bZIP peptides bind DNA sequentially as monomers and dimerize on the DNA.
		Varagona, M.J. and Raikhel, N.V. (1994) The basic domain in the bZIP regulatory protein Opaque2 serves two independent functions: DNA binding and nuclear localization.
		Mermod, N., Oneill, E.A., Kelly, T.J. and Tjian, R. (1989) The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication DNA binding domain.
	www.ejbiochem.org /cgi/content/full/268/22/5655 (7350 words)

	AIbZIP, a Novel bZIP Gene Located on Chromosome 1q21.3 That Is Highly Expressed in Prostate Tumors and of Which the ... (Site not responding. Last check: 2007-10-15)
		AIbZIP, a Novel bZIP Gene Located on Chromosome 1q21.3 That Is Highly Expressed in Prostate Tumors and of Which the Expression Is Up-Regulated by Androgens in LNCaP Human Prostate Cancer Cells -- Qi et al.
		AIbZIP, a Novel bZIP Gene Located on Chromosome 1q21.3 That Is Highly Expressed in Prostate Tumors and of Which the Expression Is Up-Regulated by Androgens in LNCaP Human Prostate Cancer Cells
		The relative positions of the basic region, putative transmembrane domains (TMD), and leucine (L) and cysteine (C) residues of the leucine zipper are indicated.
	cancerres.aacrjournals.org /cgi/content/full/62/3/721 (8895 words)

	Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to ...
		In the N-terminal region is an acidic domain (underlined), rich in negatively charged amino acids.
		On the left is the schematic representation of the structure of the ZF protein.
		All bZIP proteins, except GA15 (or CHOP, GADD153 or DDIT3) and ZF, share a consensus quintet sequence, NXXAAXX(C/S)R (X stands for any amino acid), which is essential for DNA binding.
	nar.oxfordjournals.org /cgi/content/full/28/12/2446 (5671 words)

	The K-bZIP Protein from Kaposi's Sarcoma-Associated Herpesvirus Interacts with p53 and Represses Its Transcriptional ...
		fused to the leucine zipper domain (amino acids 190 to 237).
		Indicated are the positions of the transcriptional activation domain (TAD; amino acids 1 to 42), the DNA binding domain (DBD; amino acids 100 to 300), and the carboxy-terminal region (CT; amino acids 300 to 393).
		Indicated are the amino acid positions of the putative transcriptional activation domain (TAD; amino acids 1 to 121), the putative DNA binding domain (DBD; amino acids 122 to 189), and the leucine zipper domain (ZIP; amino acids 190 to 237).
	jvi.asm.org /cgi/content/full/74/24/11977 (3580 words)

	The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth -- Szuplewski et al. 130 (16): 3651 ...
		The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth -- Szuplewski et al.
		Du, W. Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain.
		George, H. and Terracol, R. The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors.
	dev.biologists.org /cgi/content/full/130/16/3651 (7147 words)

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